Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

Journal of Medicinal Chemistry

Volumn 53, Issue 1, 2010, Pages 37-51

  Jadhav, Ajit ^a   Ferreira, Rafaela S ^b   Klumpp, Carleen ^a   Mott, Bryan T ^a   Austin, Christopher P ^a   Inglese, James ^a   Thomas, Craig J ^a   Maloney, David J ^a   Shoichet, Brian K ^b   Simeonov, Anton ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRUZIPAIN; CYSTEINE PROTEINASE INHIBITOR;

ARTICLE; ARTIFACT; AUTOFLUORESCENCE; FALSE POSITIVE RESULT; HIGH THROUGHPUT SCREENING; MOLECULAR DYNAMICS; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ARTIFACTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DETERGENTS; DRUG EVALUATION, PRECLINICAL; FLUORESCENCE; HIGH-THROUGHPUT SCREENING ASSAYS; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74849118854     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901070c     Document Type: Article

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