Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes

Biochemical Journal

Volumn 368, Issue 3, 2002, Pages 875-884

  Hers, Ingeborg ^a   Bell, Christopher J ^a   Poole, Alastair W ^b   Jiang, Donyang ^c   Denton, Richard M ^a   Schaefer, Erik ^c   Tavaré, Jeremy M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

^c Hopkinton Div of BioSource Intl   (United States)

Author keywords

IRS 1; IRS 3; Phosphospecific antibodies; SHP 2; Signalling

Indexed keywords

ENZYME INHIBITION; FEEDBACK CONTROL; INSULIN; PROTEINS;

FEEDBACK REGULATION;

BIOCHEMISTRY;

2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P85; TYROSINE; UNCLASSIFIED DRUG; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBUNIT; FEEDBACK SYSTEM; MALE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADIPOCYTES; ANDROSTADIENES; ANIMALS; BINDING SITES; CHROMONES; ENZYME INHIBITORS; EPIDIDYMIS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MORPHOLINES; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, WISTAR; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TYROSINE;

ANIMALIA;

EID: 0037115763     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020903     Document Type: Article

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