-
1
-
-
84890463477
-
Variations in virulence and molecular biology among emerging strains of Clostridium difficile
-
Hunt JJ, Ballard JD. Variations in virulence and molecular biology among emerging strains of Clostridium difficile. Microbiol Mol Biol Rev. 2013;77:567-581.
-
(2013)
Microbiol Mol Biol Rev.
, vol.77
, pp. 567-581
-
-
Hunt, J.J.1
Ballard, J.D.2
-
2
-
-
39749142406
-
Historical perspectives on studies of Clostridium difficile and C. difficile infection
-
Bartlett JG. Historical perspectives on studies of Clostridium difficile and C. difficile infection. Clin Infect Dis. 2008;46(suppl 1):S4-S11.
-
(2008)
Clin Infect Dis.
, vol.46
, pp. S4-S11
-
-
Bartlett, J.G.1
-
3
-
-
0018193196
-
Clostridium difficile and the aetiology of pseudomembranous colitis
-
Larson HE, Price AB, Honour P, et al. Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet. 1978;1:1063-1066.
-
(1978)
Lancet
, vol.1
, pp. 1063-1066
-
-
Larson, H.E.1
Price, A.B.2
Honour, P.3
-
4
-
-
0017801430
-
Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia
-
Bartlett JG, Chang TW, Gurwith M, et al. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978;298:531-534.
-
(1978)
N Engl J Med.
, vol.298
, pp. 531-534
-
-
Bartlett, J.G.1
Chang, T.W.2
Gurwith, M.3
-
5
-
-
0018136697
-
Identification of Clostridium difficile as a cause of pseudomembranous colitis
-
George RH, Symonds JM, Dimock F, et al. Identification of Clostridium difficile as a cause of pseudomembranous colitis. Br Med J. 1978;1:695.
-
(1978)
Br Med J
, vol.1
, pp. 695
-
-
George, R.H.1
Symonds, J.M.2
Dimock, F.3
-
6
-
-
44149094314
-
Recent advances in Clostridium difficile-associated disease
-
Monaghan T, Boswell T, Mahida YR. Recent advances in Clostridium difficile-associated disease. Gut. 2008;57:850-860.
-
(2008)
Gut
, vol.57
, pp. 850-860
-
-
Monaghan, T.1
Boswell, T.2
Mahida, Y.R.3
-
7
-
-
78651111353
-
Clostridium difficile infection: Epidemiology, risk factors and management
-
Ananthakrishnan AN. Clostridium difficile infection: epidemiology, risk factors and management. Nat Rev Gastroenterol Hepatol. 2011;8:17-26.
-
(2011)
Nat Rev Gastroenterol Hepatol.
, vol.8
, pp. 17-26
-
-
Ananthakrishnan, A.N.1
-
8
-
-
84884510020
-
Diverse sources of C. difficile infection identified on whole-genome sequencing
-
Eyre DW, Cule ML, Wilson DJ, et al. Diverse sources of C. difficile infection identified on whole-genome sequencing. N Engl J Med. 2013;369:1195-1205.
-
(2013)
N Engl J Med.
, vol.369
, pp. 1195-1205
-
-
Eyre, D.W.1
Cule, M.L.2
Wilson, D.J.3
-
9
-
-
84884513249
-
Clostridium difficile - Beyond the usual suspects
-
Donskey CJ. Clostridium difficile - beyond the usual suspects. N Engl J Med. 2013;369:1263-1264.
-
(2013)
N Engl J Med.
, vol.369
, pp. 1263-1264
-
-
Donskey, C.J.1
-
10
-
-
78751545522
-
Systematic review: Clostridium difficile and inflammatory bowel disease
-
Goodhand JR, Alazawi W, Rampton DS. Systematic review: Clostridium difficile and inflammatory bowel disease. Aliment Pharmacol Ther. 2011;33:428-441.
-
(2011)
Aliment Pharmacol Ther.
, vol.33
, pp. 428-441
-
-
Goodhand, J.R.1
Alazawi, W.2
Rampton, D.S.3
-
11
-
-
84888109625
-
Clostridium difficile and inflammatory bowel disease: Role in pathogenesis and implications in treatment
-
Nitzan O, Elias M, Chazan B, et al. Clostridium difficile and inflammatory bowel disease: role in pathogenesis and implications in treatment. World J Gastroenterol. 2013;19:7577-7585.
-
(2013)
World J Gastroenterol.
, vol.19
, pp. 7577-7585
-
-
Nitzan, O.1
Elias, M.2
Chazan, B.3
-
12
-
-
84876384416
-
Risk factors and outcome of PCR-detected Clostridium difficile infection in ileal pouch patients
-
Li Y, Qian J, Queener E, et al. Risk factors and outcome of PCR-detected Clostridium difficile infection in ileal pouch patients. Inflamm Bowel Dis. 2013;19:397-403.
-
(2013)
Inflamm Bowel Dis.
, vol.19
, pp. 397-403
-
-
Li, Y.1
Qian, J.2
Queener, E.3
-
13
-
-
66949151443
-
The vexed relationship between Clostridium difficile and inflammatory bowel disease: An assessment of carriage in an outpatient setting among patients in remission
-
Clayton EM, Rea MC, Shanahan F, et al. The vexed relationship between Clostridium difficile and inflammatory bowel disease: an assessment of carriage in an outpatient setting among patients in remission. Am J Gastroenterol. 2009;104:1162-1169.
-
(2009)
Am J Gastroenterol.
, vol.104
, pp. 1162-1169
-
-
Clayton, E.M.1
Rea, M.C.2
Shanahan, F.3
-
14
-
-
84893724752
-
Clostridium difficile carriage and serum antitoxin responses in children with inflammatory bowel disease
-
Hourigan SK, Chirumamilla SR, Ross T, et al. Clostridium difficile carriage and serum antitoxin responses in children with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:2744-2752.
-
(2013)
Inflamm Bowel Dis.
, vol.19
, pp. 2744-2752
-
-
Hourigan, S.K.1
Chirumamilla, S.R.2
Ross, T.3
-
15
-
-
0026089562
-
Protection against experimental pseudomembranous colitis in gnotobiotic mice by use of monoclonal antibodies against Clostridium difficile toxin A
-
Corthier G, Muller MC, Wilkins TD, et al. Protection against experimental pseudomembranous colitis in gnotobiotic mice by use of monoclonal antibodies against Clostridium difficile toxin A. Infect Immun. 1991;59:1192-1195.
-
(1991)
Infect Immun.
, vol.59
, pp. 1192-1195
-
-
Corthier, G.1
Muller, M.C.2
Wilkins, T.D.3
-
16
-
-
33750493617
-
Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters
-
Babcock GJ, Broering TJ, Hernandez HJ, et al. Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters. Infect Immun. 2006;74:6339-6347.
-
(2006)
Infect Immun.
, vol.74
, pp. 6339-6347
-
-
Babcock, G.J.1
Broering, T.J.2
Hernandez, H.J.3
-
17
-
-
77957988127
-
The role of toxin A and toxin B in Clostridium difficile infection
-
Kuehne SA, Cartman ST, Heap JT, et al. The role of toxin A and toxin B in Clostridium difficile infection. Nature. 2010;467:711-713.
-
(2010)
Nature
, vol.467
, pp. 711-713
-
-
Kuehne, S.A.1
Cartman, S.T.2
Heap, J.T.3
-
18
-
-
1542723582
-
Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping
-
van den Berg RJ, Claas EC, Oyib DH, et al. Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping. J Clin Microbiol. 2004;42:1035-1041.
-
(2004)
J Clin Microbiol.
, vol.42
, pp. 1035-1041
-
-
Van Den Berg, R.J.1
Claas, E.C.2
Oyib, D.H.3
-
19
-
-
67649391053
-
Clostridium difficile infection: New developments in epidemiology and pathogenesis
-
Rupnik M, Wilcox MH, Gerding DN. Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol. 2009;7:526-536.
-
(2009)
Nat Rev Microbiol.
, vol.7
, pp. 526-536
-
-
Rupnik, M.1
Wilcox, M.H.2
Gerding, D.N.3
-
20
-
-
84881238786
-
The agr locus regulates virulence and colonization genes in Clostridium difficile 027
-
Martin MJ, Clare S, Goulding D, et al. The agr locus regulates virulence and colonization genes in Clostridium difficile 027. J Bacteriol. 2013;195:3672-3681.
-
(2013)
J Bacteriol.
, vol.195
, pp. 3672-3681
-
-
Martin, M.J.1
Clare, S.2
Goulding, D.3
-
21
-
-
84891929627
-
Spo0A differentially regulates toxin production in evolutionarily diverse strains of Clostridium difficile
-
Mackin KE, Carter GP, Howarth P, et al. Spo0A differentially regulates toxin production in evolutionarily diverse strains of Clostridium difficile. PLoS One. 2013;8:e79666.
-
(2013)
PLoS One
, vol.8
-
-
Mackin, K.E.1
Carter, G.P.2
Howarth, P.3
-
22
-
-
84892657564
-
Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR
-
El Meouche I, Peltier J, Monot M, et al. Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR. PLoS One. 2013;8:e83748.
-
(2013)
PLoS One
, vol.8
-
-
El Meouche, I.1
Peltier, J.2
Monot, M.3
-
23
-
-
0033914385
-
Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea
-
Alfa MJ, Kabani A, Lyerly D, et al. Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea. J Clin Microbiol. 2000;38:2706-2714.
-
(2000)
J Clin Microbiol.
, vol.38
, pp. 2706-2714
-
-
Alfa, M.J.1
Kabani, A.2
Lyerly, D.3
-
24
-
-
79959213985
-
Bacterial protein toxins that modify host regulatory GTPases
-
Aktories K. Bacterial protein toxins that modify host regulatory GTPases. Nat Rev Microbiol. 2011;9:487-498.
-
(2011)
Nat Rev Microbiol.
, vol.9
, pp. 487-498
-
-
Aktories, K.1
-
25
-
-
84878486491
-
Toward a structural understanding of Clostridium difficile toxins A and B
-
Pruitt RN, Lacy DB. Toward a structural understanding of Clostridium difficile toxins A and B. Front Cell Infect Microbiol. 2012;2:28.
-
(2012)
Front Cell Infect Microbiol.
, vol.2
, pp. 28
-
-
Pruitt, R.N.1
Lacy, D.B.2
-
26
-
-
76249088522
-
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium
-
Stabler RA, He M, Dawson L, et al. Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biol. 2009;10:R102.
-
(2009)
Genome Biol.
, vol.10
, pp. R102
-
-
Stabler, R.A.1
He, M.2
Dawson, L.3
-
27
-
-
77958132074
-
Variations in TcdB activity and the hypervirulence of emerging strains of Clostridium difficile
-
Lanis JM, Barua S, Ballard JD. Variations in TcdB activity and the hypervirulence of emerging strains of Clostridium difficile. PLoS Pathog. 2010;6:e1001061.
-
(2010)
PLoS Pathog
, vol.6
-
-
Lanis, J.M.1
Barua, S.2
Ballard, J.D.3
-
28
-
-
84891773348
-
Clostridium difficile binary toxin CDT: Mechanism, epidemiology, and potential clinical importance
-
Gerding DN, Johnson S, Rupnik M, et al. Clostridium difficile binary toxin CDT: mechanism, epidemiology, and potential clinical importance. Gut Microbes. 2014;5:15-27.
-
(2014)
Gut Microbes
, vol.5
, pp. 15-27
-
-
Gerding, D.N.1
Johnson, S.2
Rupnik, M.3
-
29
-
-
80053636077
-
Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)
-
Papatheodorou P, Carette JE, Bell GW, et al. Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT). Proc Natl Acad Sci U S A. 2011;108:16422-16427.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 16422-16427
-
-
Papatheodorou, P.1
Carette, J.E.2
Bell, G.W.3
-
30
-
-
84870928347
-
CD44 promotes intoxication by the clostridial iota-family toxins
-
Wigelsworth DJ, Ruthel G, Schnell L, et al. CD44 promotes intoxication by the clostridial iota-family toxins. PLoS One. 2012;7:e51356.
-
(2012)
PLoS One
, vol.7
-
-
Wigelsworth, D.J.1
Ruthel, G.2
Schnell, L.3
-
31
-
-
84893871106
-
Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence
-
Schwan C, Kruppke AS, Nolke T, et al. Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence. Proc Natl Acad Sci U S A. 2014;111:2313-2318.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 2313-2318
-
-
Schwan, C.1
Kruppke, A.S.2
Nolke, T.3
-
32
-
-
73449097193
-
Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria
-
Schwan C, Stecher B, Tzivelekidis T, et al. Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. PLoS Pathog. 2009;5:e1000626.
-
(2009)
PLoS Pathog
, vol.5
-
-
Schwan, C.1
Stecher, B.2
Tzivelekidis, T.3
-
33
-
-
33645761368
-
Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters
-
Geric B, Carman RJ, Rupnik M, et al. Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters. J Infect Dis. 2006;193:1143-1150.
-
(2006)
J Infect Dis.
, vol.193
, pp. 1143-1150
-
-
Geric, B.1
Carman, R.J.2
Rupnik, M.3
-
34
-
-
84891353755
-
Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain
-
Kuehne SA, Collery MM, Kelly ML, et al. Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain. J Infect Dis. 2014;209:83-86.
-
(2014)
J Infect Dis.
, vol.209
, pp. 83-86
-
-
Kuehne, S.A.1
Collery, M.M.2
Kelly, M.L.3
-
35
-
-
0027729062
-
Crystalline bacterial cell surface layers
-
Sleytr UB, Messner P, Pum D, et al. Crystalline bacterial cell surface layers. Mol Microbiol. 1993;10:911-916.
-
(1993)
Mol Microbiol.
, vol.10
, pp. 911-916
-
-
Sleytr, U.B.1
Messner, P.2
Pum, D.3
-
36
-
-
0034971793
-
Molecular characterization of the surface layer proteins from Clostridium difficile
-
Calabi E, Ward S, Wren B, et al. Molecular characterization of the surface layer proteins from Clostridium difficile. Mol Microbiol. 2001;40:1187-1199.
-
(2001)
Mol Microbiol.
, vol.40
, pp. 1187-1199
-
-
Calabi, E.1
Ward, S.2
Wren, B.3
-
37
-
-
71749087319
-
Cwp84, a surface-associated cysteine protease, plays a role in the maturation of the surface layer of Clostridium difficile
-
Kirby JM, Ahern H, Roberts AK, et al. Cwp84, a surface-associated cysteine protease, plays a role in the maturation of the surface layer of Clostridium difficile. J Biol Chem. 2009;284:34666-34673.
-
(2009)
J Biol Chem.
, vol.284
, pp. 34666-34673
-
-
Kirby, J.M.1
Ahern, H.2
Roberts, A.K.3
-
38
-
-
0026035298
-
Purification and characterization of S layer proteins from Clostridium difficile GAI 0714
-
Takeoka A, Takumi K, Koga T, et al. Purification and characterization of S layer proteins from Clostridium difficile GAI 0714. J Gen Microbiol. 1991;137:261-267.
-
(1991)
J Gen Microbiol.
, vol.137
, pp. 261-267
-
-
Takeoka, A.1
Takumi, K.2
Koga, T.3
-
39
-
-
0036785598
-
Binding of Clostridium difficile surface layer proteins to gastrointestinal tissues
-
Calabi E, Calabi F, Phillips AD, et al. Binding of Clostridium difficile surface layer proteins to gastrointestinal tissues. Infect Immun. 2002;70:5770-5778.
-
(2002)
Infect Immun.
, vol.70
, pp. 5770-5778
-
-
Calabi, E.1
Calabi, F.2
Phillips, A.D.3
-
40
-
-
79955766239
-
The Clostridium difficile cell wall protein CwpV is antigenically variable between strains, but exhibits conserved aggregation-promoting function
-
Reynolds CB, Emerson JE, de la Riva L, et al. The Clostridium difficile cell wall protein CwpV is antigenically variable between strains, but exhibits conserved aggregation-promoting function. PLoS Pathog. 2011;7:e1002024.
-
(2011)
PLoS Pathog
, vol.7
-
-
Reynolds, C.B.1
Emerson, J.E.2
De La Riva, L.3
-
41
-
-
2342426803
-
Clostridium difficile associated diarrhoea in hospitalised patients: Onset in the community and hospital and role of flexible sigmoidoscopy
-
Johal SS, Hammond J, Solomon K, et al. Clostridium difficile associated diarrhoea in hospitalised patients: onset in the community and hospital and role of flexible sigmoidoscopy. Gut. 2004;53:673-677.
-
(2004)
Gut
, vol.53
, pp. 673-677
-
-
Johal, S.S.1
Hammond, J.2
Solomon, K.3
-
43
-
-
33947111354
-
Impact of Clostridium difficile on inflammatory bowel disease
-
Issa M, Vijayapal A, Graham MB, et al. Impact of Clostridium difficile on inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007;5:345-351.
-
(2007)
Clin Gastroenterol Hepatol.
, vol.5
, pp. 345-351
-
-
Issa, M.1
Vijayapal, A.2
Graham, M.B.3
-
44
-
-
77952241224
-
Prevalence and clinical impact of endoscopic pseudomembranes in patients with inflammatory bowel disease and Clostridium difficile infection
-
Ben-Horin S, Margalit M, Bossuyt P, et al. Prevalence and clinical impact of endoscopic pseudomembranes in patients with inflammatory bowel disease and Clostridium difficile infection. J Crohns Colitis. 2010;4:194-198.
-
(2010)
J Crohns Colitis
, vol.4
, pp. 194-198
-
-
Ben-Horin, S.1
Margalit, M.2
Bossuyt, P.3
-
45
-
-
0029133784
-
Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein
-
Kindon H, Pothoulakis C, Thim L, et al. Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. Gastroenterology. 1995;109:516-523.
-
(1995)
Gastroenterology
, vol.109
, pp. 516-523
-
-
Kindon, H.1
Pothoulakis, C.2
Thim, L.3
-
46
-
-
44649117522
-
Human alpha-defensins inhibit Clostridium difficile toxin B
-
Giesemann T, Guttenberg G, Aktories K. Human alpha-defensins inhibit Clostridium difficile toxin B. Gastroenterology. 2008;134:2049-2058.
-
(2008)
Gastroenterology
, vol.134
, pp. 2049-2058
-
-
Giesemann, T.1
Guttenberg, G.2
Aktories, K.3
-
47
-
-
0035128862
-
Human defensin 5 is stored in precursor form in normal paneth cells and is expressed by some villous epithelial cells and by metaplastic paneth cells in the colon in inflammatory bowel disease
-
Cunliffe RN, Rose FR, Keyte J, et al. Human defensin 5 is stored in precursor form in normal paneth cells and is expressed by some villous epithelial cells and by metaplastic paneth cells in the colon in inflammatory bowel disease. Gut. 2001;48:176-185.
-
(2001)
Gut
, vol.48
, pp. 176-185
-
-
Cunliffe, R.N.1
Rose, F.R.2
Keyte, J.3
-
48
-
-
0036216443
-
Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa
-
Cunliffe RN, Kamal M, Rose FR, et al. Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa. J Clin Pathol. 2002;55:298-304.
-
(2002)
J Clin Pathol.
, vol.55
, pp. 298-304
-
-
Cunliffe, R.N.1
Kamal, M.2
Rose, F.R.3
-
49
-
-
29144483937
-
Reduced Paneth cell alpha-defensins in ileal Crohn's disease
-
Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005;102:18129-18134.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
Salzman, N.H.2
Porter, E.3
-
50
-
-
46349102893
-
Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
-
Simms LA, Doecke JD, Walsh MD, et al. Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut. 2008;57:903-910.
-
(2008)
Gut
, vol.57
, pp. 903-910
-
-
Simms, L.A.1
Doecke, J.D.2
Walsh, M.D.3
-
51
-
-
40449103288
-
Impaired luminal processing of human defensin-5 in Crohn's disease: Persistence in a complex with chymotrypsinogen and trypsin
-
Elphick D, Liddell S, Mahida YR. Impaired luminal processing of human defensin-5 in Crohn's disease: persistence in a complex with chymotrypsinogen and trypsin. Am J Pathol. 2008;172:702-713.
-
(2008)
Am J Pathol.
, vol.172
, pp. 702-713
-
-
Elphick, D.1
Liddell, S.2
Mahida, Y.R.3
-
52
-
-
79955769157
-
The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile
-
McBride SM, Sonenshein AL. The dlt operon confers resistance to cationic antimicrobial peptides in Clostridium difficile. Microbiology. 2011;157:1457-1465.
-
(2011)
Microbiology
, vol.157
, pp. 1457-1465
-
-
McBride, S.M.1
Sonenshein, A.L.2
-
53
-
-
84924703317
-
Mucus layers in inflammatory bowel disease
-
Johansson ME. Mucus layers in inflammatory bowel disease. Inflamm Bowel Dis. 2014;20:2124-2131.
-
(2014)
Inflamm Bowel Dis.
, vol.20
, pp. 2124-2131
-
-
Johansson, M.E.1
-
54
-
-
34047167850
-
Comparative study of the intestinal mucus barrier in normal and inflamed colon
-
Swidsinski A, Loening-Baucke V, Theissig F, et al. Comparative study of the intestinal mucus barrier in normal and inflamed colon. Gut. 2007;56:343-350.
-
(2007)
Gut
, vol.56
, pp. 343-350
-
-
Swidsinski, A.1
Loening-Baucke, V.2
Theissig, F.3
-
55
-
-
0035112067
-
Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins
-
Nusrat A, von Eichel-Streiber C, Turner JR, et al. Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins. Infect Immun. 2001;69:1329-1336.
-
(2001)
Infect Immun.
, vol.69
, pp. 1329-1336
-
-
Nusrat, A.1
Von Eichel-Streiber, C.2
Turner, J.R.3
-
56
-
-
2542486247
-
Differential effects of varying concentrations of Clostridium difficile toxin A on epithelial barrier function and expression of cytokines
-
Johal SS, Solomon K, Dodson S, et al. Differential effects of varying concentrations of Clostridium difficile toxin A on epithelial barrier function and expression of cytokines. J Infect Dis. 2004;189:2110-2119.
-
(2004)
J Infect Dis.
, vol.189
, pp. 2110-2119
-
-
Johal, S.S.1
Solomon, K.2
Dodson, S.3
-
57
-
-
0029868433
-
Effect of Clostridium difficile toxin A on human intestinal epithelial cells: Induction of interleukin 8 production and apoptosis after cell detachment
-
Mahida YR, Makh S, Hyde S, et al. Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. Gut. 1996;38:337-347.
-
(1996)
Gut
, vol.38
, pp. 337-347
-
-
Mahida, Y.R.1
Makh, S.2
Hyde, S.3
-
58
-
-
0024204607
-
Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers
-
Hecht G, Pothoulakis C, LaMont JT, et al. Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers. J Clin Invest. 1988;82:1516-1524.
-
(1988)
J Clin Invest.
, vol.82
, pp. 1516-1524
-
-
Hecht, G.1
Pothoulakis, C.2
LaMont, J.T.3
-
59
-
-
49649103133
-
Essential role of toxin A in C. Difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function
-
Sutton PA, Li S, Webb J, et al. Essential role of toxin A in C. difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function. Clin Exp Immunol. 2008;153:439-447.
-
(2008)
Clin Exp Immunol.
, vol.153
, pp. 439-447
-
-
Sutton, P.A.1
Li, S.2
Webb, J.3
-
60
-
-
0034651952
-
Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers
-
Stubbe H, Berdoz J, Kraehenbuhl JP, et al. Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers. J Immunol. 2000;164:1952-1960.
-
(2000)
J Immunol.
, vol.164
, pp. 1952-1960
-
-
Stubbe, H.1
Berdoz, J.2
Kraehenbuhl, J.P.3
-
61
-
-
0043167963
-
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine
-
Savidge TC, Pan WH, Newman P, et al. Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology. 2003;125:413-420.
-
(2003)
Gastroenterology
, vol.125
, pp. 413-420
-
-
Savidge, T.C.1
Pan, W.H.2
Newman, P.3
-
62
-
-
84925504604
-
IBD candidate genes and intestinal barrier regulation
-
McCole DF. IBD candidate genes and intestinal barrier regulation. Inflamm Bowel Dis. 2014;20:1829-1849.
-
(2014)
Inflamm Bowel Dis.
, vol.20
, pp. 1829-1849
-
-
McCole, D.F.1
-
63
-
-
84893045146
-
Intestinal barrier in inflammatory bowel disease
-
Antoni L, Nuding S, Wehkamp J, et al. Intestinal barrier in inflammatory bowel disease. World J Gastroenterol. 2014;20:1165-1179.
-
(2014)
World J Gastroenterol.
, vol.20
, pp. 1165-1179
-
-
Antoni, L.1
Nuding, S.2
Wehkamp, J.3
-
64
-
-
0023906622
-
Clostridium difficile toxins A and B inhibit human immune response in vitro
-
Daubener W, Leiser E, von Eichel-Streiber C, et al. Clostridium difficile toxins A and B inhibit human immune response in vitro. Infect Immun. 1988;56:1107-1112.
-
(1988)
Infect Immun.
, vol.56
, pp. 1107-1112
-
-
Daubener, W.1
Leiser, E.2
Von Eichel-Streiber, C.3
-
65
-
-
0026047280
-
Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B
-
Flegel WA, Muller F, Daubener W, et al. Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B. Infect Immun. 1991;59:3659-3666.
-
(1991)
Infect Immun.
, vol.59
, pp. 3659-3666
-
-
Flegel, W.A.1
Muller, F.2
Daubener, W.3
-
66
-
-
0032425435
-
Effect of Clostridium difficile toxin A on human colonic lamina propria cells: Early loss of macrophages followed by T-cell apoptosis
-
Mahida YR, Galvin A, Makh S, et al. Effect of Clostridium difficile toxin A on human colonic lamina propria cells: early loss of macrophages followed by T-cell apoptosis. Infect Immun. 1998;66:5462-5469.
-
(1998)
Infect Immun.
, vol.66
, pp. 5462-5469
-
-
Mahida, Y.R.1
Galvin, A.2
Makh, S.3
-
67
-
-
15544364759
-
Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death
-
Solomon K, Webb J, Ali N, et al. Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death. Infect Immun. 2005;73:1625-1634.
-
(2005)
Infect Immun.
, vol.73
, pp. 1625-1634
-
-
Solomon, K.1
Webb, J.2
Ali, N.3
-
68
-
-
0031408125
-
Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2
-
Mahida YR, Beltinger J, Makh S, et al. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. Am J Physiol. 1997;273:G1341-G1348.
-
(1997)
Am J Physiol.
, vol.273
, pp. G1341-G1348
-
-
Mahida, Y.R.1
Beltinger, J.2
Makh, S.3
-
69
-
-
79953322027
-
Primary human colonic myofibroblasts are resistant to Clostridium difficile toxin A-induced, but not toxin B-induced, cell death
-
Mullan N, Hughes KR, Mahida YR. Primary human colonic myofibroblasts are resistant to Clostridium difficile toxin A-induced, but not toxin B-induced, cell death. Infect Immun. 2011;79:1623-1630.
-
(2011)
Infect Immun.
, vol.79
, pp. 1623-1630
-
-
Mullan, N.1
Hughes, K.R.2
Mahida, Y.R.3
-
70
-
-
0030909985
-
Early functional effects of Clostridium difficile toxin A on human colonocytes
-
Branka JE, Vallette G, Jarry A, et al. Early functional effects of Clostridium difficile toxin A on human colonocytes. Gastroenterology. 1997;112:1887-1894.
-
(1997)
Gastroenterology
, vol.112
, pp. 1887-1894
-
-
Branka, J.E.1
Vallette, G.2
Jarry, A.3
-
71
-
-
0036207579
-
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation
-
He D, Sougioultzis S, Hagen S, et al. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology. 2002;122:1048-1057.
-
(2002)
Gastroenterology
, vol.122
, pp. 1048-1057
-
-
He, D.1
Sougioultzis, S.2
Hagen, S.3
-
72
-
-
84874693787
-
MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation
-
Bobo LD, El Feghaly RE, Chen YS, et al. MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation. Infect Immun. 2013;81:713-722.
-
(2013)
Infect Immun.
, vol.81
, pp. 713-722
-
-
Bobo, L.D.1
El Feghaly, R.E.2
Chen, Y.S.3
-
73
-
-
0033571379
-
Roles of intracellular calcium and NF-kappa B in the Clostridium difficile toxin A-induced upregulation and secretion of IL-8 from human monocytes
-
Jefferson KK, Smith MF Jr, Bobak DA. Roles of intracellular calcium and NF-kappa B in the Clostridium difficile toxin A-induced upregulation and secretion of IL-8 from human monocytes. J Immunol. 1999;163:5183-5191.
-
(1999)
J Immunol.
, vol.163
, pp. 5183-5191
-
-
Jefferson, K.K.1
Smith, M.F.2
Bobak, D.A.3
-
74
-
-
0034049140
-
P38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
-
Warny M, Keates AC, Keates S, et al. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Invest. 2000;105:1147-1156.
-
(2000)
J Clin Invest.
, vol.105
, pp. 1147-1156
-
-
Warny, M.1
Keates, A.C.2
Keates, S.3
-
75
-
-
77950362382
-
The inflammasomes
-
Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140:821-832.
-
(2010)
Cell.
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
76
-
-
77955482224
-
Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome
-
Ng J, Hirota SA, Gross O, et al. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology. 2010;139:542-552. 552.e1-e3.
-
(2010)
Gastroenterology
, vol.139
-
-
Ng, J.1
Hirota, S.A.2
Gross, O.3
-
77
-
-
84907270863
-
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
-
Xu H, Yang J, Gao W, et al. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature. 2014;513:237-241.
-
(2014)
Nature
, vol.513
, pp. 237-241
-
-
Xu, H.1
Yang, J.2
Gao, W.3
-
78
-
-
34548768341
-
Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release
-
Seshadri S, Duncan MD, Hart JM, et al. Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release. J Immunol. 2007;179:1274-1281.
-
(2007)
J Immunol.
, vol.179
, pp. 1274-1281
-
-
Seshadri, S.1
Duncan, M.D.2
Hart, J.M.3
-
79
-
-
0033168120
-
Bioactive IL-18 expression is up-regulated in Crohn's disease
-
Monteleone G, Trapasso F, Parrello T, et al. Bioactive IL-18 expression is up-regulated in Crohn's disease. J Immunol. 1999;163:143-147.
-
(1999)
J Immunol.
, vol.163
, pp. 143-147
-
-
Monteleone, G.1
Trapasso, F.2
Parrello, T.3
-
80
-
-
0031921472
-
Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease
-
McAlindon ME, Hawkey CJ, Mahida YR. Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease. Gut. 1998;42:214-219.
-
(1998)
Gut
, vol.42
, pp. 214-219
-
-
McAlindon, M.E.1
Hawkey, C.J.2
Mahida, Y.R.3
-
81
-
-
0032923019
-
Investigation of the expression of IL-1beta converting enzyme and apoptosis in normal and inflammatory bowel disease (IBD) mucosal macrophages
-
McAlindon ME, Galvin A, McKaig B, et al. Investigation of the expression of IL-1beta converting enzyme and apoptosis in normal and inflammatory bowel disease (IBD) mucosal macrophages. Clin Exp Immunol. 1999;116:251-257.
-
(1999)
Clin Exp Immunol.
, vol.116
, pp. 251-257
-
-
McAlindon, M.E.1
Galvin, A.2
McKaig, B.3
-
82
-
-
79955048935
-
Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen
-
Hasegawa M, Yamazaki T, Kamada N, et al. Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. J Immunol. 2011;186:4872-4880.
-
(2011)
J Immunol.
, vol.186
, pp. 4872-4880
-
-
Hasegawa, M.1
Yamazaki, T.2
Kamada, N.3
-
83
-
-
79959828804
-
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins
-
Ryan A, Lynch M, Smith SM, et al. A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog. 2011;7:e1002076.
-
(2011)
PLoS Pathog
, vol.7
-
-
Ryan, A.1
Lynch, M.2
Smith, S.M.3
-
84
-
-
79953300500
-
Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis
-
Jarchum I, Liu M, Lipuma L, et al. Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis. Infect Immun. 2011;79:1498-1503.
-
(2011)
Infect Immun.
, vol.79
, pp. 1498-1503
-
-
Jarchum, I.1
Liu, M.2
Lipuma, L.3
-
85
-
-
84908206016
-
Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease
-
Brown M, Hughes KR, Moossavi S, et al. Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease. Clin Exp Immunol. 2014;178:28-39.
-
(2014)
Clin Exp Immunol.
, vol.178
, pp. 28-39
-
-
Brown, M.1
Hughes, K.R.2
Moossavi, S.3
-
86
-
-
0034628426
-
Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A
-
Kyne L, Warny M, Qamar A, et al. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med. 2000;342:390-397.
-
(2000)
N Engl J Med.
, vol.342
, pp. 390-397
-
-
Kyne, L.1
Warny, M.2
Qamar, A.3
-
87
-
-
0026453188
-
Systemic and mucosal antibody responses to toxin A in patients infected with Clostridium difficile
-
Johnson S, Gerding DN, Janoff EN. Systemic and mucosal antibody responses to toxin A in patients infected with Clostridium difficile. J Infect Dis. 1992;166:1287-1294.
-
(1992)
J Infect Dis.
, vol.166
, pp. 1287-1294
-
-
Johnson, S.1
Gerding, D.N.2
Janoff, E.N.3
-
88
-
-
45249096230
-
Systemic antibody response to Clostridium difficile in colonized patients with and without symptoms and matched controls
-
Sanchez-Hurtado K, Corretge M, Mutlu E, et al. Systemic antibody response to Clostridium difficile in colonized patients with and without symptoms and matched controls. J Med Microbiol. 2008;57:717-724.
-
(2008)
J Med Microbiol.
, vol.57
, pp. 717-724
-
-
Sanchez-Hurtado, K.1
Corretge, M.2
Mutlu, E.3
-
89
-
-
0021848749
-
Clostridium difficile in patients with cystic fibrosis
-
Welkon CJ, Long SS, Thompson CM Jr, et al. Clostridium difficile in patients with cystic fibrosis. Am J Dis Child. 1985;139:805-808.
-
(1985)
Am J Dis Child
, vol.139
, pp. 805-808
-
-
Welkon, C.J.1
Long, S.S.2
Thompson, C.M.3
-
90
-
-
0022497851
-
Asymptomatic carriage of Clostridium difficile in patients with cystic fibrosis
-
Peach SL, Borriello SP, Gaya H, et al. Asymptomatic carriage of Clostridium difficile in patients with cystic fibrosis. J Clin Pathol. 1986;39:1013-1018.
-
(1986)
J Clin Pathol.
, vol.39
, pp. 1013-1018
-
-
Peach, S.L.1
Borriello, S.P.2
Gaya, H.3
-
91
-
-
84883779131
-
Circulating antibody and memory B-Cell responses to C. difficile toxins A and B in patients with C. difficile-associated diarrhoea, inflammatory bowel disease and cystic fibrosis
-
Monaghan TM, Robins A, Knox A, et al. Circulating antibody and memory B-Cell responses to C. difficile toxins A and B in patients with C. difficile-associated diarrhoea, inflammatory bowel disease and cystic fibrosis. PLoS One. 2013;8:e74452.
-
(2013)
PLoS One
, vol.8
-
-
Monaghan, T.M.1
Robins, A.2
Knox, A.3
-
92
-
-
0021836686
-
Serum antibody response to Clostridium difficile toxins in patients with Clostridium difficile diarrhoea
-
Aronsson B, Granstrom M, Mollby R, et al. Serum antibody response to Clostridium difficile toxins in patients with Clostridium difficile diarrhoea. Infection. 1985;13:97-101.
-
(1985)
Infection
, vol.13
, pp. 97-101
-
-
Aronsson, B.1
Granstrom, M.2
Mollby, R.3
-
93
-
-
0027963265
-
Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea
-
Bacon AE III, Fekety R. Immunoglobulin G directed against toxins A and B of Clostridium difficile in the general population and patients with antibiotic-associated diarrhea. Diagn Microbiol Infect Dis. 1994;18:205-209.
-
(1994)
Diagn Microbiol Infect Dis.
, vol.18
, pp. 205-209
-
-
Bacon, A.E.1
Fekety, R.2
-
94
-
-
0028089161
-
Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection
-
Warny M, Vaerman JP, Avesani V, et al. Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection. Infect Immun. 1994;62:384-389.
-
(1994)
Infect Immun.
, vol.62
, pp. 384-389
-
-
Warny, M.1
Vaerman, J.P.2
Avesani, V.3
-
95
-
-
0035915688
-
Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea
-
Kyne L, Warny M, Qamar A, et al. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet. 2001;357:189-193.
-
(2001)
Lancet
, vol.357
, pp. 189-193
-
-
Kyne, L.1
Warny, M.2
Qamar, A.3
-
96
-
-
84920269708
-
Humoral immune response as predictor of recurrence in Clostridium difficile infection
-
Bauer MP, Nibbering PH, Poxton IR, et al. Humoral immune response as predictor of recurrence in Clostridium difficile infection. Clin Microbiol Infect. 2014;20:1323-1328.
-
(2014)
Clin Microbiol Infect.
, vol.20
, pp. 1323-1328
-
-
Bauer, M.P.1
Nibbering, P.H.2
Poxton, I.R.3
-
97
-
-
84881608395
-
Mortality in patients with Clostridium difficile infection correlates with host pro-inflammatory and humoral immune responses
-
Solomon K, Martin AJ, O'Donoghue C, et al. Mortality in patients with Clostridium difficile infection correlates with host pro-inflammatory and humoral immune responses. J Med Microbiol. 2013;62:1453-1460.
-
(2013)
J Med Microbiol.
, vol.62
, pp. 1453-1460
-
-
Solomon, K.1
Martin, A.J.2
O'Donoghue, C.3
-
98
-
-
74249096590
-
Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)
-
Leav BA, Blair B, Leney M, et al. Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI). Vaccine. 2010;28:965-969.
-
(2010)
Vaccine
, vol.28
, pp. 965-969
-
-
Leav, B.A.1
Blair, B.2
Leney, M.3
-
99
-
-
0026527192
-
Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A-receptor binding
-
Kelly CP, Pothoulakis C, Orellana J, et al. Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A-receptor binding. Gastroenterology. 1992;102:35-40.
-
(1992)
Gastroenterology
, vol.102
, pp. 35-40
-
-
Kelly, C.P.1
Pothoulakis, C.2
Orellana, J.3
-
100
-
-
4444252095
-
Colonic IgA producing cells and macrophages are reduced in recurrent and non-recurrent Clostridium difficile associated diarrhoea
-
Johal SS, Lambert CP, Hammond J, et al. Colonic IgA producing cells and macrophages are reduced in recurrent and non-recurrent Clostridium difficile associated diarrhoea. J Clin Pathol. 2004;57:973-979.
-
(2004)
J Clin Pathol.
, vol.57
, pp. 973-979
-
-
Johal, S.S.1
Lambert, C.P.2
Hammond, J.3
-
101
-
-
45249092259
-
Immunoreactive cell wall proteins of Clostridium difficile identified by human sera
-
Wright A, Drudy D, Kyne L, et al. Immunoreactive cell wall proteins of Clostridium difficile identified by human sera. J Med Microbiol. 2008;57:750-756.
-
(2008)
J Med Microbiol.
, vol.57
, pp. 750-756
-
-
Wright, A.1
Drudy, D.2
Kyne, L.3
-
102
-
-
15544386802
-
Immunological properties of surface proteins of Clostridium difficile
-
Pechine S, Gleizes A, Janoir C, et al. Immunological properties of surface proteins of Clostridium difficile. J Med Microbiol. 2005;54:193-196.
-
(2005)
J Med Microbiol.
, vol.54
, pp. 193-196
-
-
Pechine, S.1
Gleizes, A.2
Janoir, C.3
-
103
-
-
2942572791
-
Human antibody response to surface layer proteins in Clostridium difficile infection
-
Drudy D, Calabi E, Kyne L, et al. Human antibody response to surface layer proteins in Clostridium difficile infection. FEMS Immunol Med Microbiol. 2004;41:237-242.
-
(2004)
FEMS Immunol Med Microbiol.
, vol.41
, pp. 237-242
-
-
Drudy, D.1
Calabi, E.2
Kyne, L.3
-
104
-
-
84913588125
-
Passive and active immunization strategies against Clostridium difficile infections: State of the art
-
Mizrahi A, Collignon A, Pechine S. Passive and active immunization strategies against Clostridium difficile infections: state of the art. Anaerobe. 2014;30:210-219.
-
(2014)
Anaerobe
, vol.30
, pp. 210-219
-
-
Mizrahi, A.1
Collignon, A.2
Pechine, S.3
-
105
-
-
84862495448
-
Determination of serum antibodies to Clostridium difficile toxin B in patients with inflammatory bowel disease
-
Shakir FA, Ali T, Bigham AC, et al. Determination of serum antibodies to Clostridium difficile toxin B in patients with inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2012;8:313-317.
-
(2012)
Gastroenterol Hepatol (N Y)
, vol.8
, pp. 313-317
-
-
Shakir, F.A.1
Ali, T.2
Bigham, A.C.3
-
106
-
-
0024389095
-
Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes
-
Brandtzaeg P, Halstensen TS, Kett K, et al. Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology. 1989;97:1562-1584.
-
(1989)
Gastroenterology
, vol.97
, pp. 1562-1584
-
-
Brandtzaeg, P.1
Halstensen, T.S.2
Kett, K.3
-
107
-
-
84862276328
-
Structure, function and diversity of the healthy human microbiome
-
Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486:207-214.
-
(2012)
Nature
, vol.486
, pp. 207-214
-
-
-
108
-
-
77950251400
-
A human gut microbial gene catalogue established by metagenomic sequencing
-
Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59-65.
-
(2010)
Nature
, vol.464
, pp. 59-65
-
-
Qin, J.1
Li, R.2
Raes, J.3
-
109
-
-
32944466887
-
Ecological and evolutionary forces shaping microbial diversity in the human intestine
-
Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell. 2006;124:837-848.
-
(2006)
Cell.
, vol.124
, pp. 837-848
-
-
Ley, R.E.1
Peterson, D.A.2
Gordon, J.I.3
-
110
-
-
0035124967
-
Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles
-
Hopkins MJ, Sharp R, Macfarlane GT. Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut. 2001;48:198-205.
-
(2001)
Gut
, vol.48
, pp. 198-205
-
-
Hopkins, M.J.1
Sharp, R.2
Macfarlane, G.T.3
-
111
-
-
84886795788
-
Microbiota-mediated colonization resistance against intestinal pathogens
-
Buffie CG, Pamer EG. Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol. 2013;13:790-801.
-
(2013)
Nat Rev Immunol.
, vol.13
, pp. 790-801
-
-
Buffie, C.G.1
Pamer, E.G.2
-
112
-
-
56849106496
-
The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
-
Dethlefsen L, Huse S, Sogin ML, et al. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol. 2008;6:e280.
-
(2008)
PLoS Biol.
, vol.6
, pp. e280
-
-
Dethlefsen, L.1
Huse, S.2
Sogin, M.L.3
-
113
-
-
66549102207
-
Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation
-
Antonopoulos DA, Huse SM, Morrison HG, et al. Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation. Infect Immun. 2009;77:2367-2375.
-
(2009)
Infect Immun.
, vol.77
, pp. 2367-2375
-
-
Antonopoulos, D.A.1
Huse, S.M.2
Morrison, H.G.3
-
114
-
-
80051717743
-
The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile infection
-
Reeves AE, Theriot CM, Bergin IL, et al. The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile infection. Gut Microbes. 2011;2:145-158.
-
(2011)
Gut Microbes
, vol.2
, pp. 145-158
-
-
Reeves, A.E.1
Theriot, C.M.2
Bergin, I.L.3
-
115
-
-
84857067037
-
Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis
-
Buffie CG, Jarchum I, Equinda M, et al. Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis. Infect Immun. 2012;80:62-73.
-
(2012)
Infect Immun.
, vol.80
, pp. 62-73
-
-
Buffie, C.G.1
Jarchum, I.2
Equinda, M.3
-
116
-
-
0022493972
-
An in-vitro model of colonisation resistance to Clostridium difficile infection
-
Borriello SP, Barclay FE. An in-vitro model of colonisation resistance to Clostridium difficile infection. J Med Microbiol. 1986;21:299-309.
-
(1986)
J Med Microbiol.
, vol.21
, pp. 299-309
-
-
Borriello, S.P.1
Barclay, F.E.2
-
117
-
-
0035468838
-
Effect of antimicrobial agents on the ecological balance of human microflora
-
Sullivan A, Edlund C, Nord CE. Effect of antimicrobial agents on the ecological balance of human microflora. Lancet Infect Dis. 2001;1:101-114.
-
(2001)
Lancet Infect Dis.
, vol.1
, pp. 101-114
-
-
Sullivan, A.1
Edlund, C.2
Nord, C.E.3
-
118
-
-
34248152283
-
Long-term ecological impacts of antibiotic administration on the human intestinal microbiota
-
Jernberg C, Lofmark S, Edlund C, et al. Long-term ecological impacts of antibiotic administration on the human intestinal microbiota. ISME J. 2007;1:56-66.
-
(2007)
ISME J
, vol.1
, pp. 56-66
-
-
Jernberg, C.1
Lofmark, S.2
Edlund, C.3
-
119
-
-
39349107697
-
Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea
-
Chang JY, Antonopoulos DA, Kalra A, et al. Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea. J Infect Dis. 2008;197:435-438.
-
(2008)
J Infect Dis.
, vol.197
, pp. 435-438
-
-
Chang, J.Y.1
Antonopoulos, D.A.2
Kalra, A.3
-
120
-
-
84882779621
-
Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea
-
Antharam VC, Li EC, Ishmael A, et al. Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea. J Clin Microbiol. 2013;51:2884-2892.
-
(2013)
J Clin Microbiol.
, vol.51
, pp. 2884-2892
-
-
Antharam, V.C.1
Li, E.C.2
Ishmael, A.3
-
121
-
-
84892894991
-
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
-
Theriot CM, Koenigsknecht MJ, Carlson PE Jr, et al. Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat Commun. 2014;5:3114.
-
(2014)
Nat Commun.
, vol.5
, pp. 3114
-
-
Theriot, C.M.1
Koenigsknecht, M.J.2
Carlson, P.E.3
-
122
-
-
84885573828
-
Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
-
Ng KM, Ferreyra JA, Higginbottom SK, et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature. 2013;502:96-99.
-
(2013)
Nature
, vol.502
, pp. 96-99
-
-
Ng, K.M.1
Ferreyra, J.A.2
Higginbottom, S.K.3
-
123
-
-
84896118638
-
Harnessing microbiota to kill a pathogen: Fixing the microbiota to treat Clostridium difficile infections
-
Taur Y, Pamer EG. Harnessing microbiota to kill a pathogen: fixing the microbiota to treat Clostridium difficile infections. Nat Med. 2014;20:246-247.
-
(2014)
Nat Med.
, vol.20
, pp. 246-247
-
-
Taur, Y.1
Pamer, E.G.2
-
124
-
-
33244467651
-
Bile salt biotransformations by human intestinal bacteria
-
Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res. 2006;47:241-259.
-
(2006)
J Lipid Res.
, vol.47
, pp. 241-259
-
-
Ridlon, J.M.1
Kang, D.J.2
Hylemon, P.B.3
-
125
-
-
41549142775
-
Bile salts and glycine as cogerminants for Clostridium difficile spores
-
Sorg JA, Sonenshein AL. Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol. 2008;190:2505-2512.
-
(2008)
J Bacteriol.
, vol.190
, pp. 2505-2512
-
-
Sorg, J.A.1
Sonenshein, A.L.2
-
126
-
-
63449096364
-
Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination
-
Sorg JA, Sonenshein AL. Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination. J Bacteriol. 2009;191:1115-1117.
-
(2009)
J Bacteriol.
, vol.191
, pp. 1115-1117
-
-
Sorg, J.A.1
Sonenshein, A.L.2
-
127
-
-
84925500413
-
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
-
Buffie CG, Bucci V, Stein RR, et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature. 2015;517:205-208.
-
(2015)
Nature
, vol.517
, pp. 205-208
-
-
Buffie, C.G.1
Bucci, V.2
Stein, R.R.3
-
128
-
-
77957337708
-
Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid
-
Sorg JA, Sonenshein AL. Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J Bacteriol. 2010;192:4983-4990.
-
(2010)
J Bacteriol.
, vol.192
, pp. 4983-4990
-
-
Sorg, J.A.1
Sonenshein, A.L.2
-
129
-
-
84894105226
-
Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection
-
Weingarden AR, Chen C, Bobr A, et al. Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. Am J Physiol Gastrointest Liver Physiol. 2014;306:G310-G319.
-
(2014)
Am J Physiol Gastrointest Liver Physiol.
, vol.306
, pp. G310-G319
-
-
Weingarden, A.R.1
Chen, C.2
Bobr, A.3
-
130
-
-
84927738000
-
Bile acid malabsorption in inflammatory bowel disease
-
Vitek L. Bile acid malabsorption in inflammatory bowel disease. Inflamm Bowel Dis. 2015;21:476-483.
-
(2015)
Inflamm Bowel Dis.
, vol.21
, pp. 476-483
-
-
Vitek, L.1
-
131
-
-
84919487078
-
Bacterial bile metabolising gene abundance in Crohn's, ulcerative colitis and type 2 diabetes metagenomes
-
Labbe A, Ganopolsky JG, Martoni CJ, et al. Bacterial bile metabolising gene abundance in Crohn's, ulcerative colitis and type 2 diabetes metagenomes. PLoS One. 2014;9:e115175.
-
(2014)
PLoS One
, vol.9
-
-
Labbe, A.1
Ganopolsky, J.G.2
Martoni, C.J.3
-
132
-
-
84875952542
-
Fecal microbiota transplantation for Clostridium difficile infection: Systematic review and meta-analysis
-
Kassam Z, Lee CH, Yuan Y, et al. Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am J Gastroenterol. 2013;108:500-508.
-
(2013)
Am J Gastroenterol.
, vol.108
, pp. 500-508
-
-
Kassam, Z.1
Lee, C.H.2
Yuan, Y.3
-
133
-
-
84873019302
-
Duodenal infusion of donor feces for recurrent Clostridium difficile
-
van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 2013;368:407-415.
-
(2013)
N Engl J Med.
, vol.368
, pp. 407-415
-
-
Van Nood, E.1
Vrieze, A.2
Nieuwdorp, M.3
-
134
-
-
84896708902
-
Microbiota dynamics in patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection
-
Song Y, Garg S, Girotra M, et al. Microbiota dynamics in patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection. PLoS One. 2013;8:e81330.
-
(2013)
PLoS One
, vol.8
-
-
Song, Y.1
Garg, S.2
Girotra, M.3
-
135
-
-
84868158515
-
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice
-
Lawley TD, Clare S, Walker AW, et al. Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog. 2012;8:e1002995.
-
(2012)
PLoS Pathog
, vol.8
-
-
Lawley, T.D.1
Clare, S.2
Walker, A.W.3
-
136
-
-
0024312284
-
Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients
-
Tvede M, Rask-Madsen J. Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients. Lancet. 1989;1:1156-1160.
-
(1989)
Lancet
, vol.1
, pp. 1156-1160
-
-
Tvede, M.1
Rask-Madsen, J.2
-
137
-
-
84877020842
-
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: "RePOOPulating" the gut
-
Petrof EO, Gloor GB, Vanner SJ, et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: "RePOOPulating" the gut. Microbiome. 2013;1:3.
-
(2013)
Microbiome
, vol.1
, pp. 3
-
-
Petrof, E.O.1
Gloor, G.B.2
Vanner, S.J.3
-
138
-
-
0021845209
-
Protection of hamsters against Clostridium difficile ileocaecitis by prior colonisation with non-pathogenic strains
-
Borriello SP, Barclay FE. Protection of hamsters against Clostridium difficile ileocaecitis by prior colonisation with non-pathogenic strains. J Med Microbiol. 1985;19:339-350.
-
(1985)
J Med Microbiol.
, vol.19
, pp. 339-350
-
-
Borriello, S.P.1
Barclay, F.E.2
-
139
-
-
0037115014
-
Colonization for the prevention of Clostridium difficile disease in hamsters
-
Sambol SP, Merrigan MM, Tang JK, et al. Colonization for the prevention of Clostridium difficile disease in hamsters. J Infect Dis. 2002;186:1781-1789.
-
(2002)
J Infect Dis.
, vol.186
, pp. 1781-1789
-
-
Sambol, S.P.1
Merrigan, M.M.2
Tang, J.K.3
-
140
-
-
0023116806
-
Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strain
-
Seal D, Borriello SP, Barclay F, et al. Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strain. Eur J Clin Microbiol. 1987;6:51-53.
-
(1987)
Eur J Clin Microbiol.
, vol.6
, pp. 51-53
-
-
Seal, D.1
Borriello, S.P.2
Barclay, F.3
-
141
-
-
84866313203
-
Evaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjects
-
Villano SA, Seiberling M, Tatarowicz W, et al. Evaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjects. Antimicrob Agents Chemother. 2012;56:5224-5229.
-
(2012)
Antimicrob Agents Chemother.
, vol.56
, pp. 5224-5229
-
-
Villano, S.A.1
Seiberling, M.2
Tatarowicz, W.3
-
142
-
-
84929148131
-
Administration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C. Difficile infection: A randomized clinical trial
-
Gerding DN, Meyer T, Lee C, et al. Administration of spores of nontoxigenic Clostridium difficile strain M3 for prevention of recurrent C. difficile infection: a randomized clinical trial. JAMA. 2015;313:1719-1727.
-
(2015)
JAMA
, vol.313
, pp. 1719-1727
-
-
Gerding, D.N.1
Meyer, T.2
Lee, C.3
-
143
-
-
84898809123
-
The microbiome in inflammatory bowel disease: Current status and the future ahead
-
Kostic AD, Xavier RJ, Gevers D. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology. 2014;146:1489-1499.
-
(2014)
Gastroenterology
, vol.146
, pp. 1489-1499
-
-
Kostic, A.D.1
Xavier, R.J.2
Gevers, D.3
-
144
-
-
35348857386
-
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
-
Frank DN, St Amand AL, Feldman RA, et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104:13780-13785.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 13780-13785
-
-
Frank, D.N.1
St Amand, A.L.2
Feldman, R.A.3
-
145
-
-
79959961092
-
Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis
-
Lepage P, Hasler R, Spehlmann ME, et al. Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis. Gastroenterology. 2011;141:227-236.
-
(2011)
Gastroenterology
, vol.141
, pp. 227-236
-
-
Lepage, P.1
Hasler, R.2
Spehlmann, M.E.3
-
146
-
-
30944466824
-
Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
-
Manichanh C, Rigottier-Gois L, Bonnaud E, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut. 2006;55:205-211.
-
(2006)
Gut
, vol.55
, pp. 205-211
-
-
Manichanh, C.1
Rigottier-Gois, L.2
Bonnaud, E.3
-
147
-
-
55949124035
-
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
-
Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008;105:16731-16736.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16731-16736
-
-
Sokol, H.1
Pigneur, B.2
Watterlot, L.3
-
148
-
-
84904048875
-
A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
-
Machiels K, Joossens M, Sabino J, et al. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut. 2014;63:1275-1283.
-
(2014)
Gut
, vol.63
, pp. 1275-1283
-
-
Machiels, K.1
Joossens, M.2
Sabino, J.3
|