4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)- N -(4-methoxypyridin-2-yl) piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth

Journal of Medicinal Chemistry

Volumn 57, Issue 3, 2014, Pages 1063-1078

  Foley, Timothy L ^a   Rai, Ganesha ^a   Yasgar, Adam ^a   Daniel, Thomas ^a   Baker, Heather L ^a   Attene Ramos, Matias ^a   Kosa, Nicolas M ^b   Leister, William ^a   Burkart, Michael D ^b   Jadhav, Ajit ^a   Simeonov, Anton ^a   Maloney, David J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DIPEPTIDES; DRUG RESISTANCE, BACTERIAL; DRUG SYNERGISM; ESCHERICHIA COLI; GRAM-POSITIVE BACTERIA; HUMANS; MALE; MICE; MICROBIAL SENSITIVITY TESTS; MICROSOMES, LIVER; PYRIDINES; SECONDARY METABOLISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 84894082059     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401752p     Document Type: Article

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