메뉴 건너뛰기




Volumn 8, Issue 2, 2006, Pages 136-145

Reactive species and early manifestation of insulin resistance in type 2 diabetes

Author keywords

Adipocytes; Insulin; Lipids; Mitochondria; Muscle; Oxidative stress

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; GLUTATHIONE; INSULIN; LIPID; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; REACTIVE OXYGEN METABOLITE; SALICYLIC ACID DERIVATIVE; THIOCTIC ACID;

EID: 33646036739     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2005.00496.x     Document Type: Review
Times cited : (136)

References (71)
  • 1
    • 0001788324 scopus 로고    scopus 로고
    • Insulin resistance and its consequences: Type 2 diabetes mellitus and coronary heart disease
    • LeRoith D, Taylor SI, Olefsky JM, eds. Philadelphia: Lippincott Williams & Wilkins
    • Reaven GM. Insulin resistance and its consequences: Type 2 diabetes mellitus and coronary heart disease. In: LeRoith D, Taylor SI, Olefsky JM, eds. Diabetes Mellitus: A Fundamental and Clinical Text. Philadelphia: Lippincott Williams & Wilkins 2000, 604-615.
    • (2000) Diabetes Mellitus: A Fundamental and Clinical Text , pp. 604-615
    • Reaven, G.M.1
  • 2
    • 0035856943 scopus 로고    scopus 로고
    • Diabetes mellitus and genetically programmed defects in beta-cell function
    • Bell GI, Polonsky KS. Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 2001; 414: 788-791.
    • (2001) Nature , vol.414 , pp. 788-791
    • Bell, G.I.1    Polonsky, K.S.2
  • 3
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003; 46: 3-19.
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 4
    • 0041833732 scopus 로고    scopus 로고
    • Insulin resistance: From predisposing factor to therapeutic target in type 2 diabetes
    • Henry RR. Insulin resistance: From predisposing factor to therapeutic target in type 2 diabetes. Clin Ther 2003; 25 (Suppl. B): B47-B63.
    • (2003) Clin Ther , vol.25 , Issue.SUPPL. B
    • Henry, R.R.1
  • 5
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
    • Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes. Endocr Rev 2002; 23: 599-622.
    • (2002) Endocr Rev , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 6
    • 0034939115 scopus 로고    scopus 로고
    • The role of oxidative stress in the onset and progression of diabetes and its complications: A summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society
    • Rosen P, Nawroth PP, King G, Moller W, Tritschler HJ, Packer L. The role of oxidative stress in the onset and progression of diabetes and its complications: A summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev 2001; 17: 189-212.
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 189-212
    • Rosen, P.1    Nawroth, P.P.2    King, G.3    Moller, W.4    Tritschler, H.J.5    Packer, L.6
  • 7
    • 0842328003 scopus 로고    scopus 로고
    • Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
    • Green K, Brand MD, Murphy MP. Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes 2004; 53 (Suppl.): S110-S118.
    • (2004) Diabetes , vol.53 , Issue.SUPPL.
    • Green, K.1    Brand, M.D.2    Murphy, M.P.3
  • 8
    • 2342517248 scopus 로고    scopus 로고
    • Role of oxidative stress in pancreatic beta-cell dysfunction
    • Kajimoto Y, Kaneto H. Role of oxidative stress in pancreatic beta-cell dysfunction. Ann N Y Acad Sci 2004; 1011: 168-176.
    • (2004) Ann N Y Acad Sci , vol.1011 , pp. 168-176
    • Kajimoto, Y.1    Kaneto, H.2
  • 9
    • 0029030073 scopus 로고
    • Antioxidant characterization. Methodology mechanism
    • Halliwell B. Antioxidant characterization. Methodology mechanism. Biochem Pharmacol 1995; 49: 1341-1348.
    • (1995) Biochem Pharmacol , vol.49 , pp. 1341-1348
    • Halliwell, B.1
  • 11
    • 10744222060 scopus 로고    scopus 로고
    • Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects
    • Deng S, Vatamaniuk M, Huang X et al. Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 2004; 53: 624-632.
    • (2004) Diabetes , vol.53 , pp. 624-632
    • Deng, S.1    Vatamaniuk, M.2    Huang, X.3
  • 12
    • 3242789423 scopus 로고    scopus 로고
    • Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells
    • Fridlyand LE, Philipson LH. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells. Diabetes 2004; 53: 1942-1948.
    • (2004) Diabetes , vol.53 , pp. 1942-1948
    • Fridlyand, L.E.1    Philipson, L.H.2
  • 13
    • 0028809238 scopus 로고
    • Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
    • Rothman DL, Magnusson I, Cline G et al. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1995; 92: 983-987.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 983-987
    • Rothman, D.L.1    Magnusson, I.2    Cline, G.3
  • 14
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004; 350: 664-671.
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 15
    • 0141727767 scopus 로고    scopus 로고
    • N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: Possible role of oxidative stress
    • Haber CA, Lam TK, YuZ et al. N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: Possible role of oxidative stress. Am J Physiol Endocrinol Metab 2003; 285: E744-E753.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Haber, C.A.1    Lam, T.K.2    Yu, Z.3
  • 16
    • 2542505624 scopus 로고    scopus 로고
    • Effect of thiol antioxidant on body fat and insulin reactivity
    • Hildebrandt W, Hamann A, Krakowski-Roosen H et al. Effect of thiol antioxidant on body fat and insulin reactivity. J Mol Med 2004; 82: 336-344.
    • (2004) J Mol Med , vol.82 , pp. 336-344
    • Hildebrandt, W.1    Hamann, A.2    Krakowski-Roosen, H.3
  • 17
    • 0037026745 scopus 로고    scopus 로고
    • Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus
    • Petersen KF, Shulman GI. Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am J Cardiol 2002; 90: 11G-18G.
    • (2002) Am J Cardiol , vol.90
    • Petersen, K.F.1    Shulman, G.I.2
  • 18
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and beta-cell dysfunction
    • Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 2002; 32 (Suppl. 3): 14-23.
    • (2002) Eur J Clin Invest , vol.32 , Issue.SUPPL. 3 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 19
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD. Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002; 51: 7-18.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 20
    • 0032749848 scopus 로고    scopus 로고
    • Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms
    • Skulachev VP. Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms. Mol Aspects Med 1999; 20: 139-184.
    • (1999) Mol Aspects Med , vol.20 , pp. 139-184
    • Skulachev, V.P.1
  • 21
    • 0036420517 scopus 로고    scopus 로고
    • How mitochondrial damage affects cell function
    • James AM, Murphy MP. How mitochondrial damage affects cell function. J Biomed Sci 2002; 9: 475-487.
    • (2002) J Biomed Sci , vol.9 , pp. 475-487
    • James, A.M.1    Murphy, M.P.2
  • 22
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 2003; 552: 335-344.
    • (2003) J Physiol , vol.552 , pp. 335-344
    • Turrens, J.F.1
  • 23
    • 0030670765 scopus 로고    scopus 로고
    • Membrane-linked systems preventing superoxide formation
    • Skulachev VP. Membrane-linked systems preventing superoxide formation. Biosci Rep 1997; 17: 347-366.
    • (1997) Biosci Rep , vol.17 , pp. 347-366
    • Skulachev, V.P.1
  • 24
    • 50549202600 scopus 로고
    • The glucose fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1: 785-789.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 25
    • 0025126555 scopus 로고
    • Role of free radicals and catalytic metal ions in human disease: An overview
    • Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: An overview. Methods Enzymol 1990; 186: 1-85.
    • (1990) Methods Enzymol , vol.186 , pp. 1-85
    • Halliwell, B.1    Gutteridge, J.M.2
  • 26
    • 0034643340 scopus 로고    scopus 로고
    • Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
    • Nishikawa T, Du Edelstein D, XL et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000; 404: 787-790.
    • (2000) Nature , vol.404 , pp. 787-790
    • Nishikawa, T.1    Du Edelstein, D.2
  • 27
    • 0042804808 scopus 로고    scopus 로고
    • Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice
    • Talior I, Yarkoni M, Bashan N, Eldar-Finkelman H. Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice. Am J Physiol Endocrinol Metab 2003; 285: E295-E302.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Talior, I.1    Yarkoni, M.2    Bashan, N.3    Eldar-Finkelman, H.4
  • 28
    • 0038061012 scopus 로고    scopus 로고
    • A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
    • Negre-Salvayre A, Hirtz C, Carrera G et al. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J 1997; 11: 809-815.
    • (1997) FASEB J , vol.11 , pp. 809-815
    • Negre-Salvayre, A.1    Hirtz, C.2    Carrera, G.3
  • 29
    • 0036192111 scopus 로고    scopus 로고
    • Uncoupling protein-2: Evidence for its function as a metabolic regulator
    • Saleh MC, Wheeler MB, Chan CB. Uncoupling protein-2: Evidence for its function as a metabolic regulator. Diabetologia 2002; 45: 174-187.
    • (2002) Diabetologia , vol.45 , pp. 174-187
    • Saleh, M.C.1    Wheeler, M.B.2    Chan, C.B.3
  • 30
    • 1442349997 scopus 로고    scopus 로고
    • Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death
    • Vincent AM, Olzmann JA, Brownlee M, Sivitz WI, Russell JW. Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death. Diabetes 2004; 53: 726-734.
    • (2004) Diabetes , vol.53 , pp. 726-734
    • Vincent, A.M.1    Olzmann, J.A.2    Brownlee, M.3    Sivitz, W.I.4    Russell, J.W.5
  • 31
    • 2542593338 scopus 로고    scopus 로고
    • Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes
    • Schrauwen P, Hesselink MK. Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 2004; 53: 1412-1417.
    • (2004) Diabetes , vol.53 , pp. 1412-1417
    • Schrauwen, P.1    Hesselink, M.K.2
  • 32
    • 0037251789 scopus 로고    scopus 로고
    • Live now-pay by ageing: High performance mitochondrial activity in youth and its age-related side effects
    • Hofhaus G, Berneburg M, Wulfert M, Gattermann N. Live now-pay by ageing: high performance mitochondrial activity in youth and its age-related side effects. Exp Physiol 2003; 88: 167-174.
    • (2003) Exp Physiol , vol.88 , pp. 167-174
    • Hofhaus, G.1    Berneburg, M.2    Wulfert, M.3    Gattermann, N.4
  • 33
    • 0032775523 scopus 로고    scopus 로고
    • Controlled distribution of electrons between acceptors in chloroplasts: A theoretical consideration
    • Fridlyand LE, Scheibe R. Controlled distribution of electrons between acceptors in chloroplasts: A theoretical consideration. Biochem Biophys Acta 1999; 1413: 31-42.
    • (1999) Biochem Biophys Acta , vol.1413 , pp. 31-42
    • Fridlyand, L.E.1    Scheibe, R.2
  • 34
    • 10344236432 scopus 로고    scopus 로고
    • Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes
    • Watson RT, Kanzaki M, Pessin JE. Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. Endocr Rev 2004; 25: 177-204.
    • (2004) Endocr Rev , vol.25 , pp. 177-204
    • Watson, R.T.1    Kanzaki, M.2    Pessin, J.E.3
  • 35
    • 0033579515 scopus 로고    scopus 로고
    • Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways
    • Blair AS, Hajduch E, Litherland GJ, Hundal HS. Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways. J Biol Chem 1999; 274: 36293-36299.
    • (1999) J Biol Chem , vol.274 , pp. 36293-36299
    • Blair, A.S.1    Hajduch, E.2    Litherland, G.J.3    Hundal, H.S.4
  • 37
    • 1442300773 scopus 로고    scopus 로고
    • UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction
    • Han DH, Nolte LA, Ju JS, Coleman T, Holloszy JO, Semenkovich CF. UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. Am J Physiol Endocrinol Metab 2004; 286: E347-E353.
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Han, D.H.1    Nolte, L.A.2    Ju, J.S.3    Coleman, T.4    Holloszy, J.O.5    Semenkovich, C.F.6
  • 38
    • 0038547023 scopus 로고    scopus 로고
    • Metabolic and molecular basis of insulin resistance
    • Bajaj M, Defronzo RA. Metabolic and molecular basis of insulin resistance. J Nucl Cardiol 2003; 10: 311-323.
    • (2003) J Nucl Cardiol , vol.10 , pp. 311-323
    • Bajaj, M.1    Defronzo, R.A.2
  • 39
    • 0029744885 scopus 로고    scopus 로고
    • Sounding the alarm: Protein kinase cascades activated by stress and inflammation
    • Kyriakis JM, Avruch J. Sounding the alarm: Protein kinase cascades activated by stress and inflammation. J Biol Chem 1996; 271: 24313-24316.
    • (1996) J Biol Chem , vol.271 , pp. 24313-24316
    • Kyriakis, J.M.1    Avruch, J.2
  • 40
    • 0037219409 scopus 로고    scopus 로고
    • Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
    • Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003; 52: 1-8.
    • (2003) Diabetes , vol.52 , pp. 1-8
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 41
    • 0034794965 scopus 로고    scopus 로고
    • Turning down insulin signaling
    • Birnbaum MJ. Turning down insulin signaling. J Clin Invest 2001; 108: 655-659.
    • (2001) J Clin Invest , vol.108 , pp. 655-659
    • Birnbaum, M.J.1
  • 42
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994; 93: 2438-2446.
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 43
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, Chen Y, Cline GW et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002; 277: 50230-50236.
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3
  • 44
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 2002; 51: 2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 45
    • 0842328975 scopus 로고    scopus 로고
    • Reduced skeletal muscle oxygen uptake and reduced beta-cell function: Two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes
    • Thamer C, Stumvoll M, Niess A et al. Reduced skeletal muscle oxygen uptake and reduced beta-cell function: Two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes. Diabetes Care 2003; 26: 2126-2132.
    • (2003) Diabetes Care , vol.26 , pp. 2126-2132
    • Thamer, C.1    Stumvoll, M.2    Niess, A.3
  • 46
    • 0035083645 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity
    • He J, Watkins S, Kelley DE. Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes 2001; 50: 817-823.
    • (2001) Diabetes , vol.50 , pp. 817-823
    • He, J.1    Watkins, S.2    Kelley, D.E.3
  • 47
    • 0032752951 scopus 로고    scopus 로고
    • Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss
    • Simoneau JA, Veerkamp JH, Turcotte LP, Kelley DE. Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss. FASEB J 1999; 13: 2051-2060.
    • (1999) FASEB J , vol.13 , pp. 2051-2060
    • Simoneau, J.A.1    Veerkamp, J.H.2    Turcotte, L.P.3    Kelley, D.E.4
  • 48
    • 0035345532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance
    • Kelley DE, Goodpaster BH. Skeletal muscle triglyceride. An aspect of regional adiposity and insulin resistance. Diabetes Care 2001; 24: 933-941.
    • (2001) Diabetes Care , vol.24 , pp. 933-941
    • Kelley, D.E.1    Goodpaster, B.H.2
  • 49
    • 1442326017 scopus 로고    scopus 로고
    • Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: Evidence from cultured myotubes
    • Gaster M, Rustan AC, Aas V, Beck-Nielsen H. Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes. Diabetes 2004; 53: 542-548.
    • (2004) Diabetes , vol.53 , pp. 542-548
    • Gaster, M.1    Rustan, A.C.2    Aas, V.3    Beck-Nielsen, H.4
  • 50
    • 0031004167 scopus 로고    scopus 로고
    • Increased prevalence of mitochondrial DNA deletions in skeletal muscle of older individuals with impaired glucose tolerance
    • Liang P, Hughes V, Fukagwa NK. Increased prevalence of mitochondrial DNA deletions in skeletal muscle of older individuals with impaired glucose tolerance. Diabetes 1997; 46: 920-923.
    • (1997) Diabetes , vol.46 , pp. 920-923
    • Liang, P.1    Hughes, V.2    Fukagwa, N.K.3
  • 51
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002; 51: 2944-2950.
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 52
    • 0033499583 scopus 로고    scopus 로고
    • Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic beta-cells against glucose toxicity
    • Kaneto H, Kajimoto Y, Miyagawa J et al. Beneficial effects of antioxidants in diabetes: Possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 1999; 48: 2398-2406.
    • (1999) Diabetes , vol.48 , pp. 2398-2406
    • Kaneto, H.1    Kajimoto, Y.2    Miyagawa, J.3
  • 53
    • 0033956846 scopus 로고    scopus 로고
    • The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of Western diet feeding
    • Kobayashi K, Forte TM, Taniguchi S, Ishida BY, Oka K, Chan L. The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of Western diet feeding. Metabolism 2000; 49: 22-31.
    • (2000) Metabolism , vol.49 , pp. 22-31
    • Kobayashi, K.1    Forte, T.M.2    Taniguchi, S.3    Ishida, B.Y.4    Oka, K.5    Chan, L.6
  • 54
    • 0035929553 scopus 로고    scopus 로고
    • Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4)
    • Lu B, Ennis D, Lai R et al. Enhanced sensitivity of insulin-resistant adipocytes to vanadate is associated with oxidative stress and decreased reduction of vanadate (+5) to vanadyl (+4). J Biol Chem 2001; 276: 35589-35598.
    • (2001) J Biol Chem , vol.276 , pp. 35589-35598
    • Lu, B.1    Ennis, D.2    Lai, R.3
  • 55
    • 0031683542 scopus 로고    scopus 로고
    • Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes
    • Rudich A, Tirosh A, Potashnik R, Hemi R, Kanety H, Bashan N. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes 1998; 47: 1562-1569.
    • (1998) Diabetes , vol.47 , pp. 1562-1569
    • Rudich, A.1    Tirosh, A.2    Potashnik, R.3    Hemi, R.4    Kanety, H.5    Bashan, N.6
  • 56
    • 0033537830 scopus 로고    scopus 로고
    • Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation
    • Tirosh A, Potashnik R, Bashan N, Rudich A. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation. J Biol Chem 1999; 274: 10595-10602.
    • (1999) J Biol Chem , vol.274 , pp. 10595-10602
    • Tirosh, A.1    Potashnik, R.2    Bashan, N.3    Rudich, A.4
  • 57
    • 0035787309 scopus 로고    scopus 로고
    • Nuclear magnetic resonance studies of hepatic glucose metabolism in humans
    • Roden M, Petersen KF, Shulman GI. Nuclear magnetic resonance studies of hepatic glucose metabolism in humans. Recent Prog Horm Res 2001; 56: 219-237.
    • (2001) Recent Prog Horm Res , vol.56 , pp. 219-237
    • Roden, M.1    Petersen, K.F.2    Shulman, G.I.3
  • 58
    • 0141839103 scopus 로고    scopus 로고
    • Novel concepts in insulin regulation of hepatic gluconeogenesis
    • Barthel A, Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 2003; 285: E685-E692.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Barthel, A.1    Schmoll, D.2
  • 60
    • 0042822096 scopus 로고    scopus 로고
    • Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism
    • Bruce CR, Carey AL, Hawley JA, Febbraio MA. Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. Diabetes 2003; 52: 2338-2345.
    • (2003) Diabetes , vol.52 , pp. 2338-2345
    • Bruce, C.R.1    Carey, A.L.2    Hawley, J.A.3    Febbraio, M.A.4
  • 61
    • 1842633862 scopus 로고    scopus 로고
    • Treatment of insulin resistance in diabetes mellitus
    • Lebovitz HE, Banerji MA. Treatment of insulin resistance in diabetes mellitus. Eur J Pharmacol 2004; 490: 135-146.
    • (2004) Eur J Pharmacol , vol.490 , pp. 135-146
    • Lebovitz, H.E.1    Banerji, M.A.2
  • 62
    • 0347927335 scopus 로고    scopus 로고
    • Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production
    • Midaoui AE, Elimadi A, Wu L, Haddad PS, de Champlain J. Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production. Am J Hypertens 2003; 16: 173-179.
    • (2003) Am J Hypertens , vol.16 , pp. 173-179
    • Midaoui, A.E.1    Elimadi, A.2    Wu, L.3    Haddad, P.S.4    de Champlain, J.5
  • 63
    • 0035140346 scopus 로고    scopus 로고
    • Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by micromolar concentrations of α-lipoic acid
    • Maddux BA, See W, Lawrence JC Jr, Goldfine AL, Goldfine ID, Evans JL. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by micromolar concentrations of α-lipoic acid. Diabetes 2001; 50: 404-410.
    • (2001) Diabetes , vol.50 , pp. 404-410
    • Maddux, B.A.1    See, W.2    Lawrence Jr., J.C.3    Goldfine, A.L.4    Goldfine, I.D.5    Evans, J.L.6
  • 64
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ
    • Yuan M, Konstantopoulos N, Lee J et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ. Science 2001; 293: 1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3
  • 65
    • 0036099857 scopus 로고    scopus 로고
    • Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
    • Hundal RS, Petersen KF, Mayerson AB et al. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 2002; 109: 1321-1326.
    • (2002) J Clin Invest , vol.109 , pp. 1321-1326
    • Hundal, R.S.1    Petersen, K.F.2    Mayerson, A.B.3
  • 66
    • 0037250915 scopus 로고    scopus 로고
    • Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis
    • Goffart S, Wiesner RJ. Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis. Exp Physiol 2003; 88: 33-40.
    • (2003) Exp Physiol , vol.88 , pp. 33-40
    • Goffart, S.1    Wiesner, R.J.2
  • 67
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • Kelly DP, Scarpulla RC. Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 2004; 18: 357-368.
    • (2004) Genes Dev , vol.18 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 68
    • 0037304599 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone
    • Wilson-Fritch L, Burkart A, Bell G et al. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol 2003; 23: 1085-1094.
    • (2003) Mol Cell Biol , vol.23 , pp. 1085-1094
    • Wilson-Fritch, L.1    Burkart, A.2    Bell, G.3
  • 69
    • 0346027235 scopus 로고    scopus 로고
    • Muscle-specific Pparg deletion causes insulin resistance
    • Hevener AL, He W, Barak Y et al. Muscle-specific Pparg deletion causes insulin resistance. Nat Med 2003; 9: 1491-1497.
    • (2003) Nat Med , vol.9 , pp. 1491-1497
    • Hevener, A.L.1    He, W.2    Barak, Y.3
  • 70
    • 0029849462 scopus 로고    scopus 로고
    • Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects
    • Perseghin G, Price TB, Petersen KF et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 1996; 335: 1357-1362.
    • (1996) N Engl J Med , vol.335 , pp. 1357-1362
    • Perseghin, G.1    Price, T.B.2    Petersen, K.F.3
  • 71
    • 0037247359 scopus 로고    scopus 로고
    • Plasticity of skeletal muscle mitochondria in response to contractile activity
    • Adhihetty PJ, Irrcher I, Joseph AM, Ljubicic V, Hood DA. Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp Physiol 2003; 88: 99-107.
    • (2003) Exp Physiol , vol.88 , pp. 99-107
    • Adhihetty, P.J.1    Irrcher, I.2    Joseph, A.M.3    Ljubicic, V.4    Hood, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.