Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 12602-12611

  Do, Hai Thi ^a,b   Tselykh, Timofey V ^a,b   Mäkelä, Johanna ^a,b   Ho, Tho Huu ^b   Olkkonen, Vesa M ^b   Bornhauser, Beat C ^c   Korhonen, Laura ^a,b   Zelcer, Noam ^d   Lindholm, Dan ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^c UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CHOLESTEROL; CRITICAL FACTORS; CULTURED CELL; FIBROBLAST GROWTH; HEPATOCYTES; HUMAN DISEASE; LOW DENSITY LIPOPROTEINS; OVER-EXPRESSION; POST-TRANSCRIPTIONAL; PROTEIN LEVEL; STATINS; UBIQUITIN LIGASES; UBIQUITINATION;

BODY FLUIDS; CELLS; CYTOLOGY; EXPERIMENTS; RNA;

PROTEINS;

FIBROBLAST GROWTH FACTOR 21; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; MYLIP INTERACTING SAPOSIN LIKE PROTEIN; MYOSIN REGULATORY LIGHT CHAIN INTERACTING PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LIVER CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE; CHOLESTEROL; FIBROBLAST GROWTH FACTORS; HEPATOCYTES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPID METABOLISM; MACROPHAGES; MICE; RECEPTORS, LDL; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; UP-REGULATION;

EID: 84859752249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.341248     Document Type: Article

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