PPARγ-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of camp on renin gene expression

Molecular Endocrinology

Volumn 24, Issue 11, 2010, Pages 2139-2151

  Desch, Michael ^a   Schubert, Thomas ^a   Schreiber, Andrea ^a   Mayer, Sandra ^a   Friedrich, Björn ^b   Artunc, Ferruh ^b   Todorov, Vladimir T ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ADENYLATE CYCLASE; ADENYLATE CYCLASE 6; CYCLIC AMP; FATTY ACID BINDING PROTEIN 4; MESSENGER RNA; OLEIC ACID; OLIGONUCLEOTIDE; PALINDROMIC DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; RENIN; ROSIGLITAZONE; SPACER DNA; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; ADENYLYL CYCLASE 6; ENZYME ACTIVATOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRAIN; CELL STRAIN CALU 6; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN CELL; INTRON; KIDNEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; ANIMAL; BINDING SITE; CELL LINE; CONSENSUS SEQUENCE; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROMOTER REGION;

MUS;

ADENYLATE CYCLASE; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; CONSENSUS SEQUENCE; CYCLIC AMP; DRUG SYNERGISM; ENZYME ACTIVATORS; GENE EXPRESSION REGULATION; HUMANS; INTRONS; MICE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PPAR GAMMA; PROMOTER REGIONS, GENETIC; RENIN; THIAZOLIDINEDIONES;

EID: 78049339707     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0134     Document Type: Article

References (40)

1. Castrop H, Höcherl K, Kurtz A, Schweda F, Todorov V, Wagner C 2010 Physiology of kidney renin. Physiol Rev 90:607-673
2. Pan L, Gross KW 2005 Transcriptional regulation of renin: an update. Hypertension 45:3-8
3. Todorov VT, Desch M, Schmitt-Nilson N, Todorova A, Kurtz A 2007 Peroxisome proliferator-activated receptor-γ is involved in the control of renin gene expression. Hypertension 50:939-944 (Pubitemid 350287538)
4. Todorov VT, Desch M, Schubert T, Kurtz A 2008 The Pal3 promoter sequence is critical for the regulation of human renin gene transcription by peroxisome proliferator-activated receptor-γ. Endocrinology 149:4647-4657
5. Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT 2010 Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-γ in juxtaglomerular cells. Hypertension 55:660-666
6. Bonen A, Tandon NN, Glatz JF, Luiken JJ, Heigenhauser GJ 2006 The fatty acid transporter FAT/CD36 is upregulated in subcutaneous and visceral adipose tissues in human obesity and type 2 diabetes. Int J Obes 30:877-883 (Pubitemid 43801185)
7. Hall JE 1994 Louis K. Dahl Memorial Lecture. Renal and cardiovascular mechanisms of hypertension in obesity. Hypertension 23:381-394
8. Hall JE 2003 The kidney, hypertension, and obesity. Hypertension 41:625-633
9. Minehira K, Bettschart V, Vidal H, Vega N, Di Vetta V, Rey V, Schneiter P, Tappy L 2003 Effect of carbohydrate overfeeding on whole body and adipose tissue metabolism in humans. Obes Res 11:1096-1103 (Pubitemid 41151587)
10. Shea J, French CR, Bishop J, Martin G, Roebothan B, Pace D, Fitzpatrick D, Sun G 2009 Changes in the transcriptome of abdominal subcutaneous adipose tissue in response to short-term overfeeding in lean and obese men. Am J Clin Nutr 89:407-415
11. Wang H, Eckel RH 2009 Lipoprotein lipase: from gene to obesity. Am J Physiol Endocrinol Metab 297:E271-E288
12. Westerbacka J, Kolak M, Kiviluoto T, Arkkila P, Sirén J, Hamsten A, Fisher RM, Yki-Järvinen H 2007 Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes 56:2759-2765 (Pubitemid 350044919)
13. Chen L, Kim SM, Oppermann M, Faulhaber-Walter R, Huang Y, Mizel D, Chen M, Lopez ML, Weinstein LS, Gomez RA, Briggs JP, Schnermann J 2007 Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsα in juxtaglomerular cells. Am J Physiol Renal Physiol 292:F27-F37 (Pubitemid 46105240)
14. Chen M, Schnermann J, Smart AM, Brosius FC, Killen PD, Briggs JP 1993 Cyclic AMP selectively increases renin mRNA stability in cultured juxtaglomerular granular cells. J Biol Chem 268:24138-24144 (Pubitemid 23335396)
15. Klar J, Sandner P, Müller MW, Kurtz A 2002 Cyclic AMP stimulates renin gene transcription in juxtaglomerular cells. Pflugers Arch 444:335-344 (Pubitemid 35447407)
16. Lang JA, Ying LH, Morris BJ, Sigmund CD 1996 Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells. Am J Physiol 271:F94-F100
17. Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, Gross KW 2001 Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem 276:45530-45538
18. Ying L, Morris BJ, Sigmund CD 1997 Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. J Biol Chem 272:2412-2420 (Pubitemid 27058530)
19. Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schütz G, Schweda F 2007 Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors. J Am Soc Nephrol 18:1150-1156 (Pubitemid 46536901)
20. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A, Frisch M, Bayerlein M, Werner T 2005 MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21:2933-2942 (Pubitemid 40916416)
21. Bader M, Ganten D 2000 Regulation of renin: new evidence from cultured cells and genetically modified mice. J Mol Med 78:130-139 (Pubitemid 30337494)
22. Friis UG, Stubbe J, Uhrenholt TR, Svenningsen P, Nüsing RM, Skøtt O, Jensen BL 2005 Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells. Am J Physiol Renal Physiol 289:F989-997
23. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM 1995 15-Deoxy-δ 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812 (Pubitemid 3006324)
24. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM 1995 A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83:813-819 (Pubitemid 3006325)
25. García-Bueno B, Madrigal JL, Pérez-Nievas BG, Leza JC 2008 Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-γ activation after stress in rats. Endocrinology 149:1969-1978
26. Harris RC 2003 Interactions between COX-2 and the renin-angiotensin system in the kidney. Acta Physiol Scand 177:423-427 (Pubitemid 36411579)
27. Vitzthum H, Abt I, Einhellig S, Kurtz A 2002 Gene expression of prostanoid forming enzymes along the rat nephron. Kidney Int 62:1570-1581 (Pubitemid 35286264)
28. Hirata Y, Hayashi H, Ito S, Kikawa Y, Ishibashi M, Sudo M, Miyazaki H, Fukushima M, Narumiya S, Hayaishi O 1988 Occurrence of 9-deoxy-δ 9,δ 12-13,14-dihydroprostaglandin D2 in human urine. J Biol Chem 263:16619-16625
29. Grünberger C, Obermayer B, Klar J, Kurtz A, Schweda F 2006 The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6. Circ Res 99:1197-1206 (Pubitemid 44808656)
30. Ortiz-Capisano MC, Ortiz PA, Harding P, Garvin JL, Beierwaltes WH 2007 Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. Hypertension 49:618-624
31. Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA 2002 Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82:205-244
32. Tiwari S, Blasi ER, Heyen JR, McHarg AD, Ecelbarger CM 2008 Time course of AQP-2 and ENaC regulation in the kidney in response to PPAR agonists associated with marked edema in rats. Pharmacol Res 57:383-392
33. Nesto RW, Bell D, Bonow RO, Fonseca V, Grundy SM, Horton ES, Le Winter M, Porte D, Semenkovich CF, Smith S, Young LH, Kahn R 2003 Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003. Circulation 108:2941-2948 (Pubitemid 37517824)
34. Leong PL, Andrews GA, Johnson DE, Dyer KF, Xi S, Mai JC, Robbins PD, Gadiparthi S, Burke NA, Watkins SF, Grandis JR 2003 Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci USA 100:4138-4143 (Pubitemid 36418170)
35. Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert Jr CJ, Liu XS, Lazar MA 2008 PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 22:2941-2952
36. Nielsen R, Pedersen TA, Hagenbeek D, Moulos P, Siersbaek R, Megens E, Denissov S, Børgesen M, Francoijs KJ, Mandrup S, Stunnenberg HG 2008 Genome-wide profiling of PPARγ:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev 22:2953-2967
37. Okuno M, Arimoto E, Ikenobu Y, Nishihara T, Imagawa M 2001 Dual DNA-binding specificity of peroxisome-proliferator-activated receptor γ controlled by heterodimer formation with retinoid X receptor α. Biochem J 353:193-198 (Pubitemid 32096925)
38. Mrowka R, Steege A, Kaps C, Herzel H, Thiele BJ, Persson PB, Blüthgen N 2007 Dissecting the action of an evolutionary conserved non-coding region on renin promoter activity. Nucleic Acids Res 35:5120-5129 (Pubitemid 47394196)
39. Todorov V, Müller M, Schweda F, Kurtz A 2002 Tumor necrosis factor-α inhibits renin gene expression. Am J Physiol Regul Integr Comp Physiol 283:R1046-R1051 (Pubitemid 35216978)
40. Artunc F, Sandulache D, Nasir O, Boini KM, Friedrich B, Beier N, Dicks E, Pötzsch S, Klingel K, Amann K, Blazer-Yost BL, Scholz W, Risler T, Kuhl D, Lang F 2008 Lack of the serum and glucocorticoid-inducible kinase SGK1 attenuates the volume retention after treatment with the PPARγ agonist pioglitazone. Pflugers Arch 456:425-436