GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation

Journal of Hepatology

Volumn 56, Issue 1, 2012, Pages 184-191

  Nault, Jean Charles ^a,b   Fabre, Monique ^c   Couchy, Gabrielle ^a,b   Pilati, Camilla ^a,b   Jeannot, Emmanuelle ^a,b   Tran Van Nhieu, Jeanne ^d   Saint Paul, Marie Christine ^e   De Muret, Anne ^f   Redon, Marie José ^c   Buffet, Catherine ^c   Salenave, Sylvie ^c   Balabaud, Charles ^g   Prevot, Sophie ^h   Labrune, Philippe ^h   Bioulac Sage, Paulette ⁱ   Scoazec, Jean Yves ^j   Chanson, Philippe ^c   Zucman Rossi, Jessica ^a,b,k  

^a Université Paris 13   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c BICÊTRE HOSPITAL   (France)

^d HENRI MONDOR HOSPITAL   (France)

^e PASTEUR HOSPITAL   (France)

^f SERVICE DE DERMATOLOGIE   (France)

^g HÔPITAL SAINT ANDRÉ   (France)

^h ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

ⁱ HÔPITAL PELLEGRIN   (France)

^j EDOUARD HERRIOT HOSPITAL   (France)

^k HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

more..

Author keywords

catenin; C reactive protein; cAMP; cDNA; complementary deoxyribonucleic acid; CRP; CTNNB1; cyclic adenosine monophosphate; G protein alpha stimulatory subunit; glycoprotein 130; GNAS; gp130; GTP; guanosine 5 triphosphate; HCA; HCC; hepatocellular adenoma; hepatocellular carcinoma; hepatocyte nuclear factor 1A; HNF1A; IHCA; IL6ST; inflammatory hepatocellular adenoma; interleukine 6 signal transducer; JNK; jun N terminal kinase; macroregenerative nodule; MAP kinase; MCA; McCune Albright syndrome; mitogen activated proteins kinase; MRN; NESP55; neuroendocrine secretory protein 55; PKA; protein kinase A; SAA; serum amyloid A

Indexed keywords

CYCLIC AMP; G PROTEIN ALPHA STIMULATORY SUBUNIT; GENOMIC DNA; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INTERFERON; INTERLEUKIN 6; STAT3 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ALBRIGHT SYNDROME; ARTICLE; BENIGN TUMOR; BLADDER CANCER; CANCER SCREENING; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENETIC SCREENING; HEPATITIS B; HUMAN; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER TUMOR; MALE; MUTATIONAL ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SOMATIC MUTATION;

ADENOMA, LIVER CELL; ADULT; AGED; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; FIBROUS DYSPLASIA, POLYOSTOTIC; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MUTATION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 83555161680     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.07.018     Document Type: Article

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