Crystal structure of NF-κb (p50)2 complexed to a high-affinity RNA aptamer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 16, 2003, Pages 9268-9273

  Huang, De Bin ^a   Vu, Don ^a   Cassiday, Laura A ^b,c   Zimmerman, Jeff M ^b   Maher III, L James ^b   Ghosh, Gourisankar ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; RNA BINDING; RNA SEQUENCE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; DNA, COMPLEMENTARY; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA;

EID: 0042925463     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1632011100     Document Type: Article

References (23)

1. Karin, M. & Ben-Neriah, Y. (2000) Annu. Rev. Immunol. 18, 621-663.
2. Ghosh, S., May, M. J. & Kopp, E. B. (1998) Annu. Rev. Immunol. 16, 225-260.
3. Ghosh, G., van Duyne, G., Ghosh, S. & Sigler, P. B. (1995) Nature 373, 303-310.
4. Muller, C. W., Rey, F. A., Sodeoka, M., Verdine, G. L. & Harrison, S. C. (1995) Nature 373, 311-317.
5. Cramer, P., Larson, C. J., Verdine, G. L. & Muller, C. W. (1997) EMBO J. 16, 7078-7090.
6. Chen, Y. Q., Ghosh S. & Ghosh, G. (1998) Nat. Struct. Biol. 5, 67-73.
7. Chen, F. E., Huang, D.-B., Chen, Y.-Q. & Ghosh, G. (1998) Nature 391, 410-413.
8. Huang, D.-B., Chen, Y.-Q., Ruetsche, M., Phelps, C. B. & Ghosh, G. (2001) Structure (London) 9, 669-678.
9. Chen, F. E. & Ghosh, G. (1999) Oncogene 18, 6845-6852.
10. Lebruska, L. L. & Maher, L. J., III (1999) Biochemistry 38, 3168-3174.
11. Cassiday, L. A. & Maher, L. J., III (2001) Biochemistry 40, 2433-2438.
12. Cassiday, L. A. & Maher, L. J., III (2003) Proc. Natl. Acad. Sci. USA 100, 3930-3935.
13. Hart, D. J., Speight, R. E., Cooper, M. A., Sutherland, J. D. & Blackburn, J. M. (1999) Nucleic Acids Res. 27, 1063-1069.
14. Phelps, C. B., Sengchanthalangsy, L. L., Malek, S. & Ghosh, G. (2000) J. Biol. Chem. 275, 24392-24399.
15. Heus, H. A. & Pardi, A. (1991) Science 253, 191-194.
16. Hermann, T. & Patel, D. J. (1999) J. Mol. Biol. 294, 829-849.
17. Draper, D. E. (1999) J. Mol. Biol. 293, 255-270.
18. Pelham, H. R. & Brown, D. D. (1980) Proc. Natl. Acad. Sci. USA 77, 4170-4174.
19. Peyman, J. A. (1999) Biol. Reprod. 60, 23-31.
20. Peyman, J. A. (2001) Am. J. Reprod. Immunol. 45, 382-392.
21. Pittman, R. H., Andrews, M. T. & Setzer, D. R. (1999) J. Biol. Chem. 274, 33198-33201.
22. Cassiday, L. A. & Maher, L. J., III (2002) Nucleic Acids Res. 30, 4118-4126.
23. Nicholls, A., Bharadwaj, R. & Honig, B. (1993) Biophys. J. 64, A116-A125.