Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 21, 2015, Pages 4740-4752

  Dahlin, Jayme L ^a,b   Nissink, J Willem M ^c   Francis, Subhashree ^d   Strasser, Jessica M ^d   John, Kristen ^d   Zhang, Zhiguo ^a   Walters, Michael A ^d  

^a MAYO GRADUATE SCHOOL   (United States)

^b Mayo Clinic   (United States)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Chemical aggregation; Drug discovery; High throughput screening; PAINS; Pan assay interference compounds; Structureactivity relationships

Indexed keywords

4 AROYL 1,5 DISUBSTITUTED 3 HYDROXY 2 PYRROL 2 ONE; ANTIFUNGAL AGENT; BETA LACTAMASE; FLUCONAZOLE; HISTONE ACETYLTRANSFERASE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; 3-HYDROXY-2H-PYRROL-2-ONE; MOLECULAR LIBRARY; RTT109 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; HIGH THROUGHPUT SCREENING; NUCLEAR MAGNETIC RESONANCE; RETROSPECTIVE STUDY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; METABOLISM; MOLECULAR LIBRARY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOLOGY;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HISTONE ACETYLTRANSFERASES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PYRROLES; SACCHAROMYCES CEREVISIAE PROTEINS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84944151490     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.08.020     Document Type: Article

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