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Volumn 6, Issue 8, 2010, Pages 65-66

Variations in Tcdb activity and the hypervirulence of emerging strains of clostridium difficile

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; TRYPTOPHAN; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRULENCE FACTOR TCDB; BACTERIAL PROTEIN; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE;

EID: 77958132074     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001061     Document Type: Article
Times cited : (102)

References (50)
  • 1
    • 0000795948 scopus 로고
    • Intestinal flora in new-born infants: With a description of a new pathogenic anaerobe, Bacillus difficilis
    • Hall IC, O'Toole E (1935) Intestinal flora in new-born infants: with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child 49: 390-402.
    • (1935) Am J Dis Child , vol.49 , pp. 390-402
    • Hall, I.C.1    O'Toole, E.2
  • 2
    • 0018136697 scopus 로고
    • Identification of Clostridium difficile as a cause of pseudomembranous colitis
    • George RH, Symonds JM, Dimock F, Brown JD, Arabi Y, et al. (1978) Identification of Clostridium difficile as a cause of pseudomembranous colitis. Br Med J 1: 695.
    • (1978) Br Med J , vol.1 , pp. 695
    • George, R.H.1    Symonds, J.M.2    Dimock, F.3    Brown, J.D.4    Arabi, Y.5
  • 3
    • 0018098448 scopus 로고
    • Clindamycin-induced enterocolitis in hamsters as a model of pseudomembranous colitis in patients
    • Chang TW, Bartlett JG, Gorbach SL, Onderdonk AB (1978) Clindamycin-induced enterocolitis in hamsters as a model of pseudomembranous colitis in patients. Infect Immun 20: 526-529.
    • (1978) Infect Immun , vol.20 , pp. 526-529
    • Chang, T.W.1    Bartlett, J.G.2    Gorbach, S.L.3    Onderdonk, A.B.4
  • 4
    • 0026746192 scopus 로고
    • Antibiotic-associated diarrhea
    • Bartlett JG (1992) Antibiotic-associated diarrhea. Clin Infect Dis 15: 9.
    • (1992) Clin Infect Dis , vol.15 , pp. 9
    • Bartlett, J.G.1
  • 5
    • 20144386999 scopus 로고    scopus 로고
    • A Large Outbreak of Clostridium difficile-Associated Disease With an Unexpected Proportion of Deaths and Colectomies at a Teaching Hospital Following Increased Fluoroquinolone Use
    • Muto CA, Pokrywka M, Shutt K, Mendelsohn AB, Nouri K, et al. (2005) A Large Outbreak of Clostridium difficile-Associated Disease With an Unexpected Proportion of Deaths and Colectomies at a Teaching Hospital Following Increased Fluoroquinolone Use. Infection Control and Hospital Epidemiology 26: 273-280.
    • (2005) Infection Control and Hospital Epidemiology , vol.26 , pp. 273-280
    • Muto, C.A.1    Pokrywka, M.2    Shutt, K.3    Mendelsohn, A.B.4    Nouri, K.5
  • 6
    • 28844441314 scopus 로고    scopus 로고
    • A Predominantly Clonal Multi-Institutional Outbreak of Clostridium difficile-Associated Diarrhea with High Morbidity and Mortality
    • Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, et al. (2005) A Predominantly Clonal Multi-Institutional Outbreak of Clostridium difficile-Associated Diarrhea with High Morbidity and Mortality. N Engl J Med 353: 2442-2449.
    • (2005) N Engl J Med , vol.353 , pp. 2442-2449
    • Loo, V.G.1    Poirier, L.2    Miller, M.A.3    Oughton, M.4    Libman, M.D.5
  • 8
    • 25144469664 scopus 로고    scopus 로고
    • Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
    • Warny M, Pepin J, Fang A, Killgore G, Thompson A, et al. (2005) Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. The Lancet 366: 1079-1084.
    • (2005) The Lancet , vol.366 , pp. 1079-1084
    • Warny, M.1    Pepin, J.2    Fang, A.3    Killgore, G.4    Thompson, A.5
  • 9
    • 42449157632 scopus 로고    scopus 로고
    • Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1
    • Akerlund T, Persson I, Unemo M, Noren T, Svenungsson B, et al. (2008) Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1. J Clin Microbiol 46: 1530-1533.
    • (2008) J Clin Microbiol , vol.46 , pp. 1530-1533
    • Akerlund, T.1    Persson, I.2    Unemo, M.3    Noren, T.4    Svenungsson, B.5
  • 10
    • 33745120517 scopus 로고    scopus 로고
    • Molecular Analysis of Clostridium difficile PCR Ribotype 027 Isolates from Eastern and Western Canada
    • MacCannell DR, Louie TJ, Gregson DB, Laverdiere M, Labbe A-C, et al. (2006) Molecular Analysis of Clostridium difficile PCR Ribotype 027 Isolates from Eastern and Western Canada. J Clin Microbiol 44: 2147-2152.
    • (2006) J Clin Microbiol , vol.44 , pp. 2147-2152
    • Maccannell, D.R.1    Louie, T.J.2    Gregson, D.B.3    Laverdiere, M.4    Labbe, A.-C.5
  • 11
    • 4544379887 scopus 로고    scopus 로고
    • Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital
    • Geric B, Rupnik M, Gerding DN, Grabnar M, Johnson S (2004) Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital. J Med Microbiol 53: 887-894.
    • (2004) J Med Microbiol , vol.53 , pp. 887-894
    • Geric, B.1    Rupnik, M.2    Gerding, D.N.3    Grabnar, M.4    Johnson, S.5
  • 12
    • 2442420091 scopus 로고    scopus 로고
    • Prevalence and Characterization of a Binary Toxin (Actin-Specific ADP-Ribosyltransferase) from Clostridium difficile
    • Goncalves C, Decre D, Barbut F, Burghoffer B, Petit J-C (2004) Prevalence and Characterization of a Binary Toxin (Actin-Specific ADP-Ribosyltransferase) from Clostridium difficile. J Clin Microbiol 42: 1933-1939.
    • (2004) J Clin Microbiol , vol.42 , pp. 1933-1939
    • Goncalves, C.1    Decre, D.2    Barbut, F.3    Burghoffer, B.4    Petit, J.-C.5
  • 13
    • 73449097193 scopus 로고    scopus 로고
    • Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria
    • Schwan C, Stecher Br, Tzivelekidis T, van Ham M, Rohde M, et al. (2009) Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria. PLoS Pathog 5: e1000626.
    • (2009) PLoS Pathog , vol.5
    • Schwan, C.1    Stecher, B.R.2    Tzivelekidis, T.3    van Ham, M.4    Rohde, M.5
  • 14
    • 33749531757 scopus 로고    scopus 로고
    • In Vitro Susceptibility of Clostridium difficile Clinical Isolates from a Multi-Institutional Outbreak in Southern Quebec, Canada
    • the CDAD-CSI Study Group
    • Bourgault A-M, Lamothe F, Loo VG, Poirier L, the CDAD-CSI Study Group (2006) In Vitro Susceptibility of Clostridium difficile Clinical Isolates from a Multi-Institutional Outbreak in Southern Quebec, Canada. Antimicrob Agents Chemother 50: 3473-3475.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3473-3475
    • Bourgault, A.-M.1    Lamothe, F.2    Loo, V.G.3    Poirier, L.4
  • 15
    • 33845351752 scopus 로고    scopus 로고
    • High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile
    • Drudy D, Quinn T, O'Mahony R, Kyne L, O'Gaora P, et al. (2006) High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile. J Antimicrob Chemother 58: 1264-1267.
    • (2006) J Antimicrob Chemother , vol.58 , pp. 1264-1267
    • Drudy, D.1    Quinn, T.2    O'Mahony, R.3    Kyne, L.4    O'Gaora, P.5
  • 16
    • 33847416012 scopus 로고    scopus 로고
    • gyrA mutations in fluoroquinolone-resistant Clostridium difficile PCR-027
    • Drudy D, Kyne L, ROM S, Fanning (2007) gyrA mutations in fluoroquinolone-resistant Clostridium difficile PCR-027. Emerg Infect Dis 13: 2.
    • (2007) Emerg Infect Dis , vol.13 , pp. 2
    • Drudy, D.1    Kyne, L.2    Rom, S.3
  • 17
    • 76249088522 scopus 로고    scopus 로고
    • Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium
    • Stabler R, He M, Dawson L, Martin M, Valiente E, et al. (2009) Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biology 10: R102.
    • (2009) Genome Biology , vol.10
    • Stabler, R.1    He, M.2    Dawson, L.3    Martin, M.4    Valiente, E.5
  • 18
    • 0034960958 scopus 로고    scopus 로고
    • Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile
    • Tan KS, Wee BY, Song KP (2001) Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile. J Med Microbiol 50: 613-619.
    • (2001) J Med Microbiol , vol.50 , pp. 613-619
    • Tan, K.S.1    Wee, B.Y.2    Song, K.P.3
  • 19
    • 0028868816 scopus 로고
    • The toxigenic element of Clostridium difficile strain VPI 10463
    • Hammond GA, Johnson JL (1995) The toxigenic element of Clostridium difficile strain VPI 10463. Microbial Pathogenesis 19: 203-213.
    • (1995) Microbial Pathogenesis , vol.19 , pp. 203-213
    • Hammond, G.A.1    Johnson, J.L.2
  • 20
    • 0029054398 scopus 로고
    • Glucosylation of Rho proteins by Clostridium difficile toxin B
    • Just I, Selzer J, Wilm M, Eichel-Streiber CV, Mann M, et al. (1995) Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375: 500-503.
    • (1995) Nature , vol.375 , pp. 500-503
    • Just, I.1    Selzer, J.2    Wilm, M.3    Eichel-Streiber, C.V.4    Mann, M.5
  • 21
    • 0029086528 scopus 로고
    • Closing in on the toxic domain through analysis of a variant Clostridium difficile cytotoxin
    • Eichel-Streiber CV, Dagmar Meyer ZU Heringdorf EH, Sabine Sartingen (1995) Closing in on the toxic domain through analysis of a variant Clostridium difficile cytotoxin B. Mol Microbiol 17: 313-321.
    • (1995) B. Mol Microbiol , vol.17 , pp. 313-321
    • Eichel-Streiber, C.V.1    Dagmar, M.Z.U.2    Heringdorf, E.H.3
  • 22
    • 0032500882 scopus 로고    scopus 로고
    • The Enzymatic Domain of Clostridium difficile Toxin A Is Located within Its N-Terminal Region
    • Faust C, Ye B, Song K-P (1998) The Enzymatic Domain of Clostridium difficile Toxin A Is Located within Its N-Terminal Region. Biochemical and Biophysical Research Communications 251: 100-105.
    • (1998) Biochemical and Biophysical Research Communications , vol.251 , pp. 100-105
    • Faust, C.1    Ye, B.2    Song, K.-P.3
  • 23
    • 0030891386 scopus 로고    scopus 로고
    • Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the Holotoxin
    • Hofmann F, Busch C, Prepens U, Just I, Aktories K (1997) Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the Holotoxin. J Biol Chem 272: 11074-11078.
    • (1997) J Biol Chem , vol.272 , pp. 11074-11078
    • Hofmann, F.1    Busch, C.2    Prepens, U.3    Just, I.4    Aktories, K.5
  • 24
    • 0032584665 scopus 로고    scopus 로고
    • A Common Motif of Eukaryotic Glycosyltransferases Is Essential for the Enzyme Activity of Large Clostridial Cytotoxins
    • Busch C, Hofmann F, SelzerJr, Munro S, Jeckel D, et al. (1998) A Common Motif of Eukaryotic Glycosyltransferases Is Essential for the Enzyme Activity of Large Clostridial Cytotoxins. J Biol Chem 273: 19566-19572.
    • (1998) J Biol Chem , vol.273 , pp. 19566-19572
    • Busch, C.1    Hofmann, F.2    Selzerjr, M.S.3    Jeckel, D.4
  • 25
    • 0034607988 scopus 로고    scopus 로고
    • Involvement of a Conserved Tryptophan Residue in the UDP-Glucose Binding of Large Clostridial Cytotoxin Glycosyltransferases
    • Busch C, Hofmann F, Gerhard R, Aktories K (2000) Involvement of a Conserved Tryptophan Residue in the UDP-Glucose Binding of Large Clostridial Cytotoxin Glycosyltransferases. J Biol Chem 275: 13228-13234.
    • (2000) J Biol Chem , vol.275 , pp. 13228-13234
    • Busch, C.1    Hofmann, F.2    Gerhard, R.3    Aktories, K.4
  • 26
    • 0031887901 scopus 로고    scopus 로고
    • Chimeric Clostridial Cytotoxins: Identification of the N-Terminal Region Involved in Protein Substrate Recognition
    • Hofmann F, Busch C, Aktories K (1998) Chimeric Clostridial Cytotoxins: Identification of the N-Terminal Region Involved in Protein Substrate Recognition. Infect Immun 66: 1076-1081.
    • (1998) Infect Immun , vol.66 , pp. 1076-1081
    • Hofmann, F.1    Busch, C.2    Aktories, K.3
  • 27
    • 13444261172 scopus 로고    scopus 로고
    • Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells
    • Rupnik M, Pabst S, Rupnik M, von Eichel-Streiber C, Urlaub H, et al. (2005) Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells. Microbiology 151: 199-208.
    • (2005) Microbiology , vol.151 , pp. 199-208
    • Rupnik, M.1    Pabst, S.2    Rupnik, M.3    von Eichel-Streiber, C.4    Urlaub, H.5
  • 29
    • 34548472183 scopus 로고    scopus 로고
    • Auto-catalytic Cleavage of Clostridium difficile Toxins A and B Depends on Cysteine Protease Activity
    • Egerer M, Giesemann T, Jank T, Satchell KJF, Aktories K (2007) Auto-catalytic Cleavage of Clostridium difficile Toxins A and B Depends on Cysteine Protease Activity. J Biol Chem 282: 25314-25321.
    • (2007) J Biol Chem , vol.282 , pp. 25314-25321
    • Egerer, M.1    Giesemann, T.2    Jank, T.3    Satchell, K.J.F.4    Aktories, K.5
  • 30
    • 58149115498 scopus 로고    scopus 로고
    • Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile
    • Dingle T, Wee S, Mulvey GL, Greco A, Kitova EN, et al. (2008) Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile. Glycobiology 18: 698-706.
    • (2008) Glycobiology , vol.18 , pp. 698-706
    • Dingle, T.1    Wee, S.2    Mulvey, G.L.3    Greco, A.4    Kitova, E.N.5
  • 31
    • 0025896984 scopus 로고
    • A family of clostridial and streptococcal ligand-binding proteins with conserved C-terminal repeat sequences
    • Wren BW (1991) A family of clostridial and streptococcal ligand-binding proteins with conserved C-terminal repeat sequences. Mol Microbiol 5: 797-803.
    • (1991) Mol Microbiol , vol.5 , pp. 797-803
    • Wren, B.W.1
  • 33
    • 0025667927 scopus 로고
    • Clostridium difficile toxin A carries a C-terminal repetitive structure homologous to the carbohydrate binding region of streptococcal glycosyltransferases
    • von Eichel-Streiber C, Sauerborn M (1990) Clostridium difficile toxin A carries a C-terminal repetitive structure homologous to the carbohydrate binding region of streptococcal glycosyltransferases. Gene 96: 107-113.
    • (1990) Gene , vol.96 , pp. 107-113
    • von Eichel-Streiber, C.1    Sauerborn, M.2
  • 34
    • 33749628473 scopus 로고    scopus 로고
    • Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains
    • Stabler RA, Gerding DN, Songer JG, Drudy D, Brazier JS, et al. (2006) Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains. J Bacteriol 188: 7297-7305.
    • (2006) J Bacteriol , vol.188 , pp. 7297-7305
    • Stabler, R.A.1    Gerding, D.N.2    Songer, J.G.3    Drudy, D.4    Brazier, J.S.5
  • 35
    • 0026702564 scopus 로고
    • Evidence for a modular structure of the homologous repetitive C-terminal carbohydrate- binding sites of Clostridium difficile toxins and Streptococcus mutans glucosyltransferases
    • von Eichel-Streiber C, Sauerborn M, Kuramitsu HK (1992) Evidence for a modular structure of the homologous repetitive C-terminal carbohydrate- binding sites of Clostridium difficile toxins and Streptococcus mutans glucosyltransferases. J Bacteriol 174: 6707-6710.
    • (1992) J Bacteriol , vol.174 , pp. 6707-6710
    • von Eichel-Streiber, C.1    Sauerborn, M.2    Kuramitsu, H.K.3
  • 37
    • 33749023005 scopus 로고    scopus 로고
    • Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication
    • Hamm EE, Voth DE, Ballard JD (2006) Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication. Proc Natl Acad Sci U S A 103: 14176-14181.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14176-14181
    • Hamm, E.E.1    Voth, D.E.2    Ballard, J.D.3
  • 38
    • 0032539911 scopus 로고    scopus 로고
    • HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte
    • Claycomb WC, Lanson NA, Stallworth BS, Egeland DB, Delcarpio JB, et al. (1998) HL-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci U S A 95: 2979-2984.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2979-2984
    • Claycomb, W.C.1    Lanson, N.A.2    Stallworth, B.S.3    Egeland, D.B.4    Delcarpio, J.B.5
  • 39
    • 0029914034 scopus 로고    scopus 로고
    • Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo
    • Ballard JD, Collier RJ, Starnbach MN (1996) Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc Natl Acad Sci U S A 93: 12531-12534.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12531-12534
    • Ballard, J.D.1    Collier, R.J.2    Starnbach, M.N.3
  • 40
    • 0035159221 scopus 로고    scopus 로고
    • Cytosolic Delivery and Characterization of the TcdB Glucosylating Domain by Using a Heterologous Protein Fusion
    • Spyres LM, Qa'Dan M, Meader A, Tomasek JJ, Howard EW, et al. (2001) Cytosolic Delivery and Characterization of the TcdB Glucosylating Domain by Using a Heterologous Protein Fusion. Infect Immun 69: 599-601.
    • (2001) Infect Immun , vol.69 , pp. 599-601
    • Spyres, L.M.1    Qa'dan, M.2    Meader, A.3    Tomasek, J.J.4    Howard, E.W.5
  • 41
    • 0034114105 scopus 로고    scopus 로고
    • pH-Induced Conformational Changes in Clostridium difficile Toxin
    • Qa'Dan M, Spyres LM, Ballard JD (2000) pH-Induced Conformational Changes in Clostridium difficile Toxin B. Infect Immun 68: 2470-2474.
    • (2000) B. Infect Immun , vol.68 , pp. 2470-2474
    • Qa'Dan, M.1    Spyres, L.M.2    Ballard, J.D.3
  • 42
    • 0035815642 scopus 로고    scopus 로고
    • Low pH-induced Formation of Ion Channels by Clostridium difficile Toxin B in Target Cells
    • Barth H, Pfeifer G, Hofmann F, Maier E, Benz R, et al. (2001) Low pH-induced Formation of Ion Channels by Clostridium difficile Toxin B in Target Cells. J Biol Chem 276: 10670-10676.
    • (2001) J Biol Chem , vol.276 , pp. 10670-10676
    • Barth, H.1    Pfeifer, G.2    Hofmann, F.3    Maier, E.4    Benz, R.5
  • 43
  • 44
    • 39149127018 scopus 로고    scopus 로고
    • Infection of Hamsters with Historical and Epidemic BI Types of Clostridium difficile
    • Razaq N, Sambol S, Nagaro K, Zukowski W, Cheknis A, et al. (2007) Infection of Hamsters with Historical and Epidemic BI Types of Clostridium difficile. J Infect Dis 196: 1813-1819.
    • (2007) J Infect Dis , vol.196 , pp. 1813-1819
    • Razaq, N.1    Sambol, S.2    Nagaro, K.3    Zukowski, W.4    Cheknis, A.5
  • 45
    • 0344120340 scopus 로고    scopus 로고
    • Binary toxin producing Clostridium difficile strains
    • Rupnik M, Grabnar M, Geric B (2003) Binary toxin producing Clostridium difficile strains. Anaerobe 9: 289-294.
    • (2003) Anaerobe , vol.9 , pp. 289-294
    • Rupnik, M.1    Grabnar, M.2    Geric, B.3
  • 46
    • 20144363690 scopus 로고    scopus 로고
    • Clinical features of Clostridium difficile-associated diarrhoea due to binary toxin (actin-specific ADP-ribosyltransferase)-producing strains
    • Barbut F, Decre D, Lalande V, Burghoffer B, Noussair L, et al. (2005) Clinical features of Clostridium difficile-associated diarrhoea due to binary toxin (actin-specific ADP-ribosyltransferase)-producing strains. J Med Microbiol 54: 181-185.
    • (2005) J Med Microbiol , vol.54 , pp. 181-185
    • Barbut, F.1    Decre, D.2    Lalande, V.3    Burghoffer, B.4    Noussair, L.5
  • 47
    • 33645761368 scopus 로고    scopus 로고
    • Binary Toxin Producing, Large Clostridial Toxin Negative Clostridium difficile Strains Are Enterotoxic but Do Not Cause Disease in Hamsters
    • Geric B, Carman RJ, Rupnik M, Genheimer CW, Sambol SP, et al. (2006) Binary Toxin Producing, Large Clostridial Toxin Negative Clostridium difficile Strains Are Enterotoxic but Do Not Cause Disease in Hamsters. J Infect Dis 193: 1143-1150.
    • (2006) J Infect Dis , vol.193 , pp. 1143-1150
    • Geric, B.1    Carman, R.J.2    Rupnik, M.3    Genheimer, C.W.4    Sambol, S.P.5
  • 48
    • 67650766698 scopus 로고    scopus 로고
    • Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A
    • Murray R, Boyd D, Levett P, Mulvey M, Alfa M (2009) Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A. BMC Infectious Diseases 9: 103.
    • (2009) BMC Infectious Diseases , vol.9 , pp. 103
    • Murray, R.1    Boyd, D.2    Levett, P.3    Mulvey, M.4    Alfa, M.5
  • 49
  • 50
    • 22744452514 scopus 로고    scopus 로고
    • Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity
    • Voth DE, Hamm EE, Nguyen LG, Tucker AE, Salles II, et al. (2005) Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity. Cell Microbiol 7: 1139-1149.
    • (2005) Cell Microbiol , vol.7 , pp. 1139-1149
    • Voth, D.E.1    Hamm, E.E.2    Nguyen, L.G.3    Tucker, A.E.4    Salles, I.I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.