Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents-real hits or promiscuous artifacts?

Current Opinion in Chemical Biology

Volumn 15, Issue 1, 2011, Pages 174-182

  Johnston, Paul A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CYSTEINE; CYSTEINE PROTEINASE; HISTIDINE; HYDRAZIDE DERIVATIVE; HYDROGEN PEROXIDE; METHIONINE; PROTEIN TYROSINE PHOSPHATASE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; SELENOCYSTEINE; SULFONAMIDE; TRYPTOPHAN;

ARTIFACT; AUTOOXIDATION; CATALYSIS; CONCENTRATION (PARAMETERS); ELECTRON TRANSPORT; FALSE POSITIVE RESULT; FOLLOW UP; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; MICROSOME; MITOCHONDRION; MOLECULAR PROBE; NONHUMAN; OXIDATION REDUCTION REACTION; PEROXISOME; PLEIOTROPY; PROTEIN FOLDING; PROTEIN TARGETING; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANIMALS; BUFFERS; FALSE POSITIVE REACTIONS; HUMANS; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION;

EID: 79851516571     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2010.10.022     Document Type: Review

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