Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples

Science

Volumn 349, Issue 6252, 2015, Pages 1101-1106

  Korem, Tal ^a   Zeevi, David ^a   Suez, Jotham ^a   Weinberger, Adina ^a   Avnit Sagi, Tali ^a   Pompan Lotan, Maya ^a   Matot, Elad ^a   Jona, Ghil ^a   Harmelin, Alon ^a   Cohen, Nadav ^a   Sirota Madi, Alexandra ^b   Thaiss, Christoph A ^a   Pevsner Fischer, Meirav ^a   Sorek, Rotem ^a   Xavier, Ramnik J ^b   Elinav, Eran ^a   Segal, Eran ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA;

BACTERIUM; GENETIC ANALYSIS; GENOMICS; GROWTH RATE; HEALTH AND DISEASE; MICROBIAL COMMUNITY; PUBLIC HEALTH;

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA REPLICATION ORIGIN; GLUCOSE INTOLERANCE; GROWTH RATE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; METAGENOMICS; MICROBIAL COMMUNITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; BACTERIUM; CLASSIFICATION; CLINICAL TRIAL; GASTROINTESTINAL TRACT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METAGENOME; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY;

BACTERIA (MICROORGANISMS);

BACTERIA; DIABETES MELLITUS, TYPE 2; GASTROINTESTINAL TRACT; GENOME, BACTERIAL; HUMANS; INFLAMMATORY BOWEL DISEASES; METAGENOME; METAGENOMICS; MICROBIOTA;

EID: 84941368240     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac4812     Document Type: Article

References (27)

1. J. Qin et al., Nature 464, 59-65 (2010).
2. M. Rho, H. Tang, Y. Ye, Nucleic Acids Res. 38, e191 (2010).
3. Human Microbiome Project Consortium, Nature 486, 207-214 (2012).
4. P. J. Turnbaugh et al., Nature 457, 480-484 (2009).
5. V. M. Markowitz et al., PLOS ONE 7, e40151 (2012).
6. F. Meyer et al., BMC Bioinformatics 9, 386 (2008).
7. J. Qin et al., Nature 490, 55-60 (2012).
8. F. H. Karlsson et al., Nature 498, 99-103 (2013).
9. H. B. Nielsen et al., Nat. Biotechnol. 32, 822-828 (2014).
10. J. Oh et al., Nature 514, 59-64 (2014).
11. S. Schloissnig et al., Nature 493, 45-50 (2013).
12. E. Le Chatelier et al., Nature 500, 541-546 (2013).
13. C. Manichanh et al., Gut 55, 205-211 (2006).
14. F. Karlsson, V. Tremaroli, J. Nielsen, F. Bäckhed, Diabetes 62, 3341-3349 (2013).
15. J. Ahn et al., J. Natl. Cancer Inst. 105, 1907-1911 (2013).
16. S. Yoshimoto et al., Nature 499, 97-101 (2013).
17. J. Hinnebusch, K. Tilly, Mol. Microbiol. 10, 917-922 (1993).
18. J. D. Wang, P. A. Levin, Nat. Rev. Microbiol. 7, 822-827 (2009).
19. J. Xu et al., Genome Biol. 13, R27 (2012).
20. O. Skovgaard, M. Bak, A. Løbner-Olesen, N. Tommerup, Genome Res. 21, 1388-1393 (2011).
21. H. Bremer, G. Churchward, J. Theor. Biol. 69, 645-654 (1977).
22. S. Cooper, C. E. Helmstetter, J. Mol. Biol. 31, 519-540 (1968).
23. See the supplementary materials on Science Online for details.
24. F. Gao, H. Luo, C.-T. Zhang, Nucleic Acids Res. 41, D90-D93 (2013).
25. S. Wiles et al., Cell. Microbiol. 6, 963-972 (2004).
26. C. A. Thaiss et al., Cell 159, 514-529 (2014).
27. R. J. Koenig et al., N. Engl. J. Med. 295, 417-420 (1976).