Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

Human Molecular Genetics

Volumn 9, Issue 14, 2000, Pages 2149-2158

  Fakhrai Rad, Hossein ^a   Nikoshkov, Andrej ^a   Kamel, Ashraf ^a   Fernström, Maria ^a   Zierath, Juleen R ^a   Norgren, Svante ^a   Luthman, Holger ^a   Galli, Joakim ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ARGININE; HISTIDINE; INSULIN; INSULINASE; VALINE;

ADIPOCYTE; ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL LYSATE; CONGENIC STRAIN; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; GENE LOCUS; GENE MAPPING; GENE TRANSFER; GENETIC ANALYSIS; GENETIC CODE; GENETIC TRANSFECTION; GENOME; GLUCOSE TRANSPORT; HYPERGLYCEMIA; INSULIN DEGRADATION; INTERNALIZATION; LIPOGENESIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; RAT;

ANIMALIA; LEUCISCUS IDUS;

EID: 0034284938     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.14.2149     Document Type: Article

References (61)

1. Diabetes mellitus in identical twins
2. Diabetes in identical twins
3. Empirical risk figures for first degree relatives of non-insulin-dependent diabetics
4. Concordance for type II (non-insulin-dependent) diabetes mellitus in male twins
5. Concordance rate for type II diabetes mellitus in monozygotic twins: Actuarial analysis
6. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance - A population-based twin study
7. Mutation in mitochondrial tRNA(Leu)(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
8. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
9. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)
10. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
11. Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with MODY
12. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
13. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
14. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
15. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats
16. Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM
17. Genetic dissection of 'OLETF', a rat model for non-insulin-dependent diabetes mellitus
18. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
19. Genetic analysis of obese diabetes in the TSOD mouse
20. Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait
21. Spontaneous diabetes produced by selective breeding of normal Wistar rats
22. Spontaneously diabetic GK (Goto-Kakizaki) rats
23. Pathophysiological and genetic characterization of the major diabetes locus in GK rats
24. Identification of the metal associated with the insulin degrading enzyme
25. An unusual active site identified in a family of zinc metalloendopeptidases
26. Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors
27. Insulin degradation: Progress and potential
28. Degradation of intraendosomal insulin by insulin-degrading enzyme without acidification
29. Insulin acts intracellularly on proteasomes through insulin-degrading enzyme
30. Androgen and glucocorticoid receptors interact with insulin degrading enzyme
31. Identification of zinc ligands of the insulin-degrading enzyme
32. A radiation hybrid map of the rat genome containing 5,255 markers
33. Hyperinsulinemia of obesity is due to decreased clearance of insulin
34. Decreased hepatic insulin extraction in subjects with mild glucose intolerance
35. Insulin internalization and degradation in adipocytes from normal and type II diabetic subjects
36. Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients
37. Alterations in the glucose-stimulated insulin secretory dose-response curve and in insulin clearance in nondiabetic insulin-resistant individuals
38. Relationship of insulin clearance and secretion to insulin sensitivity in non-diabetic Mexican Americans
39. Ethnic differences in secretion, sensitivity, and hepatic extraction of insulin in black and white Americans
40. Insulin binding and degradation by muscles from streptozotocin-diabetic rats
41. Insulin degrading enzyme activity and insulin binding of erythrocytes in normal subjects and type 2 (non-insulin-dependent) diabetic patients
42. 3H]insulin in streptozotocin diabetic rats
43. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans
44. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians
45. A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10
46. Defects in adipocytes glucose transport, insulin binding, insulin internalization, and insulin receptor recycling in an animal model of non-insulin-dependent diabetes mellitus
47. Evidence of a defect in insulin-receptor recycling in adipocytes from older rats
48. Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme
49. Binding of the dye congo red to the amyloid protein pig insulin reveals a novel homology amongst amyloid-forming peptide sequences
50. Antilipolytic effect of insulin and insulin receptor messenger RNA expression in adipocytes of infants, children, and adults
51. Fasting-mediated alteration studies in insulin action on lipolysis and lipogenesis in obese women
52. A simple free fat cell bioassay for insulin
53. Changes in catecholamine-induced lipolysis in isolated human fat cells during the first year of life
54. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
55. Mapmaker: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
56. The rat insulin-degrading enzyme: Molecular cloning and characterization of tissue-specific transcripts
57. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
58. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
59. Reversibility of decreased insulin-stimulated glucose transport capacity in diabetic muscle with in vitro incubation. Insulin is not required
60. Effect of diffusion distance on measurement of rat skeletal muscle glucose transport in vitro