메뉴 건너뛰기




Volumn 394, Issue 12, 2013, Pages 1553-1570

Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain

Author keywords

Catalase; Glutathione; Inflammation; Neuroprotection; Superoxide dismutase

Indexed keywords

2 CHLORO 5 NITRO N (4 PYRIDYL)BENZAMIDE; 2 CHLORO 5 NITROBENZANILIDE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; BEZAFIBRATE; CATALASE; CIPROFIBRATE; CYTOCHROME C OXIDASE; FENOFIBRATE; GEMFIBROZIL; GW 501615; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXYNITRITE; PIOGLITAZONE; PIRINIXIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROSIGLITAZONE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; WY 14463;

EID: 84888083879     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2013-0215     Document Type: Review
Times cited : (65)

References (117)
  • 1
    • 67650792427 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-γ positively controls and PPARα negatively controls cyclooxygenase- 2 expression in rat brain astrocytes through a convergence on PPARβ/δ via mutual control of PPAR expression levels
    • Aleshin, S., Grabeklis, S., Hanck, T., Sergeeva, M., and Reiser, G. (2009). Peroxisome proliferator-activated receptor (PPAR)-γ positively controls and PPARα negatively controls cyclooxygenase- 2 expression in rat brain astrocytes through a convergence on PPARβ/δ via mutual control of PPAR expression levels. Mol. Pharmacol. 76, 414-424.
    • (2009) Mol. Pharmacol , vol.76 , pp. 414-424
    • Aleshin, S.1    Grabeklis, S.2    Hanck, T.3    Sergeeva, M.4    Reiser, G.5
  • 2
    • 84882430142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)β/δ, a possible nexus of PPARα- and PPARγ- dependent molecular pathways in neurodegenerative diseases; Review and novel hypotheses
    • Aleshin, S., Strokin, M., Sergeeva, M., and Reiser, G. (2013). Peroxisome proliferator-activated receptor (PPAR)β/δ, a possible nexus of PPARα- and PPARγ- dependent molecular pathways in neurodegenerative diseases; review and novel hypotheses. Neurochem. Int. 63, 322-330.
    • (2013) Neurochem. Int , vol.63 , pp. 322-330
    • Aleshin, S.1    Strokin, M.2    Sergeeva, M.3    Reiser, G.4
  • 3
    • 79957935719 scopus 로고    scopus 로고
    • NADPH-oxidase activation and cognition in Alzheimer disease progression
    • Ansari, M.A. and Scheff, S.W. (2011). NADPH-oxidase activation and cognition in Alzheimer disease progression. Free Radic. Biol. Med. 51, 171-178.
    • (2011) Free Radic. Biol. Med , vol.51 , pp. 171-178
    • Ansari, M.A.1    Scheff, S.W.2
  • 5
    • 84861309322 scopus 로고    scopus 로고
    • Therapeutic potential of targeting hydrogen peroxide metabolism in the treatment of brain ischaemia
    • Armogida, M., Nistico, R., and Mercuri, N.B. (2012). Therapeutic potential of targeting hydrogen peroxide metabolism in the treatment of brain ischaemia. Br. J. Pharmacol. 166, 1211-1224.
    • (2012) Br. J. Pharmacol , vol.166 , pp. 1211-1224
    • Armogida, M.1    Nistico, R.2    Mercuri, N.B.3
  • 6
    • 33644540539 scopus 로고    scopus 로고
    • Increased infarct size and lack of hyperphagic response after focal cerebral ischemia in peroxisome proliferator-activated receptor β-deficient mice
    • Arsenijevic, D., de Bilbao, F., Plamondon, J., Paradis, E., Vallet, P., Richard, D., Langhans, W., and Giannakopoulos, P. (2006). Increased infarct size and lack of hyperphagic response after focal cerebral ischemia in peroxisome proliferator-activated receptor β-deficient mice. J. Cereb. Blood Flow Metab. 26, 433-445.
    • (2006) J. Cereb. Blood Flow Metab , vol.26 , pp. 433-445
    • Arsenijevic, D.1    De Bilbao, F.2    Plamondon, J.3    Paradis, E.4    Vallet, P.5    Richard, D.6    Langhans, W.7    Giannakopoulos, P.8
  • 8
    • 42049114658 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components
    • DOI 10.1210/jc.2007-1701
    • Bastin, J., Aubey, F., Rotig, A., Munnich, A., and Djouadi, F. (2008). Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components. J. Clin. Endocrinol. Metab. 93, 1433-1441. (Pubitemid 351519745)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , Issue.4 , pp. 1433-1441
    • Bastin, J.1    Aubey, F.2    Rotig, A.3    Munnich, A.4    Djouadi, F.5
  • 10
    • 40049100693 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor-α expression during lung inflammation
    • DOI 10.1016/j.pupt.2007.08.001, PII S1094553907000727
    • Becker, J., Delayre-Orthez, C., Frossard, N., and Pons, F. (2008). Regulation of peroxisome proliferator-activated receptor-α expression during lung inflammation. Pulm. Pharmacol. Ther. 21, 324-330. (Pubitemid 351320570)
    • (2008) Pulmonary Pharmacology and Therapeutics , vol.21 , Issue.2 , pp. 324-330
    • Becker, J.1    Delayre-Orthez, C.2    Frossard, N.3    Pons, F.4
  • 12
    • 68249152624 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells
    • Bernardo, A., Bianchi, D., Magnaghi, V., and Minghetti, L. (2009). Peroxisome proliferator-activated receptor-γ agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. J. Neuropathol. Exp. Neurol. 68, 797-808.
    • (2009) J. Neuropathol. Exp. Neurol , vol.68 , pp. 797-808
    • Bernardo, A.1    Bianchi, D.2    Magnaghi, V.3    Minghetti, L.4
  • 13
    • 82255175318 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid-induced behavioral and biochemical alterations in rats: Possible neuroprotective mechanisms
    • Bhateja, D.K., Dhull, D.K., Gill, A., Sidhu, A., Sharma, S., Reddy, B.V., and Padi, S.S. (2012). Peroxisome proliferator-activated receptor-α activation attenuates 3-nitropropionic acid-induced behavioral and biochemical alterations in rats: possible neuroprotective mechanisms. Eur. J. Pharmacol. 674, 33-43.
    • (2012) Eur. J. Pharmacol , vol.674 , pp. 33-43
    • Bhateja, D.K.1    Dhull, D.K.2    Gill, A.3    Sidhu, A.4    Sharma, S.5    Reddy, B.V.6    Padi, S.S.7
  • 16
    • 34547118091 scopus 로고    scopus 로고
    • Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury
    • DOI 10.1089/neu.2006.0216
    • Chen, X.R., Besson, V.C., Palmier, B., Garcia, Y., Plotkine, M., and Marchand-Leroux, C. (2007). Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury. J. Neurotrauma 24, 1119-1131. (Pubitemid 47106286)
    • (2007) Journal of Neurotrauma , vol.24 , Issue.7 , pp. 1119-1131
    • Chen, X.R.1    Besson, V.C.2    Palmier, B.3    Garcia, Y.4    Plotkine, M.5    Marchand-Leroux, C.6
  • 18
    • 84864340428 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus
    • Chuang, Y.C., Lin, T.K., Huang, H.Y., Chang, W.N., Liou, C.W., Chen, S.D., Chang, A.Y., and Chan, S.H. (2012). Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus. J. Neuroinflammation 9, 184.
    • (2012) J. Neuroinflammation , vol.9 , pp. 184
    • Chuang, Y.C.1    Lin, T.K.2    Huang, H.Y.3    Chang, W.N.4    Liou, C.W.5    Chen, S.D.6    Chang, A.Y.7    Chan, S.H.8
  • 19
    • 12344315682 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons
    • DOI 10.1016/j.neuroscience.2004.09.043, PII S0306452204008632
    • Cimini, A., Benedetti, E., Cristiano, L., Sebastiani, P., D'Amico, M.A., D'Angelo, B., and Di Loreto, S. (2005). Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons. Neuroscience 130, 325-337. (Pubitemid 40125471)
    • (2005) Neuroscience , vol.130 , Issue.2 , pp. 325-337
    • Cimini, A.1    Benedetti, E.2    Cristiano, L.3    Sebastiani, P.4    D'Amico, M.A.5    D'Angelo, B.6    Di Loreto, S.7
  • 20
    • 33746051675 scopus 로고    scopus 로고
    • Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: Effects of the PPAR-α agonist WY14643
    • DOI 10.1016/j.freeradbiomed.2006.04.030, PII S0891584906002917
    • Collino, M., Aragno, M., Mastrocola, R., Benetti, E., Gallicchio, M., Dianzani, C., Danni, O., Thiemermann, C., and Fantozzi, R. (2006a). Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-α agonist WY14643. Free Radic. Biol. Med. 41, 579-589. (Pubitemid 44080506)
    • (2006) Free Radical Biology and Medicine , vol.41 , Issue.4 , pp. 579-589
    • Collino, M.1    Aragno, M.2    Mastrocola, R.3    Benetti, E.4    Gallicchio, M.5    Dianzani, C.6    Danni, O.7    Thiemermann, C.8    Fantozzi, R.9
  • 21
    • 29844458758 scopus 로고    scopus 로고
    • Modulation of the oxidative stress and inflammatory response by PPAR-γ agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion
    • DOI 10.1016/j.ejphar.2005.11.049, PII S0014299905012525
    • Collino, M., Aragno, M., Mastrocola, R., Gallicchio, M., Rosa, A.C., Dianzani, C., Danni, O., Thiemermann, C., and Fantozzi, R. (2006b). Modulation of the oxidative stress and inflammatory response by PPAR-γ agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur. J. Pharmacol. 530, 70-80. (Pubitemid 43037126)
    • (2006) European Journal of Pharmacology , vol.530 , Issue.1-2 , pp. 70-80
    • Collino, M.1    Aragno, M.2    Mastrocola, R.3    Gallicchio, M.4    Rosa, A.C.5    Dianzani, C.6    Danni, O.7    Thiemermann, C.8    Fantozzi, R.9
  • 22
    • 20444393107 scopus 로고    scopus 로고
    • A novel PPAR response element in the murine iNOS promoter
    • DOI 10.1016/j.molimm.2004.12.009, PII S0161589005000052
    • Crosby, M.B., Svenson, J., Gilkeson, G.S., and Nowling, T.K. (2005). A novel PPAR response element in the murine iNOS promoter. Mol. Immunol. 42, 1303-1310. (Pubitemid 40798946)
    • (2005) Molecular Immunology , vol.42 , Issue.11 , pp. 1303-1310
    • Crosby, M.B.1    Svenson, J.2    Gilkeson, G.S.3    Nowling, T.K.4
  • 23
    • 0036236378 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor α-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain
    • DOI 10.1016/S0028-3908(02)00014-X, PII S002839080200014X
    • Cullingford, T.E., Dolphin, C.T., and Sato, H. (2002). The peroxisome proliferator-activated receptor α-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain. Neuropharmacol. 42, 724-730. (Pubitemid 34457754)
    • (2002) Neuropharmacology , vol.42 , Issue.5 , pp. 724-730
    • Cullingford, T.E.1    Dolphin, C.T.2    Sato, H.3
  • 24
    • 77952240774 scopus 로고    scopus 로고
    • NO synthase: Structures and mechanisms
    • Daff, S. (2010). NO synthase: structures and mechanisms. Nitric Oxide 23, 1-11.
    • (2010) Nitric Oxide , vol.23 , pp. 1-11
    • Daff, S.1
  • 25
    • 0027434596 scopus 로고
    • Glutathione peroxidase, glial cells and Parkinson's disease
    • DOI 10.1016/0306-4522(93)90175-F
    • Damier, P., Hirsch, E.C., Zhang, P., Agid, Y., and Javoy-Agid, F. (1993). Glutathione peroxidase, glial cells and Parkinson's disease. Neuroscience 52, 1-6. (Pubitemid 23026600)
    • (1993) Neuroscience , vol.52 , Issue.1 , pp. 1-6
    • Damier, P.1    Hirsch, E.C.2    Zhang, P.3    Agid, Y.4    Javoy-Agid, F.5
  • 26
    • 66449124004 scopus 로고    scopus 로고
    • Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
    • Defaux, A., Zurich, M.G., Braissant, O., Honegger, P., and Monnet-Tschudi, F. (2009). Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination. J. Neuroinflammation 6, 15.
    • (2009) J. Neuroinflammation , vol.6 , pp. 15
    • Defaux, A.1    Zurich, M.G.2    Braissant, O.3    Honegger, P.4    Monnet-Tschudi, F.5
  • 28
    • 84864050485 scopus 로고    scopus 로고
    • Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease
    • Fransen, M., Nordgren, M., Wang, B., and Apanasets, O. (2012). Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochim. Biophys. Acta 1822, 1363-1373.
    • (2012) Biochim. Biophys. Acta , vol.1822 , pp. 1363-1373
    • Fransen, M.1    Nordgren, M.2    Wang, B.3    Apanasets, O.4
  • 29
    • 16844374020 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats
    • DOI 10.1016/j.biopsych.2005.01.007
    • Garcia-Bueno, B., Madrigal, J.L., Lizasoain, I., Moro, M.A., Lorenzo, P., and Leza, J.C. (2005). Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats. Biol. Psychiatry 57, 885-894. (Pubitemid 40488357)
    • (2005) Biological Psychiatry , vol.57 , Issue.8 , pp. 885-894
    • Garcia-Bueno, B.1    Madrigal, J.L.M.2    Lizasoain, I.3    Moro, M.A.4    Lorenzo, P.5    Leza, J.C.6
  • 30
    • 0036908619 scopus 로고    scopus 로고
    • Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter
    • DOI 10.1210/me.2002-0020
    • Girnun, G.D., Domann, F.E., Moore, S.A., and Robbins, M.E. (2002). Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Mol. Endocrinol. 16, 2793-2801. (Pubitemid 36020658)
    • (2002) Molecular Endocrinology , vol.16 , Issue.12 , pp. 2793-2801
    • Girnun, G.D.1    Domann, F.E.2    Moore, S.A.3    Robbins, M.E.C.4
  • 31
    • 77954383974 scopus 로고    scopus 로고
    • Peroxisome-proliferatoractivated receptors γ and peroxisome-proliferator-activated receptors β/δ and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain
    • Glatz, T., Stock, I., Nguyen-Ngoc, M., Gohlke, P., Herdegen, T., Culman, J., and Zhao, Y. (2010). Peroxisome-proliferatoractivated receptors γ and peroxisome-proliferator-activated receptors β/δ and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain. J. Hypertens. 28, 1488-1497.
    • (2010) J. Hypertens , vol.28 , pp. 1488-1497
    • Glatz, T.1    Stock, I.2    Nguyen-Ngoc, M.3    Gohlke, P.4    Herdegen, T.5    Culman, J.6    Zhao, Y.7
  • 32
    • 79954531943 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-α agonists protect cortical neurons from inflammatory mediators and improve peroxisomal function
    • Gray, E., Ginty, M., Kemp, K., Scolding, N., and Wilkins, A. (2011). Peroxisome proliferator-activated receptor-α agonists protect cortical neurons from inflammatory mediators and improve peroxisomal function. Eur. J. Neurosci. 33, 1421-1432.
    • (2011) Eur. J. Neurosci , vol.33 , pp. 1421-1432
    • Gray, E.1    Ginty, M.2    Kemp, K.3    Scolding, N.4    Wilkins, A.5
  • 33
    • 84859349600 scopus 로고    scopus 로고
    • The PPAR-γ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function
    • Gray, E., Ginty, M., Kemp, K., Scolding, N., and Wilkins, A. (2012). The PPAR-γ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function. J. Neuroinflammation 9, 63.
    • (2012) J. Neuroinflammation , vol.9 , pp. 63
    • Gray, E.1    Ginty, M.2    Kemp, K.3    Scolding, N.4    Wilkins, A.5
  • 35
    • 0032486173 scopus 로고    scopus 로고
    • 2+-superoxide dismutase in the liver
    • DOI 10.1016/S0024-3205(98)00249-5, PII S0024320598002495
    • Inoue, I., Noji, S., Awata, T., Takahashi, K., Nakajima, T., Sonoda, M., Komoda, T., and Katayama, S. (1998). Bezafibrate has an antioxidant effect: peroxisome proliferator-activated receptor α is associated with Cu2+, Zn2+-superoxide dismutase in the liver. Life Sci. 63, 135-144. (Pubitemid 28298667)
    • (1998) Life Sciences , vol.63 , Issue.2 , pp. 135-144
    • Inoue, I.1    Noji, S.2    Awata, T.3    Takahashi, K.4    Nakajima, T.5    Sonoda, M.6    Komoda, T.7    Katayama, S.8
  • 36
    • 84856035740 scopus 로고    scopus 로고
    • Metabolic state determines sensitivity to cellular stress in Huntington disease: Normalization by activation of PPARγ
    • Jin, Y.N., Hwang, W.Y., Jo, C., and Johnson, G.V. (2012). Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ. PLoS One 7, e30406.
    • (2012) PLoS One , vol.7
    • Jin, Y.N.1    Hwang, W.Y.2    Jo, C.3    Johnson, G.V.4
  • 37
    • 33846610917 scopus 로고    scopus 로고
    • + induced cytotoxicity via inhibition of mitochondrial dysfunction and ROS production
    • DOI 10.1016/j.jns.2006.11.020, PII S0022510X06005399
    • Jung, T.W., Lee, J.Y., Shim, W.S., Kang, E.S., Kim, S.K., Ahn, C.W., Lee, H.C., and Cha, B.S. (2007). Rosiglitazone protects human neuroblastoma SH-SY5Y cells against MPP+ induced cytotoxicity via inhibition of mitochondrial dysfunction and ROS production. J. Neurol. Sci. 253, 53-60. (Pubitemid 46185454)
    • (2007) Journal of the Neurological Sciences , vol.253 , Issue.1-2 , pp. 53-60
    • Jung, T.W.1    Lee, J.Y.2    Shim, W.S.3    Kang, E.S.4    Kim, S.K.5    Ahn, C.W.6    Lee, H.C.7    Cha, B.S.8
  • 38
    • 77953706084 scopus 로고    scopus 로고
    • Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid-induced neurotoxicity: Possible role of peroxisome proliferator activated receptor-γ (PPARγ) in Huntington's disease
    • Kalonia, H., Kumar, P., and Kumar, A. (2010). Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid-induced neurotoxicity: possible role of peroxisome proliferator activated receptor-γ (PPARγ) in Huntington's disease. Pharmacol. Biochem. Behav. 96, 115-124.
    • (2010) Pharmacol. Biochem. Behav , vol.96 , pp. 115-124
    • Kalonia, H.1    Kumar, P.2    Kumar, A.3
  • 39
    • 0035937050 scopus 로고    scopus 로고
    • Identification of protein kinase C isoforms involved in interferon-gamma-induced expression of inducible nitric oxide synthase in murine BV2 microglia
    • DOI 10.1016/S0304-3940(01)01515-4, PII S0304394001015154
    • Kang, J., Yang, M., Jou, I., and Joe, E. (2001). Identification of protein kinase C isoforms involved in interferon-gamma-induced expression of inducible nitric oxide synthase in murine BV2 microglia. Neurosci. Lett. 299, 205-208. (Pubitemid 32124847)
    • (2001) Neuroscience Letters , vol.299 , Issue.3 , pp. 205-208
    • Kang, J.1    Yang, M.-S.2    Jou, I.3    Joe, E.-H.4
  • 40
    • 70049089859 scopus 로고    scopus 로고
    • Exploring mechanism of pioglitazone-induced memory restorative effect in experimental dementia
    • Kaur, B., Singh, N., and Jaggi, A.S. (2009). Exploring mechanism of pioglitazone-induced memory restorative effect in experimental dementia. Fundam. Clin. Pharmacol. 23, 557-566.
    • (2009) Fundam. Clin. Pharmacol , vol.23 , pp. 557-566
    • Kaur, B.1    Singh, N.2    Jaggi, A.S.3
  • 41
    • 0034842626 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor α regulates amino acid metabolism
    • DOI 10.1096/fj.01-0147com
    • Kersten, S., Mandard, S., Escher, P., Gonzalez, F.J., Tafuri, S., Desvergne, B., and Wahli, W. (2001). The peroxisome proliferator-activated receptor α regulates amino acid metabolism. FASEB J. 15, 1971-1978. (Pubitemid 32848801)
    • (2001) FASEB Journal , vol.15 , Issue.11 , pp. 1971-1978
    • Kersten, S.1    Mandard, S.2    Escher, P.3    Gonzalez, F.J.4    Tafuri, S.5    Desvergne, B.6    Wahli, W.7
  • 42
    • 15744366162 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-β/δ inhibits epidermal cell proliferation by down-regulation of kinase activity
    • DOI 10.1074/jbc.M413808200
    • Kim, D.J., Murray, I.A., Burns, A.M., Gonzalez, F.J., Perdew, G.H., and Peters, J.M. (2005). Peroxisome proliferator-activated receptor- β/δ inhibits epidermal cell proliferation by down-regulation of kinase activity. J. Biol. Chem. 280, 9519-9527. (Pubitemid 40409647)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.10 , pp. 9519-9527
    • Kim, D.J.1    Murray, I.A.2    Burns, A.M.3    Gonzalez, F.J.4    Perdew, G.H.5    Peters, J.M.6
  • 43
    • 79953027322 scopus 로고    scopus 로고
    • Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells
    • Kim, H.J., Ham, S.A., Paek, K.S., Hwang JS, Jung SY, Kim MY, Jin H, Kang ES, Woo IS, Kim HJ, et al., (2011). Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 406, 564-569.
    • (2011) Biochem. Biophys. Res. Commun , vol.406 , pp. 564-569
    • Kim, H.J.1    Ham, S.A.2    Paek, K.S.3    Hwang, J.S.4    Jung, S.Y.5    Kim, M.Y.6    Jin, H.7    Kang, E.S.8    Woo, I.S.9    Kim, H.J.10
  • 44
    • 84862787777 scopus 로고    scopus 로고
    • Fructose-1,6-bisphosphate attenuates induction of nitric oxide synthase in microglia stimulated with lipopolysaccharide
    • Kim, Y.C., Park, T.Y., Baik, E., and Lee, S.H. (2012). Fructose-1,6-bisphosphate attenuates induction of nitric oxide synthase in microglia stimulated with lipopolysaccharide. Life Sci. 90, 365-372.
    • (2012) Life Sci , vol.90 , pp. 365-372
    • Kim, Y.C.1    Park, T.Y.2    Baik, E.3    Lee, S.H.4
  • 46
    • 58849147441 scopus 로고    scopus 로고
    • Nitric oxide in health and disease of the nervous system
    • Knott, A.B. and Bossy-Wetzel, E. (2009). Nitric oxide in health and disease of the nervous system. Antioxid. Redox Signal. 11, 541-554.
    • (2009) Antioxid. Redox Signal , vol.11 , pp. 541-554
    • Knott, A.B.1    Bossy-Wetzel, E.2
  • 47
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • DOI 10.1210/me.11.6.779
    • Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M.G., and Wahli, W. (1997). Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11, 779-791. (Pubitemid 27225305)
    • (1997) Molecular Endocrinology , vol.11 , Issue.6 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3    Kalkhoven, E.4    Perroud, M.5    Parker, M.G.6    Wahli, W.7
  • 48
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth, J.D. (2004). NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 4, 181-189. (Pubitemid 38339084)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.3 , pp. 181-189
    • Lambeth, J.D.1
  • 49
    • 57649198440 scopus 로고    scopus 로고
    • Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors
    • Lee, T.I., Kao, Y.H., Chen, Y.C., and Chen, Y.J. (2009). Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors. Eur. J. Clin. Invest. 39, 23-30.
    • (2009) Eur. J. Clin. Invest , vol.39 , pp. 23-30
    • Lee, T.I.1    Kao, Y.H.2    Chen, Y.C.3    Chen, Y.J.4
  • 50
    • 51449116984 scopus 로고    scopus 로고
    • A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis
    • Leisewitz, A.V., Urrutia, C.R., Martinez, G.R., Loyola, G., and Bronfman, M. (2008). A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis. J. Cell Physiol. 217, 367-376.
    • (2008) J. Cell Physiol , vol.217 , pp. 367-376
    • Leisewitz, A.V.1    Urrutia, C.R.2    Martinez, G.R.3    Loyola, G.4    Bronfman, M.5
  • 51
    • 33746080426 scopus 로고    scopus 로고
    • Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics
    • DOI 10.1194/jlr.M500504-JLR200
    • Lemay, D.G. and Hwang, D.H. (2006). Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics. J. Lipid Res. 47, 1583-1587. (Pubitemid 44079913)
    • (2006) Journal of Lipid Research , vol.47 , Issue.7 , pp. 1583-1587
    • Lemay, D.G.1    Hwang, D.H.2
  • 52
    • 84878408552 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonist rosiglitazone reduces secondary damage in experimental spinal cord injury
    • Li, X., Du, J., Xu, S., Lin, X., and Ling, Z. (2013). Peroxisome proliferator-activated receptor-γ agonist rosiglitazone reduces secondary damage in experimental spinal cord injury. J. Int. Med. Res. 41, 153-161.
    • (2013) J. Int. Med. Res , vol.41 , pp. 153-161
    • Li, X.1    Du, J.2    Xu, S.3    Lin, X.4    Ling, Z.5
  • 53
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • DOI 10.1038/nature05292, PII NATURE05292
    • Lin, M.T. and Beal, M.F. (2006). Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795. (Pubitemid 44622683)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 54
    • 0037441344 scopus 로고    scopus 로고
    • Diminished production of nitric oxide synthase cofactor tetrahydrobiopterin by rosiglitazone in adipocytes
    • DOI 10.1016/S0006-2952(02)01562-9, PII S0006295202015629
    • Linscheid, P., Keller, U., Blau, N., Schaer, D.J., and Muller, B. (2003). Diminished production of nitric oxide synthase cofactor tetrahydrobiopterin by rosiglitazone in adipocytes. Biochem. Pharmacol. 65, 593-598. (Pubitemid 36144244)
    • (2003) Biochemical Pharmacology , vol.65 , Issue.4 , pp. 593-598
    • Linscheid, P.1    Keller, U.2    Blau, N.3    Schaer, D.J.4    Muller, B.5
  • 55
    • 0036692295 scopus 로고    scopus 로고
    • The peroxisome proliferator phenylbutyric acid (PBA) protects astrocytes from ts1 MoMuLV-induced oxidative cell death
    • DOI 10.1080/13550280290100699
    • Liu, N., Qiang, W., Kuang, X., Thuillier, P., Lynn, W.S., and Wong, P.K. (2002). The peroxisome proliferator phenylbutyric acid (PBA) protects astrocytes from ts1 MoMuLV-induced oxidative cell death. J. Neurovirol. 8, 318-325. (Pubitemid 34982337)
    • (2002) Journal of NeuroVirology , vol.8 , Issue.4 , pp. 318-325
    • Liu, N.1    Qiang, W.2    Kuang, X.3    Thuillier, P.4    Lynn, W.S.5    Wong, P.K.Y.6
  • 56
    • 74149088832 scopus 로고    scopus 로고
    • Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation
    • Liu, X., Luo, D., Zheng, M., Hao, Y., Hou, L., and Zhang, S. (2010). Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation. Eur. J. Pharmacol. 629, 153-158.
    • (2010) Eur. J. Pharmacol , vol.629 , pp. 153-158
    • Liu, X.1    Luo, D.2    Zheng, M.3    Hao, Y.4    Hou, L.5    Zhang, S.6
  • 57
    • 79551492273 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor β/δ activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition
    • Liu, J., Wang, P., Luo, J., Huang, Y., He, L., Yang, H., Li, Q., Wu, S., Zhelyabovska, O., and Yang, Q. (2011). Peroxisome proliferatoractivated receptor β/δ activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition. Hypertension 57, 223-230.
    • (2011) Hypertension , vol.57 , pp. 223-230
    • Liu, J.1    Wang, P.2    Luo, J.3    Huang, Y.4    He, L.5    Yang, H.6    Li, Q.7    Wu, S.8    Zhelyabovska, O.9    Yang, Q.10
  • 58
    • 33748450699 scopus 로고    scopus 로고
    • Oxidative stress: Apoptosis in neuronal injury
    • DOI 10.2174/156720506778249515
    • Loh, K.P., Huang, S.H., De Silva, R., Tan, B.K., and Zhu, Y.Z. (2006). Oxidative stress: apoptosis in neuronal injury. Curr. Alzheimer Res. 3, 327-337. (Pubitemid 44351476)
    • (2006) Current Alzheimer Research , vol.3 , Issue.4 , pp. 327-337
    • Kok, P.L.1    Shan, H.H.2    De Silva, R.3    Tan, B.K.H.4    Yi, Z.Z.5
  • 59
    • 33645323521 scopus 로고    scopus 로고
    • Neuroprotection against focal ischemic brain injury by the peroxisome proliferatoractivated receptor-γ agonist rosiglitazone
    • Luo, Y., Yin, W., Signore, A.P., Zhang, F., Hong, Z., Wang, S., Graham, S.H., and Chen, J. (2006). Neuroprotection against focal ischemic brain injury by the peroxisome proliferatoractivated receptor-γ agonist rosiglitazone. J. Neurochem. 97, 435-448.
    • (2006) J. Neurochem , vol.97 , pp. 435-448
    • Luo, Y.1    Yin, W.2    Signore, A.P.3    Zhang, F.4    Hong, Z.5    Wang, S.6    Graham, S.H.7    Chen, J.8
  • 61
    • 36249022189 scopus 로고    scopus 로고
    • Neuroprotective actions of noradrenaline: Effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta
    • DOI 10.1111/j.1471-4159.2007.04888.x
    • Madrigal, J.L., Kalinin, S., Richardson, J.C., and Feinstein, D.L. (2007). Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta. J. Neurochem. 103, 2092-2101. (Pubitemid 350126619)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.5 , pp. 2092-2101
    • Madrigal, J.L.M.1    Kalinin, S.2    Richardson, J.C.3    Feinstein, D.L.4
  • 62
    • 0036323863 scopus 로고    scopus 로고
    • Role of superoxide dismutases in oxidative damage and neurodegenerative disorders
    • Maier, C.M. and Chan, P.H. (2002). Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist 8, 323-334. (Pubitemid 34824016)
    • (2002) Neuroscientist , vol.8 , Issue.4 , pp. 323-334
    • Maier, C.M.1    Chan, P.H.2
  • 63
    • 0020415065 scopus 로고
    • Superoxide dismutase in extracellular fluids
    • DOI 10.1016/0009-8981(82)90360-6
    • Marklund, S.L., Holme, E., and Hellner, L. (1982). Superoxide dismutase in extracellular fluids. Clin. Chim. Acta. 126, 41-51. (Pubitemid 13242364)
    • (1982) Clinica Chimica Acta , vol.126 , Issue.1 , pp. 41-51
    • Marklund, S.L.1    Holme, E.2    Hellner, L.3
  • 64
    • 34249092704 scopus 로고    scopus 로고
    • Calcium and neurodegeneration
    • Mattson, M.P. (2007). Calcium and neurodegeneration. Aging Cell 6, 337-350.
    • (2007) Aging Cell , vol.6 , pp. 337-350
    • Mattson, M.P.1
  • 65
    • 77954969568 scopus 로고    scopus 로고
    • Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice
    • Medhi, B., Aggarwal, R., and Chakrabarti, A. (2010). Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice. Indian J. Exp. Biol. 48, 793-799.
    • (2010) Indian J. Exp. Biol , vol.48 , pp. 793-799
    • Medhi, B.1    Aggarwal, R.2    Chakrabarti, A.3
  • 66
    • 69349091599 scopus 로고    scopus 로고
    • PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss
    • Miglio, G., Rosa, A.C., Rattazzi, L., Collino, M., Lombardi, G., and Fantozzi, R. (2009). PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss. Neurochem. Int. 55, 496-504.
    • (2009) Neurochem. Int , vol.55 , pp. 496-504
    • Miglio, G.1    Rosa, A.C.2    Rattazzi, L.3    Collino, M.4    Lombardi, G.5    Fantozzi, R.6
  • 67
    • 84876281916 scopus 로고    scopus 로고
    • Gemfibrozil pretreatment affecting antioxidant defense system and inflammatory, but not Nrf-2 signaling pathways resulted in female neuroprotection and male neurotoxicity in the rat models of global cerebral ischemia-reperfusion
    • Mohagheghi, F., Khalaj, L., Ahmadiani, A., and Rahmani, B. (2013). Gemfibrozil pretreatment affecting antioxidant defense system and inflammatory, but not Nrf-2 signaling pathways resulted in female neuroprotection and male neurotoxicity in the rat models of global cerebral ischemia-reperfusion. Neurotox. Res. 23, 225-237.
    • (2013) Neurotox. Res , vol.23 , pp. 225-237
    • Mohagheghi, F.1    Khalaj, L.2    Ahmadiani, A.3    Rahmani, B.4
  • 68
    • 0031974368 scopus 로고    scopus 로고
    • Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
    • Murakami, K., Kondo, T., Kawase, M., Li, Y., Sato, S., Chen, S.F., and Chan, P.H. (1998). Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J. Neurosci. 18, 205-213. (Pubitemid 28046782)
    • (1998) Journal of Neuroscience , vol.18 , Issue.1 , pp. 205-213
    • Murakami, K.1    Kondo, T.2    Kawase, M.3    Li, Y.4    Sato, S.5    Chen, S.F.6    Chan, P.H.7
  • 70
    • 27544480918 scopus 로고    scopus 로고
    • NAD(P)H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)α-mediated cardiovascular effects
    • DOI 10.1016/j.mrfmmm.2005.02.024, PII S0027510705002575
    • Newaz, M., Blanton, A., Fidelis, P., and Oyekan, A. (2005). NAD(P) H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)α-mediated cardiovascular effects. Mutat. Res. 579, 163-171. (Pubitemid 41540140)
    • (2005) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.579 , Issue.1-2 , pp. 163-171
    • Newaz, M.1    Blanton, A.2    Fidelis, P.3    Oyekan, A.4
  • 71
    • 0025309904 scopus 로고
    • Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain
    • Oliver, C.N., Starke-Reed, P.E., Stadtman, E.R., Liu, G.J., Carney, J.M., and Floyd, R.A. (1990). Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/ reperfusion-induced injury to gerbil brain. Proc. Natl. Acad. Sci. USA 87, 5144-5147.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5144-5147
    • Oliver, C.N.1    Starke-Reed, P.E.2    Stadtman, E.R.3    Liu, G.J.4    Carney, J.M.5    Floyd, R.A.6
  • 72
    • 34247490186 scopus 로고    scopus 로고
    • Mitochondria, oxidative stress and cell death
    • DOI 10.1007/s10495-007-0756-2, Special Issue on Mitochondria in Apoptosis
    • Ott, M., Gogvadze, V., Orrenius, S., and Zhivotovsky, B. (2007). Mitochondria, oxidative stress and cell death. Apoptosis 12, 913-922. (Pubitemid 46653300)
    • (2007) Apoptosis , vol.12 , Issue.5 , pp. 913-922
    • Ott, M.1    Gogvadze, V.2    Orrenius, S.3    Zhivotovsky, B.4
  • 73
    • 33646050051 scopus 로고    scopus 로고
    • IL-4-induced peroxisome proliferator-activated receptor γ activation inhibits NF-κB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: Implication for CNS-demyelinating diseases
    • Paintlia, A.S., Paintlia, M.K., Singh, I., and Singh, A.K. (2006). IL-4-induced peroxisome proliferator-activated receptor gamma activation inhibits NF-κB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases. J. Immunol. 176, 4385-4398. (Pubitemid 44264419)
    • (2006) Journal of Immunology , vol.176 , Issue.7 , pp. 4385-4398
    • Paintlia, A.S.1    Paintlia, M.K.2    Singh, I.3    Singh, A.K.4
  • 74
    • 77956216928 scopus 로고    scopus 로고
    • Reactive oxygen species: Stuck in the middle of neurodegeneration
    • Patten, D.A., Germain, M., Kelly, M.A., and Slack, R.S. (2010). Reactive oxygen species: stuck in the middle of neurodegeneration. J. Alzheimers Dis. 20 (Suppl 2), S357-S367.
    • (2010) J. Alzheimers Dis , vol.20 , Issue.SUPPL. 2
    • Patten, D.A.1    Germain, M.2    Kelly, M.A.3    Slack, R.S.4
  • 75
    • 30744460411 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ (PPARδ) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis
    • DOI 10.1016/j.cardiores.2005.10.019, PII S000863630500492X
    • Pesant, M., Sueur, S., Dutartre, P., Tallandier, M., Grimaldi, P.A., Rochette, L., and Connat, J.L. (2006). Peroxisome proliferatoractivated receptor δ (PPARδ) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis. Cardiovasc. Res. 69, 440-449. (Pubitemid 43098800)
    • (2006) Cardiovascular Research , vol.69 , Issue.2 , pp. 440-449
    • Pesant, M.1    Sueur, S.2    Dutartre, P.3    Tallandier, M.4    Grimaldi, P.A.5    Rochette, L.6    Connat, J.-L.7
  • 78
    • 0033768749 scopus 로고    scopus 로고
    • Actions of melatonin in the reduction of oxidative stress. A review
    • Reiter, R.J., Tan, D.X., Osuna, C., and Gitto, E. (2000). Actions of melatonin in the reduction of oxidative stress. A review. J. Biomed. Sci. 7, 444-458.
    • (2000) J. Biomed. Sci , vol.7 , pp. 444-458
    • Reiter, R.J.1    Tan, D.X.2    Osuna, C.3    Gitto, E.4
  • 80
    • 79959350253 scopus 로고    scopus 로고
    • Extending life span by increasing oxidative stress
    • Ristow, M. and Schmeisser, S. (2011). Extending life span by increasing oxidative stress. Free Radic. Biol. Med. 51, 327-336.
    • (2011) Free Radic. Biol. Med , vol.51 , pp. 327-336
    • Ristow, M.1    Schmeisser, S.2
  • 81
    • 80052262855 scopus 로고    scopus 로고
    • Pharmacological investigations on potential of peroxisome proliferator-activated receptor-γ agonists in hyperhomocysteinemia- induced vascular dementia in rats
    • Sain, H., Sharma, B., Jaggi, A.S., and Singh, N. (2011). Pharmacological investigations on potential of peroxisome proliferator-activated receptor-γ agonists in hyperhomocysteinemia- induced vascular dementia in rats. Neuroscience 192, 322-333.
    • (2011) Neuroscience , vol.192 , pp. 322-333
    • Sain, H.1    Sharma, B.2    Jaggi, A.S.3    Singh, N.4
  • 82
    • 0141756332 scopus 로고    scopus 로고
    • Gemfibrozil increases the specific binding of rat-cortex nuclear extracts to a PPRE probe
    • DOI 10.1016/j.lfs.2003.04.001
    • Sanguino, E., Ramon, M., Roglans, N., Alegret, M., Sanchez, R.M., Vazquez-Carrera, M., and Laguna, J.C. (2003). Gemfibrozil increases the specific binding of rat-cortex nuclear extracts to a PPRE probe. Life Sci. 73, 2927-2937. (Pubitemid 37176885)
    • (2003) Life Sciences , vol.73 , Issue.23 , pp. 2927-2937
    • Sanguino, E.1    Ramon, M.2    Roglans, N.3    Alegret, M.4    Sanchez, R.M.5    Vazquez-Carrera, M.6    Laguna, J.C.7
  • 83
    • 84867574313 scopus 로고    scopus 로고
    • PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice
    • Santhanam, A.V., d'Uscio, L.V., He, T., and Katusic, Z.S. (2012). PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice. Brain Res. 1483, 89-95.
    • (2012) Brain Res , vol.1483 , pp. 89-95
    • Santhanam, A.V.1    D'Uscio, L.V.2    He, T.3    Katusic, Z.S.4
  • 85
    • 84876003107 scopus 로고    scopus 로고
    • The PPARdelta agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation
    • Schnegg, C.I., Greene-Schloesser, D., Kooshki, M., Payne, V.S., Hsu, F.C., and Robbins, M.E. (2013). The PPARdelta agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation. Free Radic. Biol. Med. 61C, 1-9.
    • (2013) Free Radic. Biol. Med , vol.61 C , pp. 1-9
    • Schnegg, C.I.1    Greene-Schloesser, D.2    Kooshki, M.3    Payne, V.S.4    Hsu, F.C.5    Robbins, M.E.6
  • 87
    • 78651298914 scopus 로고    scopus 로고
    • PPAR activation has dichotomous control on the expression levels of cytosolic and secretory phospholipase A2 in astrocytes; Inhibition in naive, untreated cells and enhancement in LPS-stimulated cells
    • Sergeeva, M.G., Aleshin, S.E., Grabeklis, S., and Reiser, G. (2010). PPAR activation has dichotomous control on the expression levels of cytosolic and secretory phospholipase A2 in astrocytes; inhibition in naive, untreated cells and enhancement in LPS-stimulated cells. J. Neurochem. 115, 399-410.
    • (2010) J. Neurochem , vol.115 , pp. 399-410
    • Sergeeva, M.G.1    Aleshin, S.E.2    Grabeklis, S.3    Reiser, G.4
  • 88
    • 0032191581 scopus 로고    scopus 로고
    • Comparison of intrastriatal injections of quinolinic acid and 3- nitropropionic acid for use in animal models of huntington's disease
    • DOI 10.1016/S0278-5846(98)00070-0, PII S0278584698000700
    • Shear, D.A., Dong, J., Gundy, C.D., Haik-Creguer, K.L., and Dunbar, G.L. (1998). Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry. 22, 1217-1240. (Pubitemid 28511596)
    • (1998) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.22 , Issue.7 , pp. 1217-1240
    • Shear, D.A.1    Dong, J.2    Gundy, C.D.3    Haik-Creguer, K.L.4    Dunbar, G.L.5
  • 89
    • 0033591310 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse
    • DOI 10.1016/S0304-3940(99)00316-X, PII S030439409900316X
    • Sheng, H., Brady, T.C., Pearlstein, R.D., Crapo, J.D., and Warner, D.S. (1999). Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse. Neurosci. Lett. 267, 13-16. (Pubitemid 29251611)
    • (1999) Neuroscience Letters , vol.267 , Issue.1 , pp. 13-16
    • Sheng, H.1    Brady, T.C.2    Pearlstein, R.D.3    Crapo, J.D.4    Warner, D.S.5
  • 90
    • 0037022592 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor δ, an integrator of transcriptional repression and nuclear receptor signaling
    • DOI 10.1073/pnas.052707099
    • Shi, Y., Hon, M., and Evans, R.M. (2002). The peroxisome proliferator-activated receptor δ, an integrator of transcriptional repression and nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 99, 2613-2618. (Pubitemid 34240509)
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , Issue.5 , pp. 2613-2618
    • Shi, Y.1    Hon, M.2    Evans, R.M.3
  • 91
    • 12844281747 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor-γ agonist reduces infarct size in transient but not in permanent ischemia
    • DOI 10.1161/01.STR.0000152271.21943.a2
    • Shimazu, T., Inoue, I., Araki, N., Asano, Y., Sawada, M., Furuya, D., Nagoya, H., and Greenberg, J.H. (2005). A peroxisome proliferator-activated receptor-γ agonist reduces infarct size in transient but not in permanent ischemia. Stroke 36, 353-359. (Pubitemid 40170822)
    • (2005) Stroke , vol.36 , Issue.2 , pp. 353-359
    • Shimazu, T.1    Inoue, I.2    Araki, N.3    Asano, Y.4    Sawada, M.5    Furuya, D.6    Nagoya, H.7    Greenberg, J.H.8
  • 92
    • 84878068664 scopus 로고    scopus 로고
    • Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: Possible involvement of PPAR-γ agonistic property
    • Singh, B., Sharma, B., Jaggi, A.S., and Singh, N. (2013). Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible involvement of PPAR-γ agonistic property. J. Renin Angiotensin Aldosterone Syst. 14, 124-135.
    • (2013) J. Renin Angiotensin Aldosterone Syst , vol.14 , pp. 124-135
    • Singh, B.1    Sharma, B.2    Jaggi, A.S.3    Singh, N.4
  • 94
    • 84861460972 scopus 로고    scopus 로고
    • Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model
    • Stefanova, N., Georgievska, B., Eriksson, H., Poewe, W., and Wenning, G.K. (2012). Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model. Neurotox. Res. 21, 393-404.
    • (2012) Neurotox. Res , vol.21 , pp. 393-404
    • Stefanova, N.1    Georgievska, B.2    Eriksson, H.3    Poewe, W.4    Wenning, G.K.5
  • 95
    • 0037830117 scopus 로고    scopus 로고
    • Novel insight into the mechanisms involved in the regulation of the m1 muscarinic receptor, iNOS and nNOS mRNA levels
    • DOI 10.1016/S0028-3908(03)00141-2
    • Sterin-Borda, L., Ganzinelli, S., Berra, A., and Borda, E. (2003). Novel insight into the mechanisms involved in the regulation of the m1 muscarinic receptor, iNOS and nNOS mRNA levels. Neuropharmacol. 45, 260-269. (Pubitemid 36782539)
    • (2003) Neuropharmacology , vol.45 , Issue.2 , pp. 260-269
    • Sterin-Borda, L.1    Ganzinelli, S.2    Berra, A.3    Borda, E.4
  • 96
    • 84863151358 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice
    • Sun, X., Tang, Y., Tan, X., Li, Q., Zhong, W., Jia, W., McClain, C.J., and Zhou, Z. (2012). Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G548-557.
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol , vol.302
    • Sun, X.1    Tang, Y.2    Tan, X.3    Li, Q.4    Zhong, W.5    Jia, W.6    McClain, C.J.7    Zhou, Z.8
  • 98
    • 10644288528 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-α activation properties
    • DOI 10.1161/01.RES.0000150594.95988.45
    • Teissier, E., Nohara, A., Chinetti, G., Paumelle, R., Cariou, B., Fruchart, J.C., Brandes, R.P., Shah, A., and Staels, B. (2004). Peroxisome proliferator-activated receptor α induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-α activation properties. Circ. Res. 95, 1174-1182. (Pubitemid 39648208)
    • (2004) Circulation Research , vol.95 , Issue.12 , pp. 1174-1182
    • Teissier, E.1    Nohara, A.2    Chinetti, G.3    Paumelle, R.4    Cariou, B.5    Fruchart, J.-C.6    Brandes, R.P.7    Shah, A.8    Staels, B.9
  • 99
    • 33947204503 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents
    • DOI 10.1111/j.1471-4159.2006.04376.x
    • Tureyen, K., Kapadia, R., Bowen, K.K., Satriotomo, I., Liang, J., Feinstein, D.L., and Vemuganti, R. (2007). Peroxisome proliferator-activated receptor-γ agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. J. Neurochem. 101, 41-56. (Pubitemid 46426485)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.1 , pp. 41-56
    • Tureyen, K.1    Kapadia, R.2    Bowen, K.K.3    Satriotomo, I.4    Liang, J.5    Feinstein, D.L.6    Vemuganti, R.7
  • 100
    • 77956867734 scopus 로고    scopus 로고
    • Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism
    • Van Veldhoven, P.P. (2010). Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism. J. Lipid Res. 51, 2863-2895.
    • (2010) J. Lipid Res , vol.51 , pp. 2863-2895
    • Van Veldhoven, P.P.1
  • 101
    • 77953811219 scopus 로고    scopus 로고
    • Urea cycle gene expression is suppressed by PFOA treatment in rats
    • Walters, M.W. and Wallace, K.B. (2010). Urea cycle gene expression is suppressed by PFOA treatment in rats. Toxicol. Lett. 197, 46-50.
    • (2010) Toxicol. Lett , vol.197 , pp. 46-50
    • Walters, M.W.1    Wallace, K.B.2
  • 102
    • 0028799005 scopus 로고
    • Structural characterization and regulatory element analysis of the heart isoform of cytochrome c oxidase VIa
    • Wan, B. and Moreadith, R.W. (1995). Structural characterization and regulatory element analysis of the heart isoform of cytochrome c oxidase VIa. J. Biol. Chem. 270, 26433-26440.
    • (1995) J. Biol. Chem , vol.270 , pp. 26433-26440
    • Wan, B.1    Moreadith, R.W.2
  • 104
    • 33748750998 scopus 로고    scopus 로고
    • Dual effects of antioxidants in neurodegeneration: Direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation
    • Wang, J.Y., Wen, L.L., Huang, Y.N., Chen, Y.T., and Ku, M.C. (2006a). Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr. Pharm. Des. 12, 3521-3533.
    • (2006) Curr. Pharm. des , vol.12 , pp. 3521-3533
    • Wang, J.Y.1    Wen, L.L.2    Huang, Y.N.3    Chen, Y.T.4    Ku, M.C.5
  • 105
    • 33750022367 scopus 로고    scopus 로고
    • Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices
    • DOI 10.1016/j.cbi.2006.08.005, PII S0009279706002122
    • Wang, Z.J., Liang, C.L., Li, G.M., Yu, C.Y., and Yin, M. (2006b). Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices. Chem. Biol. Interact. 163, 207-217. (Pubitemid 44572226)
    • (2006) Chemico-Biological Interactions , vol.163 , Issue.3 , pp. 207-217
    • Wang, Z.-J.1    Liang, C.-L.2    Li, G.-M.3    Yu, C.-Y.4    Yin, M.5
  • 106
    • 33847183532 scopus 로고    scopus 로고
    • Stearic acid protects primary cultured cortical neurons against oxidative stress
    • Wang, Z.J., Liang, C.L., Li, G.M., Yu, C.Y., and Yin, M. (2007). Stearic acid protects primary cultured cortical neurons against oxidative stress. Acta. Pharmacol. Sin. 28, 315-326.
    • (2007) Acta. Pharmacol. Sin , vol.28 , pp. 315-326
    • Wang, Z.J.1    Liang, C.L.2    Li, G.M.3    Yu, C.Y.4    Yin, M.5
  • 107
    • 77957985215 scopus 로고    scopus 로고
    • Chronic treatment with fibrates elevates superoxide dismutase in adult mouse brain microvessels
    • Wang, G., Liu, X., Guo, Q., and Namura, S. (2010). Chronic treatment with fibrates elevates superoxide dismutase in adult mouse brain microvessels. Brain Res. 1359, 247-255.
    • (2010) Brain Res , vol.1359 , pp. 247-255
    • Wang, G.1    Liu, X.2    Guo, Q.3    Namura, S.4
  • 108
    • 0030613177 scopus 로고    scopus 로고
    • Huntington is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion
    • White, J.K., Auerbach, W., Duyao, M.P., Vonsattel, J.P., Gusella, J.F., Joyner, A.L., and MacDonald, M.E. (1997). Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nat. Genet. 17, 404-410. (Pubitemid 27518388)
    • (1997) Nature Genetics , vol.17 , Issue.4 , pp. 404-410
    • White, J.K.1    Auerbach, W.2    Duyao, M.P.3    Vonsattel, J.-P.4    Gusella, J.F.5    Joyner, A.L.6    MacDonald, M.E.7
  • 109
    • 33845712621 scopus 로고    scopus 로고
    • Chlorinative stress: An under appreciated mediator of neurodegeneration?
    • DOI 10.1016/j.cellsig.2006.06.013, PII S0898656806001562
    • Yap, Y.W., Whiteman, M., and Cheung, N.S. (2007). Chlorinative stress: an under appreciated mediator of neurodegeneration? Cell Signal. 19, 219-228. (Pubitemid 44969974)
    • (2007) Cellular Signalling , vol.19 , Issue.2 , pp. 219-228
    • Yap, Y.W.1    Whiteman, M.2    Cheung, N.S.3
  • 110
    • 56049113451 scopus 로고    scopus 로고
    • PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms
    • Yi, J.H., Park, S.W., Brooks, N., Lang, B.T., and Vemuganti, R. (2008). PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms. Brain Res. 1244, 164-172.
    • (2008) Brain Res , vol.1244 , pp. 164-172
    • Yi, J.H.1    Park, S.W.2    Brooks, N.3    Lang, B.T.4    Vemuganti, R.5
  • 111
    • 84859060800 scopus 로고    scopus 로고
    • Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain
    • Yoo, S.E., Chen, L., Na, R., Liu, Y., Rios, C., Van Remmen, H., Richardson, A., and Ran, Q. (2012). Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. Free Radic. Biol. Med. 52, 1820-1827.
    • (2012) Free Radic. Biol. Med , vol.52 , pp. 1820-1827
    • Yoo, S.E.1    Chen, L.2    Na, R.3    Liu, Y.4    Rios, C.5    Van Remmen, H.6    Richardson, A.7    Ran, Q.8
  • 112
    • 40849135452 scopus 로고    scopus 로고
    • Activation of cerebral peroxisome proliferator-activated receptors γ exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus
    • Yu, X., Shao, X.G., Sun, H., Li, Y.N., Yang, J., Deng, Y.C., and Huang, Y.G. (2008). Activation of cerebral peroxisome proliferator-activated receptors γ exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus. Brain Res. 1200, 146-158.
    • (2008) Brain Res , vol.1200 , pp. 146-158
    • Yu, X.1    Shao, X.G.2    Sun, H.3    Li, Y.N.4    Yang, J.5    Deng, Y.C.6    Huang, Y.G.7
  • 115
    • 84862832777 scopus 로고    scopus 로고
    • Hyperbaric oxygen preconditioning protects cortical neurons against oxygen-glucose deprivation injury: Role of peroxisome proliferator-activated receptor-γ
    • Zeng, Y., Xie, K., Dong, H., Zhang, H., Wang, F., Li, Y., and Xiong, L. (2012). Hyperbaric oxygen preconditioning protects cortical neurons against oxygen-glucose deprivation injury: role of peroxisome proliferator-activated receptor-γ. Brain Res. 1452, 140-150.
    • (2012) Brain Res , vol.1452 , pp. 140-150
    • Zeng, Y.1    Xie, K.2    Dong, H.3    Zhang, H.4    Wang, F.5    Li, Y.6    Xiong, L.7
  • 116
    • 34247560648 scopus 로고    scopus 로고
    • Hematoma resolution as a target for intracerebral hemorrhage treatment: Role for peroxisome proliferator-activated receptor γ in microglia/macrophages
    • DOI 10.1002/ana.21097
    • Zhao, X., Sun, G., Zhang, J., Strong, R., Song, W., Gonzales, N., Grotta, J.C., and Aronowski, J. (2007). Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor γ in microglia/ macrophages. Ann. Neurol. 61, 352-362. (Pubitemid 46676735)
    • (2007) Annals of Neurology , vol.61 , Issue.4 , pp. 352-362
    • Zhao, X.1    Sun, G.2    Zhang, J.3    Strong, R.4    Song, W.5    Gonzales, N.6    Grotta, J.C.7    Aronowski, J.8
  • 117
    • 66049135616 scopus 로고    scopus 로고
    • Neuronal PPARγ deficiency increases susceptibility to brain damage after cerebral ischemia
    • Zhao, X., Strong, R., Zhang, J., Sun, G., Tsien, J.Z., Cui, Z., Grotta, J.C., and Aronowski, J. (2009). Neuronal PPARγ deficiency increases susceptibility to brain damage after cerebral ischemia. J. Neurosci. 29, 6186-6195.
    • (2009) J. Neurosci , vol.29 , pp. 6186-6195
    • Zhao, X.1    Strong, R.2    Zhang, J.3    Sun, G.4    Tsien, J.Z.5    Cui, Z.6    Grotta, J.C.7    Aronowski, J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.