Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 184-193

  Charton, Julie ^a,b,c,d,e   Gauriot, Marion ^a,b,c,d,e   Guo, Qing ⁱ   Hennuyer, Nathalie ^a,b,c,f   Marechal, Xavier ^a,b,c,d,e   Dumont, Julie ^a,b,c,d,e   Hamdane, Malika ^b,g,h   Pottiez, Virginie ^a,b,c,d,e   Landry, Valerie ^a,b,c,d,e   Sperandio, Olivier ^a,e   Flipo, Marion ^a,b,c,d,e   Buee, Luc ^b,g,h   Staels, Bart ^a,b,c,f   Leroux, Florence ^a,b,c,d,e   Tang, Wei Jen ⁱ   Deprez, Benoit ^a,b,c,d,e   Deprez Poulain, Rebecca ^a,b,c,d,e  

^a INSERM   (France)

^b UNIV LILLE   (France)

^c INSTITUT PASTEUR DE LILLE   (France)

^d PRIM   (France)

^e CDithem Platform/IGM   (France)

^f EGID FR3508 European Genomics Institute of Diabetes   (France)

^g JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^h LILLE UNIVERSITY HOSPITAL   (France)

ⁱ UNIVERSITY OF CHICAGO   (United States)

Author keywords

Amyloid beta peptides; Enzymes; Inhibitors; Medicinal chemistry; Structure activity relationships; X ray diffraction

Indexed keywords

2 [2 (BENZOYL CARBOXYMETHYL AMINO) ACETYLAMINO] 3 (1H IMIDAZOL 4 YL) PROPIONIC ACID METHYL ESTER; 2 [2 (BENZYL CARBOXYMETHYL AMINO) ACETYLAMINO] 3 (1H IMIDAZOL 4 YL) PROPIONIC ACID METHYL ESTER; 2 [2 (BENZYL CARBOXYMETHYL AMINO) ACETYLAMINO] 3 PHENYL PROPIONIC ACID METHYL ESTER; 2 [2 (CARBOXYMETHYL PHENETHYL AMINO) ACETYLAMINO] 3 (1H IMIDAZOL 4 YL) PROPIONIC ACID METHYL ESTER; 2 [2 [CARBOXYMETHYL (3 PHENYL PROPYL) AMINO] ACETYLAMINO] 3 (1H IMIDAZOL 4 YL) PROPIONIC ACID METHYL ESTER; ACETIC ACID DERIVATIVE; AMYLOID BETA PROTEIN; ENZYME ACTIVATOR; INSULIN; INSULINASE; UNCLASSIFIED DRUG; [BENZYL [[ 2 (1H IMIDAZOL 4 YL) 1 METHYLCARBAMOYL ETHYLCARBAMOYL] METHYL] AMINO] ACETIC ACID; [[[2 (1H IMIDAZOL 4 YL) 1 METHYLCARBAMOYL ETHYLCARBAMOYL] METHYL] (3 PHENYL PROPYL) AMINO] ACETIC ACID; [[[2 (1H IMIDAZOL 4 YL) 1 METHYLCARBAMOYL ETHYLCARBAMOYL] METHYL] (3 PHENYL PROPYL) AMINO] ACETIC ACID METHYL ESTER; IMIDAZOLE; IMIDAZOLE DERIVATIVE; MOLECULAR LIBRARY;

ARTICLE; CATALYSIS; CONFORMATION; CRYSTALLIZATION; DRUG BINDING; DRUG SCREENING; ENZYME BINDING; HUMAN; HUMAN CELL; INSULIN DEGRADATION; MOLECULE; NEUROBLASTOMA CELL; PROCESS OPTIMIZATION; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HYDROLYSIS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; SYNTHESIS; TUMOR CELL CULTURE;

ACETATES; AMYLOID BETA-PEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROLYSIS; IMIDAZOLES; INSULYSIN; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84898665877     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.009     Document Type: Article

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