Aptamer-Drug Conjugates

Bioconjugate Chemistry

Volumn 26, Issue 11, 2015, Pages 2186-2197

  Zhu, Guizhi ^a   Niu, Gang ^a   Chen, Xiaoyuan ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; HISTOLOGY; LIGANDS; PHOTODYNAMIC THERAPY; TARGETED DRUG DELIVERY; TISSUE;

'CURRENT; ADVERSE SIDE EFFECTS; APTAMERS; DISEASED TISSUES; DRUG-CONJUGATES; SIDE EFFECT; SPECIFIC BINDING; TARGETING LIGANDS; THERAPEUTIC EFFECTS; WESTERN MEDICINES;

GENE THERAPY;

ANTINEOPLASTIC AGENT; APTAMER; BIOLOGICAL MARKER; GOLD NANOROD; NANOCARRIER; PHOTOSENSITIZING AGENT; DRUG CARRIER; NUCLEIC ACID; PROTEIN;

ARTICLE; CANCER CHEMOTHERAPY; CANCER GENE THERAPY; CANCER IMMUNOTHERAPY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; HUMAN; NANOPHARMACEUTICS; NONHUMAN; PHOTODYNAMIC THERAPY; VIRAL GENE THERAPY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENE THERAPY; IMMUNOTHERAPY; NEOPLASMS; PROCEDURES;

ANIMALS; ANTINEOPLASTIC AGENTS; APTAMERS, NUCLEOTIDE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GENETIC THERAPY; HUMANS; IMMUNOTHERAPY; MODELS, MOLECULAR; NEOPLASMS; NUCLEIC ACIDS; PHOTOSENSITIZING AGENTS; PROTEINS;

EID: 84947795520     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/acs.bioconjchem.5b00291     Document Type: Article

References (153)

1. American Cancer Society (2013) Cancer Facts & Figures 2013.
2. Ducry, L. and Stump, B. (2009) Antibody-Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies Bioconjugate Chem. 21, 5-13
3. Ellington, A. D. and Szostak, J. W. (1990) In vitro selection of RNA molecules that bind specific ligands Nature 346, 818-822
4. Tuerk, C. and Gold, L. (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase Science 249, 505-510
5. Mosing, R. K., Mendonsa, S. D., and Bowser, M. T. (2005) Capillary Electrophoresis-SELEX Selection of Aptamers with Affinity for HIV-1 Reverse Transcriptase Anal. Chem. 77, 6107-6112
6. Mosing, R. K. and Bowser, M. T. (2007) Microfluidic selection and applications of aptamers J. Sep. Sci. 30, 1420-1426
7. Mayer, G., Ahmed, M.-S. L., Dolf, A., Endl, E., Knolle, P. A., and Famulok, M. (2010) Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures Nat. Protoc. 5, 1993-2004
8. Huizenga, D. E. and Szostak, J. W. (1995) A DNA Aptamer That Binds Adenosine and ATP Biochemistry 34, 656-665
9. Hermann, T. and Patel, D. J. (2000) Adaptive Recognition by Nucleic Acid Aptamers Science 287, 820-825
10. Mallikaratchy, P., Stahelin, R. V., Cao, Z., Cho, W., and Tan, W. (2006) Selection of DNA ligands for protein kinase C-delta Chem. Commun. 3229-3231
11. Daniels, D. A., Chen, H., Hicke, B. J., Swiderek, K. M., and Gold, L. (2003) A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment Proc. Natl. Acad. Sci. U.S.A. 100, 15416-15421
12. Parekh, P., Tang, Z., Turner, P. C., Moyer, R. W., and Tan, W. (2010) Aptamers Recognizing Glycosylated Hemagglutinin Expressed on the Surface of Vaccinia Virus-Infected Cells Anal. Chem. 82, 8642-8649
13. Bock, L. C., Griffin, L. C., Latham, J. A., Vermaas, E. H., and Toole, J. J. (1992) Selection of single-stranded DNA molecules that bind and inhibit human thrombin Nature 355, 564-566
14. Hu, J., Wu, J., Li, C., Zhu, L., Zhang, W. Y., Kong, G., Lu, Z., and Yang, C. J. (2011) A G-Quadruplex Aptamer Inhibits the Phosphatase Activity of Oncogenic Protein Shp2 in vitro ChemBioChem 12, 424-430
15. Chen, C.-h. B., Chernis, G. A., Hoang, V. Q., and Landgraf, R. (2003) Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3 Proc. Natl. Acad. Sci. U.S.A. 100, 9226-9231
16. Khati, M., Schüman, M., Ibrahim, J., Sattentau, Q., Gordon, S., and James, W. (2003) Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2′F-RNA Aptamers J. Virol. 77, 12692-12698
17. Keefe, A. D., Pai, S., and Ellington, A. (2010) Aptamers as therapeutics Nat. Rev. Drug Discovery 9, 537-550
18. Guo, K.-T., SchÄfer, R., Paul, A., Gerber, A., Ziemer, G., and Wendel, H. P. (2006) A New Technique for the Isolation and Surface Immobilization of Mesenchymal Stem Cells from Whole Bone Marrow Using High-Specific DNA Aptamers Stem Cells 24, 2220-2231
19. Shangguan, D., Li, Y., Tang, Z., Cao, Z., Chen, H. W., Mallikaratchy, P., Sefah, K., Yang, C. J., and Tan, W. (2006) Aptamers evolved from live cells as effective molecular probes for cancer study Proc. Natl. Acad. Sci. U.S.A. 103, 11838-11843
20. Tang, Z., Shangguan, D., Wang, K., Shi, H., Sefah, K., Mallikaratchy, P., Chen, H. W., Li, Y., and Tan, W. (2007) Selection of aptamers for molecular recognition and characterization of cancer cells Anal. Chem. 79, 4900-4907
21. Shangguan, D., Meng, L., Cao, Z. C., Xiao, Z., Fang, X., Li, Y., Cardona, D., Witek, R. P., Liu, C., and Tan, W. (2008) Identification of liver cancer-specific aptamers using whole live cells Anal. Chem. 80, 721-728
22. Sefah, K., Tang, Z., Shangguan, D., Chen, H., Lopez-Colon, D., Li, Y., Parekh, P., Martin, J., Meng, L., and Phillips, J. A. et al. 2009, Molecular recognition of acute myeloid leukemia using aptamers Leukemia 23, 235-244
23. Chen, H. W., Medley, C. D., Sefah, K., Shangguan, D., Tang, Z., Meng, L., Smith, J. E., and Tan, W. (2008) Molecular recognition of small-cell lung cancer cells using aptamers ChemMedChem 3, 991-1001
24. Bayrac, A. T., Sefah, K., Parekh, P., Bayrac, C., Gulbakan, B., Oktem, H. A., and Tan, W. (2011) In Vitro Selection of DNA Aptamers to Glioblastoma Multiforme ACS Chem. Neurosci. 2, 175-181
25. Simaeys, D. V., López-Colón, D., Sefah, K., Sutphen, R., Jimenez, E., and Tan, W. (2010) Study of the Molecular Recognition of Aptamers Selected through Ovarian Cancer Cell-SELEX. PLoS One 5.
26. Zhao, Z., Xu, L., Shi, X., Tan, W., Fang, X., and Shangguan, D. (2009) Recognition of subtype non-small cell lung cancer by DNA aptamers selected from living cells Analyst 134, 1808-1814
27. Sefah, K., Yang, Z., Bradley, K. M., Hoshika, S., Jimenez, E., Zhang, L., Zhu, G., Shanker, S., Yu, F., and Turek, D. et al. 2014, In vitro selection with artificial expanded genetic information systems Proc. Natl. Acad. Sci. U.S.A. 111, 1449-1454
28. O'Donoghue, M., Shi, X., Fang, X., and Tan, W. (2012) Single-molecule atomic force microscopy on live cells compares aptamer and antibody rupture forces Anal. Bioanal. Chem. 402, 3205-3209
29. Padmanabhan, K., Padmanabhan, K. P., Ferrara, J. D., Sadler, J. E., and Tulinsky, A. (1993) The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer J. Biol. Chem. 268, 17651-4
30. Long, S. B., Long, M. B., White, R. R., and Sullenger, B. A. (2008) Crystal structure of an RNA aptamer bound to thrombin RNA 14, 2504-2512
31. Lebars, I., Legrand, P., Aime, A., Pinaud, N., Fribourg, S., and Di Primo, C. (2008) Exploring TAR-RNA aptamer loop-loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance Nucleic Acids Res. 36, 7146-7156
32. Huang, D. B., Vu, D., Cassiday, L. A., Zimmerman, J. M., Maher, L. J., and Ghosh, G. (2003) Crystal structure of NF-kappa B (p50)(2) complexed to a high-affinity RNA aptamer Proc. Natl. Acad. Sci. U.S.A. 100, 9268-9273
33. Green, L. S., Bell, C., and Janjic, N. (2001) Aptamers as reagents for high-throughput screening Biotechniques 30, 1094
34. Srivatsan, S. G. and Famulok, M. (2007) Functional nucleic acids in high throughput screening and drug discovery Comb. Chem. High Throughput Screening 10, 698-705
35. Yamazaki, S., Tan, L., Mayer, G., Hartig, J. S., Song, J.-N., Reuter, S., Restle, T., Laufer, S. D., Grohmann, D., and Kraeusslich et al. 2007, Alternative small-molecule target sites aptamer displacement identifies that escape viral resistance Chem. Biol. 14, 804-812
36. Hafner, M., Vianini, E., Albertoni, B., Marchetti, L., Gruene, I., Gloeckner, C., and Famulok, M. (2008) Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization Nat. Protoc. 3, 579-587
37. Famulok, M. (2009) Exploring Chemical Space with Aptamers J. Med. Chem. 52, 6951-6957
38. Mayer, G., Faulhammer, D., Graettinger, M., Fessele, S., and Blind, M. (2009) A RNA-Based Approach towards Small-Molecule Inhibitors ChemBioChem 10, 1993-1996
39. Yamazaki, S. and Famulok, M. (2009) Screening of Novel Inhibitors of HIV-1 Reverse Transcriptase with a Reporter Ribozyme Assay, In Methods in Molecular Biology (Mayer, G., Ed.) pp 187-199.
40. Niebel, B., Lentz, C., Pofahl, M., Mayer, G., Hoerauf, A., Pfarr, K. M., and Famulok, M. (2010) ADLOC: An Aptamer-Displacement Assay Based on Luminescent Oxygen Channeling Chem.-Eur. J. 16, 11100-11107
41. Auslaender, D., Wieland, M., Auslaender, S., Tigges, M., and Fussenegger, M. (2011) Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells. Nucleic Acids Res. 39.
42. Mueller, M., Ackermann, D., and Famulok, M. (2011) Nucleic acid based tools for pharmacology and nano-engineering C. R. Chim. 14, 819-825
43. Gragoudas, E. S., Adamis, A. P., Cunningham, E. T., Feinsod, M., and Guyer, D. R. (2004) Pegaptanib for Neovascular Age-Related Macular Degeneration N. Engl. J. Med. 351, 2805-2816
44. Ireson, C. R. and Kelland, L. R. (2006) Discovery and development of anticancer aptamers Mol. Cancer Ther. 5, 2957-2962
45. Bates, P. J., Laber, D. A., Miller, D. M., Thomas, S. D., and Trent, J. O. (2009) Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer Exp. Mol. Pathol. 86, 151-164
46. Shangguan, D., Cao, Z., Meng, L., Mallikaratchy, P., Sefah, K., Wang, H., Li, Y., and Tan, W. (2008) Cell-specific aptamer probes for membrane protein elucidation in cancer cells J. Proteome Res. 7, 2133-2139
47. Mallikaratchy, P., Tang, Z., Kwame, S., Meng, L., Shangguan, D., and Tan, W. (2007) Aptamer Directly Evolved from Live Cells Recognizes Membrane Bound Immunoglobin Heavy Mu Chain in Burkitt's Lymphoma Cells Mol. Cell. Proteomics 6, 2230-2238
48. Lupold, S. E., Hicke, B. J., Lin, Y., and Coffey, D. S. (2002) Identification and Characterization of Nuclease-stabilized RNA Molecules That Bind Human Prostate Cancer Cells via the Prostate-specific Membrane Antigen Cancer Res. 62, 4029-4033
49. Ferreira, C. S. M., Matthews, C. S., and Missailidis, S. (2006) DNA aptamers that bind to MUC1 tumour marker: Design and characterization of MUC1-binding single-stranded DNA aptamers Tumor Biol. 27, 289-301
50. Mi, J., Zhang, X., Giangrande, P. H., McNamara Ii, J. O., Nimjee, S. M., Sarraf-Yazdi, S., Sullenger, B. A., and Clary, B. M. (2005) Targeted inhibition of αvβ3 integrin with an RNA aptamer impairs endothelial cell growth and survival Biochem. Biophys. Res. Commun. 338, 956-963
51. Lebruska, L. L. and Maher, L. J. (1999) Selection and Characterization of an RNA Decoy for Transcription Factor NF-κB Biochemistry 38, 3168-3174
52. Martell, R. E., Nevins, J. R., and Sullenger, B. A. (2002) Optimizing Aptamer Activity for Gene Therapy Applications Using Expression Cassette SELEX Mol. Ther. 6, 30-34
53. Ishizaki, J., Nevins, J. R., and Sullenger, B. A. (1996) Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function Nat. Med. 2, 1386-1389
54. Chi-hong, B. C., George, A. C., Van, Q. H., and Ralf, L. (2003) Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3 Proc. Natl. Acad. Sci. U.S.A. 100, 9226-9231
55. Thiel, K. W., Hernandez, L. I., Dassie, J. P., Thiel, W. H., Liu, X., Stockdale, K. R., Rothman, A. M., Hernandez, F. J., McNamara, J. O., and Giangrande, P. H. (2012) Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers Nucleic Acids Res. 40, 6319-6337
56. 99mTc for single-photon imaging in malignant tumors Nucl. Med. Biol. 40, 980-986
57. Varmira, K., Hosseinimehr, S. J., Noaparast, Z., and Abedi, S. M. (2014) An improved radiolabelled RNA aptamer molecule for HER2 imaging in cancers J. Drug Target. 22, 116-122
58. Wang, D.-L., Song, Y.-L., Zhu, Z., Li, X.-L., Zou, Y., Yang, H.-T., Wang, J.-J., Yao, P.-S., Pan, R.-J., Yang, C. J., and Kang, D.-Z. (2014) Selection of DNA aptamers against epidermal growth factor receptor with high affinity and specificity Biochem. Biophys. Res. Commun. 453, 681-685
59. Esposito, C. L., Passaro, D., Longobardo, I., Condorelli, G., Marotta, P., Affuso, A., de Franciscis, V., and Cerchia, L. (2010) A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death. PLoS One 6.
60. Carla Lucia, E., Diana, P., Immacolata, L., Gerolama, C., Pina, M., Andrea, A., Vittorio de, F., and Laura, C. (2011) A Neutralizing RNA Aptamer against EGFR Causes Selective Apoptotic Cell Death. PLoS One 6.
61. Song, Y., Zhu, Z., An, Y., Zhang, W., Zhang, H., Liu, D., Yu, C., Duan, W., and Yang, C. J. (2013) Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture Anal. Chem. 85, 4141-4149
62. Xiang, D., Shigdar, S., Qiao, G., Wang, T., Kouzani, A. Z., Zhou, S.-F. F., Kong, L., Li, Y., Pu, C., and Duan, W. (2014) Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine Theranostics 5, 23-42
63. Zhang, P., Zhao, N., Zeng, Z., Feng, Y., Tung, C.-H. H., Chang, C.-C. C., and Zu, Y. (2009) Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cells Lab. Invest. 89, 1423-1432
64. Blake, C. M., Sullenger, B. A., Lawrence, D. A., and Fortenberry, Y. M. (2009) Antimetastatic Potential of PAI-1-Specific RNA Aptamers Oligonucleotides 19, 117-128
65. Wiegand, T., Williams, P., Dreskin, S., Jouvin, M., Kinet, J., and Tasset, D. (1996) High-affinity oligonucleotide ligands to human IgE inhibit binding to Fc epsilon receptor I J. Immunol. 157, 221-230
66. Liang, C., Guo, B., Wu, H., Shao, N., Li, D., Liu, J., Dang, L., Wang, C., Li, H., and Li, S. et al. 2015, Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy Nat. Med. 21, 288-294
67. Kruspe, S., Meyer, C., and Hahn, U. (2014) Chlorin e6 conjugated interleukin-6 receptor aptamers selectively kill target cells upon irradiation Mol. Ther. 3, e143
68. Chen, C.-h. B. H., Dellamaggiore, K. R., Ouellette, C. P., Sedano, C. D., Lizadjohry, M., Chernis, G. A., Gonzales, M., Baltasar, F. E., Fan, A. L., Myerowitz, R., and Neufeld, E. F. (2008) Aptamer-based endocytosis of a lysosomal enzyme Proc. Natl. Acad. Sci. U.S.A. 105, 15908-15913
69. Eyetech Study Group (2002) Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration Retina 2, 143-152
70. Rusconi, C. P., Roberts, J. D., Pitoc, G. A., Nimjee, S. M., White, R. R., Quick, G., Scardino, E., Fay, W. P., and Sullenger, B. A. (2004) Antidote-mediated control of an anticoagulant aptamer in vivo Nat. Biotechnol. 22, 1423-1428
71. Oney, S., Lam, R. T. S., Bompiani, K. M., Blake, C. M., Quick, G., Heidel, J. D., Liu, J. Y.-C., Mack, B. C., Davis, M. E., Leong, K. W., and Sullenger, B. A. (2009) Development of universal antidotes to control aptamer activity Nat. Med. 15, 1224-1228
72. Hughes, B. (2010) Antibody-drug conjugates for cancer: poised to deliver? Nat. Rev. Drug Discovery 9, 665-667
73. Webb, S. (2011) Pharma interest surges in antibody drug conjugates Nat. Biotechnol. 29, 297-298
74. Hu, R., Zhang, X., Zhao, Z., Zhu, G., Chen, T., Fu, T., and Tan, W. (2014) DNA nanoflowers for multiplexed cellular imaging and traceable targeted drug delivery Angew. Chem., Int. Ed. 53, 5821-5826
75. Huang, F., You, M., Chen, T., Zhu, G., Liang, H., and Tan, W. (2014) Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells Chem. Commun. 50, 3103-3105
76. Wang, J., Zhu, G., You, M., Song, E., Shukoor, M. I., Zhang, K., Altman, M. B., Chen, Y., Zhu, Z., and Huang, C. Z. et al. 2012, Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy ACS Nano 6, 5070-5077
77. Zheng, J., Zhu, G., Li, Y., Li, C., You, M., Chen, T., Song, E., Yang, R., and Tan, W. (2013) A spherical nucleic acid platform based on self-assembled DNA biopolymer for high-performance cancer therapy ACS Nano 7, 6545-6554
78. Zhou, C., Chen, T., Wu, C., Zhu, G., Qiu, L., Cui, C., Hou, W., and Tan, W. (2014) Aptamer CaCO3 nanostructures: a facile, pH-responsive, specific platform for targeted anticancer theranostics Chem.-Asian J. 10, 166-171
79. Zhu, G., Hu, R., Zhao, Z., Chen, Z., Zhang, X., and Tan, W. (2013) Noncanonical self-assembly of multifunctional DNA nanoflowers for biomedical applications J. Am. Chem. Soc. 135, 16438-16445
80. Zhu, G., Zheng, J., Song, E., Donovan, M., Zhang, K., Liu, C., and Tan, W. (2013) Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics Proc. Natl. Acad. Sci. U.S.A. 110, 7998-8003
81. Shieh, Y.-A., Yang, S.-J., Wei, M.-F., and Shieh, M.-J. (2010) Aptamer-based tumor-targeted drug delivery for photodynamic therapy ACS Nano 4, 1433-1442
82. Gu, F., Zhang, L., Teply, B. A., Mann, N., Wang, A., Radovic-Moreno, A. F., Langer, R., and Farokhzad, O. C. (2008) Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers Proc. Natl. Acad. Sci. U.S.A. 105, 2586-2591
83. Tong, G. J., Hsiao, S. C., Carrico, Z. M., and Francis, M. B. (2009) Viral capsid DNA aptamer conjugates as multivalent cell-targeting vehicles J. Am. Chem. Soc. 131, 11174-11178
84. Douglas, S. M., Bachelet, I., and Church, G. M. (2012) A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads Science 335, 831-834
85. Huang, Y.-F., Shangguan, D., Liu, H., Phillips, J. A., Zhang, X., Chen, Y., and Tan, W. (2009) Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells ChemBioChem 10, 862-868
86. Kang, H., O'Donoghue, M. B., Liu, H., and Tan, W. (2010) A liposome-based nanostructure for aptamer directed delivery Chem. Commun. 46, 249-251
87. Huang, Y.-F., Sefah, K., Bamrungsap, S., Chang, H.-T., and Tan, W. (2008) Selective Photothermal Therapy for Mixed Cancer Cells Using Aptamer-Conjugated Nanorods Langmuir 24, 11860-11865
88. Luo, Y.-L., Shiao, Y.-S., and Huang, Y.-F. (2011) Release of Photoactivatable Drugs from Plasmonic Nanoparticles for Targeted Cancer Therapy ACS Nano 5, 7796-7804
89. Wang, K., You, M., Chen, Y., Han, D., Zhu, Z., Huang, J., Williams, K., Yang, C. J., and Tan, W. (2011) Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery Angew. Chem., Int. Ed. 50, 6098-6101
90. Kang, H., Trondoli, A. C., Zhu, G., Chen, Y., Chang, Y.-J., Liu, H., Huang, Y.-F., Zhang, X., and Tan, W. (2011) Near-Infrared Light-Responsive Core-Shell Nanogels for Targeted Drug Delivery ACS Nano 5, 5094-5099
91. Zhu, G., Meng, L., Ye, M., Yang, L., Sefah, K., O'Donoghue, M. B., Chen, Y., Xiong, X., Huang, J., Song, E., and Tan, W. (2012) Self-Assembled Aptamer-Based Drug Carriers for Bispecific Cytotoxicity to Cancer Cells Chem.-Asian J. 7, 1630-1636
92. Stephanopoulos, N., Tong, G. J., Hsiao, S. C., and Francis, M. B. (2010) Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells ACS Nano 4, 6014-6020
93. Zhu, G., Cansiz, S., You, M., Qiu, L., Han, D., Zhang, L., Mei, L., Fu, T., Chen, Z., and Tan, W. (2015) Nuclease-resistant synthetic drug-DNA adducts: programmable drug-DNA conjugation for targeted anticancer drug delivery. NPG Asia Materials 7, DOI: 10.1038/am.2015.19.
94. Wang, R., Zhu, G., Mei, L., Xie, Y., Ma, H., Ye, M., Qing, F.-L., and Tan, W. (2014) Automated modular synthesis of aptamer-drug conjugates for targeted drug delivery J. Am. Chem. Soc. 136, 2731-2734
95. Han, D., Zhu, G., Wu, C., Zhu, Z., Chen, T., Zhang, X., and Tan, W. (2013) Engineering a cell-surface aptamer circuit for targeted and amplified photodynamic cancer therapy ACS Nano 7, 2312-2319
96. Wu, Y., Sefah, K., Liu, H., Wang, R., and Tan, W. (2010) DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells Proc. Natl. Acad. Sci. U.S.A. 107, 5-10
97. Mallikaratchy, P., Tang, Z., and Tan, W. (2008) Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy ChemMedChem 3, 425-428
98. Cao, Z., Tong, R., Mishra, A., Xu, W., Wong, G. C. L., Cheng, J., and Lu, Y. (2009) Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes Angew. Chem., Int. Ed. 48, 6494-6498
99. Bagalkot, V., Farokhzad, O. C., Langer, R., and Jon, S. (2006) An Aptamer-Doxorubicin Physical Conjugate as a Novel Targeted Drug-Delivery Platform Angew. Chem., Int. Ed. 45, 8149-8152
100. Chu, T. C., Marks, J. W., Lavery, L. A., Faulkner, S., Rosenblum, M. G., Ellington, A. D., and Levy, M. (2006) Aptamer:toxin conjugates that specifically target prostate tumor cells Cancer Res. 66, 5989-5992
101. McNamara, J. O., Andrechek, E. R., Wang, Y., Viles, K. D., Rempel, R. E., Gilboa, E., Sullenger, B. A., and Giangrande, P. H. (2006) Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras Nat. Biotechnol. 24, 1005-1015
102. Kim, D., Jeong, Y. Y., and Jon, S. (2010) A Drug-Loaded Aptamer-Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer ACS Nano 4, 3689-3696
103. Bagalkot, V., Zhang, L., Levy-Nissenbaum, E., Jon, S., Kantoff, P. W., Langer, R., and Farokhzad, O. C. (2007) Quantum Dot-Aptamer Conjugates for Synchronous Cancer Imaging, Therapy, and Sensing of Drug Delivery Based on Bi-Fluorescence Resonance Energy Transfer Nano Lett. 7, 3065-3070
104. Dhar, S., Kolishetti, N., Lippard, S. J., and Farokhzad, O. C. (2011) Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Proc. Natl. Acad. Sci. U.S.A. 108, 1850-1855
105. Dassie, J. P., Liu, X.-y., Thomas, G. S., Whitaker, R. M., Thiel, K. W., Stockdale, K. R., Meyerholz, D. K., McCaffrey, A. P., McNamara, J. O., and Giangrande, P. H. (2009) Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors Nat. Biotechnol. 27, 839-846
106. Ni, X., Zhang, Y., Ribas, J., Chowdhury, W. H., Castanares, M., Zhang, Z., Laiho, M., DeWeese, T. L., and Lupold, S. E. (2011) Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts J. Clin. Invest. 121, 2383-2390
107. Pieve, C. D., Perkins, A. C., and Missailidis, S. (2009) Anti-MUC1 aptamers: radiolabelling with 99mTc and biodistribution in MCF-7 tumour-bearing mice Nucl. Med. Biol. 36, 703-710
108. Savla, R., Taratula, O., Garbuzenko, O., and Minko, T. (2011) Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer J. Controlled Release 153, 16-22
109. Tan, L., Neoh, K. G., Kang, E.-T., Choe, W.-S., and Su, X. (2012) Designer tridentate mucin 1 aptamer for targeted drug delivery J. Pharma. Sci. 101, 1672-1677
110. Zhou, J., Li, H., Li, S., Zaia, J., and Rossi, J. J. (2008) Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy Mol. Ther. 16, 1481-1489
111. Wengerter, B. C., Katakowski, J. A., Rosenberg, J. M., Park, C. G., Almo, S. C., Palliser, D., and Levy, M. (2014) Aptamer-targeted antigen delivery Mol. Ther. 22, 1375-1387
112. Meng, L., Sefah, K., O'Donoghue, M. B., Zhu, G., Shangguan, D., Noorali, A., Chen, Y., Zhou, L., and Tan, W. (2010) Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway. PLoS One 5, DOI: 10.1371/journal.pone.0014018.
113. Zhu, G., Ye, M., Donovan, M. J., Song, E., Zhao, Z., and Tan, W. (2012) Nucleic acid aptamers: an emerging frontier in cancer therapy Chem. Commun. 48, 10472-10480
114. Bagalkot, V., Farokhzad, O. C., Langer, R., and Jon, S. (2006) An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform Angew. Chem., Int. Ed. 45, 8149-8152
115. Zhu, G., Meng, L., Ye, M., Yang, L., Sefah, K., O'Donoghue, M. B., Chen, Y., Xiong, X., Huang, J., Song, E., and Tan, W. (2012) Self-assembled aptamer-based drug carriers for bispecific cytotoxicity to cancer cells Chem.-Asian J. 7, 1630-1636
116. Wolf, E., Hofmeister, R., Kufer, P., Schlereth, B., and Baeuerle, P. A. (2005) BiTEs: bispecific antibody constructs with unique anti-tumor activity Drug Discovery Today 10, 1237-1244
117. Beck, A., Wurch, T., Bailly, C., and Corvaia, N. (2010) Strategies and challenges for the next generation of therapeutic antibodies Nat. Rev. Immunol. 10, 345-352
118. Dhar, S., Gu, F. X., Langer, R., Farokhzad, O. C., and Lippard, S. J. (2008) Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles Proc. Natl. Acad. Sci. U.S.A. 105, 17356-17361
119. Dhar, S., Kolishetti, N., Lippard, S. J., and Farokhzad, O. C. (2011) Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Proc. Natl. Acad. Sci. U.S.A. 108, 1850-1855
120. Farokhzad, O. C., Cheng, J., Teply, B. A., Sherifi, I., Jon, S., Kantoff, P. W., Richie, J. P., and Langer, R. (2006) Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo Proc. Natl. Acad. Sci. U.S.A. 103, 6315-6320
121. Cao, Z., Tong, R., Mishra, A., Xu, W., Wong, G. C., Cheng, J., and Lu, Y. (2008) Reversible cell-specific drug delivery with aptamer-functionalized liposomes Angew. Chem., Int. Ed. 48, 6494-6498
122. Alshaer, W., Hillaireau, H., Vergnaud, J., Ismail, S., and Fattal, E. (2014) Functionalizing Liposomes with anti-CD44 Aptamer for Selective Targeting of Cancer Cells Bioconjugate Chem. 10.1021/bc5004313
123. Li, X., Zhao, Q., and Qiu, L. (2013) Smart ligand: aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy J. Controlled Release 171, 152-162
124. Hong Yan, L. and Xiaohu, G. (2013) A Universal Protein Tag for Delivery of SiRNA-Aptamer Chimeras. Sci. Rep. 3, DOI: 10.1038/srep03129.
125. McNamara, J. O., Andrechek, E. R., Wang, Y., Viles, K. D., Rempel, R. E., Gilboa, E., Sullenger, B. A., and Giangrande, P. H. (2006) Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras Nat. Biotechnol. 24, 1005-1015
126. Dassie, J. P., Liu, X.-Y. Y., Thomas, G. S., Whitaker, R. M., Thiel, K. W., Stockdale, K. R., Meyerholz, D. K., McCaffrey, A. P., McNamara, J. O., and Giangrande, P. H. (2009) Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors Nat. Biotechnol. 27, 839-849
127. Song, P., Chou, Y. K., Zhang, X., Meza-Romero, R., Yomogida, K., Benedek, G., and Chu, C.-Q. Q. (2014) CD4 aptamer-RORγt shRNA chimera inhibits IL-17 synthesis by human CD4(+) T cells Biochem. Biophys. Res. Commun. 452, 1040-1045
128. Zhou, J. and Rossi, J. J. (2010) Aptamer-targeted RNAi for HIV-1 therapy Methods Mol. Biol. 721, 355-371
129. Subramanian, N., Kanwar, J. R., Athalya, P., Janakiraman, N., Khetan, V., Kanwar, R. K., Eluchuri, S., and Krishnakumar, S. (2015) EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex J. Biomed. Sci. 22, 4
130. Shu, D., Shu, Y., Haque, F., Abdelmawla, S., and Guo, P. (2011) Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics Nat. Nanotechnol. 6, 658-667
131. Bruno, J. G., Carrillo, M. P., and Crowell, R. (2009) Preliminary development of DNA aptamer-Fc conjugate opsonins J. Biomed. Sci. Res. A 90, 1152-1161
132. Desnick, R. J. and Schuchman, E. H. (2002) Enzyme replacement and enhancement therapies: lessons from lysosomal disorders Nat. Rev. Genet. 3, 954-966
133. Niagara Muhammad, I., Muthu Kumara, G., Jing, Z., Paul, C. H., Ratha, M., and Yong, Z. (2012) In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers Nat. Med. 18, 1580-1585
134. Cohen, B. A. and Bergkvist, M. (2013) Targeted in vitro photodynamic therapy via aptamer-labeled, porphyrin-loaded virus capsids J. Photochem. Photobiol., B 121, 67-74
135. Ferreira, C. S. M., Cheung, M. C., and Missailidis, S. (2009) Phototoxic aptamers selectively enter and kill epithelial cancer cells Nucleic Acids Res. 37, 866-76
136. Han, D., Zhu, G., Wu, C., Zhu, Z., Chen, T., Zhang, X., and Tan, W. (2013) Engineering a cell-surface aptamer circuit for targeted and amplified photodynamic cancer therapy ACS Nano 7, 2312-2319
137. Stephanopoulos, N., Tong, G. J., Hsiao, S. C., and Francis, M. B. (2010) Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells ACS Nano 4, 6014-6020
138. Wang, K., You, M., Chen, Y., Han, D., Zhu, Z., Huang, J., Williams, K., Yang, C. J., and Tan, W. (2011) Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery Angew. Chem., Int. Ed. 50, 6098-6101
139. Yuan, Q., Wu, Y., Wang, J., Lu, D., Zhao, Z., and Liu, T. (2013) Targeted Bioimaging and Photodynamic Therapy Nanoplatform Using an Aptamer-Guided G-Quadruplex DNA Carrier and Near-Infrared Light Angew. Chem., Int. Ed. 52, 13965-13969
140. You, M., Zhu, G., Chen, T., Donovan, M. J., and Tan, W. (2015) Programmable and multiparameter DNA-based logic platform for cancer recognition and targeted therapy J. Am. Chem. Soc. 137, 667-674
141. Sitaula, S. and Reed, S. M. (2008) Porphyrin conjugated to DNA by a 2′-amido-2′-deoxyuridine linkage Bioorg. Med. Chem. Lett. 18, 850-855
142. Wang, J., You, M., Zhu, G., Shukoor, M. I., Chen, Z., Zhao, Z., Altman, M. B., Yuan, Q., Zhu, Z., Chen, Y., Huang, C. Z., and Tan, W. (2013) Photosensitizer-Gold Nanorod Composite for Targeted Multimodal Therapy Small 9, 3678-3684
143. Huang, P., Lin, J., Li, W., Rong, P., Wang, Z., Wang, S., Wang, X., Sun, X., Aronova, M., and Niu, G. et al. 2013, Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy Angew. Chem., Int. Ed. 52, 13958-13964
144. Huang, X., El-Sayed, I. H., Qian, W., and El-Sayed, M. A. (2006) Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods J. Am. Chem. Soc. 128, 2115
145. 4@polydopamine core-shell nanocomposites for intracellular mRNA detection and imaging-g uided photothermal therapy ACS Nano 8, 3876-3883
146. Rong, P., Yang, K., Srivastan, A., Kiesewetter, D. O., Yue, X., Wang, F., Nie, L., Bhirde, A., Wang, Z., and Liu, Z. et al. 2013, Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy Theranostics 4, 229-239
147. Yang, L., Tseng, Y.-T., Suo, G., Chen, L., Yu, J., Chiu, W.-J., Huang, C.-C., and Lin, C.-H. (2015) Photothermal Therapeutic Response of Cancer Cells to Aptamer-Gold Nanoparticle-Hybridized Graphene Oxide under NIR Illumination ACS Appl. Mater. Interfaces 7, 5097-5106
148. Wilson, C. and Keefe, A. D. (2006) Building oligonucleotide therapeutics using non-natural chemistries Curr. Opin. Chem. Biol. 10, 607-614
149. Da Pieve, C., Blackshaw, E., Missailidis, S., and Perkins, A. C. (2012) PEGylation and biodistribution of an anti-MUC1 aptamer in MCF-7 tumor-bearing mice Bioconjugate Chem. 23, 1377-1381
150. McCauley, T. G., Kurz, J. C., Merlino, P. G., Lewis, S. D., Gilbert, M., Epstein, D. M., and Marsh, H. N. (2006) Pharmacologic and pharmacokinetic assessment of anti-TGFbeta2 aptamers in rabbit plasma and aqueous humor Pharm. Res. 23, 303-311
151. Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton-Jean, A. K. R., Han, M. S., and Mirkin, C. A. (2006) Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation Science 312, 1027-1030
152. Jacobson, O., Yan, X., Gang, N., Weiss, I. D., Ma, Y., Szajek, L. P., Shen, B., Kiesewetter, D. O., and Chen, X. (2015) PET Imaging of Tenascin-C with a Radiolabeled Single-Strand DNA Aptamer J. Nucl. Med. 56, 616-621
153. Burmeister, P. E., Lewis, S. D., Silva, R. F., Preiss, J. R., Horwitz, L. R., Pendergrast, P. S., McCauley, T. G., Kurz, J. C., Epstein, D. M., and Wilson, C. et al. 2004, Direct in vitro selection of a 2′-O-methyl aptamer to VEGF Chem. Biol. 12, 25-33