Metal impurities cause false positives in high-throughput screening campaigns

ACS Medicinal Chemistry Letters

Volumn 4, Issue 2, 2013, Pages 197-200

  Hermann, Johannes C ^a   Chen, Yingsi ^b   Wartchow, Charles ^b   Menke, John ^c   Gao, Lin ^b   Gleason, Shelley K ^a   Haynes, Nancy Ellen ^a   Scott, Nathan ^a   Petersen, Ann ^a   Gabriel, Stephen ^a   Vu, Binh ^a   George, Kelly M ^a   Narayanan, Arjun ^a   Li, Shirley H ^b   Qian, Hong ^b   Beatini, Nanda ^b   Niu, Linghao ^c   Gan, Qing Fen ^b  

^a Discovery Chemistry   (United States)

^b Discovery Technologies   (United States)

^c Inflammation Discovery   (United States)

Author keywords

assay interference; false positive; HTS; Jak3; lead identification; Pad4; promiscuous inhibitor; Ras; zinc

Indexed keywords

METAL; ORGANIC COMPOUND;

ARTICLE; BIOSENSOR; CONTAMINATION; FOLLOW UP; HIGH THROUGHPUT SCREENING; IC 50; MOLECULAR WEIGHT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 84873974757     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml3003296     Document Type: Article

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