-
1
-
-
0030719443
-
Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts
-
Bajaj-Elliott, M., E. Breese, R. Poulsom, P. D. Fairclough, and T. T. Mac-Donald. 1997. Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts. Am. J. Pathol. 151:1469-1476.
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 1469-1476
-
-
Bajaj-Elliott, M.1
Breese, E.2
Poulsom, R.3
Fairclough, P.D.4
Mac-Donald, T.T.5
-
3
-
-
0032857965
-
Human colonic subepithelial myofibroblasts modulate transepithelial resistance and secretory response
-
Beltinger, J., et al. 1999. Human colonic subepithelial myofibroblasts modulate transepithelial resistance and secretory response. Am. J. Physiol. 277: C271-C279.
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Beltinger, J.1
-
4
-
-
0030730632
-
Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis
-
Bobak, D., J. Moorman, A. Guanzon, L. Gilmer, and C. Hahn. 1997. Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis. Oncogene 15:2179-2189.
-
(1997)
Oncogene
, vol.15
, pp. 2179-2189
-
-
Bobak, D.1
Moorman, J.2
Guanzon, A.3
Gilmer, L.4
Hahn, C.5
-
5
-
-
0030909985
-
Early functional effects of Clostridium difficile toxin A on human colonocytes
-
Branka, J. E., et al. 1997. Early functional effects of Clostridium difficile toxin A on human colonocytes. Gastroenterology 112:1887-1894.
-
(1997)
Gastroenterology
, vol.112
, pp. 1887-1894
-
-
Branka, J.E.1
-
6
-
-
0037111088
-
Mechanism of Clostridium difficile toxin A-induced apoptosis in T84 cells
-
Brito, G. A., et al. 2002. Mechanism of Clostridium difficile toxin A-induced apoptosis in T84 cells. J. Infect. Dis. 186:1438-1447.
-
(2002)
J. Infect. Dis.
, vol.186
, pp. 1438-1447
-
-
Brito, G.A.1
-
7
-
-
0842281652
-
Rho and Rac take center stage
-
Burridge, K., and K. Wennerberg. 2004. Rho and Rac take center stage. Cell 116:167-179.
-
(2004)
Cell
, vol.116
, pp. 167-179
-
-
Burridge, K.1
Wennerberg, K.2
-
8
-
-
0028987414
-
Involvement of Ras-related Rho proteins in the mechanisms of action of Clostridium difficile toxin A and toxin B
-
Dillon, S. T., et al. 1995. Involvement of Ras-related Rho proteins in the mechanisms of action of Clostridium difficile toxin A and toxin B. Infect. Immun. 63:1421-1426.
-
(1995)
Infect. Immun.
, vol.63
, pp. 1421-1426
-
-
Dillon, S.T.1
-
9
-
-
66649106333
-
Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures
-
Di Sabatino, A., et al. 2009. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut 58:777-789.
-
(2009)
Gut
, vol.58
, pp. 777-789
-
-
Di Sabatino, A.1
-
10
-
-
0025367873
-
Interaction of Clostridium difficile toxin A with cultured cells: cytoskeletal changes and nuclear polarization
-
Fiorentini, C., et al. 1990. Interaction of Clostridium difficile toxin A with cultured cells: cytoskeletal changes and nuclear polarization. Infect. Immun. 58:2329-2336.
-
(1990)
Infect. Immun.
, vol.58
, pp. 2329-2336
-
-
Fiorentini, C.1
-
11
-
-
33646942752
-
Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B
-
Genth, H., et al. 2006. Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B. FEBS Lett. 580:3565-3569.
-
(2006)
FEBS Lett
, vol.580
, pp. 3565-3569
-
-
Genth, H.1
-
12
-
-
0036088374
-
IL-17 stimulates inflammatory responses via NFkappaB and MAP kinase pathways in human colonic myofibroblasts
-
Hata, K., et al. 2002. IL-17 stimulates inflammatory responses via NFkappaB and MAP kinase pathways in human colonic myofibroblasts. Am. J. Physiol. Gastrointest. Liver Physiol. 282:G1035-G1044.
-
(2002)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.282
-
-
Hata, K.1
-
13
-
-
0036207579
-
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation
-
He, D., et al. 2002. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology 122:1048-1057.
-
(2002)
Gastroenterology
, vol.122
, pp. 1048-1057
-
-
He, D.1
-
14
-
-
50149083752
-
Mammalian Rho GTPases: new insights into their functions from in vivo studies
-
Heasman, S. J., and A. J. Ridley. 2008. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell. Biol. 9:690-701.
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 690-701
-
-
Heasman, S.J.1
Ridley, A.J.2
-
15
-
-
0024204607
-
Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers
-
Hecht, G., C. Pothoulakis, J. T. LaMont, and J. L. Madara. 1988. Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers. J. Clin. Invest. 82: 1516-1524.
-
(1988)
J. Clin. Invest.
, vol.82
, pp. 1516-1524
-
-
Hecht, G.1
Pothoulakis, C.2
LaMont, J.T.3
Madara, J.L.4
-
16
-
-
0036784378
-
Rho protein inactivation induced apoptosis of cultured human endothelial cells
-
Hippenstiel, S., et al. 2002. Rho protein inactivation induced apoptosis of cultured human endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L830-L838.
-
(2002)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.283
-
-
Hippenstiel, S.1
-
17
-
-
33846807241
-
Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470
-
Huelsenbeck, J., et al. 2007. Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470. Infect. Immun. 75:801-809.
-
(2007)
Infect. Immun.
, vol.75
, pp. 801-809
-
-
Huelsenbeck, J.1
-
18
-
-
78650077745
-
Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells
-
Hughes, K. R., F. Sablitzky, and Y. R. Mahida. 2011. Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells. Inflamm. Bowel Dis. 17:213-220.
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 213-220
-
-
Hughes, K.R.1
Sablitzky, F.2
Mahida, Y.R.3
-
19
-
-
33947260554
-
Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function
-
Jank, T., T. Giesemann, and K. Aktories. 2007. Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function. Glycobiology 17:15R-22R.
-
(2007)
Glycobiology
, vol.17
-
-
Jank, T.1
Giesemann, T.2
Aktories, K.3
-
20
-
-
2542486247
-
Differential effects of varying concentrations of Clostridium difficile toxin A on epithelial barrier function and expression of cytokines
-
Johal, S. S., K. Solomon, S. Dodson, S. P. Borriello, and Y. R. Mahida. 2004. Differential effects of varying concentrations of Clostridium difficile toxin A on epithelial barrier function and expression of cytokines. J. Infect. Dis. 189:2110-2119.
-
(2004)
J. Infect. Dis.
, vol.189
, pp. 2110-2119
-
-
Johal, S.S.1
Solomon, K.2
Dodson, S.3
Borriello, S.P.4
Mahida, Y.R.5
-
21
-
-
0024440715
-
Purification and characterisation of Clostridium difficile toxin A by bovine thyroglobulin affinity chromatography and dissociation in denaturing conditions with or without reduction
-
Kamiya, S., P. J. Reed, and S. P. Borriello. 1989. Purification and characterisation of Clostridium difficile toxin A by bovine thyroglobulin affinity chromatography and dissociation in denaturing conditions with or without reduction. J. Med. Microbiol. 30:69-77.
-
(1989)
J. Med. Microbiol.
, vol.30
, pp. 69-77
-
-
Kamiya, S.1
Reed, P.J.2
Borriello, S.P.3
-
22
-
-
0242490282
-
Reduced migration of fibroblasts in inflammatory bowel disease: role of inflammatory mediators and focal adhesion kinase
-
Leeb, S. N., et al. 2003. Reduced migration of fibroblasts in inflammatory bowel disease: role of inflammatory mediators and focal adhesion kinase. Gastroenterology 125:1341-1354.
-
(2003)
Gastroenterology
, vol.125
, pp. 1341-1354
-
-
Leeb, S.N.1
-
23
-
-
0022460391
-
Characterization of toxins A and B of Clostridium difficile with monoclonal antibodies
-
Lyerly, D. M., C. J. Phelps, J. Toth, and T. D. Wilkins. 1986. Characterization of toxins A and B of Clostridium difficile with monoclonal antibodies. Infect. Immun. 54:70-76.
-
(1986)
Infect. Immun.
, vol.54
, pp. 70-76
-
-
Lyerly, D.M.1
Phelps, C.J.2
Toth, J.3
Wilkins, T.D.4
-
24
-
-
0031408125
-
Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2
-
Mahida, Y. R., et al. 1997. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. Am. J. Physiol. 273:G1341-G1348.
-
(1997)
Am. J. Physiol.
, vol.273
-
-
Mahida, Y.R.1
-
25
-
-
0032425435
-
Effect of Clostridium difficile toxin A on human colonic lamina propria cells: early loss of macrophages followed by T-cell apoptosis
-
Mahida, Y. R., et al. 1998. Effect of Clostridium difficile toxin A on human colonic lamina propria cells: early loss of macrophages followed by T-cell apoptosis. Infect. Immun. 66:5462-5469.
-
(1998)
Infect. Immun.
, vol.66
, pp. 5462-5469
-
-
Mahida, Y.R.1
-
26
-
-
0029868433
-
Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment
-
Mahida, Y. R., S. Makh, S. Hyde, T. Gray, and S. P. Borriello. 1996. Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. Gut 38:337-347.
-
(1996)
Gut
, vol.38
, pp. 337-347
-
-
Mahida, Y.R.1
Makh, S.2
Hyde, S.3
Gray, T.4
Borriello, S.P.5
-
27
-
-
0036073299
-
Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
-
McKaig, B. C., K. Hughes, P. J. Tighe, and Y. R. Mahida. 2002. Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts. Am. J. Physiol. Cell Physiol. 282:C172-C182.
-
(2002)
Am. J. Physiol. Cell Physiol.
, vol.282
-
-
McKaig, B.C.1
Hughes, K.2
Tighe, P.J.3
Mahida, Y.R.4
-
28
-
-
0033049460
-
Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3
-
McKaig, B. C., S. S. Makh, C. J. Hawkey, D. K. Podolsky, and Y. R. Mahida. 1999. Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3. Am. J. Physiol. 276:G1087-G1093.
-
(1999)
Am. J. Physiol.
, vol.276
-
-
McKaig, B.C.1
Makh, S.S.2
Hawkey, C.J.3
Podolsky, D.K.4
Mahida, Y.R.5
-
29
-
-
0345237913
-
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
-
McKaig, B. C., D. McWilliams, S. A. Watson, and Y. R. Mahida. 2003. Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease. Am. J. Pathol. 162:1355-1360.
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 1355-1360
-
-
McKaig, B.C.1
McWilliams, D.2
Watson, S.A.3
Mahida, Y.R.4
-
30
-
-
0023923499
-
Purification and characterization of toxin B from Clostridium difficile
-
Meador, J., III, and R. K. Tweten. 1988. Purification and characterization of toxin B from Clostridium difficile. Infect. Immun. 56:1708-1714.
-
(1988)
Infect. Immun.
, vol.56
, pp. 1708-1714
-
-
Meador III, J.1
Tweten, R.K.2
-
31
-
-
0024426122
-
Villus contraction aids repair of intestinal epithelium after injury
-
Moore, R., S. Carlson, and J. L. Madara. 1989. Villus contraction aids repair of intestinal epithelium after injury. Am. J. Physiol. 257:G274-G283.
-
(1989)
Am. J. Physiol.
, vol.257
-
-
Moore, R.1
Carlson, S.2
Madara, J.L.3
-
32
-
-
0029991647
-
Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in murine T lymphoma EL4
-
Moorman, J. P., D. A. Bobak, and C. S. Hahn. 1996. Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in murine T lymphoma EL4. J. Immunol. 156:4146-4153.
-
(1996)
J. Immunol.
, vol.156
, pp. 4146-4153
-
-
Moorman, J.P.1
Bobak, D.A.2
Hahn, C.S.3
-
33
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
-
Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63.
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
34
-
-
0025726216
-
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
-
Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139: 271-279.
-
(1991)
J. Immunol. Methods
, vol.139
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Pagliacci, M.C.3
Grignani, F.4
Riccardi, C.5
-
35
-
-
0022618287
-
Purification and properties of Clostridium difficile cytotoxin B
-
Pothoulakis, C., et al. 1986. Purification and properties of Clostridium difficile cytotoxin B. J. Biol. Chem. 261:1316-1321.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 1316-1321
-
-
Pothoulakis, C.1
-
36
-
-
0032782848
-
Myofibroblasts. I. Paracrine cells important in health and disease
-
Powell, D. W., et al. 1999. Myofibroblasts. I. Paracrine cells important in health and disease. Am. J. Physiol. 277:C1-C9.
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Powell, D.W.1
-
37
-
-
0032833987
-
Myofibroblasts. II. Intestinal subepithelial myofibroblasts
-
Powell, D. W., et al. 1999. Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am. J. Physiol. 277:C183-C201.
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Powell, D.W.1
-
39
-
-
0026778133
-
The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
-
Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399.
-
(1992)
Cell
, vol.70
, pp. 389-399
-
-
Ridley, A.J.1
Hall, A.2
-
40
-
-
0026654125
-
The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
-
Ridley, A. J., H. F. Paterson, C. L. Johnston, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
-
(1992)
Cell
, vol.70
, pp. 401-410
-
-
Ridley, A.J.1
Paterson, H.F.2
Johnston, C.L.3
Diekmann, D.4
Hall, A.5
-
41
-
-
0028935286
-
Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro
-
Riegler, M., et al. 1995. Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro. J. Clin. Invest. 95:2004-2011.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2004-2011
-
-
Riegler, M.1
-
42
-
-
15544364759
-
Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death
-
Solomon, K., J. Webb, N. Ali, R. A. Robins, and Y. R. Mahida. 2005. Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death. Infect. Immun. 73:1625-1634.
-
(2005)
Infect. Immun.
, vol.73
, pp. 1625-1634
-
-
Solomon, K.1
Webb, J.2
Ali, N.3
Robins, R.A.4
Mahida, Y.R.5
-
43
-
-
0034651952
-
Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers
-
Stubbe, H., J. Berdoz, J. P. Kraehenbuhl, and B. Corthesy. 2000. Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers. J. Immunol. 164:1952-1960.
-
(2000)
J. Immunol.
, vol.164
, pp. 1952-1960
-
-
Stubbe, H.1
Berdoz, J.2
Kraehenbuhl, J.P.3
Corthesy, B.4
-
44
-
-
0020003645
-
Purification and characterization of toxins A and B of Clostridium difficile
-
Sullivan, N. M., S. Pellett, and T. D. Wilkins. 1982. Purification and characterization of toxins A and B of Clostridium difficile. Infect. Immun. 35: 1032-1040.
-
(1982)
Infect. Immun.
, vol.35
, pp. 1032-1040
-
-
Sullivan, N.M.1
Pellett, S.2
Wilkins, T.D.3
-
45
-
-
49649103133
-
Essential role of toxin A in C. difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function
-
Sutton, P. A., et al. 2008. Essential role of toxin A in C. difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function. Clin. Exp. Immunol. 153:439-447.
-
(2008)
Clin. Exp. Immunol.
, vol.153
, pp. 439-447
-
-
Sutton, P.A.1
-
46
-
-
17444366186
-
Clostridium difficile toxins: mechanism of action and role in disease
-
Voth, D. E., and J. D. Ballard. 2005. Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev. 18:247-263.
-
(2005)
Clin. Microbiol. Rev.
, vol.18
, pp. 247-263
-
-
Voth, D.E.1
Ballard, J.D.2
|