-
1
-
-
0038037859
-
Mechanisms of activation, inhibition and specificity: Crystal structures of the NMDA receptor NR1 ligand-binding core
-
Furukawa, H.; Gouaux, E. Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core EMBO J. 2003, 22, 2873-2885
-
(2003)
EMBO J.
, vol.22
, pp. 2873-2885
-
-
Furukawa, H.1
Gouaux, E.2
-
2
-
-
27744500994
-
Subunit arrangement and function in NMDA receptors
-
Furukawa, H.; Singh, S. K.; Mancusso, R.; Gouaux, E. Subunit arrangement and function in NMDA receptors Nature 2005, 438 (7065) 185-192
-
(2005)
Nature
, vol.438
, Issue.7065
, pp. 185-192
-
-
Furukawa, H.1
Singh, S.K.2
Mancusso, R.3
Gouaux, E.4
-
3
-
-
77952363301
-
Glutamate Receptor Ion Channels: Structure, Regulation and Function
-
Traynelis, S.; Wollmuth, L.; McBain, C.; Menniti, F.; Vance, K.; Ogden, K.; Hansen, K.; Yuan, H.; Myers, S.; Dingledine, R. Glutamate Receptor Ion Channels: Structure, Regulation and Function Pharmacol. Rev. 2010, 62, 405-496
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 405-496
-
-
Traynelis, S.1
Wollmuth, L.2
McBain, C.3
Menniti, F.4
Vance, K.5
Ogden, K.6
Hansen, K.7
Yuan, H.8
Myers, S.9
Dingledine, R.10
-
4
-
-
0028048223
-
Differential expression of five N -methyl- d -aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats
-
Akazawa, C.; Shigemoto, R.; Bessho, Y.; Nakanishi, S.; Mizuno, N. Differential expression of five N -methyl- d -aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats J. Comp. Neurol. 1994, 347, 150-160
-
(1994)
J. Comp. Neurol.
, vol.347
, pp. 150-160
-
-
Akazawa, C.1
Shigemoto, R.2
Bessho, Y.3
Nakanishi, S.4
Mizuno, N.5
-
5
-
-
0028343648
-
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
-
Monyer, H.; Burnashev, N.; Laurie, D. J.; Sakmann, B.; Seeburg, P. H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors Neuron 1994, 12, 529-540
-
(1994)
Neuron
, vol.12
, pp. 529-540
-
-
Monyer, H.1
Burnashev, N.2
Laurie, D.J.3
Sakmann, B.4
Seeburg, P.H.5
-
6
-
-
2642598047
-
Functional and pharmacological differences between recombinant N -methyl- d -aspartate receptors
-
Vicini, S.; Wang, J. F.; Li, J. H.; Zhu, W. J.; Wang, Y. H.; Luo, J. H.; Wolfe, B. B.; Grayson, D. R. Functional and pharmacological differences between recombinant N -methyl- d -aspartate receptors J Neurophysiol. 1998, 72, 555-566
-
(1998)
J Neurophysiol.
, vol.72
, pp. 555-566
-
-
Vicini, S.1
Wang, J.F.2
Li, J.H.3
Zhu, W.J.4
Wang, Y.H.5
Luo, J.H.6
Wolfe, B.B.7
Grayson, D.R.8
-
7
-
-
70349610345
-
Control of NMDA receptor function by the NR2 subunit amino-terminal domain
-
Yuan, H.; Hansen, K. B.; Vance, K. M.; Ogden, K. K.; Traynelis, S. F. Control of NMDA receptor function by the NR2 subunit amino-terminal domain J. Neurosci. 2009, 29, 12045-12058
-
(2009)
J. Neurosci.
, vol.29
, pp. 12045-12058
-
-
Yuan, H.1
Hansen, K.B.2
Vance, K.M.3
Ogden, K.K.4
Traynelis, S.F.5
-
8
-
-
33846920665
-
NMDA receptor subunits: Function and pharmacology
-
Paoletti, P.; Neyton, J. NMDA receptor subunits: function and pharmacology Curr. Opin. Pharmacol. 2007, 7, 39-47
-
(2007)
Curr. Opin. Pharmacol.
, vol.7
, pp. 39-47
-
-
Paoletti, P.1
Neyton, J.2
-
9
-
-
0026437728
-
Molecular diversity of glutamate receptors and implications for brain function
-
Nakanishi, S. Molecular diversity of glutamate receptors and implications for brain function Science 1992, 258, 597-603
-
(1992)
Science
, vol.258
, pp. 597-603
-
-
Nakanishi, S.1
-
10
-
-
0033047334
-
Expression mechanisms underlying NMDA receptor-dependent long-term potentiation
-
Nicoll, R. A.; Malenka, R. C. Expression mechanisms underlying NMDA receptor-dependent long-term potentiation Ann. N. Y. Acad. Sci. 1999, 868, 515-525
-
(1999)
Ann. N. Y. Acad. Sci.
, vol.868
, pp. 515-525
-
-
Nicoll, R.A.1
Malenka, R.C.2
-
11
-
-
0025265926
-
The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death
-
Choi, D. W.; Rothman, S. M. The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death Annu. Rev. Neurosci. 1990, 13, 171-182
-
(1990)
Annu. Rev. Neurosci.
, vol.13
, pp. 171-182
-
-
Choi, D.W.1
Rothman, S.M.2
-
12
-
-
84855523295
-
Glutamate receptors in preclinical research on Alzheimer's disease: Update on recent advances
-
Hu, N.-W.; Ondrejcak, T.; Rowan, M. J. Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances Pharmacol., Biochem. Behav. 2012, 100, 855-862
-
(2012)
Pharmacol., Biochem. Behav.
, vol.100
, pp. 855-862
-
-
Hu, N.-W.1
Ondrejcak, T.2
Rowan, M.J.3
-
13
-
-
84868322939
-
Glutamatergic synaptic disregulation in schizophrenia: Therapeutic implications
-
Coyle, J. T.; Basu, A.; Benneyworth, M.; Balu, D.; Konopaske, G. Glutamatergic synaptic disregulation in schizophrenia: therapeutic implications Handb. Exp. Pharmacol. 2012, 213, 267-295
-
(2012)
Handb. Exp. Pharmacol.
, vol.213
, pp. 267-295
-
-
Coyle, J.T.1
Basu, A.2
Benneyworth, M.3
Balu, D.4
Konopaske, G.5
-
14
-
-
84856818407
-
Ketamine for Treatment-Resistant Unipolar Depression
-
Mathew, S. J.; Shah, A.; Lapidus, K.; Clark, C.; Jarun, N.; Ostermeyer, B.; Murrough, J. W. Ketamine for Treatment-Resistant Unipolar Depression CNS Drugs 2012, 26, 189-204
-
(2012)
CNS Drugs
, vol.26
, pp. 189-204
-
-
Mathew, S.J.1
Shah, A.2
Lapidus, K.3
Clark, C.4
Jarun, N.5
Ostermeyer, B.6
Murrough, J.W.7
-
15
-
-
33646824867
-
Dopamine D1 Activation Potentiates Striatal NMDA Receptors by Tyrosine Phosphorylation-Dependent Subunit Trafficking
-
Hallett, P. J.; Spoelgen, R.; Hyman, B. T.; Standaert, D. G.; Dunah, A. W. Dopamine D1 Activation Potentiates Striatal NMDA Receptors by Tyrosine Phosphorylation-Dependent Subunit Trafficking J. Neurosci. 2006, 26, 4690-4700
-
(2006)
J. Neurosci.
, vol.26
, pp. 4690-4700
-
-
Hallett, P.J.1
Spoelgen, R.2
Hyman, B.T.3
Standaert, D.G.4
Dunah, A.W.5
-
16
-
-
2542431131
-
Rationale for and use of NMDA receptor antagonists in Parkinson's disease
-
Hallett, P. J.; Standaert, D. G. Rationale for and use of NMDA receptor antagonists in Parkinson's disease Pharmacol. Ther. 2004, 102, 155-174
-
(2004)
Pharmacol. Ther.
, vol.102
, pp. 155-174
-
-
Hallett, P.J.1
Standaert, D.G.2
-
17
-
-
14744290753
-
Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease
-
Hallett, P. J.; Dunah, A. W.; Ravenscroft, P.; Zhou, S.; Bezard, E.; Crossman, A. R.; Brotchie, J. M.; Standaert, D. G. Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease Neuropharmacology 2005, 48, 503-516
-
(2005)
Neuropharmacology
, vol.48
, pp. 503-516
-
-
Hallett, P.J.1
Dunah, A.W.2
Ravenscroft, P.3
Zhou, S.4
Bezard, E.5
Crossman, A.R.6
Brotchie, J.M.7
Standaert, D.G.8
-
18
-
-
84873417885
-
Targeting Glutamate Receptors to Tackle the Pathogenesis, Clinical Symptoms and Levodopa-Induced Dyskinesia Associated with Parkinson's Disease
-
Duty, S. Targeting Glutamate Receptors to Tackle the Pathogenesis, Clinical Symptoms and Levodopa-Induced Dyskinesia Associated with Parkinson's Disease CNS Drugs 2012, 26, 1017-1032
-
(2012)
CNS Drugs
, vol.26
, pp. 1017-1032
-
-
Duty, S.1
-
19
-
-
84897453675
-
Excitatory amino acids, S-nitrosylation, and protein misfolding in neurodegenerative disease protection by memantine and nitromemantine at NMDA-gated channels
-
Micronutrients and Brain Health
-
Nakamura, T.; Lipton, S. A. Excitatory amino acids, S-nitrosylation, and protein misfolding in neurodegenerative disease protection by memantine and nitromemantine at NMDA-gated channels Oxid. Stress Dis. 2010, 26 (Micronutrients and Brain Health) 59-78
-
(2010)
Oxid. Stress Dis.
, vol.26
, pp. 59-78
-
-
Nakamura, T.1
Lipton, S.A.2
-
20
-
-
84880252318
-
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors
-
Mullasseril, P.; Hansen, K.; Vance, K.; Ogden, K.; Yuan, H.; Kurtkaya, N.; Santangelo, R.; Orr, A.; Le, P.; Vellano, K.; Liotta, D.; Traynelis, S. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors Nature Commun. 2010, 1, 90
-
(2010)
Nature Commun.
, vol.1
, pp. 90
-
-
Mullasseril, P.1
Hansen, K.2
Vance, K.3
Ogden, K.4
Yuan, H.5
Kurtkaya, N.6
Santangelo, R.7
Orr, A.8
Le, P.9
Vellano, K.10
Liotta, D.11
Traynelis, S.12
-
21
-
-
77955365676
-
Quinazolin-4-one Derivatives: A Novel Class of Noncompetitive NR2C/D Subunit-Selective N -Methyl- d -aspartate Receptor Antagonists
-
Mosley, C. A.; Acker, T. M.; Hansen, K. B.; Mullasseril, P.; Andersen, K. T.; Le, P.; Vellano, K. M.; Bräuner-Osborne, H.; Liotta, D. C.; Traynelis, S. F. Quinazolin-4-one Derivatives: A Novel Class of Noncompetitive NR2C/D Subunit-Selective N -Methyl- d -aspartate Receptor Antagonists J. Med. Chem. 2010, 53, 5476-5490
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5476-5490
-
-
Mosley, C.A.1
Acker, T.M.2
Hansen, K.B.3
Mullasseril, P.4
Andersen, K.T.5
Le, P.6
Vellano, K.M.7
Bräuner-Osborne, H.8
Liotta, D.C.9
Traynelis, S.F.10
-
22
-
-
78649580597
-
Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors
-
Bettini, E.; Sava, A.; Griffante, C.; Carignani, C.; Buson, A.; Capelli, A. M.; Negri, M.; Andreeta, F.; Senar-Sancho, S. A.; Guiral, L.; Cardullo, F. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors J. Pharmacol. Exp. Ther. 2010, 335, 636-644
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.335
, pp. 636-644
-
-
Bettini, E.1
Sava, A.2
Griffante, C.3
Carignani, C.4
Buson, A.5
Capelli, A.M.6
Negri, M.7
Andreeta, F.8
Senar-Sancho, S.A.9
Guiral, L.10
Cardullo, F.11
-
23
-
-
78649582336
-
A Novel Family of Negative and Positive Allosteric Modulators of NMDA Receptors
-
Costa, B. M.; Irvine, M. W.; Fang, G.; Eaves, R. J.; Mayo-Martin, M. B.; Skifter, D. A.; Jane, D. E.; Monaghan, D. T. A Novel Family of Negative and Positive Allosteric Modulators of NMDA Receptors J. Pharmacol. Exp. Ther. 2010, 335, 614-621
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.335
, pp. 614-621
-
-
Costa, B.M.1
Irvine, M.W.2
Fang, G.3
Eaves, R.J.4
Mayo-Martin, M.B.5
Skifter, D.A.6
Jane, D.E.7
Monaghan, D.T.8
-
24
-
-
80054781460
-
Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N -Methyl- d -aspartate Receptor Subunit-Selective Modulators
-
Acker, T. M.; Yuan, H.; Hansen, K. B.; Vance, K. M.; Ogden, K. K.; Jensen, H. S.; Burger, P. B.; Mullasseril, P.; Snyder, J. P.; Liotta, D. C.; Traynelis, S. F. Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N -Methyl- d -aspartate Receptor Subunit-Selective Modulators Mol. Pharmacol. 2011, 80, 782-795
-
(2011)
Mol. Pharmacol.
, vol.80
, pp. 782-795
-
-
Acker, T.M.1
Yuan, H.2
Hansen, K.B.3
Vance, K.M.4
Ogden, K.K.5
Jensen, H.S.6
Burger, P.B.7
Mullasseril, P.8
Snyder, J.P.9
Liotta, D.C.10
Traynelis, S.F.11
-
25
-
-
84880159894
-
Synthesis and Structure-Activity Relationship of Tetrahydroisoquinoline- Based Potentiators of GluN2C and GluN2D Containing N -Methyl- d -aspartate Receptors
-
Santangelo Freel, R. M.; Ogden, K. K.; Strong, K. L.; Khatri, A.; Chepiga, K. M.; Jensen, H. S.; Traynelis, S. F.; Liotta, D. C. Synthesis and Structure-Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N -Methyl- d -aspartate Receptors J. Med. Chem. 2013, 56, 5351-5381
-
(2013)
J. Med. Chem.
, vol.56
, pp. 5351-5381
-
-
Santangelo Freel, R.M.1
Ogden, K.K.2
Strong, K.L.3
Khatri, A.4
Chepiga, K.M.5
Jensen, H.S.6
Traynelis, S.F.7
Liotta, D.C.8
-
26
-
-
84883198508
-
Structure-Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Containing Class of GluN2C/GluN2D Selective Antagonists
-
Acker, T. M.; Khatri, A.; Vance, K. M.; Slabber, C.; Bacsa, J.; Snyder, J. P.; Traynelis, S. F.; Liotta, D. C. Structure-Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Containing Class of GluN2C/GluN2D Selective Antagonists J. Med. Chem. 2013, 56, 6434-6456
-
(2013)
J. Med. Chem.
, vol.56
, pp. 6434-6456
-
-
Acker, T.M.1
Khatri, A.2
Vance, K.M.3
Slabber, C.4
Bacsa, J.5
Snyder, J.P.6
Traynelis, S.F.7
Liotta, D.C.8
-
27
-
-
84860321928
-
Subunit-selective allosteric inhibition of glycine binding to NMDA receptors
-
Hansen, B. K.; Ogden, K. K.; Traynelis, S. F. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors J. Neurosci. 2012, 32, 6197-6208
-
(2012)
J. Neurosci.
, vol.32
, pp. 6197-6208
-
-
Hansen, B.K.1
Ogden, K.K.2
Traynelis, S.F.3
-
28
-
-
0036311298
-
Superoxide dismutase mimetics: Synthesis and structure-activity relationship study of MnTBAP analogues
-
Gauuan, P. J. F.; Trova, M. P.; Gregor-Boros, L.; Bocckino, S. B.; Crapo, J. D.; Day, B. J. Superoxide dismutase mimetics: synthesis and structure-activity relationship study of MnTBAP analogues Bioorg. Med. Chem. 2002, 10, 3013-3021
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 3013-3021
-
-
Gauuan, P.J.F.1
Trova, M.P.2
Gregor-Boros, L.3
Bocckino, S.B.4
Crapo, J.D.5
Day, B.J.6
-
29
-
-
84876019993
-
-
US 2006/0194801.
-
Kelly, M. G.; Kincaid, J.; Duncton, M.; Sahasrabudhe, K.; Janagani, S.; Upasani, R. B.; Wu, G.; Fang, Y.; Weig, Z.-L. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using same. US 2006/0194801, 2006.
-
(2006)
Amide Derivatives As Ion-channel Ligands and Pharmaceutical Compositions and Methods of Using Same
-
-
Kelly, M.G.1
Kincaid, J.2
Duncton, M.3
Sahasrabudhe, K.4
Janagani, S.5
Upasani, R.B.6
Wu, G.7
Fang, Y.8
Weig, Z.-L.9
-
30
-
-
85082949923
-
A convenient preparation of t -butyl esters
-
Widmer, U. A convenient preparation of t -butyl esters Synthesis 1983, 135-136
-
(1983)
Synthesis
, pp. 135-136
-
-
Widmer, U.1
-
31
-
-
84879087027
-
Structural determinants of agonist efficacy at the glutamate binding site of N -methyl- d -aspartate receptors
-
Hansen, K. B.; Tajima, N.; Risgaard, R.; Perszyk, R. E.; Jørgensen, L.; Vance, K. M.; Ogden, K. K.; Clausen, R. P.; Furukawa, H.; Traynelis, S. F. Structural determinants of agonist efficacy at the glutamate binding site of N -methyl- d -aspartate receptors Mol. Pharmacol. 2013, 84, 114-127
-
(2013)
Mol. Pharmacol.
, vol.84
, pp. 114-127
-
-
Hansen, K.B.1
Tajima, N.2
Risgaard, R.3
Perszyk, R.E.4
Jørgensen, L.5
Vance, K.M.6
Ogden, K.K.7
Clausen, R.P.8
Furukawa, H.9
Traynelis, S.F.10
-
32
-
-
44249093505
-
Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements
-
Hansen, K. B.; Brauner-Osborne, H.; Egebjerg, J. Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements Comb. Chem. High Throughput Screening 2008, 11, 304-315
-
(2008)
Comb. Chem. High Throughput Screening
, vol.11
, pp. 304-315
-
-
Hansen, K.B.1
Brauner-Osborne, H.2
Egebjerg, J.3
-
33
-
-
77952327490
-
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N -methyl- d -aspartate receptor antagonists
-
Hansen, K. B.; Mullasseril, P.; Dawit, S.; Kurtkaya, N.; Yuan, H.; Vance, K.; Orr, A.; Kvist, T.; Ogden, K.; Le, P. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N -methyl- d -aspartate receptor antagonists J. Pharmacol. Exp. Ther. 2010, 333, 650-662
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.333
, pp. 650-662
-
-
Hansen, K.B.1
Mullasseril, P.2
Dawit, S.3
Kurtkaya, N.4
Yuan, H.5
Vance, K.6
Orr, A.7
Kvist, T.8
Ogden, K.9
Le, P.10
|