-
1
-
-
48249125791
-
Malignant gliomas in adults
-
Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008;359:492-507.
-
(2008)
N Engl J Med
, vol.359
, pp. 492-507
-
-
Wen, P.Y.1
Kesari, S.2
-
2
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-60.
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
Hao, Y.4
Shi, Q.5
Hjelmeland, A.B.6
-
3
-
-
84861399134
-
Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
-
Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, et al. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell 2012;21:601-13.
-
(2012)
Cancer Cell
, vol.21
, pp. 601-613
-
-
Swartling, F.J.1
Savov, V.2
Persson, A.I.3
Chen, J.4
Hackett, C.S.5
Northcott, P.A.6
-
4
-
-
0017785769
-
Primary bioassay of human tumor stem cells
-
Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science 1977;197:461-3.
-
(1977)
Science
, vol.197
, pp. 461-463
-
-
Hamburger, A.W.1
Salmon, S.E.2
-
5
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
6
-
-
84858608410
-
Cancer stem cells: Impact, heterogeneity, and uncertainty
-
Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 2012;21:283-96.
-
(2012)
Cancer Cell
, vol.21
, pp. 283-296
-
-
Magee, J.A.1
Piskounova, E.2
Morrison, S.J.3
-
7
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell JE Jr. Transcription factors as targets for cancer therapy. Nat Rev Cancer 2002;2:740-9.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 740-749
-
-
Darnell, J.E.1
-
8
-
-
20944441928
-
Validating Stat3 in cancer therapy
-
Darnell JE. Validating Stat3 in cancer therapy. Nat Med 2005;11:595-6.
-
(2005)
Nat Med
, vol.11
, pp. 595-596
-
-
Darnell, J.E.1
-
9
-
-
70350500225
-
STATs in cancer inflammation and immunity: A leading role for STAT3
-
Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-809.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
10
-
-
33845865825
-
Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
-
Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
11
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009;15:103-13.
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
Mucida, D.4
Yu, G.Y.5
Vallabhapurapu, S.6
-
12
-
-
37349098725
-
Autocrine IL-6 signaling: A key event in tumorigenesis?
-
Grivennikov S, Karin M. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell 2008;13:7-9.
-
(2008)
Cancer Cell
, vol.13
, pp. 7-9
-
-
Grivennikov, S.1
Karin, M.2
-
13
-
-
58649119388
-
Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment
-
Kortylewski M, Xin H, Kujawski M, Lee H, Liu Y, Harris T, et al. Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell 2009;15:114-23.
-
(2009)
Cancer Cell
, vol.15
, pp. 114-123
-
-
Kortylewski, M.1
Xin, H.2
Kujawski, M.3
Lee, H.4
Liu, Y.5
Harris, T.6
-
14
-
-
84861399789
-
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites
-
Deng J, Liu Y, Lee H, Herrmann A, Zhang W, Zhang C, et al. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 2012;21:642-54.
-
(2012)
Cancer Cell
, vol.21
, pp. 642-654
-
-
Deng, J.1
Liu, Y.2
Lee, H.3
Herrmann, A.4
Zhang, W.5
Zhang, C.6
-
15
-
-
70350212976
-
STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
-
Sherry MM, Reeves A, Wu JK, Cochran BH. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 2009;27:2383-92.
-
(2009)
Stem Cells
, vol.27
, pp. 2383-2392
-
-
Sherry, M.M.1
Reeves, A.2
Wu, J.K.3
Cochran, B.H.4
-
16
-
-
75149195336
-
The transcriptional network for mesenchymal transformation of brain tumours
-
Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 2010;463:318-25.
-
(2010)
Nature
, vol.463
, pp. 318-325
-
-
Carro, M.S.1
Lim, W.K.2
Alvarez, M.J.3
Bollo, R.J.4
Zhao, X.5
Snyder, E.Y.6
-
17
-
-
79959956046
-
The JAK2/STAT3 signaling pathway is required for growth of CD44 (+) CD24 (-) stem cell-like breast cancer cells in human tumors
-
Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, et al. The JAK2/STAT3 signaling pathway is required for growth of CD44 (+) CD24 (-) stem cell-like breast cancer cells in human tumors. J Clin Invest 2011;121:2723-35.
-
(2011)
J Clin Invest
, vol.121
, pp. 2723-2735
-
-
Marotta, L.L.1
Almendro, V.2
Marusyk, A.3
Shipitsin, M.4
Schemme, J.5
Walker, S.R.6
-
18
-
-
79953757100
-
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
-
Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, et al. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell 2011;19:498-511.
-
(2011)
Cancer Cell
, vol.19
, pp. 498-511
-
-
Guryanova, O.A.1
Wu, Q.2
Cheng, L.3
Lathia, J.D.4
Huang, Z.5
Yang, J.6
-
19
-
-
5444262511
-
Toll-like receptor control of the adaptive immune responses
-
Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004;5:987-95.
-
(2004)
Nat Immunol
, vol.5
, pp. 987-995
-
-
Iwasaki, A.1
Medzhitov, R.2
-
20
-
-
34249677845
-
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
-
Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007;13:552-9.
-
(2007)
Nat Med
, vol.13
, pp. 552-559
-
-
Kanzler, H.1
Barrat, F.J.2
Hessel, E.M.3
Coffman, R.L.4
-
21
-
-
33847183077
-
Cooperation of Toll-like receptor signals in innate immune defence
-
Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007;7:179-90.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 179-190
-
-
Trinchieri, G.1
Sher, A.2
-
23
-
-
65549111372
-
Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy
-
Kortylewski M, Kujawski M, Herrmann A, Yang C, Wang L, Liu Y, et al. Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy. Cancer Res 2009;69:2497-505.
-
(2009)
Cancer Res
, vol.69
, pp. 2497-2505
-
-
Kortylewski, M.1
Kujawski, M.2
Herrmann, A.3
Yang, C.4
Wang, L.5
Liu, Y.6
-
25
-
-
37849002321
-
Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
-
Krieg AM. Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 2008;27:161-7.
-
(2008)
Oncogene
, vol.27
, pp. 161-167
-
-
Krieg, A.M.1
-
26
-
-
28644445445
-
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
-
Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11:1314-21.
-
(2005)
Nat Med
, vol.11
, pp. 1314-1321
-
-
Kortylewski, M.1
Kujawski, M.2
Wang, T.3
Wei, S.4
Zhang, S.5
Pilon-Thomas, S.6
-
27
-
-
70349971417
-
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
-
Kortylewski M, Swiderski P, Herrmann A, Wang L, Kowolik C, Kujawski M, et al. In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol 2009;27:925-32.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 925-932
-
-
Kortylewski, M.1
Swiderski, P.2
Herrmann, A.3
Wang, L.4
Kowolik, C.5
Kujawski, M.6
-
28
-
-
77957327205
-
Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells
-
Herrmann A, Kortylewski M, Kujawski M, Zhang C, Reckamp K, Armstrong B, et al. Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells. Cancer Res 2010;70:7455-64.
-
(2010)
Cancer Res
, vol.70
, pp. 7455-7464
-
-
Herrmann, A.1
Kortylewski, M.2
Kujawski, M.3
Zhang, C.4
Reckamp, K.5
Armstrong, B.6
-
29
-
-
34248169629
-
Development of TLR9 agonists for cancer therapy
-
Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest 2007;117:1184-94.
-
(2007)
J Clin Invest
, vol.117
, pp. 1184-1194
-
-
Krieg, A.M.1
-
30
-
-
84855196132
-
TLR9 expression is associated with prognosis in patients with glioblastoma multiforme
-
Leng L, Jiang T, Zhang Y. TLR9 expression is associated with prognosis in patients with glioblastoma multiforme. J Clin Neurosci 2008;19:75-80.
-
(2008)
J Clin Neurosci
, vol.19
, pp. 75-80
-
-
Leng, L.1
Jiang, T.2
Zhang, Y.3
-
31
-
-
42349106146
-
Expression of TLR9 within human glioblastoma
-
Meng Y, Kujas M, Marie Y, Paris S, Thillet J, Delattre JY, et al. Expression of TLR9 within human glioblastoma. J Neurooncol 2008;88:19-25.
-
(2008)
J Neurooncol
, vol.88
, pp. 19-25
-
-
Meng, Y.1
Kujas, M.2
Marie, Y.3
Paris, S.4
Thillet, J.5
Delattre, J.Y.6
-
32
-
-
84867605321
-
STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation
-
Tye H, Kennedy CL, Najdovska M, McLeod L, McCormack W, Hughes N, et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 2012;22:466-78.
-
(2012)
Cancer Cell
, vol.22
, pp. 466-478
-
-
Tye, H.1
Kennedy, C.L.2
Najdovska, M.3
McLeod, L.4
McCormack, W.5
Hughes, N.6
-
33
-
-
84879000598
-
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
-
Kim E, Kim M, Woo DH, Shin Y, Shin J, Chang N, et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 2013;23:839-52.
-
(2013)
Cancer Cell
, vol.23
, pp. 839-852
-
-
Kim, E.1
Kim, M.2
Woo, D.H.3
Shin, Y.4
Shin, J.5
Chang, N.6
-
34
-
-
67650444760
-
ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
-
Hu Y, Smyth GK. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J Immunol Methods 2009;347:70-8.
-
(2009)
J Immunol Methods
, vol.347
, pp. 70-78
-
-
Hu, Y.1
Smyth, G.K.2
-
36
-
-
84859820456
-
Stem-like tumor-initiating cells isolated from IL13Ralpha2 expressing gliomas are targeted and killed by IL13-zetakine-redirected T Cells
-
Brown CE, Starr R, Aguilar B, Shami AF, Martinez C, D'Apuzzo M, et al. Stem-like tumor-initiating cells isolated from IL13Ralpha2 expressing gliomas are targeted and killed by IL13-zetakine-redirected T Cells. Clin Cancer Res 2012;18:2199-209.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2199-2209
-
-
Brown, C.E.1
Starr, R.2
Aguilar, B.3
Shami, A.F.4
Martinez, C.5
D'Apuzzo, M.6
-
37
-
-
84865847962
-
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells
-
Janiszewska M, Suva ML, Riggi N, Houtkooper RH, Auwerx J, Clement-Schatlo V, et al. Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. Genes Dev 2012;26:1926-44.
-
(2012)
Genes Dev
, vol.26
, pp. 1926-1944
-
-
Janiszewska, M.1
Suva, M.L.2
Riggi, N.3
Houtkooper, R.H.4
Auwerx, J.5
Clement-Schatlo, V.6
-
39
-
-
79954575702
-
Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation
-
Jin X, Jeon HY, Joo KM, Kim JK, Jin J, Kim SH, et al. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Res 2011;71:3066-75.
-
(2011)
Cancer Res
, vol.71
, pp. 3066-3075
-
-
Jin, X.1
Jeon, H.Y.2
Joo, K.M.3
Kim, J.K.4
Jin, J.5
Kim, S.H.6
-
40
-
-
84874449237
-
TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo
-
Zhang Q, Hossain DM, Nechaev S, Kozlowska A, Zhang W, Liu Y, et al. TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo. Blood 2013;121:1304-15.
-
(2013)
Blood
, vol.121
, pp. 1304-1315
-
-
Zhang, Q.1
Hossain, D.M.2
Nechaev, S.3
Kozlowska, A.4
Zhang, W.5
Liu, Y.6
-
42
-
-
33745946911
-
Therapeutic potential of Toll-like receptor 9 activation
-
Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006;5:471-84.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 471-484
-
-
Krieg, A.M.1
-
43
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001;1:135-45.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
45
-
-
56749160139
-
Generation of pluripotent stem cells from adult human testis
-
Conrad S, Renninger M, Hennenlotter J, Wiesner T, Just L, Bonin M, et al. Generation of pluripotent stem cells from adult human testis. Nature 2008;456:344-9.
-
(2008)
Nature
, vol.456
, pp. 344-349
-
-
Conrad, S.1
Renninger, M.2
Hennenlotter, J.3
Wiesner, T.4
Just, L.5
Bonin, M.6
-
46
-
-
36048963331
-
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
-
Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A 2007;104:16158-63.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 16158-16163
-
-
Zhou, J.1
Wulfkuhle, J.2
Zhang, H.3
Gu, P.4
Yang, Y.5
Deng, J.6
-
47
-
-
77957275514
-
Highly efficient osteogenic differentiation of human mesenchymal stem cells by eradication of STAT3 signaling
-
Levy O, Ruvinov E, Reem T, Granot Y, Cohen S. Highly efficient osteogenic differentiation of human mesenchymal stem cells by eradication of STAT3 signaling. Int J Biochem Cell Biol 2010;42:1823-30.
-
(2010)
Int J Biochem Cell Biol
, vol.42
, pp. 1823-1830
-
-
Levy, O.1
Ruvinov, E.2
Reem, T.3
Granot, Y.4
Cohen, S.5
-
48
-
-
0035902140
-
The Hedgehog and Wnt signalling pathways in cancer
-
Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001;411:349-54.
-
(2001)
Nature
, vol.411
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
49
-
-
67649515610
-
Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades
-
Katoh M, Katoh M. Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. Int J Mol Med 2009;23:763-9.
-
(2009)
Int J Mol Med
, vol.23
, pp. 763-769
-
-
Katoh, M.1
Katoh, M.2
|