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Volumn 171, Issue 2, 2013, Pages 152-162

Smart ligand: Aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy

Author keywords

Aptamer; Cancer therapy; Drug delivery; Gene delivery; Nanoparticle

Indexed keywords

DISEASES; DRUG DELIVERY; DRUG THERAPY; GENE THERAPY; GENE TRANSFER; LIGANDS; MEDICAL APPLICATIONS; NANOPARTICLES; OLIGONUCLEOTIDES; ONCOLOGY;

EID: 84881146974     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.06.006     Document Type: Review
Times cited : (126)

References (96)
  • 1
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • C. Tuerk, L. Gold, Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase, Science 249 (1990) 505-510.
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 2
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • A.D. Ellington, J.W. Szostak, In vitro selection of RNA molecules that bind specific ligands, Nature 346 (1990) 818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 4
    • 84866704799 scopus 로고    scopus 로고
    • Single-step nanoplasmonic VEGF165 aptasensor for early cancer diagnosis
    • H.S. Cho, E.C. Yeh, R. Sinha, T.A. Laurence, J.P. Bearinger, L.P. Lee, Single-step nanoplasmonic VEGF165 aptasensor for early cancer diagnosis, ACS Nano 6 (2012) 7607-7614.
    • (2012) ACS Nano , vol.6 , pp. 7607-7614
    • Cho, H.S.1    Yeh, E.C.2    Sinha, R.3    Laurence, T.A.4    Bearinger, J.P.5    Lee, L.P.6
  • 5
    • 76249127542 scopus 로고    scopus 로고
    • DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells
    • Y.R. Wu, K. Sefah, H.P. Liu, R.W. Wang, W.H. Tan, DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells, PNAS 107 (2010) 5-10.
    • (2010) PNAS , vol.107 , pp. 5-10
    • Wu, Y.R.1    Sefah, K.2    Liu, H.P.3    Wang, R.W.4    Tan, W.H.5
  • 6
    • 77955667310 scopus 로고    scopus 로고
    • Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates
    • J.H. Lee, M.V. Yigit, D. Mazumdar, Y. Lu, Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates, Adv. Drug Deliv. Rev. 62 (2010) 592-605.
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 592-605
    • Lee, J.H.1    Yigit, M.V.2    Mazumdar, D.3    Lu, Y.4
  • 7
    • 77956876990 scopus 로고    scopus 로고
    • Targeting cancer cells with nucleic acid aptamers
    • L. Cerchia, V. de Franciscis, Targeting cancer cells with nucleic acid aptamers, Trends Biotechnol. 128 (2010) 517-525.
    • (2010) Trends Biotechnol. , vol.128 , pp. 517-525
    • Cerchia, L.1    De Franciscis, V.2
  • 8
    • 33846252731 scopus 로고    scopus 로고
    • Discovery and development of anticancer aptamers
    • DOI 10.1158/1535-7163.MCT-06-0172
    • C.R. Ireson, L.R. Kelland, Discovery and development of anticancer aptamers, Mol. Cancer Ther. 5 (2006) 2957-2962. (Pubitemid 46092036)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.12 , pp. 2957-2962
    • Ireson, C.R.1    Kelland, L.R.2
  • 9
    • 84869103855 scopus 로고    scopus 로고
    • Multifunctional nanoparticles: Cost versus benefit of adding targeting and imaging capabilities
    • Z.L. Cheng, A.A. Zaki, J.Z. Hui, V.R. Muzykantov, A. Tsourkas, Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities, Science 338 (2012) 903-910.
    • (2012) Science , vol.338 , pp. 903-910
    • Cheng, Z.L.1    Zaki, A.A.2    Hui, J.Z.3    Muzykantov, V.R.4    Tsourkas, A.5
  • 10
    • 0344876636 scopus 로고    scopus 로고
    • Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) therapy of malignant gliomas
    • DOI 10.1023/A:1026246500788
    • M. Weaver, D.W. Laske, Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM 107) for therapy of malignant gliomas, J. Neurooncol 65 (2003) 3-13. (Pubitemid 37441310)
    • (2003) Journal of Neuro-Oncology , vol.65 , Issue.1 , pp. 3-13
    • Weaver, M.1    Laske, D.W.2
  • 11
    • 0031451777 scopus 로고    scopus 로고
    • Tumor regression with regional distribution of the targeted toxin TF- CRM107 in patients with malignant brain tumors
    • DOI 10.1038/nm1297-1362
    • D.W. Laske, R.J. Youle, E.H. Oldfield, Tumor regression with regional distribution of the targeted toxin TF-CRM 107 in patients with malignant brain tumors, Nat. Med. 3 (1997) 1362-1368. (Pubitemid 28011036)
    • (1997) Nature Medicine , vol.3 , Issue.12 , pp. 1362-1368
    • Laske, D.W.1    Youle, R.J.2    Oldfield, E.H.3
  • 12
    • 0842324901 scopus 로고    scopus 로고
    • Safety and Efficacy of Radioimmunotherapy with Yttrium 90 Ibritumomab Tiuxetan (Zevalin)
    • H. Borghaei, R.J. Schilder, Efficacy and safety of radio immunotherapy with yttrium 90 ibritumomab tiuxetan (Zevalin), Semin. Oncol. Med. 20 (2004) 4-9. (Pubitemid 38177115)
    • (2004) Seminars in Nuclear Medicine , vol.34 , Issue.1 SUPPL. 1 , pp. 4-9
    • Borghaei, H.1    Schilder, R.J.2
  • 14
    • 78649315943 scopus 로고    scopus 로고
    • To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    • F. Danhier, O. Feron, V. Preat, To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery, J. Control. Release 148 (2010) 135-146.
    • (2010) J. Control. Release , vol.148 , pp. 135-146
    • Danhier, F.1    Feron, O.2    Preat, V.3
  • 16
    • 0033793794 scopus 로고    scopus 로고
    • Receptor-specific delivery of liposomes via folate-PEG-chol
    • W. Guo, T. Lee, J. Sudimack, R.J. Lee, Receptor-specific delivery of liposomes via folate-PEG-chol, J. Liposome Res. 10 (2000) 179-195.
    • (2000) J. Liposome Res. , vol.10 , pp. 179-195
    • Guo, W.1    Lee, T.2    Sudimack, J.3    Lee, R.J.4
  • 17
    • 41449098351 scopus 로고    scopus 로고
    • Targeted drug delivery via folate receptors
    • DOI 10.1517/17425247.5.3.309
    • X.B. Zhao, H. Li, R.J. Lee, Targeted drug delivery via folate receptors, Expert Opin. Drug Deliv. 5 (2008) 309-319. (Pubitemid 351454380)
    • (2008) Expert Opinion on Drug Delivery , vol.5 , Issue.3 , pp. 309-319
    • Zhao, X.1    Li, H.2    Lee, R.J.3
  • 18
    • 0037072555 scopus 로고    scopus 로고
    • Folate-mediated delivery of macromolecular anticancer therapeutic agents
    • DOI 10.1016/S0169-409X(02)00042-X, PII S0169409X0200042X
    • Y.J. Lu, P.S. Low, Folate-mediated delivery of macromolecular anticancer therapeutic agents, Adv. Drug Deliv. Rev. 54 (2002) 675-693. (Pubitemid 35247522)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.5 , pp. 675-693
    • Lu, Y.1    Low, P.S.2
  • 19
    • 0028224199 scopus 로고
    • High-resolution molecular discrimination by RNA
    • R.D. Jenison, S.C. Gill, A. Pardi, B. Polisky, High-resolution molecular discrimination by RNA, Science 263 (1994) 1425-1429. (Pubitemid 24137828)
    • (1994) Science , vol.263 , Issue.5152 , pp. 1425-1429
    • Jenison, R.D.1    Gill, S.C.2    Pardi, A.3    Polisky, B.4
  • 20
    • 38849087269 scopus 로고    scopus 로고
    • Surface immobilization methods for aptamer diagnostic applications
    • DOI 10.1007/s00216-007-1587-2, Aptamers and their applications
    • S. Balamurugan, A. Obubuafo, S.A. Soper, D.A. Spivak, Surface immobilization methods for aptamer diagnostic applications, Anal. Bioanal. Chem. 390 (2008) 1009-1021. (Pubitemid 351207800)
    • (2008) Analytical and Bioanalytical Chemistry , vol.390 , Issue.4 , pp. 1009-1021
    • Balamurugan, S.1    Obubuafo, A.2    Soper, S.A.3    Spivak, D.A.4
  • 21
    • 0021151237 scopus 로고
    • Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
    • K.M. Tewey, T.C. Rowe, L. Yang, B.D. Halligan, L.F. Liu, Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II, Science 226 (1984) 466-468. (Pubitemid 14012819)
    • (1984) Science , vol.226 , Issue.4673 , pp. 466-468
    • Tewey, K.M.1    Rowe, T.C.2    Yang, L.3
  • 22
    • 33845723241 scopus 로고    scopus 로고
    • An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform
    • DOI 10.1002/anie.200602251
    • V. Bagalkot, O.C. Farokhzad, R. Langer, S.Y. Jon, An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform, Chem. Int. Ed. Engl. 45 (2006) 8149-8152. (Pubitemid 44974149)
    • (2006) Angewandte Chemie - International Edition , vol.45 , Issue.48 , pp. 8149-8152
    • Bagalkot, V.1    Farokhzad, O.C.2    Langer, R.3    Jon, S.4
  • 23
    • 77950145605 scopus 로고    scopus 로고
    • Aptamer-based tumor-targeted drug delivery for photodynamic therapy
    • Y.A. Shieh, S.J. Yang, M.F. Wei, M.J. Shieh, Aptamer-based tumor-targeted drug delivery for photodynamic therapy, ACS Nano 4 (2010) 1433-1442.
    • (2010) ACS Nano , vol.4 , pp. 1433-1442
    • Shieh, Y.A.1    Yang, S.J.2    Wei, M.F.3    Shieh, M.J.4
  • 24
    • 65549102827 scopus 로고    scopus 로고
    • Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells
    • Y.F. Huang, D. Shangguan, H. Liu, J.A. Phillips, X. Zhang, Y. Chen, W. Tan, Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells, Chembiochem 10 (2009) 862-868.
    • (2009) Chembiochem , vol.10 , pp. 862-868
    • Huang, Y.F.1    Shangguan, D.2    Liu, H.3    Phillips, J.A.4    Zhang, X.5    Chen, Y.6    Tan, W.7
  • 26
    • 84858590366 scopus 로고    scopus 로고
    • Monolayer coated gold nanoparticles for delivery applications
    • S. Rana, A. Bajaj, R. Mout, V.M. Rotello, Monolayer coated gold nanoparticles for delivery applications, Adv. Drug Deliv. Rev. 64 (2012) 200-216.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 200-216
    • Rana, S.1    Bajaj, A.2    Mout, R.3    Rotello, V.M.4
  • 27
    • 80054972260 scopus 로고    scopus 로고
    • Release of photoactivatable drugs from plasmonic nanoparticles for targeted cancer therapy
    • Y.L. Luo, Y.S. Shiao, Y.F. Huang, Release of photoactivatable drugs from plasmonic nanoparticles for targeted cancer therapy, ACS Nano 5 (2011) 7796-7804.
    • (2011) ACS Nano , vol.5 , pp. 7796-7804
    • Luo, Y.L.1    Shiao, Y.S.2    Huang, Y.F.3
  • 28
    • 84861809558 scopus 로고    scopus 로고
    • Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles
    • X.J. Yang, X. Liu, Z. Liu, F. Pu, J.S. Ren, X.G. Qu, Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles, Adv. Mater. 24 (2012) 2890-2895.
    • (2012) Adv. Mater. , vol.24 , pp. 2890-2895
    • Yang, X.J.1    Liu, X.2    Liu, Z.3    Pu, F.4    Ren, J.S.5    Qu, X.G.6
  • 30
    • 33745915834 scopus 로고    scopus 로고
    • Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent
    • DOI 10.1097/01.rli.0000197669.80475.dd, PII 0000442420060300000015
    • P. Bourrinet, H.H. Bengele, B. Bonnemain, A. Dencausse, J.M. Idee, P.M. Jacobs, J.M. Lewis, Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent, Invest. Radiol. 41 (2006) 313-324. (Pubitemid 44406193)
    • (2006) Investigative Radiology , vol.41 , Issue.3 , pp. 313-324
    • Bourrinet, P.1    Bengele, H.H.2    Bonnemain, B.3    Dencausse, A.4    Idee, J.-M.5    Jacobs, P.M.6    Lewis, J.M.7
  • 31
    • 0034753215 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide contrast agents: Physicochemical characteristics and applications in MR imaging
    • DOI 10.1007/s003300100908
    • Y.X. Wang, S.M. Hussain, G.P. Krestin, Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging, Eur. Radiol. 11 (2001) 2319-2331. (Pubitemid 33041104)
    • (2001) European Radiology , vol.11 , Issue.11 , pp. 2319-2331
    • Wang, Y.-X.J.1    Hussain, S.M.2    Krestin, G.P.3
  • 32
    • 0025257041 scopus 로고
    • Ultrasmall superparamagnetic iron oxide: Characterization of a new class of contrast agents for MR imaging
    • R. Weissleder, G. Elizondo, J. Wittenberg, C.A. Rabito, H.H. Bengele, L. Josephson, Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging, Radiology 175 (1990) 489-493. (Pubitemid 20135290)
    • (1990) Radiology , vol.175 , Issue.2 , pp. 489-493
    • Weissleder, R.1    Elizondo, G.2    Wittenberg, J.3    Rabito, C.A.4    Bengele, H.H.5    Josephson, L.6
  • 34
    • 83555177197 scopus 로고    scopus 로고
    • Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors
    • L.J. Meng, X.K. Zhang, Q.H. Lu, Z.F. Fei, J.P. Dyson, Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin to tumors, Biomaterials 33 (2012) 1689-1698.
    • (2012) Biomaterials , vol.33 , pp. 1689-1698
    • Meng, L.J.1    Zhang, X.K.2    Lu, Q.H.3    Fei, Z.F.4    Dyson, J.P.5
  • 35
    • 50249133647 scopus 로고    scopus 로고
    • Regulation of singlet oxygen generation using single-walled carbon nanotubes
    • Z. Zhu, Z.W. Tang, J.A. Phillips, R.H. Yang, H. Wang, W.H. Tan, Regulation of singlet oxygen generation using single-walled carbon nanotubes, J. Am. Chem. Soc. 130 (2008) 10856-10857.
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 10856-10857
    • Zhu, Z.1    Tang, Z.W.2    Phillips, J.A.3    Yang, R.H.4    Wang, H.5    Tan, W.H.6
  • 41
    • 75649089648 scopus 로고    scopus 로고
    • A liposome-based nanostructure for aptamer directed delivery
    • H.Z. Kang, M.B. O'Donoghue, H.P. Liu, W.H. Tan, A liposome-based nanostructure for aptamer directed delivery, Chem. Commun. 46 (2010) 249-251.
    • (2010) Chem. Commun. , vol.46 , pp. 249-251
    • Kang, H.Z.1    O'Donoghue, M.B.2    Liu, H.P.3    Tan, W.H.4
  • 42
    • 0032580354 scopus 로고    scopus 로고
    • Drug delivery and targeting
    • R. Langer, Drug delivery and targeting, Nature 392 (1998) 5-10. (Pubitemid 28215187)
    • (1998) Nature , vol.392 , Issue.6679 SUPPL. , pp. 5-10
    • Langer, R.1
  • 43
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • F. Alexis, E. Pridgen, L.K. Molnar, O.C. Farokhzad, Factors affecting the clearance and biodistribution of polymeric nanoparticles, Mol. Pharmacol. 5 (2008) 505-515.
    • (2008) Mol. Pharmacol. , vol.5 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 46
    • 56249097260 scopus 로고    scopus 로고
    • Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized pt (IV) prodrug-plga-PEG nanoparticles
    • S. Dhar, F.X. Gu, R. Langer, O.C. Farokhzad, S.J. Lippard, Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt (IV) prodrug-PlGA-PEG nanoparticles, Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 17356-17361.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 17356-17361
    • Dhar, S.1    Gu, F.X.2    Langer, R.3    Farokhzad, O.C.4    Lippard, S.J.5
  • 47
    • 79952165883 scopus 로고    scopus 로고
    • Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo
    • S. Dhara, N. Kolishettib, S.J. Lipparda, O.C. Farokhzad, Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo, PNAS 5 (2011) 1850-1855.
    • (2011) PNAS , vol.5 , pp. 1850-1855
    • Dhara, S.1    Kolishettib, N.2    Lipparda, S.J.3    Farokhzad, O.C.4
  • 49
    • 34247377403 scopus 로고    scopus 로고
    • Synthesis and self-assembly of amphiphilic polymeric microparticles
    • DOI 10.1021/la062512i
    • D. Dendukuri, T.A. Hatton, P.S. Doyle, Synthesis and self-assembly of amphiphilic polymeric microparticles, Langmuir 23 (2007) 4669-4674. (Pubitemid 46643206)
    • (2007) Langmuir , vol.23 , Issue.8 , pp. 4669-4674
    • Dendukuri, D.1    Hatton, T.A.2    Doyle, P.S.3
  • 50
    • 69949156057 scopus 로고    scopus 로고
    • Supramolecular assemblies of amphiphilic homopolymers
    • T.S. Kale, A. Klaikherd, B. Popere, S. Thayumanavan, Supramolecular assemblies of amphiphilic homopolymers, Langmuir 25 (2009) 9660-9670.
    • (2009) Langmuir , vol.25 , pp. 9660-9670
    • Kale, T.S.1    Klaikherd, A.2    Popere, B.3    Thayumanavan, S.4
  • 51
    • 76249127542 scopus 로고    scopus 로고
    • DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells
    • Y.R. Wu, K. Sefah, H.P. Liu, R.W. Wang, W.H. Tana, DNA aptamer-micelle as an efficient detection/delivery vehicle toward cancer cells, PNAS 107 (2010) 5-10.
    • (2010) PNAS , vol.107 , pp. 5-10
    • Wu, Y.R.1    Sefah, K.2    Liu, H.P.3    Wang, R.W.4    Tana, W.H.5
  • 52
    • 0030998781 scopus 로고    scopus 로고
    • Preparation of hydrophobic and hydrophilic albumin microspheres and determination of surface carboxylic acid and amino residues
    • DOI 10.1016/S0378-5173(97)04886-2, PII S0378517397048862
    • A.B. MacAdam, Z.B. Shafi, S.L. James, C. Marriott, G.P. Martin, Preparation Of hydrophobic and hydrophilic albumin microspheres and determination of surface carboxylic acid and amino residues, Int. J. Pharm. 151 (1997) 47-55. (Pubitemid 27212303)
    • (1997) International Journal of Pharmaceutics , vol.151 , Issue.1 , pp. 47-55
    • MacAdam, A.B.1    Shafi, Z.B.2    James, S.L.3    Marriott, C.4    Martin, G.P.5
  • 53
    • 45849090317 scopus 로고    scopus 로고
    • Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles
    • DOI 10.1517/17425247.5.5.499
    • G. Wang, H. Uludag, Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles, Expert Opin. Drug Deliv. 5 (2008) 499-515. (Pubitemid 351877431)
    • (2008) Expert Opinion on Drug Delivery , vol.5 , Issue.5 , pp. 499-515
    • Wang, G.1    Uludag, H.2
  • 54
    • 33745458519 scopus 로고    scopus 로고
    • Albumin-bound paclitaxel: A next-generation taxane
    • DOI 10.1517/14656566.7.8.1041
    • W.J. Gradishar, Albumin-bound paclitaxel: a next-generation taxane, Expert Opin. Pharmacother. 7 (2006) 1041-1053. (Pubitemid 43949942)
    • (2006) Expert Opinion on Pharmacotherapy , vol.7 , Issue.8 , pp. 1041-1053
    • Gradishar, W.J.1
  • 55
    • 84863230640 scopus 로고    scopus 로고
    • Bovine serum albumin nanoparticles modified with multilayers and aptamers for pH-responsive and targeted anti-cancer drug delivery
    • L.L. Xie, W.J. Tong, D.H. Yu, J.Q. Xu, J. Li, C.Y. Gao, Bovine serum albumin nanoparticles modified with multilayers and aptamers for pH-responsive and targeted anti-cancer drug delivery, J. Mater. Chem. 22 (2012) 6053-6060.
    • (2012) J. Mater. Chem. , vol.22 , pp. 6053-6060
    • Xie, L.L.1    Tong, W.J.2    Yu, D.H.3    Xu, J.Q.4    Li, J.5    Gao, C.Y.6
  • 56
    • 78649315943 scopus 로고    scopus 로고
    • To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    • F. Danhier, O. Feron, V. Préat, To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery, J. Control. Release 148 (2010) 135-146.
    • (2010) J. Control. Release , vol.148 , pp. 135-146
    • Danhier, F.1    Feron, O.2    Préat, V.3
  • 57
    • 70350404331 scopus 로고    scopus 로고
    • Exploring dendrimer towards dual drug delivery: Ph responsive simultaneous drug-release kinetics
    • R.K. Tekade, T. Dutta, V. Gajbhiye, N.K. Jain, Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics, J. Microencapsul. 26 (2009) 87-96.
    • (2009) J. Microencapsul. , vol.26 , pp. 87-96
    • Tekade, R.K.1    Dutta, T.2    Gajbhiye, V.3    Jain, N.K.4
  • 58
    • 84862682470 scopus 로고    scopus 로고
    • Biofunctional nanosystems based on dendritic polymers
    • M.A. Quadir, R. Haag, Biofunctional nanosystems based on dendritic polymers, J. Control. Release 161 (2012) 484-495.
    • (2012) J. Control. Release , vol.161 , pp. 484-495
    • Quadir, M.A.1    Haag, R.2
  • 59
    • 79954579637 scopus 로고    scopus 로고
    • Design of biocompatible dendrimers for cancer diagnosis and therapy: Current status and future perspectives
    • Y. Cheng, L. Zhao, Y. Li, T. Xu, Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives, Chem. Soc. Rev. 40 (2011) 2673-2703.
    • (2011) Chem. Soc. Rev. , vol.40 , pp. 2673-2703
    • Cheng, Y.1    Zhao, L.2    Li, Y.3    Xu, T.4
  • 60
    • 84858679264 scopus 로고    scopus 로고
    • Multifunctional dendritic polymers in nanomedicine: Opportunities and challenges
    • J. Khandare, M. Calderon, N.M. Dagia, R. Haag, Multifunctional dendritic polymers in nanomedicine: opportunities and challenges, Chem. Soc. Rev. 41 (2012) 2824-2848.
    • (2012) Chem. Soc. Rev. , vol.41 , pp. 2824-2848
    • Khandare, J.1    Calderon, M.2    Dagia, N.M.3    Haag, R.4
  • 61
    • 80052182569 scopus 로고    scopus 로고
    • Targeting the lymphatics using dendritic polymers (dendrimers)
    • L.M. Kaminskas, C.J.H. Porter, Targeting the lymphatics using dendritic polymers (dendrimers), Adv. Drug Deliv. Rev. 63 (2011) 890-900.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 890-900
    • Kaminskas, L.M.1    Porter, C.J.H.2
  • 62
    • 80054681184 scopus 로고    scopus 로고
    • Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates
    • I.H. Lee, S. An, M.K. Yu, H.K. Kwon, S.H. Im, S.Y. Jon, Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates, J. Control. Release 3 (2011) 435-441.
    • (2011) J. Control. Release , vol.3 , pp. 435-441
    • Lee, I.H.1    An, S.2    Yu, M.K.3    Kwon, H.K.4    Im, S.H.5    Jon, S.Y.6
  • 63
    • 56749185962 scopus 로고    scopus 로고
    • Folate and folate-PEG-PAMAM dendrimers: Synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice
    • P. Singh, U. Gupta, A. Asthana, N.K. Jain, Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice, Bioconjug. Chem. 19 (2008) 2239-2252.
    • (2008) Bioconjug. Chem. , vol.19 , pp. 2239-2252
    • Singh, P.1    Gupta, U.2    Asthana, A.3    Jain, N.K.4
  • 64
    • 0742323734 scopus 로고    scopus 로고
    • Circulating tumour cells in breast cancer
    • DOI 10.1016/S1470-2045(04)01381-6, PII S1470204504013816
    • A. Ring, I.E. Smith, M. Dowsett, Circulating tumour cells in breast cancer, Lancet Oncol. 5 (2004) 79-88. (Pubitemid 38145890)
    • (2004) Lancet Oncology , vol.5 , Issue.2 , pp. 79-88
    • Ring, A.1    Smith, I.E.2    Dowsett, M.3
  • 65
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, C.C. Mello, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature 391 (1998) 806-811. (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 66
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • DOI 10.1038/nature02870
    • G.J. Hannon, J.J. Rossi, Unlocking the potential of the human genome with RNA interference, Nature 431 (2004) 371-378. (Pubitemid 39265678)
    • (2004) Nature , vol.431 , Issue.7006 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 67
    • 0242617623 scopus 로고
    • The properties of streptavidin a biotin-binding protein produced by streptomycetes
    • L. Chaiet, F.J. Wolf, The properties of streptavidin a biotin-binding protein produced by streptomycetes, Arch. Biochem. Biophys. 106 (1964) 1-5.
    • (1964) Arch. Biochem. Biophys. , vol.106 , pp. 1-5
    • Chaiet, L.1    Wolf, F.J.2
  • 70
    • 24944565527 scopus 로고    scopus 로고
    • Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology
    • DOI 10.1021/nl051264s
    • A. Khaled, S. Guo, F. Li, P. Guo, Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology, Nano Lett. 5 (2005) 1797-1808. (Pubitemid 41396168)
    • (2005) Nano Letters , vol.5 , Issue.9 , pp. 1797-1808
    • Khaled, A.1    Guo, S.2    Li, F.3    Guo, P.4
  • 71
    • 24944512987 scopus 로고    scopus 로고
    • Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA
    • S. Guo, N. Tschammer, S. Mohammed, P. Guo, Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA, Hum. Gene Ther. 16 (2005) 1097-1110.
    • (2005) Hum. Gene Ther. , vol.16 , pp. 1097-1110
    • Guo, S.1    Tschammer, N.2    Mohammed, S.3    Guo, P.4
  • 74
    • 55449127119 scopus 로고    scopus 로고
    • Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2
    • U. Wullner, I. Neef, A. Eller, M. Kleines, M.K. Tur, S. Barth, Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2, Curr. Cancer Drug Targets 8 (2008) 554-565.
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 554-565
    • Wullner, U.1    Neef, I.2    Eller, A.3    Kleines, M.4    Tur, M.K.5    Barth, S.6
  • 75
    • 54949106632 scopus 로고    scopus 로고
    • Model-guided design of ligand-regulated RNAi for programmable control of gene expression
    • C.L. Beisel, T.S. Bayer, K.G. Hoff, C.D. Smolke, Model-guided design of ligand-regulated RNAi for programmable control of gene expression, Mol. Syst. Biol. 4 (2008) 224.
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 224
    • Beisel, C.L.1    Bayer, T.S.2    Hoff, K.G.3    Smolke, C.D.4
  • 76
    • 65249099011 scopus 로고    scopus 로고
    • N/P ratio significantly influences the transfection efficiency and cytotoxicity of a polyethylenimine/chitosan/DNA complex
    • Q.Q. Zhao, J.L. Chen, T.F. Lv, C.X. He, G.P. Tang, W.Q. Liang, Y. Tabata, J.Q. Gao, N/P ratio significantly influences the transfection efficiency and cytotoxicity of a polyethylenimine/chitosan/DNA complex, Biol. Pharm. Bull. 32 (2009) 706-710.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 706-710
    • Zhao, Q.Q.1    Chen, J.L.2    Lv, T.F.3    He, C.X.4    Tang, G.P.5    Liang, W.Q.6    Tabata, Y.7    Gao, J.Q.8
  • 77
    • 70350324304 scopus 로고    scopus 로고
    • Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells
    • J.S. Park, K. Na, D.G. Woo, H.N. Yang, J.M. Kim, J.H. Kim, H.M. Chung, K.H. Park, Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells, Biomaterials 31 (2010) 124-132.
    • (2010) Biomaterials , vol.31 , pp. 124-132
    • Park, J.S.1    Na, K.2    Woo, D.G.3    Yang, H.N.4    Kim, J.M.5    Kim, J.H.6    Chung, H.M.7    Park, K.H.8
  • 78
    • 75549089094 scopus 로고    scopus 로고
    • Stability and cellular uptake of polymerized siRNA (poly-siRNA)/ polyethylenimine (PEI) complexes for efficient gene silencing
    • S.Y. Lee, M.S. Huh,S. Lee, S.J. Lee, H. Chung, J.H. Park, Y.K. Oh,K. Choi,K. Kim, I.C. Kwon, Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing, J. Control. Release 141 (2010) 339-346.
    • (2010) J. Control. Release , vol.141 , pp. 339-346
    • Lee, S.Y.1    Huh, M.S.2    Lee, S.3    Lee, S.J.4    Chung, H.5    Park, J.H.6    Oh, Y.K.7    Choi, K.8    Kim, K.9    Kwon, I.C.10
  • 79
    • 79251568958 scopus 로고    scopus 로고
    • A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma
    • N.X. Zhao, H.G. Bagaria, M.S. Wong, Y.L. Zu, A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma, J. Nanobiotechnol. 9 (2011) 2.
    • (2011) J. Nanobiotechnol. , vol.9 , pp. 2
    • Zhao, N.X.1    Bagaria, H.G.2    Wong, M.S.3    Zu, Y.L.4
  • 80
    • 80055004444 scopus 로고    scopus 로고
    • SiRNA-aptamer chimeras on nanoparticles: Preserving targeting functionality for effective gene silencing
    • V. Bagalkot, X.H. Gao, siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing, ACS Nano 5 (2011) 8131-8139.
    • (2011) ACS Nano , vol.5 , pp. 8131-8139
    • Bagalkot, V.1    Gao, X.H.2
  • 81
    • 48349105059 scopus 로고    scopus 로고
    • Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy
    • J.H. Zhou, H.T. Li, S. Li, J. Zaia, J.J. Rossi, Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy, Mol. Ther. 16 (2008) 1481-1489.
    • (2008) Mol. Ther. , vol.16 , pp. 1481-1489
    • Zhou, J.H.1    Li, H.T.2    Li, S.3    Zaia, J.4    Rossi, J.J.5
  • 82
    • 77951168054 scopus 로고    scopus 로고
    • Breaking down the barriers: Sirna delivery and endosome escape
    • M. Dominska, D.M. Dykxhoorn, Breaking down the barriers: siRNA delivery and endosome escape, J. Cell Sci. 123 (2010) 1183-1189.
    • (2010) J. Cell Sci. , vol.123 , pp. 1183-1189
    • Dominska, M.1    Dykxhoorn, D.M.2
  • 83
    • 67649295505 scopus 로고    scopus 로고
    • SiRNA delivery systems for cancer treatment
    • Y.K. Oh, T.G. Park, siRNA delivery systems for cancer treatment, Adv. Drug Deliv. Rev. 61 (2009) 850-862.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 850-862
    • Oh, Y.K.1    Park, T.G.2
  • 84
    • 0015462030 scopus 로고
    • Combination cancer therapy: Presidential address
    • E. Frei, Combination cancer therapy: presidential address, Cancer Res. 32 (1972) 2593-2607.
    • (1972) Cancer Res. , vol.32 , pp. 2593-2607
    • Frei, E.1
  • 85
    • 56049117207 scopus 로고    scopus 로고
    • Combination chemotherapy and photodynamic therapy with fab? Fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells
    • J. Hongrapipat, P. Kopeckova, J. Liu, S. Prakongpan, J. Kopecek, Combination chemotherapy and photodynamic therapy with Fab? fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells, Mol. Pharm. 5 (2008) 696-709.
    • (2008) Mol. Pharm. , vol.5 , pp. 696-709
    • Hongrapipat, J.1    Kopeckova, P.2    Liu, J.3    Prakongpan, S.4    Kopecek, J.5
  • 86
    • 64249107600 scopus 로고    scopus 로고
    • Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect
    • N. Wiradharma, Y.W. Tong, Y. Yang, Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect, Biomaterials 30 (2009) 3100-3109.
    • (2009) Biomaterials , vol.30 , pp. 3100-3109
    • Wiradharma, N.1    Tong, Y.W.2    Yang, Y.3
  • 87
    • 35549013192 scopus 로고    scopus 로고
    • Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy
    • DOI 10.1021/mp0700559
    • H. Lee, M. Hu, R.M. Reilly, C. Allen, Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy, Mol. Pharm. 4 (2007) 769-781. (Pubitemid 350004277)
    • (2007) Molecular Pharmaceutics , vol.4 , Issue.5 , pp. 769-781
    • Lee, H.1    Hu, M.2    Reilly, R.M.3    Allen, C.4
  • 90
    • 58849095012 scopus 로고    scopus 로고
    • Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells
    • S. Yadav, L.E. van Vlerken, S.R. Little, M.M. Amiji, Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells, Cancer Chemother. Pharmacol. 63 (2009) 711-722.
    • (2009) Cancer Chemother. Pharmacol. , vol.63 , pp. 711-722
    • Yadav, S.1    Van Vlerken, L.E.2    Little, S.R.3    Amiji, M.M.4
  • 91
    • 78650134637 scopus 로고    scopus 로고
    • Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line
    • H. Meng, M. Liong, T. Xia, Z. Li, Z. Ji, J.I. Zink, Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line, ACS Nano 4 (2010) 4539-4550.
    • (2010) ACS Nano , vol.4 , pp. 4539-4550
    • Meng, H.1    Liong, M.2    Xia, T.3    Li, Z.4    Ji, Z.5    Zink, J.I.6
  • 92
    • 77954599597 scopus 로고    scopus 로고
    • Multifunctional nanoparticles delivering small interfering RNA and doxorubicin overcome drug resistance in cancer
    • Y. Chen, S.R. Bathula, J. Li, L. Huang, Multifunctional nanoparticles delivering small interfering RNA and doxorubicin overcome drug resistance in cancer, J. Biol. Chem. 285 (2010) 22639-22650.
    • (2010) J. Biol. Chem. , vol.285 , pp. 22639-22650
    • Chen, Y.1    Bathula, S.R.2    Li, J.3    Huang, L.4
  • 93
    • 70350707597 scopus 로고    scopus 로고
    • The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
    • Y.B. Patil, S.K. Swaminathan, T. Sadhukha, L. Ma, J. Panyam, The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance, Biomaterials 31 (2010) 358-365.
    • (2010) Biomaterials , vol.31 , pp. 358-365
    • Patil, Y.B.1    Swaminathan, S.K.2    Sadhukha, T.3    Ma, L.4    Panyam, J.5
  • 94
    • 77950051368 scopus 로고    scopus 로고
    • Prostate cancer cell death produced by the co-delivery of bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex
    • E.J. Kim, Y.Y. Jung, H. Choi, J. Yang, J.S. Suh, Y.M. Huh, K.H. Kim, S. Haam, Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex, Biomaterials 31 (2010) 4592-4599.
    • (2010) Biomaterials , vol.31 , pp. 4592-4599
    • Kim, E.J.1    Jung, Y.Y.2    Choi, H.3    Yang, J.4    Suh, J.S.5    Huh, Y.M.6    Kim, K.H.7    Haam, S.8
  • 95
    • 0027163099 scopus 로고
    • In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits
    • L.C. Griffin, G.F. Tidmarsh, L.C. Bock, J.J. Toole, L.L. Leung, In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits, Blood 81 (1993) 3271-3276. (Pubitemid 23172909)
    • (1993) Blood , vol.81 , Issue.12 , pp. 3271-3276
    • Griffin, L.C.1    Tidmarsh, G.F.2    Bock, L.C.3    Toole, J.J.4    Leung, L.L.K.5


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