Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 273, Issue 6 36-6, 1997, Pages

  Mahida, Y R ^a   Beltinger, J ^a   Makh, S ^a   Goke M ^b,c   Gray, T ^a   Podolsky, D K ^b   Hawkey, C J ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Basement membrane; Collagen; Laminin; Prostaglandin

Indexed keywords

ALPHA ACTIN; COLLAGEN TYPE 4; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FIBRONECTIN; LAMININ; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; RNA; SCLEROPROTEIN; VIMENTIN;

ADULT; ARTICLE; CELL CULTURE; COLON MUCOSA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MYOFIBROBLAST; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0031408125     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.273.6.g1341     Document Type: Article

References (18)

1. Bern, M. J., C. W. Sturbaum, S. S. Karayalcin, H. M. Berschneider, J. T. Wachsman, and D. W. Powell. Immune system control of rat and rabbit colonic electrolyte transport. Role of prostaglandins and enteric nervous system. J. Clin. Invest. 83: 1810-1820, 1989.
2. Castro, G. A., and C. J. Arntzen. Immunophysiology of the gut: a research frontier for integrative studies of the common mucosal immune system. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28): G599-G610, 1993.
3. Dean, H. W. Some electron microscopic observations on the lamina propria of the gut, with comments on the close association of macrophages, plasma cells and eosinophils. Anal. Rec. 149: 453-473, 1964.
4. Desmoulière, A., and G. Gabbiani. The role of the myofibroblast in wound healing and fibrocontractive diseases. In: The Molecular and Cellular Biology of Wound Repair (2nd ed.), edited by R. A. F. Clark. New York: Plenum, 1996, chapt. 13, p. 391-423.
5. De Witt, D., and W. L. Smith. Yes, but do they still get headaches? Cell 83: 345-348, 1995.
6. Diaz, A., A. M. Reginato, and S. A. Jimenez. Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor β1, interleukin 1β and tumor necrosis factor α. J. Biol. Chem. 267: 10816-10822, 1992.
7. Dignass, A. U., S. Tsunekawa, and D. K. Podolsky. Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology 106: 1254-1262, 1994.
8. Donnellan, W. L. The structure of the colonic mucosa. The epithelium and subepithelial reticulohistiocytic complex. Gastroenterology 49: 496-514, 1965.
9. Duluc, I., J.-N. Freund, C. Leberquier, and M. Kedinger. Fetal endoderm primarily holds the temporal and positional information required for mammalian intestinal development. J. Cell Biol. 126: 211-221, 1994.
10. Futaki, N., S. Takahashi, I. Yokoyama, I. Arai, S. Higuchi, and S. Otomo. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47: 55-59, 1994.
11. Göke, M., A. Zuk, and D. K. Podolsky. Regulation and function of extracellular matrix in intestinal epithelial restitution in vitro. Am. J. Physiol. 271 (Gastrointest. Liver Physiol. 34): G729-G740, 1996.
12. Grinnell, F. Mini-review on the cellular mechanisms of disease. Fibroblasts, myofibroblasts and wound contraction. J. Cell Biol. 124: 401-404, 1994.
13. - secretion in T84 cells. Am. J. Physiol. 271 (Cell Physiol. 40): C1262-C1268, 1996.
14. Hla, T., and K. Neilson. Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. USA 89: 7384-7388, 1992.
15. Joyce, N. C., M. F. Haire, and G. E. Palade. Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa. Gastroenterology 92: 68-81, 1987.
16. Kaye, G. I., N. Lane, and R. R. Pascal. Colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. II. Fine structural aspects of normal rabbit and human colon. Gastroenterology 54: 852-865, 1968.
17. Kedinger, M., P. Simon-Assmann, F. Bouziges, C. Arnold, E. Alexandre, and K. Haffen. Smooth muscle actin expression during rat gut development and induction in fetal skin fibroblastic cells associated with intestinal embryonic epithelium. Differentiation 43: 87-97, 1990.
18. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277: 680-684, 1970.