Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function

Nature Medicine

Volumn 2, Issue 12, 1996, Pages 1386-1389

  Ishizaki, Jun ^a   Nevins, Joseph R ^a   Sullenger, Bruce A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; TRANSCRIPTION FACTOR;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST CULTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; BLOOD; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELLS, CULTURED; CLONING, MOLECULAR; DNA; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; FIBROBLASTS; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; RNA; RNA-BINDING PROTEINS; S PHASE; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS;

EID: 0029800326     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1296-1386     Document Type: Article

References (27)

1. Sherr, C.J. Mammalian G1 cyclins. Cell 73, 1059-1065 (1993).
2. Hunter, T. Braking the cycle. Cell 75, 839-841 (1993).
3. Kevins, J.R. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258, 424-429 (1992).
4. Helin, K. & Harlow, E. The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol. 3, 43-46 (1993).
5. La Thangue, N.B. DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19, 108-114 (1994).
6. 1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163 (1995).
7. Weinberg, R.A. The retinoblastoma protein and cell cycle control. Cell 81, 323-330 (1995).
8. Gold, L., Polisky, B., Uhlenbeck, O. & Yarus, M. Diversity of oligonucleotide functions. Annu. Rev. Biochem. 64, 763-797 (1995).
9. Szostak, J.W. In vitro genetics. Trends Biochem. Sci. 17, 89-93 (1992).
10. Tuerk, C. & Gold, L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249, 505-510 (1990).
11. Tuerk, C. & MacDougal-Waugh, S. In vitro evolution of functional nucleic acids: High-affinity RNA ligands of HIV-1 proteins. Gene 137, 33-39 (1993).
12. Cress, W.D., Johnson, D.G. & Kevins, J.R. A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4. Mol. Cell. Biol. 13, 6314-6325 (1993).
13. Zuker, M. On finding all suboptimal foldings of an RNA molecule. Science 244, 48-52 (1989).
14. Jaeger, J.A., Turner, D.H. & Zuker, M. Improved predictions of secondary structures for RNA. Proc. Natl. Acad. Sci. USA 86, 7706-7710 (1989).
15. Jaeger, J.A., Turner, D.H. & Zuker, M. Predicting optimal and suboptimal secondary structure for RNA. Methods Enzymol. 183, 281-306 (1989).
16. Duronio, R.J., O'Farrell, P.H., Xie, J.-E., Brook, A. & Dyson, N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 9, 1445-1455 (1995).
17. Dobrowolski, S.F., Stacey, D.W., Harter, M.L., Stine, J.T. & Hiebert, S.W. An E2F dominant negative mutant blocks E1A induced cell cycle progression. Oncogene 9, 2605-2612 (1994).
18. 1. Mol. Cell. Biol. 16, 3698-3706 (1996).
19. Asano, M., Nevins, J.R. & Wharton, R.P. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev. 10, 1422-1432 (1996).
20. DeGregori, J., Leone, G., Ohtani, K., Miron, A. & Nevins, J.R. E2F1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev. 9, 2873-2887 (1995).
21. Johnson, D.G., Schwarz, J.K., Cress, W.D. & Nevins, J.R. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365, 349-352 (1993).
22. Qin, X.-Q., Livingston, D.M., Kaelin, W.G. & Adams, P.D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91, 10918-10922 (1994).
23. Yamasaki, L. et al. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85, 537-548 (1996).
24. Field, S.J. et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549-561 (1996).
25. Doudna, J.A., Cech, T.R. & Sullenger, B. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proc. Natl. Acad. Sci. USA 92, 2355-2359 (1995).
26. Ikeda, M.-A., Jakoi, L. & Nevins, J.R. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl. Acad. Sci. USA 93, 3215-3220 (1996).
27. INK4B through an Sp1 consensus site. J. Biol. Chem. 270, 26750-26753 (1995).