Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1

Pharmacology and Therapeutics

Volumn 156, Issue , 2015, Pages 69-74

  Chan, Julie Y H ^a   Chan, Samuel H H ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Disease oriented therapy; DJ 1; Endogenous antioxidant; Mechanism oriented therapy

Indexed keywords

ALPHA SYNUCLEIN; ANTIOXIDANT; DAXX PROTEIN; DJ 1 PROTEIN; GLUTATHIONE; MORTALIN; PARKIN; PHENYLBUTYRATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PINK PROTEIN; PROTEIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THIOREDOXIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ONCOPROTEIN; PARK7 PROTEIN, HUMAN; SIGNAL PEPTIDE;

AEROBIC METABOLISM; APOPTOSIS; AUTOPHAGY; BRAIN; CARCINOGENESIS; CARDIOVASCULAR DISEASE; GLUTATHIONE METABOLISM; HEART FAILURE; HUMAN; INFLAMMATION; LIPID PEROXIDATION; MITOCHONDRION; NEOPLASM; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; RESPIRATORY CHAIN; REVIEW; AGONISTS; BIOSYNTHESIS; DEGENERATIVE DISEASE; METABOLISM;

ANTIOXIDANTS; CARDIOVASCULAR DISEASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASMS; NEURODEGENERATIVE DISEASES; ONCOGENE PROTEINS; PARKINSON DISEASE; REACTIVE OXYGEN SPECIES;

EID: 84947914546     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2015.09.005     Document Type: Review

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