Differential activation of mTOR Complex 1 Signaling in human brain with mild to severe Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 38, Issue 2, 2014, Pages 437-444

  Sun, Yong Xin ^a   Ji, Xunming ^a   Mao, Xiaoou ^b   Xie, Lin ^b   Jia, Jianping ^a   Galvan, Veronica ^c   Greenberg, David A ^b   Jin, Kunlin ^a,b,d  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Alzheimer's disease; cognitive impairment; mTOR; RagC; rapamycin

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; RAGC PROTEIN; RAPAMYCIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE SEVERITY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ALZHEIMER'S DISEASE; COGNITIVE IMPAIRMENT; MTOR; RAGC; RAPAMYCIN;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; COGNITION DISORDERS; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MALE; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; POSTMORTEM CHANGES; PSYCHIATRIC STATUS RATING SCALES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; YOUNG ADULT;

EID: 84889587250     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-131124     Document Type: Article

References (27)

1. Wiederrecht GJ, Sabers CJ, Brunn GJ, Martin MM, Dumont FJ, Abraham RT (1995) Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res 1, 53-71.
2. Laplante M, SabatiniDM(2009) mTOR signaling at a glance. J Cell Sci 122, 3589-3594.
3. Hoeffer CA, Klann E (2010) mTOR signaling: At the crossroads of plasticity, memory and disease. Trends Neurosci 33, 67-75.
4. Vignot S, Faivre S, Aguirre D, Raymond E (2005) mTORtargeted therapy of cancer with rapamycin derivatives. Ann Oncol 16, 525-537. (Pubitemid 40613318)
5. Chong ZZ, Shang YC, Maiese K (2011) Cardiovascular disease and mTOR signaling. Trends Cardiovasc Med 21, 151-155.
6. Dazert E, Hall MN (2011) mTOR signaling in disease. Current Opin Cell Biol 23, 744-755.
7. Chauhan A, Sharma U, Jagannathan NR, Reeta KH, Gupta YK(2011) Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats. Behav Brain Res 225, 603-609.
8. Don AS, Tsang CK, Kazdoba TM, D'Arcangelo G, Young W, Zheng XF (2012) Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries. Drug Disc Today 17, 861-868.
9. Chong ZZ, Shang YC, Zhang L, Wang S, Maiese K (2010) Mammalian target of rapamycin: Hitting the bull's-eye for neurological disorders. Oxid Med Cell Longev 3, 374-391.
10. Caccamo A, Majumder S, Richardson A, Strong R, Oddo S (2010) Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and tau: Effects on cognitive impairments. J Biol Chem 285, 13107-13120.
11. Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V (2010) Inhibition ofmTORby rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 5, e9979.
12. Jin K, Peel AL, Mao XO, Xie L, Cottrell BA, Henshall DC, GreenbergDA(2004) Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci USA 101, 343-347. (Pubitemid 38084252)
13. Mirra S, Heyman A, McKeel D, Sumi S, Crain B, Brownlee L, Vogel F, Hughes J, van Belle G, Berg L (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Neurology 41, 479-486.
14. Wang X, Mao X, Xie L, Greenberg DA, Jin K (2009) Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo. J Cereb Blood Flow Metab 29, 1644-1654.
15. Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM (2012) Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150, 1196-1208.
16. Puighermanal E, Marsicano G, Busquets-Garcia A, Lutz B, Maldonado R, Ozaita A (2009) Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nature Neurosci 12, 1152-1158.
17. Tischmeyer W, Schicknick H, Kraus M, Seidenbecher CI, Staak S, Scheich H, Gundelfinger ED (2003) Rapamycinsensitive signalling in long-term consolidation of auditory cortex-dependent memory. Eur J Neurosci 18, 942-950. (Pubitemid 37059704)
18. Ehninger D, Han S, ShilyanskyC, ZhouY, LiW, Kwiatkowski DJ, Ramesh V, Silva AJ (2008) Reversal of learning deficits in a Tsc2+/-mouse model of tuberous sclerosis. Nat Med 14, 843-848.
19. Majumder S, Richardson A, Strong R, Oddo S (2011) Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One 6, e25416.
20. Cuervo AM, Bergamini E, Brunk UT, Droge W, Ffrench M, Terman A (2005) Autophagy and aging: The importance of maintaining "clean" cells. Autophagy 1, 131-140.
21. Caccamo A, Maldonado MA, Majumder S, Medina DX, Holbein W, Magri A, Oddo S (2011) Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism. J Biol Chem 286, 8924-8932.
22. Rasool S, Albay R, 3rd, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG (2012) Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Mol Neurodegener 7, 37.
23. Ma Y, Li Y, Zong LX, Xing XN, Zhang WG, Cao YP (2011) Improving memory and decreasing cognitive impairment in Tg-APPswe/PSEN1dE9 mice with Abeta3-10 repeat fragment plasmid by reducing Abeta deposition and inflammatory response. Brain Res 1400, 112-124.
24. Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (2001) Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J Biol Chem 276, 7246-7257.
25. Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, SabatiniDM(2008) The Rag GTPases bind raptor and mediate amino acid signaling tomTORC1. Science 320, 1496-1501. (Pubitemid 351929429)
26. Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL (2008) Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 10, 935-945.
27. Narita M,Young AR, Arakawa S, Samarajiwa SA, Nakashima T,Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M,Tavare S, Inoki K, Shimizu S (2011) Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 332, 966-970.