Structure-activity relationships of imidazole-derived 2-[ N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme

European Journal of Medicinal Chemistry

Volumn 90, Issue , 2015, Pages 547-567

  Charton, Julie ^a,b,c,d,e   Gauriot, Marion ^a,b,c,d,e   Totobenazara, Jane ^a,b,c,d,e   Hennuyer, Nathalie ^a,b,c,f   Dumont, Julie ^a,b,c,d,e   Bosc, Damien ^a,b,c,d,e   Marechal, Xavier ^a,b,c,d,e   Elbakali, Jamal ^a,b,c,d,e   Herledan, Adrien ^a,b,c,d,e   Wen, Xiaoan ^a,b,c,d,e   Ronco, Cyril ^a,b,c,d,e   Gras Masse, Helene ^a,b,c,d,e   Heninot, Antoine ^a,b,c,d,e   Pottiez, Virginie ^a,b,c,d,e   Landry, Valerie ^a,b,c,d,e   Staels, Bart ^a,b,c,f   Liang, Wenguang G ^g   Leroux, Florence ^a,b,c,d,e   Tang, Wei Jen ^g   Deprez, Benoit ^a,b,c,d,e   Deprez Poulain, Rebecca ^a,b,c,d,e   more..

^a INSERM   (France)

^b Lille ^*  (France)

^c INSTITUT PASTEUR DE LILLE   (France)

^d PRIM   (France)

^e IGM   (France)

^f France   (France)

^g UNIVERSITY OF CHICAGO   (United States)

Author keywords

Enzymes; Structureeactivity relationships

Indexed keywords

((4 TERT BUTYL BENZYL)CARBOXYMETHYL AMINO)ACETIC ACID; (BENZOYL CARBOXYMETHYL AMINO)ACETIC ACID; (BENZYLOXYCARBONYL CARBOXYMETHYL AMINO)ACETIC ACID; (CARBOXYMETHYL (2 (1H INDOL 3 YL)ETHYL)AMINO)ACETIC ACID; (CARBOXYMETHYL (3 PHENYL PROPIONYL)AMINO)ACETIC ACID; (CARBOXYMETHYL (3 PHENYL PROPYL)AMINO)ACETIC ACID; (CARBOXYMETHYL (4 FLUORO BENZYL)AMINO)ACETIC ACID; (CARBOXYMETHYL (4 TRIFLUOROMETHYL BENZYL)AMINO)ACETIC ACID; (CARBOXYMETHYL HEXYL AMINO)ACETIC ACID; (CARBOXYMETHYL NAPHTHALEN 2 YLMETHYL AMINO)ACETIC ACID; (CARBOXYMETHYL PHENETHYL AMINO)ACETIC ACID; (CARBOXYMETHYL PHENYLACETYL AMINO)ACETIC ACID; (TERT BUTOXYCARBONYL CARBOXYMETHYL AMINO)ACETIC ACID; 2 (2 ((4 TERT BUTYL BENZYL)CARBOXYMETHYL AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (BENZYL CARBOXYMETHYL AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (BENZYL CARBOXYMETHYL AMINO)ACETYLAMINO) 3 (1H INDOL 3 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (BENZYL CARBOXYMETHYL AMINO)ACETYLAMINO) 3 PHENYL PROPIONIC ACID METHYL ESTER; 2 (2 (BENZYL CARBOXYMETHYL AMINO)ACETYLAMINO) 5 GUANIDINO PENTANOIC ACID METHYL ESTER; 2 (2 (CARBOXYMETHYL (2 (1H INDOL 3 YL)ETHYL)AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (CARBOXYMETHYL (3 PHENYL PROPYL)AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (CARBOXYMETHYL (4 FLUORO BENZYL)AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (CARBOXYMETHYL (4 METHYL BENZYL)AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (CARBOXYMETHYL (4 TRIFLUOROMETHYL BENZYL)AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (CARBOXYMETHYL NAPHTHALEN 2 YLMETHYL AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (CARBOXYMETHYL PHENETHYL AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (2 (CARBOXYMETHYL PYRIDIN 4 YLMETHYL AMINO)ACETYLAMINO) 3 (1H IMIDAZOL 4 YL)PROPIONIC ACID METHYL ESTER; ACETIC ACID DERIVATIVE; IMIDAZOLE DERIVATIVE; INSULINASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; CARBAMIC ACID DERIVATIVE; CARBOXYLIC ACID; ENZYME INHIBITOR; OXADIAZOLE DERIVATIVE;

AREA UNDER THE CURVE; ARTICLE; CRYSTALLIZATION; DRUG ACTIVITY; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; MICROSOME; MOLECULAR DOCKING; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; SYNTHESIS;

CARBAMATES; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INSULYSIN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXADIAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84949116723     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.12.005     Document Type: Article

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