Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2246-2255

  Abdul Hay, Samer O ^a   Lane, Amy L ^b   Caulfield, Thomas R ^a   Claussin, Clémence ^a   Bertrand, Juliette ^a   Masson, Amandine ^a   Choudhry, Shakeel ^a   Fauq, Abdul H ^a   Maharvi, Guhlam M ^a   Leissring, Malcolm A ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF NORTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXAMIC ACID DERIVATIVE; INSULINASE; METALLOPROTEINASE INHIBITOR; PEPTIDE HYDROXAMATE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; PROCESS OPTIMIZATION;

DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; INSULYSIN; MOLECULAR DOCKING SIMULATION; PEPTIDES; PROTEIN CONFORMATION; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84875750447     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301280p     Document Type: Article

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