-
1
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul,S.F. et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
-
2
-
-
8444225024
-
NIH Molecular Libraries Initiative
-
Austin,C.P. et al. (2004) NIH Molecular Libraries Initiative. Science, 306, 1138-1139.
-
(2004)
Science
, vol.306
, pp. 1138-1139
-
-
Austin, C.P.1
-
3
-
-
35248817286
-
Modeling promiscuity based on in vitro safety pharmacology profiling data
-
Azzaoui,K. et al. (2007) Modeling promiscuity based on in vitro safety pharmacology profiling data. Chem. Med. Chem., 2, 874-880.
-
(2007)
Chem. Med. Chem
, vol.2
, pp. 874-880
-
-
Azzaoui, K.1
-
4
-
-
0031152073
-
New technologies for high-throughput screening
-
Burbaum,J.J. and Sigal,N.H. (1997) New technologies for high-throughput screening. Curr. Opin. Chem. Biol., 1, 72-78.
-
(1997)
Curr. Opin. Chem. Biol
, vol.1
, pp. 72-78
-
-
Burbaum, J.J.1
Sigal, N.H.2
-
5
-
-
39349094523
-
Small-molecule aggregates inhibit amyloid polymerization
-
Feng,B.Y. et al. (2008) Small-molecule aggregates inhibit amyloid polymerization. Nat. Chem. Biol., 4, 197-199.
-
(2008)
Nat. Chem. Biol
, vol.4
, pp. 197-199
-
-
Feng, B.Y.1
-
6
-
-
12844283957
-
High-throughput drug discovery: What can we expect from HTS?
-
Gribbon,P. and Sewing,A. (2005) High-throughput drug discovery: What can we expect from HTS? Drug Discov. Today, 10, 17-22.
-
(2005)
Drug Discov. Today
, vol.10
, pp. 17-22
-
-
Gribbon, P.1
Sewing, A.2
-
7
-
-
2942564021
-
Pursuing the leadlikeness concept in pharmaceutical research
-
Hann,M.M. and Oprea,T.I. (2004) Pursuing the leadlikeness concept in pharmaceutical research. Curr. Opin. Chem. Biol., 8, 255-263.
-
(2004)
Curr. Opin. Chem. Biol
, vol.8
, pp. 255-263
-
-
Hann, M.M.1
Oprea, T.I.2
-
8
-
-
34848916118
-
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1
-
Lee,K.W. et al. (2007) Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis, 28, 1918-1927.
-
(2007)
Carcinogenesis
, vol.28
, pp. 1918-1927
-
-
Lee, K.W.1
-
9
-
-
33646233781
-
Inhibition of Mammalian thioredoxin reductase by some flavonoids: Implications for myricetin and quercetin anticancer activity
-
Lu,J. et al. (2006) Inhibition of Mammalian thioredoxin reductase by some flavonoids: Implications for myricetin and quercetin anticancer activity. Cancer Res., 66, 4410-4418.
-
(2006)
Cancer Res
, vol.66
, pp. 4410-4418
-
-
Lu, J.1
-
10
-
-
33645887230
-
Critical review of the role of HTS in drug discovery
-
Macarron,R. (2006) Critical review of the role of HTS in drug discovery. Drug Discov. Today, 11, 277-279.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 277-279
-
-
Macarron, R.1
-
12
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
McGovern,S.L. et al. (2002) A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem., 45, 1712-1722.
-
(2002)
J. Med. Chem
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
-
13
-
-
51349085387
-
Data completeness-the Achilles heel of drug-target networks
-
Mestres,J. et al. (2008) Data completeness-the Achilles heel of drug-target networks. Nat. Biotechnol., 26, 983-984.
-
(2008)
Nat. Biotechnol
, vol.26
, pp. 983-984
-
-
Mestres, J.1
-
14
-
-
1642452747
-
Research and development costs for drugs
-
Riggs,T.L. (2004) Research and development costs for drugs. Lancet 363, 184.
-
(2004)
Lancet
, vol.363
, pp. 184
-
-
Riggs, T.L.1
-
15
-
-
0041842684
-
Effect of detergent on 'promiscuous' inhibitors
-
Ryan,A.J. et al. (2003) Effect of detergent on 'promiscuous' inhibitors. J. Med. Chem., 46, 3448-3451.
-
(2003)
J. Med. Chem
, vol.46
, pp. 3448-3451
-
-
Ryan, A.J.1
-
16
-
-
0141923641
-
Identification and prediction of promiscuous aggregating inhibitors among known drugs
-
Seidler,J. et al. (2003) Identification and prediction of promiscuous aggregating inhibitors among known drugs. J. Med. Chem. 46, 4477-4486.
-
(2003)
J. Med. Chem
, vol.46
, pp. 4477-4486
-
-
Seidler, J.1
-
17
-
-
4344616168
-
Inhibition of human cytochromes P450 by components of Ginkgo biloba
-
von Moltke,L.L. et al. (2004) Inhibition of human cytochromes P450 by components of Ginkgo biloba. J. Pharm. Pharmacol., 56, 1039-1044.
-
(2004)
J. Pharm. Pharmacol
, vol.56
, pp. 1039-1044
-
-
von Moltke, L.L.1
-
18
-
-
26944446576
-
Keynote review: In vitro safety pharmacology profiling: An essential tool for successful drug development
-
Whitebread,S. et al. (2005) Keynote review: in vitro safety pharmacology profiling: An essential tool for successful drug development. Drug Discov. Today, 10, 1421-1433.
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1421-1433
-
-
Whitebread, S.1
-
19
-
-
53249095482
-
D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin
-
Wu,D. et al. (2008) D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int. J. Antimicrob. Agents, 32, 421-426.
-
(2008)
Int. J. Antimicrob. Agents
, vol.32
, pp. 421-426
-
-
Wu, D.1
-
20
-
-
0141642224
-
Medicine. The NIH Roadmap
-
Zerhouni,E. (2003) Medicine. The NIH Roadmap. Science, 302, 63-72.
-
(2003)
Science
, vol.302
, pp. 63-72
-
-
Zerhouni, E.1
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