Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions

Angewandte Chemie - International Edition

Volumn 49, Issue 24, 2010, Pages 4129-4132

  Rose, Rolf ^a   Erdmann, Silke ^a   Bovens, Stefanie ^a   Wolf, Alexander ^a   Rose, Micheline ^a   Hennig, Sven ^a   Waldmann, Herbert ^b,c   Ottmann, Christian ^a  

^a CHEMICAL GENOMICS CENTRE OF THE MAX PLANCK SOCIETY   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c TU DORTMUND UNIVERSITY   (Germany)

Author keywords

14 3 3 proteins; Crystal structures; Drug discovery; Protein protein interactions; Surface plasmon resonance

Indexed keywords

14-3-3 PROTEINS; BINDING KINETICS; DRUG DISCOVERY; IN-VIVO; PROTEIN-PROTEIN INTERACTIONS; PROTON PUMP; SMALL MOLECULES; TERNARY COMPLEX;

BINDING SITES; BIOLOGICAL MEMBRANES; COMPLEXATION; DRUG INTERACTIONS; MOLECULES; PLASMONS; SURFACE PLASMON RESONANCE;

PROTEINS;

2 PYRROLIDONE DERIVATIVE; FUSICOCCIN; GLYCOSIDE; PROTEIN 14 3 3; PROTON PUMP;

ARTICLE; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; DRUG DEVELOPMENT; KINETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

14-3-3 PROTEINS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; GLYCOSIDES; KINETICS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTON PUMPS; PYRROLIDINONES; SURFACE PLASMON RESONANCE;

EID: 77953106214     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200907203     Document Type: Article

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