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Bioorganic & medicinal chemistry letters

Volumn 11, Issue 21, 2001, Pages 2867-2870

Pyrimidinylimidazole inhibitors of p38: Cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity

(10) Adams, Jerry L a Boehm, Jeffrey C a Gallagher, Timothy F a Kassis, Shouki a Webb, Edward F a Hall, Ralph a Sorenson, Margaret a,b Garigipati, Ravi a,c Griswold, Don E a,d Lee, John C a

a GLAXOSMITHKLINE (United States)

b BRISTOL MYERS SQUIBB (United States)

c PFIZER GLOBAL RESEARCH AND DEVELOPMENT (United States)

d CENTOCOR INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; LIPOXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN SYNTHASE; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LIVER; MOUSE; ORAL DRUG ADMINISTRATION; RAT;

ADMINISTRATION, ORAL; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; IMIDAZOLES; LIPOXYGENASE; LIVER; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRIMIDINES; RATS;

EID: 18044405088 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(01)00570-4 Document Type: Article

Times cited : (112)

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