Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons

Neuropharmacology

Volumn 102, Issue , 2016, Pages 266-275

  Mäkelä, Johanna ^a,b   Tselykh, Timofey V ^a,b   Kukkonen, Jyrki P ^c   Eriksson, Ove ^b   Korhonen, Laura T ^b,d   Lindholm, Dan ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

CREB; Dopaminergic neurons; Mitochondria; PGC 1 ; PPAR ; SIRT1

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYDROGEN PEROXIDE; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; ROTENONE; SIRTUIN 1; BENZOPHENONE DERIVATIVE; NEUROPROTECTIVE AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PPARGC1A PROTEIN, HUMAN; SIRT1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TYROSINE;

ARTICLE; BRAIN DISEASE; CELL RESPIRATION; CELL VIABILITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRION; NERVE CELL CULTURE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; AGONISTS; ANALOGS AND DERIVATIVES; CELL LINE; DRUG EFFECTS; METABOLISM; ORGANELLE BIOGENESIS; PHOSPHORYLATION;

BENZOPHENONES; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOPAMINERGIC NEURONS; HUMANS; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; ORGANELLE BIOGENESIS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PHOSPHORYLATION; PPAR GAMMA; SIRTUIN 1; TRANSCRIPTION FACTORS; TYROSINE;

EID: 84949524280     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.11.020     Document Type: Article

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