Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes

Diabetes

Volumn 64, Issue 5, 2015, Pages 1794-1803

  Duan, Franklin F ^a   Liu, Joy H ^a   March, John C ^a  

^a Department of Biological and Environmental Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 6; INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; CELL FUNCTION; CELL REPROGRAMMING TECHNIQUE; COLONY FORMING UNIT; COMMENSAL; CONTROLLED STUDY; FEMALE; HYPERGLYCEMIA; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINAL TISSUE; INTESTINE; INTESTINE CELL; INTESTINE EPITHELIUM; LACTOBACILLUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM; STIMULATION; ANIMAL; CELL LINE; CYTOLOGY; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; HUMAN; INTESTINE MUCOSA; METABOLISM; NUCLEAR REPROGRAMMING; PHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; CELL LINE; CELLULAR REPROGRAMMING; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; HUMANS; INSULIN; INTESTINAL MUCOSA; LACTOBACILLUS; RATS;

EID: 84964694501     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0635     Document Type: Article

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