Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2

American Journal of Cancer Research

Volumn 5, Issue 5, 2015, Pages 1610-1620

  Cai, Tianchi ^a   Kuang, Yingmin ^a   Zhang, Chunhua ^a,b   Zhang, Zheng ^a   Chen, Long ^a   Li, Bo ^a   Li, Yuqian ^a   Wang, Yanling ^a   Yang, Huixin ^a   Han, Qiaoqiao ^a   Zhu, Yuechun ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

^b Yunnan Maternal and Child Health Hospital   (China)

Author keywords

C SRC; CDK4; Cyclin D1; Glucose 6 phosphate dehydrogenase; NOX4; SHP2; STAT3 5

Indexed keywords

EID: 85006233472     PISSN: None     EISSN: 21566976     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Wadasadawala T, Trivedi S, Gupta T, Epari S and Jalali R. The diagnostic dilemma of primary central nervous system melanoma. J Clin Neurosci 2010; 17: 1014-1017.
2. Xie Q, Lan G, Zhou Y, Huang J, Liang Y, Zheng W, Fu X, Fan C and Chen T. Strategy to enhance the anticancer efficacy of X-ray radiotherapy in melanoma cells by platinum complexes, the role of ROS-mediated signaling pathways. Cancer Lett 2014; 354: 58-67.
3. Pandolfi PP, Sonati F, Rivi R, Mason P, Grosveld F and Luzzatto L. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J 1995; 14: 5209-5215.
4. Love NR, Ziegler M, Chen Y and Amaya E. Carbohydrate metabolism during vertebrate appendage regeneration: what is its role? How is it regulated?: A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis. Bioessays 2014; 36: 27-33.
5. Vaca G, Arambula E and Esparza A. Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Mexico: overall results of a 7-year project. Blood Cells Mol Dis 2002; 28: 436-444.
6. Yan T, Cai R, Mo O, Zhu D, Ouyang H, Huang L, Zhao M, Huang F, Li L, Liang X and Xu X. Incidence and complete molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Guangxi Zhuang autonomous region of southern China: description of four novel mutations. Haematologica 2006; 91: 1321-1328.
7. Hu T, Zhang C, Tang Q, Su Y, Li B, Chen L, Zhang Z, Cai T and Zhu Y. Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model. BMC Cancer 2013; 13: 251.
8. Cheng G, Cao Z, Xu X, van Meir EG and Lam-beth JD. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001; 269: 131-140.
9. Spencer NY, Yan Z, Boudreau RL, Zhang Y, Luo M, Li Q, Tian X, Shah AM, Davisson RL, Davi-dson B, Banfi B and Engelhardt JF. Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem 2011; 286: 8977-8987.
10. Chong ZZ and Maiese K. The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. Histol Histopathol 2007; 22: 1251-1267.
11. Kleniewska P, Piechota A, Skibska B and Go-raca A. The NADPH oxidase family and its inhibitors. Arch Immunol Ther Exp (Warsz) 2012; 60: 277-294.
12. Liu L, Nam S, Tian Y, Yang F, Wu J, Wang Y, Scu-to A, Polychronopoulos P, Magiatis P, Skal-tsounis L and Jove R. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res 2011; 71: 3972-3979.
13. Nam S, Xie J, Perkins A, Ma Y, Yang F, Wu J, Wang Y, Xu RZ, Huang W, Horne DA and Jove R. Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Mol Oncol 2012; 6: 484-493.
14. Zhang C, Zhang Z, Zhu Y and Qin S. Glucose-6-phosphate dehydrogenase: a biomarker and potential therapeutic target for cancer. An-ticancer Agents Med Chem 2014; 14: 280-289.
15. Nguyen AV, Wu YY, Liu Q, Wang D, Nguyen S, Loh R, Pang J, Friedman K, Orlofsky A, Augenlicht L, Pollard JW and Lin EY. STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon. Neoplasia 2013; 15: 998-1008.
16. Haricharan S and Li Y. STAT signaling in mammary gland differentiation, cell survival and tumorigenesis. Mol Cell Endocrinol 2014; 382: 560-569.
17. Yin D, Li Y, Lin H, Guo B, Du Y, Li X, Jia H, Zhao X, Tang J and Zhang L. Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo. Nanotechnology 2013; 24: 105102.
18. Tworkoski K, Singhal G, Szpakowski S, Zito CI, Bacchiocchi A, Muthusamy V, Bosenberg M, Krauthammer M, Halaban R and Stern DF. Ph-osphoproteomic screen identifies potential therapeutic targets in melanoma. Mol Cancer Res 2011; 9: 801-812.
19. Niu G, Wright KL, Ma Y, Wright GM, Huang M, Irby R, Briggs J, Karras J, Cress WD, Pardoll D, Jove R, Chen J and Yu H. Role of Stat3 in regulating p53 expression and function. Mol Cell Biol 2005; 25: 7432-7440.
20. Bill MA, Bakan C, Benson DM Jr, Fuchs J, Young G and Lesinski GB. Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Mol Cancer Ther 2009; 8: 2726-2735.
21. Chen CY, Chen YK, Wang JJ, Hsu CC, Tsai FY, Sung PJ, Lin HC, Chang LS and Hu WP. DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways. Cell Biol Toxicol 2013; 29: 85-99.
22. Soldaini E, John S, Moro S, Bollenbacher J, Schindler U and Leonard WJ. DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. Mol Cell Biol 2000; 20: 389-401.