Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining

Environmental Health Perspectives

Volumn 121, Issue 1, 2013, Pages 85-91

  Engström, Karin ^a   Ameer, Shegufta ^a   Bernaudat, Ludovic ^b   Drasch, Gustav ^c   Baeuml, Jennifer ^d   Skerfving, Staffan ^a   Bose O'Reilly, Stephan ^d,e   Broberg, Karin ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNITED NATIONS INDUSTRIAL DEVELOPMENT ORGANIZATION   (Austria)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY FOR HEALTH SCIENCES   (Austria)

^e LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Gold mining; Inorganic mercury; LAT1; MDR1; MRP1; OAT1; OAT3; SLC22A6; SLC22A8; SLC3A2

Indexed keywords

BIOLOGICAL MARKER; CREATININE; GOLD; LYMPHOID ENHANCER FACTOR 1; MERCURY; MULTIDRUG RESISTANCE PROTEIN 2; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR SOX4; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 217;

ADOLESCENT; ADULT; ALCOHOL CONSUMPTION; ALLELE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BIOINFORMATICS; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC ASSOCIATION; GENOTYPE; GENOTYPING TECHNIQUE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINING; PRIORITY JOURNAL; QUALITY CONTROL; SINGLE NUCLEOTIDE POLYMORPHISM; URINALYSIS;

ADULT; FEMALE; GOLD; HUMANS; MALE; MERCURY; MIDDLE AGED; MINING; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84872064733     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1204951     Document Type: Article

References (30)

1. 2-treated tubular MDCK cells. Toxicology 206:137-151.
2. Baeuml J, Bose-O'Reilly S, Matteucci Gothe R, Lettmeier B, Roider G, Drasch G, et al. 2011. Human biomonitoring data from mercury exposed miners in six artisanal small-scale gold mining areas in Asia and Africa. Minerals 1:122-143.
3. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
4. Bose-O'Reilly S, Drasch G, Beinhoff C, Rodrigues-Filho S, Roider G, Lettmeier B, et al. 2010a. Health assessment of artisanal gold miners in Indonesia. Sci Total Environ 408:713-725.
5. Bose-O'Reilly S, Drasch G, Beinhoff C, Tesha A, Drasch K, Roider G, et al. 2010b. Health assessment of artisanal gold miners in Tanzania. Sci Total Environ 408:796-805.
6. Bridges CC, Joshee L, Zalups RK. 2011. MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. Toxicol Appl Pharmacol 251:50-58.
7. Bridges CC, Zalups RK. 2005. Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol 204:274-308.
8. Clarkson TW, Magos L. 2006. The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 36:609-662.
9. Custodio HM, Harari R, Gerhardsson L, Skerfving S, Broberg K. 2005. Genetic influences on the retention of inorganic mercury. Arch Environ Occup Health 60:17-23.
10. del Amo EM, Urtti A, Yliperttula M. 2008. Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. Eur J Pharm Sci 35:161-174.
11. Deo AK, Prasad B, Balogh L, Lai Y, Unadkat JD. 2012. Inter-individual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by LC/MS/MS. Drug Metab Dispos 40:852-855.
12. Drasch G, Bose-O'Reilly S, Beinhoff C, Roider G, Maydl S. 2001. The Mt. Diwata study on the Philippines 1999-assessing mercury intoxication of the population by small scale gold mining. Sci Total Environ 267:151-168.
13. Haenisch S, Zimmermann U, Dazert E, Wruck CJ, Dazert P, Siegmund W, et al. 2007. Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex. Pharmacogenomics J 7:56-65.
14. Harari R, Harari F, Gerhardsson L, Lundh T, Skerfving S, Stromberg U, et al. 2012. Exposure and toxic effects of elemental mercury in gold-mining activities in Ecuador. Toxicol Lett. 213:75-82.
15. Lettmeier B, Boese-O'Reilly S, Drasch G. 2010. Proposal for a revised reference concentration (RfC) for mercury vapour in adults. Sci Total Environ 408:3530-3535.
16. Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, et al. 2001. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Mol Pharmacol 60:302-309.
17. Mazzachi BC, Peake MJ, Ehrhardt V. 2000. Reference range and method comparison studies for enzymatic and Jaffe creatinine assays in plasma and serum and early morning urine. Clin Lab 46:53-55.
18. Moriya Y, Nakamura T, Horinouchi M, Sakaeda T, Tamura T, Aoyama N, et al. 2002. Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects. Biol Pharm Bull 25:1356-1359.
19. National Center for Biotechnology Information. 2006. SNP Database. Available: http://www.ncbi.nlm.nih.gov/SNP [accessed 9 January 2012].
20. Nordberg G, Fowler B, Nordberg M, Friberg L. 2007. Handbook on the toxicology of metals. 3rd edition. New York:Elsevier.
21. Schlawicke Engström K, Stromberg U, Lundh T, Johansson I, Vessby B, Hallmans G, et al. 2008. Genetic variation in glutathione-related genes and body burden of methylmercury. Environ Health Perspect 116:734-739.
22. Simmons-Willis TA, Koh AS, Clarkson TW, Ballatori N. 2002. Transport of a neurotoxicant by molecular mimicry: the methylmercury-l-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2. Biochem J. 367:239-246.
23. Skerfving S, Bencko V, Vahter M, Schütz A, Gerhardsson L. 1999. Environmental health in the Baltic region-toxic metals. Scand J Work Environ Health. 25(suppl 3):40-64.
24. Song WY, Park J, Mendoza-Cozatl DG, Suter-Grotemeyer M, Shim D, Hortensteiner S, et al. 2010. Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters. Proc Natl Acad Sci USA 107:21187-21192.
25. Spiegel SJ, Yassi A, Spiegel JM, Veiga MM. 2005. Reducing mercury and responding to the global gold rush. Lancet 366:2070-2072.
26. Thorisson GA, Smith AV, Krishnan L, Stein LD. 2005. The International HapMap Project web site. Genome Res 15:1592-1593.
27. United Nations Environment Programme. 2002. Global Mercury Assessment Report, December 2002. Geneva:UNEP Chemicals. Available: http://www.unep.org/hazardoussubstances/Mercury/MercuryPublications/ReportsPublications/GlobalMercuryAssessmentReportDecember2002/tabid/3617/Default.aspx [accessed 27 November 2012].
28. Vahter M, Akesson A, Lidén C, Ceccatelli S, Berglund M. 2007. Gender differences in the disposition and toxicity of metals. Environ Res 104:85-95.
29. Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, et al. 2009. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol 10:R130; doi:10.1186/gb-2009-10-11-r130 [Online 17 November 2009].
30. Zhang Y, Zhao T, Li W, Vore M. 2010. The 5′-untranslated region of multidrug resistance associated protein 2 (MRP2; ABCC2) regulates downstream open reading frame expression through translational regulation. Mol Pharmacol 77:237-246.