Capture hydrolysis signals in the microsomal stability assay: Molecular mechanisms of the alkyl ester drug and prodrug metabolism

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 989-995

  Sun, Hao ^a  

^a PFIZER INC   (United States)

Author keywords

Carboxylesterase; Carboxylic acid ester; Drug metabolism; Human liver microsome; Hydrolysis

Indexed keywords

ALKYLESTER; ESTER DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CORRELATION ANALYSIS; DENSITY FUNCTIONAL THEORY; DRUG METABOLISM; HUMAN; HYDROLYSIS; LIVER MICROSOME; METABOLIC RATE; MOLECULAR DOCKING; MOLECULAR DYNAMICS;

CARBOXYLIC ACIDS; CYTOCHROME P-450 ENZYME SYSTEM; ESTERS; HUMANS; HYDROLYSIS; MICROSOMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PRODRUGS; QUANTUM THEORY; SIGNAL TRANSDUCTION;

EID: 84855644511     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.005     Document Type: Article

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