Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

Experimental Gerontology

Volumn 68, Issue , 2015, Pages 66-70

  Nacarelli, Timothy ^a   Azar, Ashley ^a   Sell, Christian ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Mitochondria; MTOR; P53; P70S6K; ROS; S6 kinase; Senescence

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; S6 KINASE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; REACTIVE OXYGEN METABOLITE; TARGET OF RAPAMYCIN KINASE;

AGING; ARTICLE; CELL AGING; CELL GROWTH; CELL SURVIVAL; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GROWTH REGULATION; HUMAN; INTRACELLULAR SIGNALING; LIFESPAN; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA TRANSLATION; SENESCENCE; TRANSLATION INITIATION; ANIMAL; AUTOPHAGY; LONGEVITY; METABOLISM; MOUSE; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

AGING; ANIMALS; AUTOPHAGY; CELL AGING; HUMANS; LONGEVITY; MICE; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES;

EID: 84941272088     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.11.004     Document Type: Article

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