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Volumn 26, Issue 12, 2015, Pages 758-770

Linking Microbiota to Human Diseases: A Systems Biology Perspective

Author keywords

Diet; Germ free mice; Human disease; Microbiota; Systems medicine

Indexed keywords

BACTERIAL DNA; BUTYRIC ACID; CARNITINE; GLUCAGON LIKE PEPTIDE 1; PHOSPHATIDYLCHOLINE; PREBIOTIC AGENT; PROTEOME; SHORT CHAIN FATTY ACID; TRANSCRIPTOME;

EID: 84949553094     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2015.09.011     Document Type: Review
Times cited : (120)

References (123)
  • 1
    • 84876414806 scopus 로고    scopus 로고
    • The gut microbiota - masters of host development and physiology
    • Sommer F., Bäckhed F. The gut microbiota - masters of host development and physiology. Nat. Rev. Microbiol. 2013, 11:227-238.
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 227-238
    • Sommer, F.1    Bäckhed, F.2
  • 2
    • 84925517557 scopus 로고    scopus 로고
    • Insights from 20 years of bacterial genome sequencing
    • Land M., et al. Insights from 20 years of bacterial genome sequencing. Funct. Integr. Genomics 2015, 15:141-161.
    • (2015) Funct. Integr. Genomics , vol.15 , pp. 141-161
    • Land, M.1
  • 3
    • 84877249773 scopus 로고    scopus 로고
    • Medicines from microbiota
    • Olle B. Medicines from microbiota. Nat. Biotechnol. 2013, 31:309-315.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 309-315
    • Olle, B.1
  • 4
    • 84903134830 scopus 로고    scopus 로고
    • Persistent gut microbiota immaturity in malnourished Bangladeshi children
    • Subramanian S., et al. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature 2014, 510:417-421.
    • (2014) Nature , vol.510 , pp. 417-421
    • Subramanian, S.1
  • 5
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • Le Chatelier E., et al. Richness of human gut microbiome correlates with metabolic markers. Nature 2013, 500:541-546.
    • (2013) Nature , vol.500 , pp. 541-546
    • Le Chatelier, E.1
  • 6
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh P.J., et al. A core gut microbiome in obese and lean twins. Nature 2009, 457:480-484.
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1
  • 7
    • 84907225684 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in liver cirrhosis
    • Qin N., et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 2014, 513:59-64.
    • (2014) Nature , vol.513 , pp. 59-64
    • Qin, N.1
  • 8
    • 84921417572 scopus 로고    scopus 로고
    • The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases
    • Brown J.M., Hazen S.L. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu. Rev. Med. 2015, 66:343-359.
    • (2015) Annu. Rev. Med. , vol.66 , pp. 343-359
    • Brown, J.M.1    Hazen, S.L.2
  • 9
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • Karlsson F.H., et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013, 498:99-103.
    • (2013) Nature , vol.498 , pp. 99-103
    • Karlsson, F.H.1
  • 10
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin J., et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012, 490:55-60.
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1
  • 11
    • 84907300008 scopus 로고    scopus 로고
    • Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease
    • Palm N.W., et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 2014, 158:1000-1010.
    • (2014) Cell , vol.158 , pp. 1000-1010
    • Palm, N.W.1
  • 12
    • 84910116215 scopus 로고    scopus 로고
    • The human gut microbiome as a screening tool for colorectal cancer
    • Zackular J.P., et al. The human gut microbiome as a screening tool for colorectal cancer. Cancer Prev. Res. (Phila.) 2014, 7:1112-1121.
    • (2014) Cancer Prev. Res. (Phila.) , vol.7 , pp. 1112-1121
    • Zackular, J.P.1
  • 13
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao E.Y., et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013, 155:1451-1463.
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 14
    • 84931451067 scopus 로고    scopus 로고
    • Composition and temporal stability of the gut microbiota in older persons
    • Published online June 19, 2015
    • Jeffery I.B., et al. Composition and temporal stability of the gut microbiota in older persons. ISME J. 2015, Published online June 19, 2015. 10.1038/ismej.2015.88.
    • (2015) ISME J.
    • Jeffery, I.B.1
  • 15
    • 33749241734 scopus 로고    scopus 로고
    • Who are we? Indigenous microbes and the ecology of human diseases
    • Blaser M.J. Who are we? Indigenous microbes and the ecology of human diseases. EMBO Rep. 2006, 7:956-960.
    • (2006) EMBO Rep. , vol.7 , pp. 956-960
    • Blaser, M.J.1
  • 16
    • 2342442430 scopus 로고    scopus 로고
    • Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    • Ott S.J., et al. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut 2004, 53:685-693.
    • (2004) Gut , vol.53 , pp. 685-693
    • Ott, S.J.1
  • 17
    • 84908325271 scopus 로고    scopus 로고
    • Artificial sweeteners induce glucose intolerance by altering the gut microbiota
    • Suez J., et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 2014, 514:181-186.
    • (2014) Nature , vol.514 , pp. 181-186
    • Suez, J.1
  • 18
    • 84924301510 scopus 로고    scopus 로고
    • Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
    • Chassaing B., et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 2015, 519:92-96.
    • (2015) Nature , vol.519 , pp. 92-96
    • Chassaing, B.1
  • 19
    • 84923080032 scopus 로고    scopus 로고
    • Gut microbiome of the Hadza hunter-gatherers
    • Schnorr S.L., et al. Gut microbiome of the Hadza hunter-gatherers. Nat. Commun. 2014, 5:3654.
    • (2014) Nat. Commun. , vol.5 , pp. 3654
    • Schnorr, S.L.1
  • 20
    • 84996584385 scopus 로고    scopus 로고
    • The microbiome of uncontacted Amerindians
    • Clemente J.C., et al. The microbiome of uncontacted Amerindians. Sci. Adv. 2015, 1:e1500183.
    • (2015) Sci. Adv. , vol.1 , pp. e1500183
    • Clemente, J.C.1
  • 21
    • 79954442937 scopus 로고    scopus 로고
    • Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics
    • Ajslev T.A., et al. Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics. Int. J. Obes. 2011, 35:522-529.
    • (2011) Int. J. Obes. , vol.35 , pp. 522-529
    • Ajslev, T.A.1
  • 22
    • 84865477413 scopus 로고    scopus 로고
    • Antibiotics in early life alter the murine colonic microbiome and adiposity
    • Cho I., et al. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 2012, 488:621-626.
    • (2012) Nature , vol.488 , pp. 621-626
    • Cho, I.1
  • 23
    • 84907563983 scopus 로고    scopus 로고
    • Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences
    • Cox L.M., et al. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 2014, 158:705-721.
    • (2014) Cell , vol.158 , pp. 705-721
    • Cox, L.M.1
  • 24
    • 84929297936 scopus 로고    scopus 로고
    • Dynamics and stabilization of the human gut microbiome during the first year of life
    • Bäckhed F., et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 2015, 17:690-703.
    • (2015) Cell Host Microbe , vol.17 , pp. 690-703
    • Bäckhed, F.1
  • 25
    • 84879744885 scopus 로고    scopus 로고
    • The long-term stability of the human gut microbiota
    • Faith J.J., et al. The long-term stability of the human gut microbiota. Science 2013, 341:1237439.
    • (2013) Science , vol.341 , pp. 1237439
    • Faith, J.J.1
  • 26
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • Yatsunenko T., et al. Human gut microbiome viewed across age and geography. Nature 2012, 486:222-227.
    • (2012) Nature , vol.486 , pp. 222-227
    • Yatsunenko, T.1
  • 27
    • 84908074440 scopus 로고    scopus 로고
    • Biogeography and individuality shape function in the human skin metagenome
    • Oh J., et al. Biogeography and individuality shape function in the human skin metagenome. Nature 2014, 514:59-64.
    • (2014) Nature , vol.514 , pp. 59-64
    • Oh, J.1
  • 28
    • 84897128562 scopus 로고    scopus 로고
    • Kingdom-agnostic metagenomics and the importance of complete characterization of enteric microbial communities
    • Norman J.M., et al. Kingdom-agnostic metagenomics and the importance of complete characterization of enteric microbial communities. Gastroenterology 2014, 146:1459-1469.
    • (2014) Gastroenterology , vol.146 , pp. 1459-1469
    • Norman, J.M.1
  • 29
    • 70350346049 scopus 로고    scopus 로고
    • The development of intestinal lymphoid tissues at the interface of self and microbiota
    • Eberl G., Lochner M. The development of intestinal lymphoid tissues at the interface of self and microbiota. Mucosal Immunol. 2009, 2:478-485.
    • (2009) Mucosal Immunol. , vol.2 , pp. 478-485
    • Eberl, G.1    Lochner, M.2
  • 30
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian S.K., et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005, 122:107-118.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1
  • 31
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov I.I., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009, 139:485-498.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 32
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • Gaboriau-Routhiau V., et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009, 31:677-689.
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1
  • 33
    • 84887889962 scopus 로고    scopus 로고
    • Microbial modulation of energy availability in the colon regulates intestinal transit
    • Wichmann A., et al. Microbial modulation of energy availability in the colon regulates intestinal transit. Cell Host Microbe 2013, 14:582-590.
    • (2013) Cell Host Microbe , vol.14 , pp. 582-590
    • Wichmann, A.1
  • 34
    • 70350662669 scopus 로고    scopus 로고
    • Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
    • Cani P.D., et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am. J. Clin. Nutr. 2009, 90:1236-1243.
    • (2009) Am. J. Clin. Nutr. , vol.90 , pp. 1236-1243
    • Cani, P.D.1
  • 35
    • 84910028337 scopus 로고    scopus 로고
    • Therapies for inter-relating diabetes and obesity - GLP-1 and obesity
    • Iepsen E.W., et al. Therapies for inter-relating diabetes and obesity - GLP-1 and obesity. Expert Opin. Pharmacother. 2014, 15:2487-2500.
    • (2014) Expert Opin. Pharmacother. , vol.15 , pp. 2487-2500
    • Iepsen, E.W.1
  • 36
    • 84962086818 scopus 로고    scopus 로고
    • GLP-1R agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte GLP-1R
    • Yusta B., et al. GLP-1R agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte GLP-1R. Diabetes 2015, 64:2537-2549.
    • (2015) Diabetes , vol.64 , pp. 2537-2549
    • Yusta, B.1
  • 37
    • 84921424406 scopus 로고    scopus 로고
    • Microbiota controls the homeostasis of glial cells in the gut lamina propria
    • Kabouridis P.S., et al. Microbiota controls the homeostasis of glial cells in the gut lamina propria. Neuron 2015, 85:289-295.
    • (2015) Neuron , vol.85 , pp. 289-295
    • Kabouridis, P.S.1
  • 38
    • 84908302963 scopus 로고    scopus 로고
    • Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis
    • Thaiss C.A., et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 2014, 159:514-529.
    • (2014) Cell , vol.159 , pp. 514-529
    • Thaiss, C.A.1
  • 39
    • 84908234204 scopus 로고    scopus 로고
    • Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism
    • Tong M., et al. Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism. ISME J. 2014, 8:2193-2206.
    • (2014) ISME J. , vol.8 , pp. 2193-2206
    • Tong, M.1
  • 40
    • 77955398591 scopus 로고    scopus 로고
    • Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    • McGovern D.P., et al. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum. Mol. Genet. 2010, 19:3468-3476.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3468-3476
    • McGovern, D.P.1
  • 41
    • 84910096224 scopus 로고    scopus 로고
    • Human genetics shape the gut microbiome
    • Goodrich J.K., et al. Human genetics shape the gut microbiome. Cell 2014, 159:789-799.
    • (2014) Cell , vol.159 , pp. 789-799
    • Goodrich, J.K.1
  • 42
    • 84866461477 scopus 로고    scopus 로고
    • Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
    • Ubeda C., et al. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J. Exp. Med. 2012, 209:1445-1456.
    • (2012) J. Exp. Med. , vol.209 , pp. 1445-1456
    • Ubeda, C.1
  • 43
    • 84925852614 scopus 로고    scopus 로고
    • Promoting health and longevity through diet: from model organisms to humans
    • Fontana L., Partridge L. Promoting health and longevity through diet: from model organisms to humans. Cell 2015, 161:106-118.
    • (2015) Cell , vol.161 , pp. 106-118
    • Fontana, L.1    Partridge, L.2
  • 44
    • 84920909558 scopus 로고    scopus 로고
    • Diet dominates host genotype in shaping the murine gut microbiota
    • Carmody R.N., et al. Diet dominates host genotype in shaping the murine gut microbiota. Cell Host Microbe 2015, 17:72-84.
    • (2015) Cell Host Microbe , vol.17 , pp. 72-84
    • Carmody, R.N.1
  • 45
    • 84892828465 scopus 로고    scopus 로고
    • Diet rapidly and reproducibly alters the human gut microbiome
    • David L.A., et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014, 505:559-563.
    • (2014) Nature , vol.505 , pp. 559-563
    • David, L.A.1
  • 46
    • 70350110294 scopus 로고    scopus 로고
    • High-fat diet determines the composition of the murine gut microbiome independently of obesity
    • Hildebrandt M.A., et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 2009, 137:1716-1724.
    • (2009) Gastroenterology , vol.137 , pp. 1716-1724
    • Hildebrandt, M.A.1
  • 47
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-term dietary patterns with gut microbial enterotypes
    • Wu G.D., et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011, 334:105-108.
    • (2011) Science , vol.334 , pp. 105-108
    • Wu, G.D.1
  • 48
    • 77957075815 scopus 로고    scopus 로고
    • Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
    • De Filippo C., et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:14691-14696.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 14691-14696
    • De Filippo, C.1
  • 49
    • 84955613013 scopus 로고    scopus 로고
    • Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production
    • Published online November 26, 2014
    • Wu G.D., et al. Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production. Gut 2014, Published online November 26, 2014. 10.1136/gutjnl-2014-308209.
    • (2014) Gut
    • Wu, G.D.1
  • 50
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth R.A., et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat. Med. 2013, 19:576-585.
    • (2013) Nat. Med. , vol.19 , pp. 576-585
    • Koeth, R.A.1
  • 51
    • 0034959553 scopus 로고    scopus 로고
    • Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides
    • Topping D.L., Clifton P.M. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 2001, 81:1031-1064.
    • (2001) Physiol. Rev. , vol.81 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 52
    • 84876708253 scopus 로고    scopus 로고
    • Fiber and prebiotics: mechanisms and health benefits
    • Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients 2013, 5:1417-1435.
    • (2013) Nutrients , vol.5 , pp. 1417-1435
    • Slavin, J.1
  • 53
    • 78751580602 scopus 로고    scopus 로고
    • Dominant and diet-responsive groups of bacteria within the human colonic microbiota
    • Walker A.W., et al. Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J. 2011, 5:220-230.
    • (2011) ISME J. , vol.5 , pp. 220-230
    • Walker, A.W.1
  • 54
    • 27244434038 scopus 로고    scopus 로고
    • Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism
    • Robertson M.D., et al. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am. J. Clin. Nutr. 2005, 82:559-567.
    • (2005) Am. J. Clin. Nutr. , vol.82 , pp. 559-567
    • Robertson, M.D.1
  • 55
    • 84908233518 scopus 로고    scopus 로고
    • Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men
    • Salonen A., et al. Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men. ISME J. 2014, 8:2218-2230.
    • (2014) ISME J. , vol.8 , pp. 2218-2230
    • Salonen, A.1
  • 56
    • 84885573828 scopus 로고    scopus 로고
    • Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
    • Ng K.M., et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature 2013, 502:96-99.
    • (2013) Nature , vol.502 , pp. 96-99
    • Ng, K.M.1
  • 57
    • 84891789294 scopus 로고    scopus 로고
    • An ecological network of polysaccharide utilization among human intestinal symbionts
    • Rakoff-Nahoum S., et al. An ecological network of polysaccharide utilization among human intestinal symbionts. Curr. Biol. 2014, 24:40-49.
    • (2014) Curr. Biol. , vol.24 , pp. 40-49
    • Rakoff-Nahoum, S.1
  • 58
    • 84991929179 scopus 로고    scopus 로고
    • Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy
    • 276ra224
    • Kau A.L., et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci. Transl. Med. 2015, 7:276ra224.
    • (2015) Sci. Transl. Med. , vol.7
    • Kau, A.L.1
  • 59
    • 84925600482 scopus 로고    scopus 로고
    • Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota
    • Thompson J.A., et al. Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota. Cell Rep. 2015, 10:1861-1871.
    • (2015) Cell Rep. , vol.10 , pp. 1861-1871
    • Thompson, J.A.1
  • 60
    • 84872488958 scopus 로고    scopus 로고
    • Bacteriocins - a viable alternative to antibiotics?
    • Cotter P.D., et al. Bacteriocins - a viable alternative to antibiotics?. Nat. Rev. Microbiol. 2013, 11:95-105.
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 95-105
    • Cotter, P.D.1
  • 61
    • 84882703646 scopus 로고    scopus 로고
    • The gut microbiota and obesity: from correlation to causality
    • Zhao L. The gut microbiota and obesity: from correlation to causality. Nat. Rev. Microbiol. 2013, 11:639-647.
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 639-647
    • Zhao, L.1
  • 62
    • 33846542071 scopus 로고    scopus 로고
    • Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    • Bäckhed F., et al. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:979-984.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 979-984
    • Bäckhed, F.1
  • 63
    • 77957262599 scopus 로고    scopus 로고
    • Absence of intestinal microbiota does not protect mice from diet-induced obesity
    • Fleissner C.K., et al. Absence of intestinal microbiota does not protect mice from diet-induced obesity. Br. J. Nutr. 2010, 104:919-929.
    • (2010) Br. J. Nutr. , vol.104 , pp. 919-929
    • Fleissner, C.K.1
  • 64
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Bäckhed F., et al. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:15718-15723.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 15718-15723
    • Bäckhed, F.1
  • 65
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh P.J., et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 66
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura V.K., et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013, 341:1241214.
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.K.1
  • 67
    • 84978328160 scopus 로고    scopus 로고
    • Weight gain after fecal microbiota transplantation
    • ofv004
    • Alang N., Kelly C.R. Weight gain after fecal microbiota transplantation. Open Forum Infect. Dis. 2015, 2:ofv004.
    • (2015) Open Forum Infect. Dis. , vol.2
    • Alang, N.1    Kelly, C.R.2
  • 68
    • 84924594572 scopus 로고    scopus 로고
    • The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes
    • Seeley R.J., et al. The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes. Cell Metab. 2015, 21:369-378.
    • (2015) Cell Metab. , vol.21 , pp. 369-378
    • Seeley, R.J.1
  • 69
    • 60549086580 scopus 로고    scopus 로고
    • Human gut microbiota in obesity and after gastric bypass
    • Zhang H., et al. Human gut microbiota in obesity and after gastric bypass. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2365-2370.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 2365-2370
    • Zhang, H.1
  • 70
    • 78650037263 scopus 로고    scopus 로고
    • Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
    • Furet J.P., et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes 2010, 59:3049-3057.
    • (2010) Diabetes , vol.59 , pp. 3049-3057
    • Furet, J.P.1
  • 71
    • 84888133800 scopus 로고    scopus 로고
    • Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters
    • Graessler J., et al. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters. Pharmacogenomics J. 2013, 13:514-522.
    • (2013) Pharmacogenomics J. , vol.13 , pp. 514-522
    • Graessler, J.1
  • 72
    • 84879442146 scopus 로고    scopus 로고
    • Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes
    • Kong L.C., et al. Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes. Am. J. Clin. Nutr. 2013, 98:16-24.
    • (2013) Am. J. Clin. Nutr. , vol.98 , pp. 16-24
    • Kong, L.C.1
  • 73
    • 84938559816 scopus 로고    scopus 로고
    • Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation
    • Tremaroli V., et al. Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation. Cell Metab. 2015, 22:228-238.
    • (2015) Cell Metab. , vol.22 , pp. 228-238
    • Tremaroli, V.1
  • 75
    • 84895910457 scopus 로고    scopus 로고
    • Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner
    • Myronovych A., et al. Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner. Obesity 2014, 22:390-400.
    • (2014) Obesity , vol.22 , pp. 390-400
    • Myronovych, A.1
  • 76
    • 69749127975 scopus 로고    scopus 로고
    • Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism
    • Patti M.E., et al. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) 2009, 17:1671-1677.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1671-1677
    • Patti, M.E.1
  • 77
    • 84898051705 scopus 로고    scopus 로고
    • FXR is a molecular target for the effects of vertical sleeve gastrectomy
    • Ryan K.K., et al. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature 2014, 509:183-188.
    • (2014) Nature , vol.509 , pp. 183-188
    • Ryan, K.K.1
  • 78
    • 77958027965 scopus 로고    scopus 로고
    • Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population
    • Fontaine-Bisson B., et al. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. Diabetologia 2010, 53:2155-2162.
    • (2010) Diabetologia , vol.53 , pp. 2155-2162
    • Fontaine-Bisson, B.1
  • 79
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • Vrieze A., et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012, 143:913-916.
    • (2012) Gastroenterology , vol.143 , pp. 913-916
    • Vrieze, A.1
  • 80
    • 84896401262 scopus 로고    scopus 로고
    • Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
    • Vrieze A., et al. Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity. J. Hepatol. 2014, 60:824-831.
    • (2014) J. Hepatol. , vol.60 , pp. 824-831
    • Vrieze, A.1
  • 81
    • 84884696748 scopus 로고    scopus 로고
    • The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system
    • Schele E., et al. The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system. Endocrinology 2013, 154:3643-3651.
    • (2013) Endocrinology , vol.154 , pp. 3643-3651
    • Schele, E.1
  • 82
    • 0020710588 scopus 로고
    • Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats
    • Wostmann B.S., et al. Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats. Lab. Anim. Sci. 1983, 33:46-50.
    • (1983) Lab. Anim. Sci. , vol.33 , pp. 46-50
    • Wostmann, B.S.1
  • 83
    • 78649741587 scopus 로고    scopus 로고
    • Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism
    • Rabot S., et al. Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. FASEB J. 2010, 24:4948-4959.
    • (2010) FASEB J. , vol.24 , pp. 4948-4959
    • Rabot, S.1
  • 84
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • Cani P.D., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56:1761-1772.
    • (2007) Diabetes , vol.56 , pp. 1761-1772
    • Cani, P.D.1
  • 85
    • 84868687011 scopus 로고    scopus 로고
    • Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
    • Caesar R., et al. Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice. Gut 2012, 61:1701-1707.
    • (2012) Gut , vol.61 , pp. 1701-1707
    • Caesar, R.1
  • 86
    • 0034089572 scopus 로고    scopus 로고
    • Infection and atherosclerosis: potential roles of pathogen burden and molecular mimicry
    • Epstein S.E., et al. Infection and atherosclerosis: potential roles of pathogen burden and molecular mimicry. Arterioscler. Thromb. Vasc. Biol. 2000, 20:1417-1420.
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 1417-1420
    • Epstein, S.E.1
  • 87
    • 28644446048 scopus 로고    scopus 로고
    • Dental infections and cardiovascular diseases: a review
    • Mattila K.J., et al. Dental infections and cardiovascular diseases: a review. J. Periodontol. 2005, 76:2085-2088.
    • (2005) J. Periodontol. , vol.76 , pp. 2085-2088
    • Mattila, K.J.1
  • 88
    • 38349103047 scopus 로고    scopus 로고
    • Unexpected antimicrobial effect of statins
    • Jerwood S., Cohen J. Unexpected antimicrobial effect of statins. J. Antimicrob. Chemother. 2008, 61:362-364.
    • (2008) J. Antimicrob. Chemother. , vol.61 , pp. 362-364
    • Jerwood, S.1    Cohen, J.2
  • 89
    • 80054059835 scopus 로고    scopus 로고
    • Enteric microbiome metabolites correlate with response to simvastatin treatment
    • Kaddurah-Daouk R., et al. Enteric microbiome metabolites correlate with response to simvastatin treatment. PLoS ONE 2011, 6:e25482.
    • (2011) PLoS ONE , vol.6 , pp. e25482
    • Kaddurah-Daouk, R.1
  • 90
    • 79952758083 scopus 로고    scopus 로고
    • Human oral, gut, and plaque microbiota in patients with atherosclerosis
    • Koren O., et al. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc. Natl. Acad. Sci. U.S.A. 2011, 108(Suppl. 1):4592-4598.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 4592-4598
    • Koren, O.1
  • 91
    • 33645064033 scopus 로고    scopus 로고
    • Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease
    • Ott S.J., et al. Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease. Circulation 2006, 113:929-937.
    • (2006) Circulation , vol.113 , pp. 929-937
    • Ott, S.J.1
  • 92
    • 84871814687 scopus 로고    scopus 로고
    • Symptomatic atherosclerosis is associated with an altered gut metagenome
    • Karlsson F.H., et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat. Commun. 2012, 3:1245.
    • (2012) Nat. Commun. , vol.3 , pp. 1245
    • Karlsson, F.H.1
  • 93
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang Z., et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011, 472:57-63.
    • (2011) Nature , vol.472 , pp. 57-63
    • Wang, Z.1
  • 94
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • Tang W.H., et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 2013, 368:1575-1584.
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1575-1584
    • Tang, W.H.1
  • 95
    • 84901847186 scopus 로고    scopus 로고
    • Relating the metatranscriptome and metagenome of the human gut
    • Franzosa E.A., et al. Relating the metatranscriptome and metagenome of the human gut. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:E2329-E2338.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. E2329-E2338
    • Franzosa, E.A.1
  • 96
    • 84858439862 scopus 로고    scopus 로고
    • Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
    • Vogel C., Marcotte E.M. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat. Rev. Genet. 2012, 13:227-232.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 227-232
    • Vogel, C.1    Marcotte, E.M.2
  • 97
    • 79960578471 scopus 로고    scopus 로고
    • Quantification of mRNA and protein and integration with protein turnover in a bacterium
    • Maier T., et al. Quantification of mRNA and protein and integration with protein turnover in a bacterium. Mol. Syst. Biol. 2011, 7:511.
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 511
    • Maier, T.1
  • 98
    • 34447296622 scopus 로고    scopus 로고
    • Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut
    • Samuel B.S., et al. Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:10643-10648.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 10643-10648
    • Samuel, B.S.1
  • 99
    • 84904993698 scopus 로고    scopus 로고
    • Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis
    • Duran-Pinedo A.E., et al. Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis. ISME J. 2014, 8:1659-1672.
    • (2014) ISME J. , vol.8 , pp. 1659-1672
    • Duran-Pinedo, A.E.1
  • 100
    • 84941368240 scopus 로고    scopus 로고
    • Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples
    • Korem T., et al. Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples. Science 2015, 349:1101-1106.
    • (2015) Science , vol.349 , pp. 1101-1106
    • Korem, T.1
  • 101
    • 0037315564 scopus 로고    scopus 로고
    • Global RNA half-life analysis in Escherichia coli reveals positional patterns of transcript degradation
    • Selinger D.W., et al. Global RNA half-life analysis in Escherichia coli reveals positional patterns of transcript degradation. Genome Res. 2003, 13:216-223.
    • (2003) Genome Res. , vol.13 , pp. 216-223
    • Selinger, D.W.1
  • 102
    • 84870322666 scopus 로고    scopus 로고
    • Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease
    • Erickson A.R., et al. Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease. PLoS ONE 2012, 7:e49138.
    • (2012) PLoS ONE , vol.7 , pp. e49138
    • Erickson, A.R.1
  • 103
    • 84908554334 scopus 로고    scopus 로고
    • Bacterial protein signals are associated with Crohn's disease
    • Juste C., et al. Bacterial protein signals are associated with Crohn's disease. Gut 2014, 63:1566-1577.
    • (2014) Gut , vol.63 , pp. 1566-1577
    • Juste, C.1
  • 104
    • 84944147974 scopus 로고    scopus 로고
    • Colonic metaproteomic signatures of active bacteria and the host in obesity
    • Kolmeder C.A., et al. Colonic metaproteomic signatures of active bacteria and the host in obesity. Proteomics 2015, 15:3544-3552.
    • (2015) Proteomics , vol.15 , pp. 3544-3552
    • Kolmeder, C.A.1
  • 105
    • 84859573112 scopus 로고    scopus 로고
    • Exploring mixed microbial community functioning: recent advances in metaproteomics
    • Siggins A., et al. Exploring mixed microbial community functioning: recent advances in metaproteomics. FEMS Microbiol. Ecol. 2012, 80:265-280.
    • (2012) FEMS Microbiol. Ecol. , vol.80 , pp. 265-280
    • Siggins, A.1
  • 106
    • 79952023211 scopus 로고    scopus 로고
    • Proteomics: challenges, techniques and possibilities to overcome biological sample complexity
    • Chandramouli K., Qian P.Y. Proteomics: challenges, techniques and possibilities to overcome biological sample complexity. Hum. Genomics Proteomics 2009, 2009:239204.
    • (2009) Hum. Genomics Proteomics , vol.2009 , pp. 239204
    • Chandramouli, K.1    Qian, P.Y.2
  • 107
    • 84871454511 scopus 로고    scopus 로고
    • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk
    • Holmes E., et al. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell Metab. 2012, 16:559-564.
    • (2012) Cell Metab. , vol.16 , pp. 559-564
    • Holmes, E.1
  • 108
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • Nicholson J.K., et al. Host-gut microbiota metabolic interactions. Science 2012, 336:1262-1267.
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1
  • 109
    • 77950669604 scopus 로고    scopus 로고
    • The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice
    • Turnbaugh P.J., et al. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci. Transl. Med. 2009, 1:6ra14.
    • (2009) Sci. Transl. Med. , vol.1 , pp. 6ra14
    • Turnbaugh, P.J.1
  • 110
    • 84867898654 scopus 로고    scopus 로고
    • Humanized mice for immune system investigation: progress, promise and challenges
    • Shultz L.D., et al. Humanized mice for immune system investigation: progress, promise and challenges. Nat. Rev. Immunol. 2012, 12:786-798.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 786-798
    • Shultz, L.D.1
  • 111
    • 84883154681 scopus 로고    scopus 로고
    • Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome
    • McNulty N.P., et al. Effects of diet on resource utilization by a model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome. PLoS Biol. 2013, 11:e1001637.
    • (2013) PLoS Biol. , vol.11 , pp. e1001637
    • McNulty, N.P.1
  • 112
    • 84905495117 scopus 로고    scopus 로고
    • Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity
    • Chen Z., et al. Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. J. Clin. Invest. 2014, 124:3391-3406.
    • (2014) J. Clin. Invest. , vol.124 , pp. 3391-3406
    • Chen, Z.1
  • 113
    • 84964694501 scopus 로고    scopus 로고
    • Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes
    • Duan F.F., et al. Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes. Diabetes 2015, 64:1794-1803.
    • (2015) Diabetes , vol.64 , pp. 1794-1803
    • Duan, F.F.1
  • 114
    • 84925297047 scopus 로고    scopus 로고
    • Human intestinal gas measurement systems: in vitro fermentation and gas capsules
    • Ou J.Z., et al. Human intestinal gas measurement systems: in vitro fermentation and gas capsules. Trends Biotechnol. 2015, 33:208-213.
    • (2015) Trends Biotechnol. , vol.33 , pp. 208-213
    • Ou, J.Z.1
  • 115
    • 84908293710 scopus 로고    scopus 로고
    • Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids
    • Lukovac S., et al. Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids. MBio 2014, 5:e01438-e1514.
    • (2014) MBio , vol.5 , pp. e01438-e1514
    • Lukovac, S.1
  • 116
    • 77956569409 scopus 로고    scopus 로고
    • Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    • Garrett W.S., et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 2010, 8:292-300.
    • (2010) Cell Host Microbe , vol.8 , pp. 292-300
    • Garrett, W.S.1
  • 117
    • 84939135810 scopus 로고    scopus 로고
    • Inter-individual differences in the gene content of human gut bacterial species
    • Zhu A., et al. Inter-individual differences in the gene content of human gut bacterial species. Genome Biol. 2015, 16:82.
    • (2015) Genome Biol. , vol.16 , pp. 82
    • Zhu, A.1
  • 118
    • 84944448807 scopus 로고    scopus 로고
    • High throughput sequencing reveals distinct microbial populations within the mucosal and luminal niches in healthy individuals
    • Ringel Y., et al. High throughput sequencing reveals distinct microbial populations within the mucosal and luminal niches in healthy individuals. Gut Microbes 2015, 6:173-181.
    • (2015) Gut Microbes , vol.6 , pp. 173-181
    • Ringel, Y.1
  • 119
    • 84905730165 scopus 로고    scopus 로고
    • An integrated catalog of reference genes in the human gut microbiome
    • Li J., et al. An integrated catalog of reference genes in the human gut microbiome. Nat. Biotechnol. 2014, 32:834-841.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 834-841
    • Li, J.1
  • 120
    • 84907487928 scopus 로고    scopus 로고
    • Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics
    • Carmody R.N., Turnbaugh P.J. Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics. J. Clin. Invest. 2014, 124:4173-4181.
    • (2014) J. Clin. Invest. , vol.124 , pp. 4173-4181
    • Carmody, R.N.1    Turnbaugh, P.J.2
  • 121
    • 84875738351 scopus 로고    scopus 로고
    • Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
    • Cabreiro F., et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 2013, 153:228-239.
    • (2013) Cell , vol.153 , pp. 228-239
    • Cabreiro, F.1
  • 122
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • Shin N.R., et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 2014, 63:727-735.
    • (2014) Gut , vol.63 , pp. 727-735
    • Shin, N.R.1
  • 123
    • 84880439384 scopus 로고    scopus 로고
    • Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta
    • Haiser H.J., et al. Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. Science 2013, 341:295-298.
    • (2013) Science , vol.341 , pp. 295-298
    • Haiser, H.J.1


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