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Volumn 26, Issue 5, 2015, Pages 499-506

Mutations leading to constitutive active gp130/JAK1/STAT3 pathway

Author keywords

FRK; GNAS; Gp130; Inflammatory hepatocellular adenomas; JAK1; STAT3

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ANTINEOPLASTIC AGENT; CARDIOTROPHIN 1; CILIARY NEUROTROPHIC FACTOR RECEPTOR; CURCUMIN; DASATINIB; GLYCOPROTEIN GP 130; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INTERLEUKIN 11; INTERLEUKIN 27; INTERLEUKIN 3; INTERLEUKIN 6; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; LEUKEMIA INHIBITORY FACTOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NUCLEAR RECEPTOR COACTIVATOR 2; ONCOSTATIN M; PROTEIN SH2; RUXOLITINIB; SRCL 1; SRCL 5; STAT3 PROTEIN; UNCLASSIFIED DRUG; FRK PROTEIN, HUMAN; IL6ST PROTEIN, HUMAN; JAK1 PROTEIN, HUMAN; PROTEIN TYROSINE KINASE; STAT3 PROTEIN, HUMAN; TUMOR PROTEIN;

EID: 84941882702     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2015.07.010     Document Type: Short Survey
Times cited : (43)

References (95)
  • 1
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: novel molecular targets for cancer drug discovery
    • Turkson J., Jove R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 2000, 19:6613-6626.
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 2
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg J. Stat proteins and oncogenesis. J. Clin. Invest. 2002, 109:1139-1142.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 3
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
    • Boulanger M.J., Chow D.C., Brevnova E.E., Garcia K.C. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 2003, 300:2101-2104.
    • (2003) Science , vol.300 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.C.2    Brevnova, E.E.3    Garcia, K.C.4
  • 4
    • 0028064835 scopus 로고
    • High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130
    • Ward L.D., Howlett G.J., Discolo G., Yasukawa K., Hammacher A., Moritz R.L., et al. High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J. Biol. Chem. 1994, 269:23286-23289.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23286-23289
    • Ward, L.D.1    Howlett, G.J.2    Discolo, G.3    Yasukawa, K.4    Hammacher, A.5    Moritz, R.L.6
  • 5
    • 0028811302 scopus 로고
    • Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations
    • Cherqui D., Rahmouni A., Charlotte F., Boulahdour H., Metreau J.M., Meignan M., et al. Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations. Hepatology 1995, 22:1674-1681.
    • (1995) Hepatology , vol.22 , pp. 1674-1681
    • Cherqui, D.1    Rahmouni, A.2    Charlotte, F.3    Boulahdour, H.4    Metreau, J.M.5    Meignan, M.6
  • 6
    • 84876494014 scopus 로고    scopus 로고
    • Hepatocellular benign tumors-from molecular classification to personalized clinical care
    • Nault J.C., Bioulac-Sage P., Zucman-Rossi J. Hepatocellular benign tumors-from molecular classification to personalized clinical care. Gastroenterology 2013, 144:888-902.
    • (2013) Gastroenterology , vol.144 , pp. 888-902
    • Nault, J.C.1    Bioulac-Sage, P.2    Zucman-Rossi, J.3
  • 7
    • 33645223878 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC
    • Zucman-Rossi J., Jeannot E., Nhieu J.T., Scoazec J.Y., Guettier C., Rebouissou S., et al. Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 2006, 43:515-524.
    • (2006) Hepatology , vol.43 , pp. 515-524
    • Zucman-Rossi, J.1    Jeannot, E.2    Nhieu, J.T.3    Scoazec, J.Y.4    Guettier, C.5    Rebouissou, S.6
  • 8
    • 0242490240 scopus 로고    scopus 로고
    • Familial liver adenomatosis associated with hepatocyte nuclear factor 1alpha inactivation
    • Bacq Y., Jacquemin E., Balabaud C., Jeannot E., Scotto B., Branchereau S., et al. Familial liver adenomatosis associated with hepatocyte nuclear factor 1alpha inactivation. Gastroenterology 2003, 125:1470-1475.
    • (2003) Gastroenterology , vol.125 , pp. 1470-1475
    • Bacq, Y.1    Jacquemin, E.2    Balabaud, C.3    Jeannot, E.4    Scotto, B.5    Branchereau, S.6
  • 10
    • 84984537259 scopus 로고    scopus 로고
    • P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia
    • Chen Y.W., Jeng Y.M., Yeh S.H., Chen P.J. P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. Hepatology 2002, 36:927-935.
    • (2002) Hepatology , vol.36 , pp. 927-935
    • Chen, Y.W.1    Jeng, Y.M.2    Yeh, S.H.3    Chen, P.J.4
  • 11
    • 84898445933 scopus 로고    scopus 로고
    • Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation
    • Pilati C., Letouze E., Nault J.C., Imbeaud S., Boulai A., Calderaro J., et al. Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. Cancer Cell 2014, 25:428-441.
    • (2014) Cancer Cell , vol.25 , pp. 428-441
    • Pilati, C.1    Letouze, E.2    Nault, J.C.3    Imbeaud, S.4    Boulai, A.5    Calderaro, J.6
  • 12
    • 34250763945 scopus 로고    scopus 로고
    • Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
    • Bioulac-Sage P., Rebouissou S., Thomas C., Blanc J.F., Saric J., Sa Cunha A., et al. Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology 2007, 46:740-748.
    • (2007) Hepatology , vol.46 , pp. 740-748
    • Bioulac-Sage, P.1    Rebouissou, S.2    Thomas, C.3    Blanc, J.F.4    Saric, J.5    Sa Cunha, A.6
  • 13
    • 58149326854 scopus 로고    scopus 로고
    • Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S., Amessou M., Couchy G., Poussin K., Imbeaud S., Pilati C., et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 2009, 457:200-204.
    • (2009) Nature , vol.457 , pp. 200-204
    • Rebouissou, S.1    Amessou, M.2    Couchy, G.3    Poussin, K.4    Imbeaud, S.5    Pilati, C.6
  • 14
    • 84894583202 scopus 로고    scopus 로고
    • Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma
    • Poussin K., Pilati C., Couchy G., Calderaro J., Bioulac-Sage P., Bacq Y., et al. Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma. Oncoimmunology 2013, 2:e27090.
    • (2013) Oncoimmunology , vol.2 , pp. e27090
    • Poussin, K.1    Pilati, C.2    Couchy, G.3    Calderaro, J.4    Bioulac-Sage, P.5    Bacq, Y.6
  • 15
    • 79960346759 scopus 로고    scopus 로고
    • Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
    • Pilati C., Amessou M., Bihl M.P., Balabaud C., Nhieu J.T., Paradis V., et al. Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. J. Exp. Med. 2011, 208:1359-1366.
    • (2011) J. Exp. Med. , vol.208 , pp. 1359-1366
    • Pilati, C.1    Amessou, M.2    Bihl, M.P.3    Balabaud, C.4    Nhieu, J.T.5    Paradis, V.6
  • 16
    • 83555161680 scopus 로고    scopus 로고
    • GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation
    • Nault J.C., Fabre M., Couchy G., Pilati C., Jeannot E., Tran Van Nhieu J., et al. GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation. J. Hepatol. 2012, 56:184-191.
    • (2012) J. Hepatol. , vol.56 , pp. 184-191
    • Nault, J.C.1    Fabre, M.2    Couchy, G.3    Pilati, C.4    Jeannot, E.5    Tran Van Nhieu, J.6
  • 17
    • 0028279791 scopus 로고
    • Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
    • Boulton T.G., Stahl N., Yancopoulos G.D. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 1994, 269:11648-11655.
    • (1994) J. Biol. Chem. , vol.269 , pp. 11648-11655
    • Boulton, T.G.1    Stahl, N.2    Yancopoulos, G.D.3
  • 18
    • 0141527338 scopus 로고    scopus 로고
    • Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
    • Boulanger M.J., Bankovich A.J., Kortemme T., Baker D., Garcia K.C. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol. Cell 2003, 12:577-589.
    • (2003) Mol. Cell , vol.12 , pp. 577-589
    • Boulanger, M.J.1    Bankovich, A.J.2    Kortemme, T.3    Baker, D.4    Garcia, K.C.5
  • 19
    • 50249158577 scopus 로고    scopus 로고
    • Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex
    • Skiniotis G., Lupardus P.J., Martick M., Walz T., Garcia K.C. Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol. Cell 2008, 31:737-748.
    • (2008) Mol. Cell , vol.31 , pp. 737-748
    • Skiniotis, G.1    Lupardus, P.J.2    Martick, M.3    Walz, T.4    Garcia, K.C.5
  • 22
  • 23
    • 0028230312 scopus 로고
    • Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene
    • Lee J., Wang Z., Luoh S.M., Wood W.I., Scadden D.T. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. Gene 1994, 138:247-251.
    • (1994) Gene , vol.138 , pp. 247-251
    • Lee, J.1    Wang, Z.2    Luoh, S.M.3    Wood, W.I.4    Scadden, D.T.5
  • 24
    • 0037150728 scopus 로고    scopus 로고
    • Src in cancer: deregulation and consequences for cell behaviour
    • Frame M.C. Src in cancer: deregulation and consequences for cell behaviour. Biochim. Biophys. Acta 2002, 1602:114-130.
    • (2002) Biochim. Biophys. Acta , vol.1602 , pp. 114-130
    • Frame, M.C.1
  • 25
    • 0342501594 scopus 로고
    • Activation of the transforming potential of p60c-src by a single amino acid change
    • Levy J.B., Iba H., Hanafusa H. Activation of the transforming potential of p60c-src by a single amino acid change. Proc. Natl. Acad. Sci. U.S.A 1986, 83:4228-4232.
    • (1986) Proc. Natl. Acad. Sci. U.S.A , vol.83 , pp. 4228-4232
    • Levy, J.B.1    Iba, H.2    Hanafusa, H.3
  • 26
    • 0028349904 scopus 로고
    • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    • Shuai K., Horvath C.M., Huang L.H., Qureshi S.A., Cowburn D., Darnell J.E. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 1994, 76:821-828.
    • (1994) Cell , vol.76 , pp. 821-828
    • Shuai, K.1    Horvath, C.M.2    Huang, L.H.3    Qureshi, S.A.4    Cowburn, D.5    Darnell, J.E.6
  • 27
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z., Zhong Z., Darnell J.E. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995, 82:241-250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell, J.E.3
  • 29
    • 34347399157 scopus 로고    scopus 로고
    • A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis
    • Scarzello A.J., Romero-Weaver A.L., Maher S.G., Veenstra T.D., Zhou M., Qin A., et al. A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis. Mol. Biol. Cell 2007, 18:2455-2462.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 2455-2462
    • Scarzello, A.J.1    Romero-Weaver, A.L.2    Maher, S.G.3    Veenstra, T.D.4    Zhou, M.5    Qin, A.6
  • 33
    • 0033834679 scopus 로고    scopus 로고
    • The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6
    • Zhang T., Kee W.H., Seow K.T., Fung W., Cao X. The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6. Mol. Cell. Biol. 2000, 20:7132-7139.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7132-7139
    • Zhang, T.1    Kee, W.H.2    Seow, K.T.3    Fung, W.4    Cao, X.5
  • 35
    • 77955660663 scopus 로고    scopus 로고
    • Diverse somatic mutation patterns and pathway alterations in human cancers
    • Kan Z., Jaiswal B.S., Stinson J., Janakiraman V., Bhatt D., Stern H.M., et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 2010, 466:869-873.
    • (2010) Nature , vol.466 , pp. 869-873
    • Kan, Z.1    Jaiswal, B.S.2    Stinson, J.3    Janakiraman, V.4    Bhatt, D.5    Stern, H.M.6
  • 37
    • 56749156643 scopus 로고    scopus 로고
    • Prevalence of mutations in TSHR, GNAS PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain
    • Palos-Paz F., Perez-Guerra O., Cameselle-Teijeiro J., Rueda-Chimeno C., Barreiro-Morandeira F., Lado-Abeal J., et al. Prevalence of mutations in TSHR, GNAS PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain. Eur. J. Endocrinol. 2008, 159:623-631.
    • (2008) Eur. J. Endocrinol. , vol.159 , pp. 623-631
    • Palos-Paz, F.1    Perez-Guerra, O.2    Cameselle-Teijeiro, J.3    Rueda-Chimeno, C.4    Barreiro-Morandeira, F.5    Lado-Abeal, J.6
  • 38
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006, 314:268-274.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3    Parsons, D.W.4    Lin, J.5    Barber, T.D.6
  • 40
    • 0028116687 scopus 로고
    • Expression of mutationally activated G alpha s stimulates growth and differentiation of thyroid FRTL5 cells
    • Muca C., Vallar L. Expression of mutationally activated G alpha s stimulates growth and differentiation of thyroid FRTL5 cells. Oncogene 1994, 9:3647-3653.
    • (1994) Oncogene , vol.9 , pp. 3647-3653
    • Muca, C.1    Vallar, L.2
  • 42
    • 84862907593 scopus 로고    scopus 로고
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    • Zhang J., Ding L., Holmfeldt L., Wu G., Heatley S.L., Payne-Turner D., et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature 2012, 481:157-163.
    • (2012) Nature , vol.481 , pp. 157-163
    • Zhang, J.1    Ding, L.2    Holmfeldt, L.3    Wu, G.4    Heatley, S.L.5    Payne-Turner, D.6
  • 44
    • 77950684805 scopus 로고    scopus 로고
    • Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
    • Quintas-Cardama A., Vaddi K., Liu P., Manshouri T., Li J., Scherle P.A., et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 2010, 115:3109-3117.
    • (2010) Blood , vol.115 , pp. 3109-3117
    • Quintas-Cardama, A.1    Vaddi, K.2    Liu, P.3    Manshouri, T.4    Li, J.5    Scherle, P.A.6
  • 45
    • 0035157978 scopus 로고    scopus 로고
    • The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome
    • Miyamoto N., Sugita K., Goi K., Inukai T., Lijima K., Tezuka T., et al. The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. Leukemia 2001, 15:1758-1768.
    • (2001) Leukemia , vol.15 , pp. 1758-1768
    • Miyamoto, N.1    Sugita, K.2    Goi, K.3    Inukai, T.4    Lijima, K.5    Tezuka, T.6
  • 47
    • 77951474381 scopus 로고    scopus 로고
    • Src kinase inhibitors: an emerging therapeutic treatment option for prostate cancer
    • Edwards J. Src kinase inhibitors: an emerging therapeutic treatment option for prostate cancer. Expert Opin. Invest. Drugs 2010, 19:605-614.
    • (2010) Expert Opin. Invest. Drugs , vol.19 , pp. 605-614
    • Edwards, J.1
  • 48
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H., Shah N.P., Hochhaus A., Cortes J., Shah S., Ayala M., et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 2010, 362:2260-2270.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3    Cortes, J.4    Shah, S.5    Ayala, M.6
  • 49
    • 84890780466 scopus 로고    scopus 로고
    • STAT3 inhibitors for cancer therapy: have all roads been explored?
    • Fagard R., Metelev V., Souissi I., Baran-Marszak F. STAT3 inhibitors for cancer therapy: have all roads been explored?. Jak-Stat 2013, 2:e22882.
    • (2013) Jak-Stat , vol.2 , pp. e22882
    • Fagard, R.1    Metelev, V.2    Souissi, I.3    Baran-Marszak, F.4
  • 50
    • 84899842603 scopus 로고    scopus 로고
    • Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations
    • Rajala H.L., Porkka K., Maciejewski J.P., Loughran T.P., Mustjoki S. Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations. Ann. Med. 2014, 46:114-122.
    • (2014) Ann. Med. , vol.46 , pp. 114-122
    • Rajala, H.L.1    Porkka, K.2    Maciejewski, J.P.3    Loughran, T.P.4    Mustjoki, S.5
  • 51
    • 84887008705 scopus 로고    scopus 로고
    • STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model
    • Couronne L., Scourzic L., Pilati C., Della Valle V., Duffourd Y., Solary E., et al. STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model. Haematologica 2013, 98:1748-1752.
    • (2013) Haematologica , vol.98 , pp. 1748-1752
    • Couronne, L.1    Scourzic, L.2    Pilati, C.3    Della Valle, V.4    Duffourd, Y.5    Solary, E.6
  • 52
    • 84928015700 scopus 로고    scopus 로고
    • Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma
    • Crescenzo R., Abate F., Lasorsa E., Tabbo F., Gaudiano M., Chiesa N., et al. Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer Cell 2015, 27:516-532.
    • (2015) Cancer Cell , vol.27 , pp. 516-532
    • Crescenzo, R.1    Abate, F.2    Lasorsa, E.3    Tabbo, F.4    Gaudiano, M.5    Chiesa, N.6
  • 53
    • 79953012435 scopus 로고    scopus 로고
    • Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases
    • Stoot J.H., Coelen R.J., De Jong M.C., Dejong C.H. Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases. HPB (Oxford) 2010, 12:509-522.
    • (2010) HPB (Oxford) , vol.12 , pp. 509-522
    • Stoot, J.H.1    Coelen, R.J.2    De Jong, M.C.3    Dejong, C.H.4
  • 54
    • 78651245794 scopus 로고    scopus 로고
    • Changing trends in malignant transformation of hepatocellular adenoma
    • Farges O., Ferreira N., Dokmak S., Belghiti J., Bedossa P., Paradis V. Changing trends in malignant transformation of hepatocellular adenoma. Gut 2011, 60:85-89.
    • (2011) Gut , vol.60 , pp. 85-89
    • Farges, O.1    Ferreira, N.2    Dokmak, S.3    Belghiti, J.4    Bedossa, P.5    Paradis, V.6
  • 55
    • 84861625981 scopus 로고    scopus 로고
    • Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    • Guichard C., Amaddeo G., Imbeaud S., Ladeiro Y., Pelletier L., Maad I.B., et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat. Genet. 2012, 44:694-698.
    • (2012) Nat. Genet. , vol.44 , pp. 694-698
    • Guichard, C.1    Amaddeo, G.2    Imbeaud, S.3    Ladeiro, Y.4    Pelletier, L.5    Maad, I.B.6
  • 56
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V., Boureux A., Valle V.D., Poirel H., Quang C.T., Mauchauffe M., et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 1997, 278:1309-1312.
    • (1997) Science , vol.278 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3    Poirel, H.4    Quang, C.T.5    Mauchauffe, M.6
  • 57
    • 0030852328 scopus 로고    scopus 로고
    • Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia
    • Peeters P., Raynaud S.D., Cools J., Wlodarska I., Grosgeorge J., Philip P., et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 1997, 90:2535-2540.
    • (1997) Blood , vol.90 , pp. 2535-2540
    • Peeters, P.1    Raynaud, S.D.2    Cools, J.3    Wlodarska, I.4    Grosgeorge, J.5    Philip, P.6
  • 58
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter E.J., Scott L.M., Campbell P.J., East C., Fourouclas N., Swanton S., et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005, 365:1054-1061.
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3    East, C.4    Fourouclas, N.5    Swanton, S.6
  • 59
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C., Ugo V., Le Couedic J.P., Staerk J., Delhommeau F., Lacout C., et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 2005, 434:1144-1148.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3    Staerk, J.4    Delhommeau, F.5    Lacout, C.6
  • 61
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine R.L., Wadleigh M., Cools J., Ebert B.L., Wernig G., Huntly B.J., et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005, 7:387-397.
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3    Ebert, B.L.4    Wernig, G.5    Huntly, B.J.6
  • 66
    • 47149115129 scopus 로고    scopus 로고
    • Identification of somatic JAK1 mutations in patients with acute myeloid leukemia
    • Xiang Z., Zhao Y., Mitaksov V., Fremont D.H., Kasai Y., Molitoris A., et al. Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood 2008, 111:4809-4812.
    • (2008) Blood , vol.111 , pp. 4809-4812
    • Xiang, Z.1    Zhao, Y.2    Mitaksov, V.3    Fremont, D.H.4    Kasai, Y.5    Molitoris, A.6
  • 67
    • 80053638747 scopus 로고    scopus 로고
    • FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma
    • Elliott N.E., Cleveland S.M., Grann V., Janik J., Waldmann T.A., Dave U.P. FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma. Blood 2011, 118:3911-3921.
    • (2011) Blood , vol.118 , pp. 3911-3921
    • Elliott, N.E.1    Cleveland, S.M.2    Grann, V.3    Janik, J.4    Waldmann, T.A.5    Dave, U.P.6
  • 68
    • 84866314162 scopus 로고    scopus 로고
    • Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma
    • Koo G.C., Tan S.Y., Tang T., Poon S.L., Allen G.E., Tan L., et al. Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma. Cancer Discov. 2012, 2:591-597.
    • (2012) Cancer Discov. , vol.2 , pp. 591-597
    • Koo, G.C.1    Tan, S.Y.2    Tang, T.3    Poon, S.L.4    Allen, G.E.5    Tan, L.6
  • 69
    • 84883718528 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
    • Kan Z., Zheng H., Liu X., Li S., Barber T.D., Gong Z., et al. Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res. 2013, 23:1422-1433.
    • (2013) Genome Res. , vol.23 , pp. 1422-1433
    • Kan, Z.1    Zheng, H.2    Liu, X.3    Li, S.4    Barber, T.D.5    Gong, Z.6
  • 70
    • 65649096940 scopus 로고    scopus 로고
    • Mutational analysis of JAK1 gene in human hepatocellular carcinoma
    • Xie H.J., Bae H.J., Noh J.H., Eun J.W., Kim J.K., Jung K.H., et al. Mutational analysis of JAK1 gene in human hepatocellular carcinoma. Neoplasma 2009, 56:136-140.
    • (2009) Neoplasma , vol.56 , pp. 136-140
    • Xie, H.J.1    Bae, H.J.2    Noh, J.H.3    Eun, J.W.4    Kim, J.K.5    Jung, K.H.6
  • 71
    • 52449119447 scopus 로고    scopus 로고
    • Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers
    • (An Official Journal of the American Association for Cancer Research)
    • Jeong E.G., Kim M.S., Nam H.K., Min C.K., Lee S., Chung Y.J., et al. Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. Clin. Cancer Res. 2008, 14:3716-3721. (An Official Journal of the American Association for Cancer Research).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3716-3721
    • Jeong, E.G.1    Kim, M.S.2    Nam, H.K.3    Min, C.K.4    Lee, S.5    Chung, Y.J.6
  • 72
    • 29644439240 scopus 로고    scopus 로고
    • JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor
    • Staerk J., Kallin A., Demoulin J.B., Vainchenker W., Constantinescu S.N. JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor. J. Biol. Chem. 2005, 280:41893-41899.
    • (2005) J. Biol. Chem. , vol.280 , pp. 41893-41899
    • Staerk, J.1    Kallin, A.2    Demoulin, J.B.3    Vainchenker, W.4    Constantinescu, S.N.5
  • 73
    • 0033965488 scopus 로고    scopus 로고
    • Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains
    • Chen M., Cheng A., Candotti F., Zhou Y.J., Hymel A., Fasth A., et al. Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains. Mol. Cell. Biol. 2000, 20:947-956.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 947-956
    • Chen, M.1    Cheng, A.2    Candotti, F.3    Zhou, Y.J.4    Hymel, A.5    Fasth, A.6
  • 74
    • 0035045092 scopus 로고    scopus 로고
    • Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
    • Lindauer K., Loerting T., Liedl K.R., Kroemer R.T. Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation. Protein Eng. 2001, 14:27-37.
    • (2001) Protein Eng. , vol.14 , pp. 27-37
    • Lindauer, K.1    Loerting, T.2    Liedl, K.R.3    Kroemer, R.T.4
  • 75
    • 0037033012 scopus 로고    scopus 로고
    • The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
    • Saharinen P., Silvennoinen O. The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J. Biol. Chem. 2002, 277:47954-47963.
    • (2002) J. Biol. Chem. , vol.277 , pp. 47954-47963
    • Saharinen, P.1    Silvennoinen, O.2
  • 76
    • 84901840527 scopus 로고    scopus 로고
    • Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
    • Lupardus P.J., Ultsch M., Wallweber H., Bir Kohli P., Johnson A.R., Eigenbrot C. Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:8025-8030.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 8025-8030
    • Lupardus, P.J.1    Ultsch, M.2    Wallweber, H.3    Bir Kohli, P.4    Johnson, A.R.5    Eigenbrot, C.6
  • 79
    • 84867815120 scopus 로고    scopus 로고
    • STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
    • Jerez A., Clemente M.J., Makishima H., Koskela H., Leblanc F., Peng Ng K., et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood 2012, 120:3048-3057.
    • (2012) Blood , vol.120 , pp. 3048-3057
    • Jerez, A.1    Clemente, M.J.2    Makishima, H.3    Koskela, H.4    Leblanc, F.5    Peng Ng, K.6
  • 81
    • 34548317417 scopus 로고    scopus 로고
    • Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
    • Minegishi Y., Saito M., Tsuchiya S., Tsuge I., Takada H., Hara T., et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 2007, 448:1058-1062.
    • (2007) Nature , vol.448 , pp. 1058-1062
    • Minegishi, Y.1    Saito, M.2    Tsuchiya, S.3    Tsuge, I.4    Takada, H.5    Hara, T.6
  • 82
  • 84
    • 0033521886 scopus 로고    scopus 로고
    • Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530
    • Egan C., Pang A., Durda D., Cheng H.C., Wang J.H., Fujita D.J. Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530. Oncogene 1999, 18:1227-1237.
    • (1999) Oncogene , vol.18 , pp. 1227-1237
    • Egan, C.1    Pang, A.2    Durda, D.3    Cheng, H.C.4    Wang, J.H.5    Fujita, D.J.6
  • 86
    • 0032932248 scopus 로고    scopus 로고
    • Activating SRC mutation in a subset of advanced human colon cancers
    • Irby R.B., Mao W., Coppola D., Kang J., Loubeau J.M., Trudeau W., et al. Activating SRC mutation in a subset of advanced human colon cancers. Nat. Genet. 1999, 21:187-190.
    • (1999) Nat. Genet. , vol.21 , pp. 187-190
    • Irby, R.B.1    Mao, W.2    Coppola, D.3    Kang, J.4    Loubeau, J.M.5    Trudeau, W.6
  • 87
    • 0032987119 scopus 로고    scopus 로고
    • Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma
    • Masaki T., Okada M., Tokuda M., Shiratori Y., Hatase O., Shirai M., et al. Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma. Hepatology 1999, 29:379-384.
    • (1999) Hepatology , vol.29 , pp. 379-384
    • Masaki, T.1    Okada, M.2    Tokuda, M.3    Shiratori, Y.4    Hatase, O.5    Shirai, M.6
  • 89
    • 84915748822 scopus 로고    scopus 로고
    • LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer
    • Schwarz L.J., Fox E.M., Balko J.M., Garrett J.T., Kuba M.G., Estrada M.V., et al. LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer. J. Clin. Invest. 2014, 124:5490-5502.
    • (2014) J. Clin. Invest. , vol.124 , pp. 5490-5502
    • Schwarz, L.J.1    Fox, E.M.2    Balko, J.M.3    Garrett, J.T.4    Kuba, M.G.5    Estrada, M.V.6
  • 90
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • Dalgliesh G.L., Furge K., Greenman C., Chen L., Bignell G., Butler A., et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010, 463:360-363.
    • (2010) Nature , vol.463 , pp. 360-363
    • Dalgliesh, G.L.1    Furge, K.2    Greenman, C.3    Chen, L.4    Bignell, G.5    Butler, A.6
  • 91
    • 78651403369 scopus 로고    scopus 로고
    • Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing
    • Zang Z.J., Ong C.K., Cutcutache I., Yu W., Zhang S.L., Huang D., et al. Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. Cancer Res. 2011, 71:29-39.
    • (2011) Cancer Res. , vol.71 , pp. 29-39
    • Zang, Z.J.1    Ong, C.K.2    Cutcutache, I.3    Yu, W.4    Zhang, S.L.5    Huang, D.6
  • 94
    • 70349929295 scopus 로고    scopus 로고
    • Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer
    • Kubo T., Kuroda Y., Kokubu A., Hosoda F., Arai Y., Hiraoka N., et al. Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer. Pancreas 2009, 38:e200-e206.
    • (2009) Pancreas , vol.38 , pp. e200-e206
    • Kubo, T.1    Kuroda, Y.2    Kokubu, A.3    Hosoda, F.4    Arai, Y.5    Hiraoka, N.6
  • 95
    • 84930615212 scopus 로고    scopus 로고
    • Cancer-associated mutations in breast tumor kinase/PTK6 differentially affect enzyme activity and substrate recognition
    • Tsui T., Miller W.T. Cancer-associated mutations in breast tumor kinase/PTK6 differentially affect enzyme activity and substrate recognition. Biochemistry 2015, 54:173-182.
    • (2015) Biochemistry , vol.54 , pp. 173-182
    • Tsui, T.1    Miller, W.T.2


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