Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway

Molecular and Cellular Endocrinology

Volumn 419, Issue , 2016, Pages 1-11

  Al Lahham, Rabab ^a   Deford, James H ^a   Papaconstantinou, John ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

AKT PKB; GSK3 ; IRS 1; Mitochondrial dysfunction; P38MAPK; Serine phosphorylation

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; COLLAGENASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; ROTENONE; SERINE; SERINE 473; UNCLASSIFIED DRUG; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; IMIDAZOLE DERIVATIVE; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, MOUSE; PYRIDINE DERIVATIVE; TRANSCRIPTOME;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; INSULIN RESISTANCE; MALE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; STRESS; WESTERN BLOTTING; YOUNG ADULT; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; LIVER CELL; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; HEPATOCYTES; IMIDAZOLES; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MITOCHONDRIA; PHOSPHORYLATION; PYRIDINES; REACTIVE OXYGEN SPECIES; ROTENONE; TRANSCRIPTOME;

EID: 84949604431     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.09.013     Document Type: Article

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