Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells

Aging Cell

Volumn 13, Issue 4, 2014, Pages 744-754

  Khoo, Melissa L M ^a   Carlin, Stephen M ^a   Lutherborrow, Mark A ^a   Jayaswal, Vivek ^b,c   Ma, David D F ^a   Moore, John J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Aging; Cellular immunology; Gene expression; Human; Molecular biology of aging; Mononuclear cells; T cell

Indexed keywords

BETA CATENIN; CD34 ANTIGEN; CD7 ANTIGEN; LYMPHOID ENHANCER FACTOR 1; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTOME;

ADULT; AGE; AGED; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL LOSS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE ONTOLOGY; GENE TARGETING; GENETIC ASSOCIATION; HEMATOPOIETIC STEM CELL; HUMAN; IN VITRO STUDY; PRE T LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; UMBILICAL CORD BLOOD; UPREGULATION; WNT SIGNALING PATHWAY; AGING; CELL CULTURE; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; REAL TIME POLYMERASE CHAIN REACTION; YOUNG ADULT;

ADULT; AGING; BETA CATENIN; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIETIC STEM CELLS; HUMANS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TRANSCRIPTOME; WNT SIGNALING PATHWAY; YOUNG ADULT;

EID: 84904967098     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12229     Document Type: Article

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