Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease

Journal of Biological Chemistry

Volumn 286, Issue 17, 2011, Pages 14941-14951

  Zhou, Wenbo ^a,b   Bercury, Kathryn ^b   Cummiskey, Jessica ^b   Luong, Nancy ^b   Lebin, Jacob ^c   Freed, Curt R ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED DETERIORATION; ANIMAL MODEL; CELL LINES; COGNITIVE FUNCTIONS; DOPAMINE NEURONS; GENETIC PREDISPOSITION; GLUTATHIONES; HISTONE DEACETYLASE INHIBITOR; LEWY BODIES; LOW LEVEL; MIDBRAIN; OVER-EXPRESSION; PARKINSON DISEASE; PROTEIN AGGREGATION; RATE-LIMITING STEPS; SMALL MOLECULES; SYNUCLEIN; TRANSGENIC MICE;

AMINO ACIDS; ANIMAL CELL CULTURE; BRAIN; CELL CULTURE; GENE EXPRESSION; OXIDATIVE STRESS; PARKS; PROTEINS; TOXICITY;

DISEASES;

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 4 PHENYLBUTYRIC ACID; ALPHA SYNUCLEIN; BUTYRIC ACID; DJ 1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOTOXICITY; DIFFUSE LEWY BODY DISEASE; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; GENE EXPRESSION REGULATION; LONG TERM CARE; MOTOR DYSFUNCTION; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; CELLS, CULTURED; HISTONE DEACETYLASE INHIBITORS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; ONCOGENE PROTEINS; OXIDATIVE STRESS; PARKINSON DISEASE; PHENYLBUTYRATES; PROTEINS; UP-REGULATION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 79955369578     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.211029     Document Type: Article

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