메뉴 건너뛰기




Volumn 153, Issue 3, 2008, Pages 439-447

Essential role of toxin A in C. difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function

Author keywords

Anti toxin antibody; Colitis; Paracellular permeability

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN A MONOCLONAL ANTIBODY; CLOSTRIDIUM DIFFICILE TOXIN B; DEXTRAN; MONOCLONAL ANTIBODY; SEPHAROSE; UNCLASSIFIED DRUG;

EID: 49649103133     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03690.x     Document Type: Article
Times cited : (19)

References (39)
  • 1
    • 0024204607 scopus 로고
    • Clostridium difficile toxin a perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers
    • Hecht G, Pothoulakis C, LaMont JT, Madara JL. Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers. J Clin Invest 1988 82 : 1516 24.
    • (1988) J Clin Invest , vol.82 , pp. 1516-24
    • Hecht, G.1    Pothoulakis, C.2    Lamont, J.T.3    Madara, J.L.4
  • 2
    • 0029868433 scopus 로고    scopus 로고
    • Effect of Clostridium difficile toxin a on human intestinal epithelial cells: Induction of interleukin 8 production and apoptosis after cell detachment
    • Mahida YR, Makh S, Hyde S, Gray T, Borriello SP. Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. Gut 1996 38 : 337 47.
    • (1996) Gut , vol.38 , pp. 337-47
    • Mahida, Y.R.1    Makh, S.2    Hyde, S.3    Gray, T.4    Borriello, S.P.5
  • 3
    • 0030909985 scopus 로고    scopus 로고
    • Early functional effects of Clostridium difficile toxin a on human colonocytes
    • Branka JE, Vallette G, Jarry A et al. Early functional effects of Clostridium difficile toxin A on human colonocytes. Gastroenterology 1997 112 : 1887 94.
    • (1997) Gastroenterology , vol.112 , pp. 1887-94
    • Branka, J.E.1    Vallette, G.2    Jarry, A.3
  • 5
    • 2542486247 scopus 로고    scopus 로고
    • Differential effects of varying concentrations of Clostridium difficile toxin a on epithelial barrier function and expression of cytokines
    • Johal SS, Solomon K, Dodson S, Borriello SP, Mahida YR. Differential effects of varying concentrations of Clostridium difficile toxin A on epithelial barrier function and expression of cytokines. J Infect Dis 2004 189 : 2110 19.
    • (2004) J Infect Dis , vol.189 , pp. 2110-19
    • Johal, S.S.1    Solomon, K.2    Dodson, S.3    Borriello, S.P.4    Mahida, Y.R.5
  • 6
    • 0034917210 scopus 로고    scopus 로고
    • GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis
    • Kurtz CB, Cannon EP, Brezzani A et al. GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis. Antimicrob Agents Chemother 2001 45 : 2340 7.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2340-7
    • Kurtz, C.B.1    Cannon, E.P.2    Brezzani, A.3
  • 7
    • 33645971969 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile
    • Maroo S, Lamont JT. Recurrent Clostridium difficile. Gastroenterology 2006 130 : 1311 16.
    • (2006) Gastroenterology , vol.130 , pp. 1311-16
    • Maroo, S.1    Lamont, J.T.2
  • 8
    • 0034628426 scopus 로고    scopus 로고
    • Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin a
    • Kyne L, Warny M, Qamar A, Kelly CP. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 2000 342 : 390 7.
    • (2000) N Engl J Med , vol.342 , pp. 390-7
    • Kyne, L.1    Warny, M.2    Qamar, A.3    Kelly, C.P.4
  • 9
    • 4444252095 scopus 로고    scopus 로고
    • Colonic IgA producing cells and macrophages are reduced in recurrent and non-recurrent Clostridium difficile associated diarrhoea
    • Johal SS, Lambert CP, Hammond J, James PD, Borriello SP, Mahida YR. Colonic IgA producing cells and macrophages are reduced in recurrent and non-recurrent Clostridium difficile associated diarrhoea. J Clin Pathol 2004 57 : 973 9.
    • (2004) J Clin Pathol , vol.57 , pp. 973-9
    • Johal, S.S.1    Lambert, C.P.2    Hammond, J.3    James, P.D.4    Borriello, S.P.5    Mahida, Y.R.6
  • 10
    • 0031948840 scopus 로고    scopus 로고
    • Antibodies to recombinant Clostridium difficile toxins a and B are an effective treatment and prevent relapse of C. difficile-associated disease in a hamster model of infection
    • Kink JA, Williams JA. Antibodies to recombinant Clostridium difficile toxins A and B are an effective treatment and prevent relapse of C. difficile-associated disease in a hamster model of infection. Infect Immun 1998 66 : 2018 25.
    • (1998) Infect Immun , vol.66 , pp. 2018-25
    • Kink, J.A.1    Williams, J.A.2
  • 11
    • 0021995801 scopus 로고
    • Effects of Clostridium difficile toxins given intragastrically to animals
    • Lyerly DM, Saum KE, MacDonald DK, Wilkins TD. Effects of Clostridium difficile toxins given intragastrically to animals. Infect Immun 1985 47 : 349 52.
    • (1985) Infect Immun , vol.47 , pp. 349-52
    • Lyerly, D.M.1    Saum, K.E.2    MacDonald, D.K.3    Wilkins, T.D.4
  • 12
    • 0022646133 scopus 로고
    • Effect of toxin a and B of Clostridium difficile on rabbit ileum and colon
    • Mitchell TJ, Ketley JM, Haslam SC et al. Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon. Gut 1986 27 : 78 85.
    • (1986) Gut , vol.27 , pp. 78-85
    • Mitchell, T.J.1    Ketley, J.M.2    Haslam, S.C.3
  • 14
    • 0028935286 scopus 로고
    • Clostridium difficile toxin B is more potent than toxin a in damaging human colonic epithelium in vitro
    • Riegler M, Sedivy R, Pothoulakis C et al. Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro. J Clin Invest 1995 95 : 2004 11.
    • (1995) J Clin Invest , vol.95 , pp. 2004-11
    • Riegler, M.1    Sedivy, R.2    Pothoulakis, C.3
  • 16
    • 0033914385 scopus 로고    scopus 로고
    • Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea
    • Alfa MJ, Kabani A, Lyerly D et al. Characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea. J Clin Microbiol 2000 38 : 2706 14.
    • (2000) J Clin Microbiol , vol.38 , pp. 2706-14
    • Alfa, M.J.1    Kabani, A.2    Lyerly, D.3
  • 17
    • 28844494086 scopus 로고    scopus 로고
    • An epidemic, toxin gene-variant strain of Clostridium difficile
    • McDonald LC, Killgore GE, Thompson A et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005 353 : 2433 41.
    • (2005) N Engl J Med , vol.353 , pp. 2433-41
    • McDonald, L.C.1    Killgore, G.E.2    Thompson, A.3
  • 18
    • 28844441314 scopus 로고    scopus 로고
    • A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
    • Loo VG, Poirier L, Miller MA et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005 353 : 2442 9.
    • (2005) N Engl J Med , vol.353 , pp. 2442-9
    • Loo, V.G.1    Poirier, L.2    Miller, M.A.3
  • 19
    • 0032901542 scopus 로고    scopus 로고
    • PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes
    • Stubbs SL, Brazier JS, O'Neill GL, Duerden BI. PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J Clin Microbiol 1999 37 : 461 3.
    • (1999) J Clin Microbiol , vol.37 , pp. 461-3
    • Stubbs, S.L.1    Brazier, J.S.2    O'Neill, G.L.3    Duerden, B.I.4
  • 20
    • 25144469664 scopus 로고    scopus 로고
    • Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
    • Warny M, Pepin J, Fang A et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 2005 366 : 1079 84.
    • (2005) Lancet , vol.366 , pp. 1079-84
    • Warny, M.1    Pepin, J.2    Fang, A.3
  • 21
    • 0024440715 scopus 로고
    • Purification and characterisation of Clostridium difficile toxin a by bovine thyroglobulin affinity chromatography and dissociation in denaturing conditions with or without reduction
    • Kamiya S, Reed PJ, Borriello SP. Purification and characterisation of Clostridium difficile toxin A by bovine thyroglobulin affinity chromatography and dissociation in denaturing conditions with or without reduction. J Med Microbiol 1989 30 : 69 77.
    • (1989) J Med Microbiol , vol.30 , pp. 69-77
    • Kamiya, S.1    Reed, P.J.2    Borriello, S.P.3
  • 22
    • 15544364759 scopus 로고    scopus 로고
    • Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death
    • Solomon K, Webb J, Ali N, Robins RA, Mahida YR. Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death. Infect Immun 2005 73 : 1625 34.
    • (2005) Infect Immun , vol.73 , pp. 1625-34
    • Solomon, K.1    Webb, J.2    Ali, N.3    Robins, R.A.4    Mahida, Y.R.5
  • 23
    • 0032857965 scopus 로고    scopus 로고
    • Human colonic subepithelial myofibroblasts modulate transepithelial resistance and secretory response
    • Beltinger J, McKaig BC, Makh S, Stack WA, Hawkey CJ, Mahida YR. Human colonic subepithelial myofibroblasts modulate transepithelial resistance and secretory response. Am J Physiol 1999 277 (2 Pt 1 C271 9.
    • (1999) Am J Physiol , vol.277 , Issue.2 PART 1
    • Beltinger, J.1    McKaig, B.C.2    Makh, S.3    Stack, W.A.4    Hawkey, C.J.5    Mahida, Y.R.6
  • 24
    • 0022460391 scopus 로고
    • Characterization of toxins a and B of Clostridium difficile with monoclonal antibodies
    • Lyerly DM, Phelps CJ, Toth J, Wilkins TD. Characterization of toxins A and B of Clostridium difficile with monoclonal antibodies. Infect Immun 1986 54 : 70 6.
    • (1986) Infect Immun , vol.54 , pp. 70-6
    • Lyerly, D.M.1    Phelps, C.J.2    Toth, J.3    Wilkins, T.D.4
  • 25
    • 0026764540 scopus 로고
    • Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin a
    • Frey SM, Wilkins TD. Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin A. Infect Immun 1992 60 : 2488 92.
    • (1992) Infect Immun , vol.60 , pp. 2488-92
    • Frey, S.M.1    Wilkins, T.D.2
  • 27
    • 0034651952 scopus 로고    scopus 로고
    • Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin a damaging of T84 monolayers
    • Stubbe H, Berdoz J, Kraehenbuhl JP, Corthesy B. Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers. J Immunol 2000 164 : 1952 60.
    • (2000) J Immunol , vol.164 , pp. 1952-60
    • Stubbe, H.1    Berdoz, J.2    Kraehenbuhl, J.P.3    Corthesy, B.4
  • 28
    • 0035321325 scopus 로고    scopus 로고
    • Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
    • Rescigno M, Urbano M, Valzasina B et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001 2 : 361 7.
    • (2001) Nat Immunol , vol.2 , pp. 361-7
    • Rescigno, M.1    Urbano, M.2    Valzasina, B.3
  • 29
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • Niess JH, Brand S, Gu X et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005 307 : 254 8.
    • (2005) Science , vol.307 , pp. 254-8
    • Niess, J.H.1    Brand, S.2    Gu, X.3
  • 30
    • 0030909889 scopus 로고    scopus 로고
    • The involvement of macrophage-derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B
    • Souza MH, Melo-Filho AA, Rocha MF et al. The involvement of macrophage-derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B. Immunology 1997 91 : 281 8.
    • (1997) Immunology , vol.91 , pp. 281-8
    • Souza, M.H.1    Melo-Filho, A.A.2    Rocha, M.F.3
  • 31
    • 0345447585 scopus 로고    scopus 로고
    • Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms
    • Bruewer M, Luegering A, Kucharzik T et al. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 2003 171 : 6164 72.
    • (2003) J Immunol , vol.171 , pp. 6164-72
    • Bruewer, M.1    Luegering, A.2    Kucharzik, T.3
  • 32
    • 0032005048 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line
    • Marano CW, Lewis SA, Garulacan LA, Soler AP, Mullin JM. Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of CACO-2 BBE, a human intestinal epithelial cell line. J Membr Biol 1998 161 : 263 74.
    • (1998) J Membr Biol , vol.161 , pp. 263-74
    • Marano, C.W.1    Lewis, S.A.2    Garulacan, L.A.3    Soler, A.P.4    Mullin, J.M.5
  • 33
    • 0001675278 scopus 로고
    • Use of cultured cell lines in studies of intestinal cell differntiation and function
    • In: Schultz, S.G., Field, M., Rauner, B.B., eds. Bethesda, MD: American Physiological Society
    • Zweibaum A, Laburthe M, Grasset E, Louvard D. Use of cultured cell lines in studies of intestinal cell differntiation and function. In : Schultz SG, Field M, Rauner BB, eds. Handbook of physiology. Bethesda, MD : American Physiological Society, 1991 : 223 55.
    • (1991) Handbook of Physiology. , pp. 223-55
    • Zweibaum, A.1    Laburthe, M.2    Grasset, E.3    Louvard, D.4
  • 34
    • 0022393433 scopus 로고
    • Occluding junction structure-function relationships in a cultured epithelial monolayer
    • Madara JL, Dharmsathaphorn K. Occluding junction structure-function relationships in a cultured epithelial monolayer. J Cell Biol 1985 101 : 2124 33.
    • (1985) J Cell Biol , vol.101 , pp. 2124-33
    • Madara, J.L.1    Dharmsathaphorn, K.2
  • 35
    • 1542723582 scopus 로고    scopus 로고
    • Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping
    • van den Berg RJ, Claas EC, Oyib DH et al. Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping. J Clin Microbiol 2004 42 : 1035 41.
    • (2004) J Clin Microbiol , vol.42 , pp. 1035-41
    • Van Den Berg, R.J.1    Claas, E.C.2    Oyib, D.H.3
  • 36
    • 32044469434 scopus 로고    scopus 로고
    • Prevalence and association of PCR ribotypes of Clostridium difficile isolated from symptomatic patients from Warsaw with macrolide-lincosamide- streptogramin B (MLSB) type resistance
    • Pituch H, Brazier JS, Obuch-Woszczatynski P, Wultanska D, Meisel-Mikolajczyk F, Luczak M. Prevalence and association of PCR ribotypes of Clostridium difficile isolated from symptomatic patients from Warsaw with macrolide-lincosamide-streptogramin B (MLSB) type resistance. J Med Microbiol 2006 55 : 207 13.
    • (2006) J Med Microbiol , vol.55 , pp. 207-13
    • Pituch, H.1    Brazier, J.S.2    Obuch-Woszczatynski, P.3    Wultanska, D.4    Meisel-Mikolajczyk, F.5    Luczak, M.6
  • 37
    • 0026671536 scopus 로고
    • Molecular, immunological, and biological characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile
    • Borriello SP, Wren BW, Hyde S et al. Molecular, immunological, and biological characterization of a toxin A-negative, toxin B-positive strain of Clostridium difficile. Infect Immun 1992 60 : 4192 9.
    • (1992) Infect Immun , vol.60 , pp. 4192-9
    • Borriello, S.P.1    Wren, B.W.2    Hyde, S.3
  • 38
    • 33645761368 scopus 로고    scopus 로고
    • Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters
    • Geric B, Carman RJ, Rupnik M et al. Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters. J Infect Dis 2006 193 : 1143 50.
    • (2006) J Infect Dis , vol.193 , pp. 1143-50
    • Geric, B.1    Carman, R.J.2    Rupnik, M.3
  • 39
    • 0022970442 scopus 로고
    • Increased intestinal permeability in patients with Crohn's disease and their relatives. a possible etiologic factor
    • Hollander D, Vadheim CM, Brettholz E, Petersen GM, Delahunty T, Rotter JI. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann Intern Med 1986 105 : 883 5.
    • (1986) Ann Intern Med , vol.105 , pp. 883-5
    • Hollander, D.1    Vadheim, C.M.2    Brettholz, E.3    Petersen, G.M.4    Delahunty, T.5    Rotter, J.I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.