STAT3 mutations are highly specific for large granular lymphocytic leukemia

Leukemia

Volumn 27, Issue 7, 2013, Pages 1598-1600

  Fasan, A ^a   Kern, W ^a   Grossmann, V ^a   Haferlach, C ^a   Haferlach, T ^a   Schnittger, S ^a  

^a MLL MUNICH LEUKEMIA LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; HEMOGLOBIN; STAT3 PROTEIN; T LYMPHOCYTE RECEPTOR;

AMINO TERMINAL SEQUENCE; ANEMIA; AUTOIMMUNE DISEASE; CYTOTOXIC T LYMPHOCYTE; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; FLOW CYTOMETRY; HEMOGLOBIN BLOOD LEVEL; HUMAN; IMMUNOPHENOTYPING; LARGE GRANULAR LYMPHOCYTE LEUKEMIA; LETTER; LEUKOCYTE COUNT; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NATURAL KILLER CELL; NEUTROPENIA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECURRENT INFECTION; RHEUMATOID ARTHRITIS; SPLENOMEGALY; THROMBOCYTE COUNT; WILD TYPE;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC; MALE; MIDDLE AGED; MUTATION; STAT3 TRANSCRIPTION FACTOR; YOUNG ADULT;

EID: 84880255142     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.350     Document Type: Letter

References (9)

1. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. (International Agency for Research on Cancer (IARC): Lyon, 2008.
2. Sokol L, Loughran TP Jr. Large granular lymphocyte leukemia. Oncologist 2006; 11: 263-273.
3. Koskela HL, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanmaki H, Andersson EI et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med 2012; 366: 1905-1913.
4. Jerez A, Clemente MJ, Makishima H, Koskela H, Leblanc F, Ng KP et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T cell large granular lymphocyte leukemia. Blood 2012; 120: 3048-3057.
5. Kern W, Bacher U, Haferlach C, Alpermann T, Dicker F, Schnittger S et al. Frequency and prognostic impact of the aberrant CD8 expression in 5,523 patients with chronic lymphocytic leukemia. Cytometry B Clin Cytom 2012; 82: 145-150.
6. van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257-2317.
7. Lamy T, Loughran TP Jr. How I treat LGL leukemia. Blood 2011; 117: 2764-2774.
8. Sosin MD, Handa SI. Spontaneous remission of large granular lymphocytic leukaemia. Int J Clin Pract 2003; 57: 551-552.
9. Shichishima T, Kawaguchi M, Ono N, Oshimi K, Nakamura N, Maruyama Y. Gammadelta T-cell large granular lymphocyte (LGL) leukemia with spontaneous remission. Am J Hematol 2004; 75: 168-172.