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Volumn 154, Issue 10, 2013, Pages 3643-3651

The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; AMPHETAMINE; BRAIN DERIVED NEUROTROPHIC FACTOR; COCAINE; GLUCAGON LIKE PEPTIDE 1; LEPTIN; NEUROPEPTIDE Y; PROGLUCAGON; PROOPIOMELANOCORTIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; X BOX BINDING PROTEIN 1;

EID: 84884696748     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-2151     Document Type: Article
Times cited : (155)

References (59)
  • 1
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457:480-484.
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1    Hamady, M.2    Yatsunenko, T.3
  • 2
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • DOI 10.1038/nature05414, PII NATURE05414
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027-1031. (Pubitemid 46018515)
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 5
    • 78649741587 scopus 로고    scopus 로고
    • Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism
    • Rabot S, Membrez M, Bruneau A, et al. Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. FASEB J. 2010;23:4948-4959
    • (2010) FASEB J , vol.23 , pp. 4948-4959
    • Rabot, S.1    Membrez, M.2    Bruneau, A.3
  • 6
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57:1470-1481.
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3
  • 9
    • 77955153069 scopus 로고    scopus 로고
    • The endocannabinoid system links gut microbiota to adipogenesis
    • Muccioli GG, Naslain D, Bäckhed F, et al. The endocannabinoid system links gut microbiota to adipogenesis. Mol Syst Biol. 2010;6:392.
    • (2010) Mol Syst Biol , vol.6 , pp. 392
    • Muccioli, G.G.1    Naslain, D.2    Bäckhed, F.3
  • 12
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • DOI 10.1038/372425a0
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-432. (Pubitemid 24365442)
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 13
    • 0032998652 scopus 로고    scopus 로고
    • Leptin receptor mrna identifies a subpopulation of neuropeptide y neurons activated by fasting in rat hypothalamus
    • Baskin DG, Breininger JF, Schwartz MW. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes. 1999;48:828-833. (Pubitemid 29153083)
    • (1999) Diabetes , vol.48 , Issue.4 , pp. 828-833
    • Baskin, D.G.1    Breininger, J.F.2    Schwartz, M.W.3
  • 14
    • 0030928715 scopus 로고    scopus 로고
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
    • DOI 10.1210/en.138.10.4489
    • Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology. 1997;138:4489-4492. (Pubitemid 27408500)
    • (1997) Endocrinology , vol.138 , Issue.10 , pp. 4489-4492
    • Cheung, C.C.1    Clifton, D.K.2    Steiner, R.A.3
  • 16
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • DOI 10.1016/0196-9781(86)90149-X
    • Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides. 1986;7:1189-1192. (Pubitemid 17226746)
    • (1986) Peptides , vol.7 , Issue.6 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 21
    • 0029098589 scopus 로고
    • The role of neuropeptide Y in the antiobesity action of the obese gene product
    • Stephens TW, Basinski M, Bristow PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 1995;377:530-532.
    • (1995) Nature , vol.377 , pp. 530-532
    • Stephens, T.W.1    Basinski, M.2    Bristow, P.K.3
  • 23
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • Hahn TM, Breininger JF, Baskin DG, Schwartz MW. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci. 1998;1:271-272. (Pubitemid 128652670)
    • (1998) Nature Neuroscience , vol.1 , Issue.4 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 24
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich RC, Hamann A, Anderson S, Löllmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1995;1:1311-1314.
    • (1995) Nat Med , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3    Löllmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 27
    • 0033525870 scopus 로고    scopus 로고
    • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    • Elchebly M, Payette P, Michaliszyn E, et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science. 1999;283:1544-1548.
    • (1999) Science , vol.283 , pp. 1544-1548
    • Elchebly, M.1    Payette, P.2    Michaliszyn, E.3
  • 28
    • 3142782772 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    • DOI 10.1038/nm1072
    • Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med. 2004;10:734-738. (Pubitemid 38937639)
    • (2004) Nature Medicine , vol.10 , Issue.7 , pp. 734-738
    • Howard, J.K.1    Cave, B.J.2    Oksanen, L.J.3    Tzameli, I.4    Bjoorbaek, C.5    Flier, J.S.6
  • 30
    • 56749112559 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces leptin resistance
    • Hosoi T, Sasaki M, Miyahara T, et al. Endoplasmic reticulum stress induces leptin resistance. Mol Pharmacol. 2008;74:1610-1619.
    • (2008) Mol Pharmacol , vol.74 , pp. 1610-1619
    • Hosoi, T.1    Sasaki, M.2    Miyahara, T.3
  • 31
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • Ozcan L, Ergin AS, Lu A, et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009;9:35-51.
    • (2009) Cell Metab , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3
  • 34
    • 37549055474 scopus 로고    scopus 로고
    • Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
    • Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M. Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci. 2007;27:14265-14274.
    • (2007) J Neurosci , vol.27 , pp. 14265-14274
    • Unger, T.J.1    Calderon, G.A.2    Bradley, L.C.3    Sena-Esteves, M.4    Rios, M.5
  • 35
    • 33744789644 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview
    • DOI 10.1016/j.autneu.2006.02.027, PII S1566070206000786
    • Lebrun B, Bariohay B, Moyse E, Jean A. Brain-derived neurotrophic factor (BDNF) and food intake regulation: a minireview. Auton Neurosci. 2006;126-127:30-38. (Pubitemid 43833352)
    • (2006) Autonomic Neuroscience: Basic and Clinical , vol.126-127 , pp. 30-38
    • Lebrun, B.1    Bariohay, B.2    Moyse, E.3    Jean, A.4
  • 36
    • 0031004888 scopus 로고    scopus 로고
    • Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: Evidence for anterograde axonal transport
    • Conner JM, Lauterborn JC, Yan Q, Gall CM, Varon S. Distribution of brain-derived neurotrophic factor (BDNF) protein andmRNAin the normal adult rat CNS: evidence for anterograde axonal transport. J Neurosci. 1997;17:2295-2313. (Pubitemid 27137397)
    • (1997) Journal of Neuroscience , vol.17 , Issue.7 , pp. 2295-2313
    • Conner, J.M.1    Lauterborn, J.C.2    Yan, Q.3    Gall, C.M.4    Varon, S.5
  • 37
    • 33646139871 scopus 로고    scopus 로고
    • Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus
    • Komori T, Morikawa Y, Nanjo K, Senba E. Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Neuroscience. 2006;139:1107-1115.
    • (2006) Neuroscience , vol.139 , pp. 1107-1115
    • Komori, T.1    Morikawa, Y.2    Nanjo, K.3    Senba, E.4
  • 38
    • 27844512893 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex
    • DOI 10.1210/en.2005-0419
    • Bariohay B, Lebrun B, Moyse E, Jean A. Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology. 2005;146:5612-5620. (Pubitemid 41653078)
    • (2005) Endocrinology , vol.146 , Issue.12 , pp. 5612-5620
    • Bariohay, B.1    Lebrun, B.2    Moyse, E.3    Jean, A.4
  • 39
    • 36248944567 scopus 로고    scopus 로고
    • Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function
    • DOI 10.1111/j.1365-2826.2007.01610.x
    • Nicholson JR, Peter JC, Lecourt AC, Barde YA, Hofbauer KG. Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function. J Neuroendocrinol. 2007;19:974-982. (Pubitemid 350131084)
    • (2007) Journal of Neuroendocrinology , vol.19 , Issue.12 , pp. 974-982
    • Nicholson, J.R.1    Peter, J.-C.2    Lecourt, A.-C.3    Barde, Y.-A.4    Hofbauer, K.G.5
  • 41
    • 66649122305 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control
    • Bariohay B, Roux J, Tardivel C, Trouslard J, Jean A, Lebrun B. Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control. Endocrinology. 2009;150:2646-2653.
    • (2009) Endocrinology , vol.150 , pp. 2646-2653
    • Bariohay, B.1    Roux, J.2    Tardivel, C.3    Trouslard, J.4    Jean, A.5    Lebrun, B.6
  • 42
    • 0036553037 scopus 로고    scopus 로고
    • The melanocortin receptors: Lessons from knockout models
    • Butler AA, Cone RD. The melanocortin receptors: lessons from knockout models. Neuropeptides. 2002;36:77-84.
    • (2002) Neuropeptides , vol.36 , pp. 77-84
    • Butler, A.A.1    Cone, R.D.2
  • 43
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • DOI 10.1038/nature05026, PII NATURE05026
    • Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW. Central nervous system control of food intake and body weight. Nature. 2006;443:289-295. (Pubitemid 44435142)
    • (2006) Nature , vol.443 , Issue.7109 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3    Barsh, G.S.4    Schwartz, M.W.5
  • 45
    • 84859560308 scopus 로고    scopus 로고
    • Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin
    • Liao GY, An JJ, Gharami K, et al. Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin. Nat Med. 2012;18:564-571.
    • (2012) Nat Med , vol.18 , pp. 564-571
    • Liao, G.Y.1    An, J.J.2    Gharami, K.3
  • 46
    • 84859603926 scopus 로고    scopus 로고
    • Hypothalamic BDNF and obesity: Found in translation
    • Schwartz E, Mobbs CV. Hypothalamic BDNF and obesity: found in translation. Nat Med. 2012;18:496-497.
    • (2012) Nat Med , vol.18 , pp. 496-497
    • Schwartz, E.1    Mobbs, C.V.2
  • 47
    • 84868687011 scopus 로고    scopus 로고
    • Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
    • Caesar R, Reigstad CS, Bäckhed HK, et al. Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice. Gut. 2012;61:1701-1707.
    • (2012) Gut , vol.61 , pp. 1701-1707
    • Caesar, R.1    Reigstad, C.S.2    Bäckhed, H.K.3
  • 50
    • 84856509724 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
    • Tolhurst G, Heffron H, Lam YS, et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes. 2012;61:364-371.
    • (2012) Diabetes , vol.61 , pp. 364-371
    • Tolhurst, G.1    Heffron, H.2    Lam, Y.S.3
  • 51
    • 0037562083 scopus 로고    scopus 로고
    • Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor
    • DOI 10.1210/en.2002-0113
    • Duan W, Guo Z, Jiang H, Ware M, Mattson MP. Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Endocrinology. 2003;144:2446-2453. (Pubitemid 36629896)
    • (2003) Endocrinology , vol.144 , Issue.6 , pp. 2446-2453
    • Duan, W.1    Guo, Z.2    Jiang, H.3    Ware, M.4    Mattson, M.P.5
  • 52
    • 79952601424 scopus 로고    scopus 로고
    • Normal gut microbiota modulates brain development and behavior
    • Diaz Heijtz R, Wang S, Anuar F, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA. 2011;108:3047-3052.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3047-3052
    • Diaz Heijtz, R.1    Wang, S.2    Anuar, F.3
  • 53
    • 80051535923 scopus 로고    scopus 로고
    • The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    • Bercik P, Denou E, Collins J, et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology. 2011;141:599-609, 609.e1-3.
    • (2011) Gastroenterology , vol.141
    • Bercik, P.1    Denou, E.2    Collins, J.3
  • 54
    • 72249092928 scopus 로고    scopus 로고
    • Recent advances in understanding leptin signaling and leptin resistance
    • Morris DL, Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab. 2009;297:E1247-E1259.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Morris, D.L.1    Rui, L.2
  • 55
    • 0025194735 scopus 로고
    • Depressed liver regenerating after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant mice
    • DOI 10.1002/hep.1840110603
    • Cornell RP, Liljequist BL, Bartizal KF. Depressed liver regeneration after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant mice. Hepatology. 1990;11:916-922. (Pubitemid 20221025)
    • (1990) Hepatology , vol.11 , Issue.6 , pp. 916-922
    • Cornell, R.P.1    Liljequist, B.L.2    Bartizal, K.F.3
  • 56
    • 0028109959 scopus 로고
    • Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat
    • Uribe A, Alam M, Johansson O, Midtvedt T, Theodorsson E. Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat. Gastroenterology. 1994;107:1259-1269. (Pubitemid 24328261)
    • (1994) Gastroenterology , vol.107 , Issue.5 , pp. 1259-1269
    • Uribe, A.1    Alam, M.2    Johansson, O.3    Midtvedt, T.4    Theodorsson, E.5
  • 57
    • 77951087292 scopus 로고    scopus 로고
    • The gut microbiota modulates host energy and lipid metabolism in mice
    • Velagapudi VR, Hezaveh R, Reigstad CS, et al. The gut microbiota modulates host energy and lipid metabolism in mice. J Lipid Res. 2010;51:1101-1112.
    • (2010) J Lipid Res , vol.51 , pp. 1101-1112
    • Velagapudi, V.R.1    Hezaveh, R.2    Reigstad, C.S.3
  • 58
    • 84856536388 scopus 로고    scopus 로고
    • Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion
    • Osundiji MA, Lam DD, Shaw J, et al. Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion. Diabetes. 2012;61:321-328.
    • (2012) Diabetes , vol.61 , pp. 321-328
    • Osundiji, M.A.1    Lam, D.D.2    Shaw, J.3
  • 59
    • 0022339662 scopus 로고
    • Alterations in insulin and glucagon secretion by monosodium glutamate lesions of the hypothalamic arcuate nucleus
    • Sartin JL, Lamperti AA, Kemppainen RJ. Alterations in insulin and glucagon secretion by monosodium glutamate lesions of the hypothalamic arcuate nucleus. Endocr Res. 1985;11:145-155. (Pubitemid 16126187)
    • (1985) Endocrine Research , vol.11 , Issue.3-4 , pp. 145-155
    • Sartin, J.L.1    Lamperti, A.A.2    Kemppainen, R.J.3


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