메뉴 건너뛰기




Volumn 6, Issue MAY, 2015, Pages

Genetic variants in microRNA genes: Impact on microRNA expression, function, and disease

Author keywords

Disease; Expression; Function; Genetic variants; microRNA

Indexed keywords

ARGONAUTE PROTEIN; DICER; DROSHA; EXPORTIN 5; MICRORNA; MIRTRON; RIBONUCLEASE; RNA INDUCED SILENCING COMPLEX; UNCLASSIFIED DRUG;

EID: 84940107800     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2015.00186     Document Type: Review
Times cited : (111)

References (121)
  • 1
    • 84928821944 scopus 로고    scopus 로고
    • Update on non-canonical microRNAs
    • Abdelfattah, A. M., Park, C., and Choi, M. Y. (2014). Update on non-canonical microRNAs. Biomol. Concepts 5, 275-287. doi: 10.1515/bmc-2014-0012.
    • (2014) Biomol. Concepts , vol.5 , pp. 275-287
    • Abdelfattah, A.M.1    Park, C.2    Choi, M.Y.3
  • 2
    • 65649106561 scopus 로고    scopus 로고
    • Prediction of guide strand of microRNAs from its sequence and secondary structure
    • Ahmed, F., Ansari, H. R., and Raghava, G. P. S. (2009). Prediction of guide strand of microRNAs from its sequence and secondary structure. BMC Bioinformatics 10:105. doi: 10.1186/1471-2105-10-105.
    • (2009) BMC Bioinformatics , vol.10 , pp. 105
    • Ahmed, F.1    Ansari, H.R.2    Raghava, G.P.S.3
  • 3
    • 84885338088 scopus 로고    scopus 로고
    • PHDcleav: a SVM based method for predicting human Dicer cleavage sites using sequence and secondary structure of miRNA precursors
    • Ahmed, F., Kaundal, R., and Raghava, G. P. S. (2013). PHDcleav: a SVM based method for predicting human Dicer cleavage sites using sequence and secondary structure of miRNA precursors. BMC Bioinformatics 14(Suppl. 14):S9. doi: 10.1186/1471-2105-14-S14-S9.
    • (2013) BMC Bioinformatics , vol.14 , pp. S9
    • Ahmed, F.1    Kaundal, R.2    Raghava, G.P.S.3
  • 4
    • 84874086395 scopus 로고    scopus 로고
    • Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing
    • Auyeung, V. C., Ulitsky, I., McGeary, S. E., and Bartel, D. P. (2013). Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Cell 152, 844-858. doi: 10.1016/j.cell.2013.01.031.
    • (2013) Cell , vol.152 , pp. 844-858
    • Auyeung, V.C.1    Ulitsky, I.2    McGeary, S.E.3    Bartel, D.P.4
  • 5
    • 77951164018 scopus 로고    scopus 로고
    • Differential regulation of microRNA stability
    • Bail, S., Swerdel, M., Liu, H., Jiao, X., Goff, L. A., Hart, R. P., et al. (2010). Differential regulation of microRNA stability. RNA 16, 1032-1039. doi: 10.1261/rna.1851510.
    • (2010) RNA , vol.16 , pp. 1032-1039
    • Bail, S.1    Swerdel, M.2    Liu, H.3    Jiao, X.4    Goff, L.A.5    Hart, R.P.6
  • 6
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel, D. P. (2009). MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233. doi: 10.1016/j.cell.2009.01.002.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 7
    • 13944260434 scopus 로고    scopus 로고
    • Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes
    • Baskerville, S., and Bartel, D. P. (2005). Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 11, 241-247. doi: 10.1261/rna.7240905.
    • (2005) RNA , vol.11 , pp. 241-247
    • Baskerville, S.1    Bartel, D.P.2
  • 8
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E., Caudy, A. A., Hammond, S. M., and Hannon, G. J. (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366. doi: 10.1038/35053110.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 9
    • 79957622234 scopus 로고    scopus 로고
    • miRvar: a comprehensive database for genomic variations in microRNAs
    • Bhartiya, D., Laddha, S. V., Mukhopadhyay, A., and Scaria, V. (2011). miRvar: a comprehensive database for genomic variations in microRNAs. Hum. Mutat. 32, E2226-E2245. doi: 10.1002/humu.21482.
    • (2011) Hum. Mutat , vol.32 , pp. E2226-E2245
    • Bhartiya, D.1    Laddha, S.V.2    Mukhopadhyay, A.3    Scaria, V.4
  • 10
    • 84891770518 scopus 로고    scopus 로고
    • PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways
    • Bhattacharya, A., Ziebarth, J. D., and Cui, Y. (2014). PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways. Nucleic Acids Res. 42, D86-D91. doi: 10.1093/nar/gkt1028.
    • (2014) Nucleic Acids Res , vol.42 , pp. D86-D91
    • Bhattacharya, A.1    Ziebarth, J.D.2    Cui, Y.3
  • 11
    • 1642499415 scopus 로고    scopus 로고
    • Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
    • Bohnsack, M. T., Czaplinski, K., and Gorlich, D. (2004). Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10, 185-191. doi: 10.1261/rna.5167604.
    • (2004) RNA , vol.10 , pp. 185-191
    • Bohnsack, M.T.1    Czaplinski, K.2    Gorlich, D.3
  • 12
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin, G. A., and Croce, C. M. (2006). MicroRNA signatures in human cancers. Nat. Rev. Cancer 6, 857-866. doi: 10.1038/nrc1997.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 13
    • 27244434788 scopus 로고    scopus 로고
    • A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    • Calin, G. A., Ferracin, M., Cimmino, A., Di Leva, G., Shimizu, M., Wojcik, S. E., et al. (2005). A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N. Engl. J. Med. 353, 1793-1801. doi: 10.1056/NEJMoa050995.
    • (2005) N. Engl. J. Med , vol.353 , pp. 1793-1801
    • Calin, G.A.1    Ferracin, M.2    Cimmino, A.3    Di Leva, G.4    Shimizu, M.5    Wojcik, S.E.6
  • 14
    • 84874631107 scopus 로고    scopus 로고
    • Concordant and discordant regulation of target genes by miR-31 and its isoforms
    • Chan, Y.-T., Lin, Y.-C., Lin, R.-J., Kuo, H.-H., Thang, W.-C., Chiu, K.-P., et al. (2013). Concordant and discordant regulation of target genes by miR-31 and its isoforms. PLoS ONE 8:e58169. doi: 10.1371/journal.pone.0058169.
    • (2013) PLoS ONE , vol.8
    • Chan, Y.-T.1    Lin, Y.-C.2    Lin, R.-J.3    Kuo, H.-H.4    Thang, W.-C.5    Chiu, K.-P.6
  • 15
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen, C.-Z., Li, L., Lodish, H. F., and Bartel, D. P. (2004). MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83-86. doi: 10.1126/science.1091903.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.-Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 16
    • 84938995518 scopus 로고    scopus 로고
    • YM500v2: a small RNA sequencing (smRNA-seq) database for human cancer miRNome research
    • Cheng, W.-C., Chung, I.-F., Tsai, C.-F., Huang, T.-S., Chen, C.-Y., Wang, S.-C., et al. (2015). YM500v2: a small RNA sequencing (smRNA-seq) database for human cancer miRNome research. Nucleic Acids Res. 43, D862-D867. doi: 10.1093/nar/gku1156.
    • (2015) Nucleic Acids Res , vol.43 , pp. D862-D867
    • Cheng, W.-C.1    Chung, I.-F.2    Tsai, C.-F.3    Huang, T.-S.4    Chen, C.-Y.5    Wang, S.-C.6
  • 17
    • 67749132423 scopus 로고    scopus 로고
    • Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    • Chi, S. W., Zang, J. B., Mele, A., and Darnell, R. B. (2009). Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 460, 479-486. doi: 10.1038/nature08170.
    • (2009) Nature , vol.460 , pp. 479-486
    • Chi, S.W.1    Zang, J.B.2    Mele, A.3    Darnell, R.B.4
  • 18
    • 84855168259 scopus 로고    scopus 로고
    • MicroRNAs and their isomiRs function cooperatively to target common biological pathways
    • Cloonan, N., Wani, S., Xu, Q., Gu, J., Lea, K., Heater, S., et al. (2011). MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biol. 12:R126. doi: 10.1186/gb-2011-12-12-r126.
    • (2011) Genome Biol , vol.12 , pp. R126
    • Cloonan, N.1    Wani, S.2    Xu, Q.3    Gu, J.4    Lea, K.5    Heater, S.6
  • 19
    • 78650306521 scopus 로고    scopus 로고
    • Small RNA sorting: matchmaking for Argonautes
    • Czech, B., and Hannon, G. J. (2011). Small RNA sorting: matchmaking for Argonautes. Nat. Rev. Genet. 12, 19-31. doi: 10.1038/nrg2916.
    • (2011) Nat. Rev. Genet , vol.12 , pp. 19-31
    • Czech, B.1    Hannon, G.J.2
  • 20
    • 84878769614 scopus 로고    scopus 로고
    • Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease
    • de Boer, H. C., van Solingen, C., Prins, J., Duijs, J. M. G. J., Huisman, M. V., Rabelink, T. J., et al. (2013). Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease. Eur. Heart J. 34, 3451-3457. doi: 10.1093/eurheartj/eht007.
    • (2013) Eur. Heart J , vol.34 , pp. 3451-3457
    • de Boer, H.C.1    van Solingen, C.2    Prins, J.3    Duijs, J.M.G.J.4    Huisman, M.V.5    Rabelink, T.J.6
  • 21
    • 9144224451 scopus 로고    scopus 로고
    • Processing of primary microRNAs by the Microprocessor complex
    • Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., and Hannon, G. J. (2004). Processing of primary microRNAs by the Microprocessor complex. Nature 432, 231-235. doi: 10.1038/nature03049.
    • (2004) Nature , vol.432 , pp. 231-235
    • Denli, A.M.1    Tops, B.B.J.2    Plasterk, R.H.A.3    Ketting, R.F.4    Hannon, G.J.5
  • 22
    • 33745700209 scopus 로고    scopus 로고
    • Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing
    • Diederichs, S., and Haber, D. A. (2006). Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing. Cancer Res. 66, 6097-6104. doi: 10.1158/0008-5472.CAN-06-0537.
    • (2006) Cancer Res , vol.66 , pp. 6097-6104
    • Diederichs, S.1    Haber, D.A.2
  • 23
    • 34447319406 scopus 로고    scopus 로고
    • Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA
    • Duan, R., Pak, C., and Jin, P. (2007). Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum. Mol. Genet. 16, 1124-1131. doi: 10.1093/hmg/ddm062.
    • (2007) Hum. Mol. Genet , vol.16 , pp. 1124-1131
    • Duan, R.1    Pak, C.2    Jin, P.3
  • 24
    • 77955119567 scopus 로고    scopus 로고
    • DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures
    • Faller, M., Toso, D., Matsunaga, M., Atanasov, I., Senturia, R., Chen, Y., et al. (2010). DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA 16, 1570-1583. doi: 10.1261/rna.2111310.
    • (2010) RNA , vol.16 , pp. 1570-1583
    • Faller, M.1    Toso, D.2    Matsunaga, M.3    Atanasov, I.4    Senturia, R.5    Chen, Y.6
  • 25
    • 84884898026 scopus 로고    scopus 로고
    • miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-a, CCNJ, and MEGF9
    • Feliciano, A., Castellvi, J., Artero-Castro, A., Leal, J. A., Romagosa, C., Hernández-Losa, J., et al. (2013). miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-a, CCNJ, and MEGF9. PLoS ONE 8:e76247. doi: 10.1371/journal.pone.0076247.
    • (2013) PLoS ONE , vol.8
    • Feliciano, A.1    Castellvi, J.2    Artero-Castro, A.3    Leal, J.A.4    Romagosa, C.5    Hernández-Losa, J.6
  • 26
    • 67651241751 scopus 로고    scopus 로고
    • Evidence for X-chromosomal schizophrenia associated with microRNA alterations
    • Feng, J., Sun, G., Yan, J., Noltner, K., Li, W., Buzin, C. H., et al. (2009). Evidence for X-chromosomal schizophrenia associated with microRNA alterations. PLoS ONE 4:e6121. doi: 10.1371/journal.pone.0006121.
    • (2009) PLoS ONE , vol.4
    • Feng, J.1    Sun, G.2    Yan, J.3    Noltner, K.4    Li, W.5    Buzin, C.H.6
  • 27
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    • Filipowicz, W., Bhattacharyya, S. N., and Sonenberg, N. (2008). Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat. Rev. Genet. 9, 102-114. doi: 10.1038/nrg2290.
    • (2008) Nat. Rev. Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 29
    • 84880416653 scopus 로고    scopus 로고
    • No association of functional variant in pri-miR-218 and risk of congenital heart disease in a Chinese population
    • Gao, X., Yang, L., Ma, Y., Yang, J., Zhang, G., Huang, G., et al. (2013). No association of functional variant in pri-miR-218 and risk of congenital heart disease in a Chinese population. Gene 523, 173-177. doi: 10.1016/j.gene.2013.03.119.
    • (2013) Gene , vol.523 , pp. 173-177
    • Gao, X.1    Yang, L.2    Ma, Y.3    Yang, J.4    Zhang, G.5    Huang, G.6
  • 30
    • 84857691987 scopus 로고    scopus 로고
    • Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis
    • Gong, J., Tong, Y., Zhang, H.-M., Wang, K., Hu, T., Shan, G., et al. (2012). Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Hum. Mutat. 33, 254-263. doi: 10.1002/humu.21641.
    • (2012) Hum. Mutat , vol.33 , pp. 254-263
    • Gong, J.1    Tong, Y.2    Zhang, H.-M.3    Wang, K.4    Hu, T.5    Shan, G.6
  • 31
    • 9144225636 scopus 로고    scopus 로고
    • The Microprocessor complex mediates the genesis of microRNAs
    • Gregory, R. I., Yan, K.-P., Amuthan, G., Chendrimada, T., Doratotaj, B., Cooch, N., et al. (2004). The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235-240. doi: 10.1038/nature03120.
    • (2004) Nature , vol.432 , pp. 235-240
    • Gregory, R.I.1    Yan, K.-P.2    Amuthan, G.3    Chendrimada, T.4    Doratotaj, B.5    Cooch, N.6
  • 32
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok, A., Pasquinelli, A. E., Conte, D., Li, N., Parrish, S., Ha, I., et al. (2001). Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106, 23-34. doi: 10.1016/S0092-8674(01)00431-7.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6
  • 34
    • 84869037267 scopus 로고    scopus 로고
    • The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo
    • Gu, S., Jin, L., Zhang, Y., Huang, Y., Zhang, F., Valdmanis, P. N., et al. (2012). The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell 151, 900-911. doi: 10.1016/j.cell.2012.09.042.
    • (2012) Cell , vol.151 , pp. 900-911
    • Gu, S.1    Jin, L.2    Zhang, Y.3    Huang, Y.4    Zhang, F.5    Valdmanis, P.N.6
  • 35
    • 77950920903 scopus 로고    scopus 로고
    • Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
    • Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., et al. (2010). Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141, 129-141. doi: 10.1016/j.cell.2010.03.009.
    • (2010) Cell , vol.141 , pp. 129-141
    • Hafner, M.1    Landthaler, M.2    Burger, L.3    Khorshid, M.4    Hausser, J.5    Berninger, P.6
  • 36
    • 70349820140 scopus 로고    scopus 로고
    • Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells
    • Hagan, J. P., Piskounova, E., and Gregory, R. I. (2009). Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat. Struct. Mol. Biol. 16, 1021-1025. doi: 10.1038/nsmb.1676.
    • (2009) Nat. Struct. Mol. Biol , vol.16 , pp. 1021-1025
    • Hagan, J.P.1    Piskounova, E.2    Gregory, R.I.3
  • 37
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • Han, J., Lee, Y., Yeom, K.-H., Kim, Y.-K., Jin, H., and Kim, V. N. (2004). The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18, 3016-3027. doi: 10.1101/gad.1262504.
    • (2004) Genes Dev , vol.18 , pp. 3016-3027
    • Han, J.1    Lee, Y.2    Yeom, K.-H.3    Kim, Y.-K.4    Jin, H.5    Kim, V.N.6
  • 38
    • 33744520104 scopus 로고    scopus 로고
    • Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex
    • Han, J., Lee, Y., Yeom, K.-H., Nam, J.-W., Heo, I., Rhee, J.-K., et al. (2006). Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 125, 887-901. doi: 10.1016/j.cell.2006.03.043.
    • (2006) Cell , vol.125 , pp. 887-901
    • Han, J.1    Lee, Y.2    Yeom, K.-H.3    Nam, J.-W.4    Heo, I.5    Rhee, J.-K.6
  • 39
    • 84892418266 scopus 로고    scopus 로고
    • Comprehensive analysis of single nucleotide polymorphisms in human microRNAs
    • Han, M., and Zheng, Y. (2013). Comprehensive analysis of single nucleotide polymorphisms in human microRNAs. PLoS ONE 8:e78028. doi: 10.1371/journal.pone.0078028.
    • (2013) PLoS ONE , vol.8
    • Han, M.1    Zheng, Y.2
  • 40
    • 84876935138 scopus 로고    scopus 로고
    • Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding
    • Helwak, A., Kudla, G., Dudnakova, T., and Tollervey, D. (2013). Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Cell 153, 654-665. doi: 10.1016/j.cell.2013.03.043.
    • (2013) Cell , vol.153 , pp. 654-665
    • Helwak, A.1    Kudla, G.2    Dudnakova, T.3    Tollervey, D.4
  • 41
    • 84868153864 scopus 로고    scopus 로고
    • Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs
    • Heo, I., Ha, M., Lim, J., Yoon, M.-J., Park, J.-E., Kwon, S. C., et al. (2012). Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs. Cell 151, 521-532. doi: 10.1016/j.cell.2012.09.022.
    • (2012) Cell , vol.151 , pp. 521-532
    • Heo, I.1    Ha, M.2    Lim, J.3    Yoon, M.-J.4    Park, J.-E.5    Kwon, S.C.6
  • 42
    • 53949088050 scopus 로고    scopus 로고
    • Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA
    • Heo, I., Joo, C., Cho, J., Ha, M., Han, J., and Kim, V. N. (2008). Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol. Cell 32, 276-284. doi: 10.1016/j.molcel.2008.09.014.
    • (2008) Mol. Cell , vol.32 , pp. 276-284
    • Heo, I.1    Joo, C.2    Cho, J.3    Ha, M.4    Han, J.5    Kim, V.N.6
  • 43
    • 68749102148 scopus 로고    scopus 로고
    • TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
    • Heo, I., Joo, C., Kim, Y.-K., Ha, M., Yoon, M.-J., Cho, J., et al. (2009). TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138, 696-708. doi: 10.1016/j.cell.2009.08.002.
    • (2009) Cell , vol.138 , pp. 696-708
    • Heo, I.1    Joo, C.2    Kim, Y.-K.3    Ha, M.4    Yoon, M.-J.5    Cho, J.6
  • 44
    • 70350271175 scopus 로고    scopus 로고
    • Sequence features associated with microRNA strand selection in humans and flies
    • Hu, H. Y., Yan, Z., Xu, Y., Hu, H., Menzel, C., Zhou, Y. H., et al. (2009). Sequence features associated with microRNA strand selection in humans and flies. BMC Genomics 10:413. doi: 10.1186/1471-2164-10-413.
    • (2009) BMC Genomics , vol.10 , pp. 413
    • Hu, H.Y.1    Yan, Z.2    Xu, Y.3    Hu, H.4    Menzel, C.5    Zhou, Y.H.6
  • 45
    • 84907918081 scopus 로고    scopus 로고
    • Involvement of inflammation-related miR-155 and miR-146a in diabetic nephropathy: implications for glomerular endothelial injury
    • Huang, Y., Liu, Y., Li, L., Su, B., Yang, L., Fan, W., et al. (2014). Involvement of inflammation-related miR-155 and miR-146a in diabetic nephropathy: implications for glomerular endothelial injury. BMC Nephrol. 15:142. doi: 10.1186/1471-2369-15-142.
    • (2014) BMC Nephrol , vol.15 , pp. 142
    • Huang, Y.1    Liu, Y.2    Li, L.3    Su, B.4    Yang, L.5    Fan, W.6
  • 46
    • 80955145750 scopus 로고    scopus 로고
    • Mutation altering the miR-184 seed region causes familial keratoconus with cataract
    • Hughes, A. E., Bradley, D. T., Campbell, M., Lechner, J., Dash, D. P., Simpson, D. A., et al. (2011). Mutation altering the miR-184 seed region causes familial keratoconus with cataract. Am. J. Hum. Genet. 89, 628-633. doi: 10.1016/j.ajhg.2011.09.014.
    • (2011) Am. J. Hum. Genet , vol.89 , pp. 628-633
    • Hughes, A.E.1    Bradley, D.T.2    Campbell, M.3    Lechner, J.4    Dash, D.P.5    Simpson, D.A.6
  • 47
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, E., Tuschl, T., and Zamore, P. D. (2001). A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293, 834-838. doi: 10.1126/science.1062961.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvágner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Bálint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 48
    • 80055088409 scopus 로고    scopus 로고
    • Feed-forward microprocessing and splicing activities at a microRNA-containing intron
    • Janas, M. M., Khaled, M., Schubert, S., Bernstein, J. G., Golan, D., Veguilla, R. A., et al. (2011). Feed-forward microprocessing and splicing activities at a microRNA-containing intron. PLoS Genet. 7:e1002330. doi: 10.1371/journal.pgen.1002330.
    • (2011) PLoS Genet , vol.7
    • Janas, M.M.1    Khaled, M.2    Schubert, S.3    Bernstein, J.G.4    Golan, D.5    Veguilla, R.A.6
  • 49
    • 60849084449 scopus 로고    scopus 로고
    • Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer
    • Jazdzewski, K., Liyanarachchi, S., Swierniak, M., Pachucki, J., Ringel, M. D., Jarzab, B., et al. (2009). Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. Proc. Natl. Acad. Sci. U.S.A. 106, 1502-1505. doi: 10.1073/pnas.0812591106.
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 1502-1505
    • Jazdzewski, K.1    Liyanarachchi, S.2    Swierniak, M.3    Pachucki, J.4    Ringel, M.D.5    Jarzab, B.6
  • 50
    • 44449153200 scopus 로고    scopus 로고
    • Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma
    • Jazdzewski, K., Murray, E. L., Franssila, K., Jarzab, B., Schoenberg, D. R., and de la Chapelle, A. (2008). Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc. Natl. Acad. Sci. U.S.A. 105, 7269-7274. doi: 10.1073/pnas.0802682105.
    • (2008) Proc. Natl. Acad. Sci. U.S.A , vol.105 , pp. 7269-7274
    • Jazdzewski, K.1    Murray, E.L.2    Franssila, K.3    Jarzab, B.4    Schoenberg, D.R.5    de la Chapelle, A.6
  • 51
    • 84865618700 scopus 로고    scopus 로고
    • Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response
    • Kan, A. A., van Erp, S., Derijck, A. A. H. A., de Wit, M., Hessel, E. V. S., O'Duibhir, E., et al. (2012). Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cell. Mol. Life Sci. 69, 3127-3145. doi: 10.1007/s00018-012-0992-7.
    • (2012) Cell. Mol. Life Sci , vol.69 , pp. 3127-3145
    • Kan, A.A.1    van Erp, S.2    Derijck, A.A.H.A.3    de Wit, M.4    Hessel, E.V.S.5    O'Duibhir, E.6
  • 52
    • 84894431229 scopus 로고    scopus 로고
    • Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes
    • Kawahara, Y. (2014). Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes. Congenit. Anom. (Kyoto) 54, 12-21. doi: 10.1111/cga.12043.
    • (2014) Congenit. Anom. (Kyoto) , vol.54 , pp. 12-21
    • Kawahara, Y.1
  • 53
    • 33847317017 scopus 로고    scopus 로고
    • Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
    • Kawahara, Y., Zinshteyn, B., Sethupathy, P., Iizasa, H., Hatzigeorgiou, A. G., and Nishikura, K. (2007). Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 315, 1137-1140. doi: 10.1126/science.1138050.
    • (2007) Science , vol.315 , pp. 1137-1140
    • Kawahara, Y.1    Zinshteyn, B.2    Sethupathy, P.3    Iizasa, H.4    Hatzigeorgiou, A.G.5    Nishikura, K.6
  • 55
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting, R. F., Fischer, S. E., Bernstein, E., Sijen, T., Hannon, G. J., and Plasterk, R. H. (2001). Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15, 2654-2659. doi: 10.1101/gad.927801.
    • (2001) Genes Dev , vol.15 , pp. 2654-2659
    • Ketting, R.F.1    Fischer, S.E.2    Bernstein, E.3    Sijen, T.4    Hannon, G.J.5    Plasterk, R.H.6
  • 56
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova, A., Reynolds, A., and Jayasena, S. D. (2003). Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209-216. doi: 10.1016/S0092-8674(03)00801-8.
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 57
    • 0035929322 scopus 로고    scopus 로고
    • A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans
    • Knight, S. W., and Bass, B. L. (2001). A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science 293, 2269-2271. doi: 10.1126/science.1062039.
    • (2001) Science , vol.293 , pp. 2269-2271
    • Knight, S.W.1    Bass, B.L.2
  • 58
    • 84891818318 scopus 로고    scopus 로고
    • miRBase: annotating high confidence microRNAs using deep sequencing data
    • Kozomara, A., and Griffiths-Jones, S. (2014). miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42, D68-D73. doi: 10.1093/nar/gkt1181.
    • (2014) Nucleic Acids Res , vol.42 , pp. D68-D73
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 59
    • 79959946169 scopus 로고    scopus 로고
    • Cross-linking, ligation, and sequencing of hybrids reveals RNA-RNA interactions in yeast
    • Kudla, G., Granneman, S., Hahn, D., Beggs, J. D., and Tollervey, D. (2011). Cross-linking, ligation, and sequencing of hybrids reveals RNA-RNA interactions in yeast. Proc. Natl. Acad. Sci. U.S.A. 108, 10010-10015. doi: 10.1073/pnas.1017386108.
    • (2011) Proc. Natl. Acad. Sci. U.S.A , vol.108 , pp. 10010-10015
    • Kudla, G.1    Granneman, S.2    Hahn, D.3    Beggs, J.D.4    Tollervey, D.5
  • 60
    • 84865837750 scopus 로고    scopus 로고
    • Discovery of hundreds of mirtrons in mouse and human small RNA data
    • Ladewig, E., Okamura, K., Flynt, A. S., Westholm, J. O., and Lai, E. C. (2012). Discovery of hundreds of mirtrons in mouse and human small RNA data. Genome Res. 22, 1634-1645. doi: 10.1101/gr.133553.111.
    • (2012) Genome Res , vol.22 , pp. 1634-1645
    • Ladewig, E.1    Okamura, K.2    Flynt, A.S.3    Westholm, J.O.4    Lai, E.C.5
  • 61
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana, M., Rauhut, R., Lendeckel, W., and Tuschl, T. (2001). Identification of novel genes coding for small expressed RNAs. Science 294, 853-858. doi: 10.1126/science.1064921.
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 62
    • 34250877841 scopus 로고    scopus 로고
    • A mammalian microRNA expression atlas based on small RNA library sequencing
    • Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., et al. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129, 1401-1414. doi: 10.1016/j.cell.2007.04.040.
    • (2007) Cell , vol.129 , pp. 1401-1414
    • Landgraf, P.1    Rusu, M.2    Sheridan, R.3    Sewer, A.4    Iovino, N.5    Aravin, A.6
  • 63
    • 10344248903 scopus 로고    scopus 로고
    • The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis
    • Landthaler, M., Yalcin, A., and Tuschl, T. (2004). The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Curr. Biol. 14, 2162-2167. doi: 10.1016/j.cub.2004.11.001.
    • (2004) Curr. Biol , vol.14 , pp. 2162-2167
    • Landthaler, M.1    Yalcin, A.2    Tuschl, T.3
  • 64
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau, N. C., Lim, L. P., Weinstein, E. G., and Bartel, D. P. (2001). An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862. doi: 10.1126/science.1065062.
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 65
    • 84880411222 scopus 로고    scopus 로고
    • Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
    • Lee, H. Y., Zhou, K., Smith, A. M., Noland, C. L., and Doudna, J. A. (2013). Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Res. 41, 6568-6576. doi: 10.1093/nar/gkt361.
    • (2013) Nucleic Acids Res , vol.41 , pp. 6568-6576
    • Lee, H.Y.1    Zhou, K.2    Smith, A.M.3    Noland, C.L.4    Doudna, J.A.5
  • 66
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • Lee, R. C., and Ambros, V. (2001). An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864. doi: 10.1126/science.1065329.
    • (2001) Science , vol.294 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 67
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, R. C., Feinbaum, R. L., and Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854. doi: 10.1016/0092-8674(93)90529-Y.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 68
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., et al. (2003). The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415-419. doi: 10.1038/nature01957.
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3    Choi, H.4    Kim, J.5    Yim, J.6
  • 69
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., et al. (2005). Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433, 769-773. doi: 10.1038/nature03315.
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Grimson, A.4    Schelter, J.M.5    Castle, J.6
  • 70
    • 84863245920 scopus 로고    scopus 로고
    • A genetic variant in the promoter region of miR-106b-25 cluster and risk of HBV infection and hepatocellular carcinoma
    • Liu, Y., Zhang, Y., Wen, J., Liu, L., Zhai, X., Liu, J., et al. (2012). A genetic variant in the promoter region of miR-106b-25 cluster and risk of HBV infection and hepatocellular carcinoma. PLoS ONE 7:e32230. doi: 10.1371/journal.pone.0032230.
    • (2012) PLoS ONE , vol.7
    • Liu, Y.1    Zhang, Y.2    Wen, J.3    Liu, L.4    Zhai, X.5    Liu, J.6
  • 72
    • 84924388328 scopus 로고    scopus 로고
    • Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs
    • Londin, E., Loher, P., Telonis, A. G., Quann, K., Clark, P., Jing, Y., et al. (2015). Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs. Proc. Natl. Acad. Sci. U.S.A. 112, E1106-E1115. doi: 10.1073/pnas.1420955112.
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. E1106-E1115
    • Londin, E.1    Loher, P.2    Telonis, A.G.3    Quann, K.4    Clark, P.5    Jing, Y.6
  • 73
    • 34250677322 scopus 로고    scopus 로고
    • Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs
    • Lund, E., and Dahlberg, J. E. (2006). Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs. Cold Spring Harb. Symp. Quant. Biol. 71, 59-66. doi: 10.1101/sqb.2006.71.050.
    • (2006) Cold Spring Harb. Symp. Quant. Biol , vol.71 , pp. 59-66
    • Lund, E.1    Dahlberg, J.E.2
  • 74
  • 75
    • 79959836816 scopus 로고    scopus 로고
    • A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
    • Luo, X., Yang, W., Ye, D.-Q., Cui, H., Zhang, Y., Hirankarn, N., et al. (2011). A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS Genet. 7:e1002128. doi: 10.1371/journal.pgen.1002128.
    • (2011) PLoS Genet , vol.7
    • Luo, X.1    Yang, W.2    Ye, D.-Q.3    Cui, H.4    Zhang, Y.5    Hirankarn, N.6
  • 76
    • 84890835664 scopus 로고    scopus 로고
    • Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site
    • Ma, H., Wu, Y., Choi, J.-G., and Wu, H. (2013). Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site. Proc. Natl. Acad. Sci. U.S.A. 110, 20687-20692. doi: 10.1073/pnas.1311639110.
    • (2013) Proc. Natl. Acad. Sci. U.S.A , vol.110 , pp. 20687-20692
    • Ma, H.1    Wu, Y.2    Choi, J.-G.3    Wu, H.4
  • 77
    • 79952898846 scopus 로고    scopus 로고
    • Identification of blood microRNAs associated to Parkinsonis disease
    • Margis, R., Margis, R., and Rieder, C. R. M. (2011). Identification of blood microRNAs associated to Parkinsonis disease. J. Biotechnol. 152, 96-101. doi: 10.1016/j.jbiotec.2011.01.023.
    • (2011) J. Biotechnol , vol.152 , pp. 96-101
    • Margis, R.1    Margis, R.2    Rieder, C.R.M.3
  • 78
    • 84918542774 scopus 로고    scopus 로고
    • PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs
    • Marsico, A., Huska, M. R., Lasserre, J., Hu, H., Vucicevic, D., Musahl, A., et al. (2013). PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs. Genome Biol. 14:R84. doi: 10.1186/gb-2013-14-8-r84.
    • (2013) Genome Biol , vol.14 , pp. R84
    • Marsico, A.1    Huska, M.R.2    Lasserre, J.3    Hu, H.4    Vucicevic, D.5    Musahl, A.6
  • 79
    • 77958471215 scopus 로고    scopus 로고
    • A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing
    • Martí, E., Pantano, L., Bañez-Coronel, M., Llorens, F., Miñones-Moyano, E., Porta, S., et al. (2010). A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing. Nucleic Acids Res. 38, 7219-7235. doi: 10.1093/nar/gkq575.
    • (2010) Nucleic Acids Res , vol.38 , pp. 7219-7235
    • Martí, E.1    Pantano, L.2    Bañez-Coronel, M.3    Llorens, F.4    Miñones-Moyano, E.5    Porta, S.6
  • 80
    • 84906828527 scopus 로고    scopus 로고
    • Influence of the confounding factors age and sex on microRNA profiles from peripheral blood
    • Meder, B., Backes, C., Haas, J., Leidinger, P., Stähler, C., Großmann, T., et al. (2014). Influence of the confounding factors age and sex on microRNA profiles from peripheral blood. Clin. Chem. 60, 1200-1208. doi: 10.1373/clinchem.2014.224238.
    • (2014) Clin. Chem , vol.60 , pp. 1200-1208
    • Meder, B.1    Backes, C.2    Haas, J.3    Leidinger, P.4    Stähler, C.5    Großmann, T.6
  • 81
    • 67349223927 scopus 로고    scopus 로고
    • Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss
    • Mencía, A., Modamio-Høybjør, S., Redshaw, N., Morín, M., Mayo-Merino, F., Olavarrieta, L., et al. (2009). Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat. Genet. 41, 609-613. doi: 10.1038/ng.355.
    • (2009) Nat. Genet , vol.41 , pp. 609-613
    • Mencía, A.1    Modamio-Høybjør, S.2    Redshaw, N.3    Morín, M.4    Mayo-Merino, F.5    Olavarrieta, L.6
  • 82
    • 41649106136 scopus 로고    scopus 로고
    • Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
    • Morin, R. D., O'Connor, M. D., Griffith, M., Kuchenbauer, F., Delaney, A., Prabhu, A.-L., et al. (2008). Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res. 18, 610-621. doi: 10.1101/gr.7179508.
    • (2008) Genome Res , vol.18 , pp. 610-621
    • Morin, R.D.1    O'Connor, M.D.2    Griffith, M.3    Kuchenbauer, F.4    Delaney, A.5    Prabhu, A.-L.6
  • 83
    • 84867736206 scopus 로고    scopus 로고
    • IsomiRs-the overlooked repertoire in the dynamic microRNAome
    • Neilsen, C. T., Goodall, G. J., and Bracken, C. P. (2012). IsomiRs-the overlooked repertoire in the dynamic microRNAome. Trends Genet. 28, 544-549. doi: 10.1016/j.tig.2012.07.005.
    • (2012) Trends Genet , vol.28 , pp. 544-549
    • Neilsen, C.T.1    Goodall, G.J.2    Bracken, C.P.3
  • 84
    • 84874541064 scopus 로고    scopus 로고
    • A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance
    • Ohanian, M., Humphreys, D. T., Anderson, E., Preiss, T., and Fatkin, D. (2013). A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance. BMC Genet. 14:18. doi: 10.1186/1471-2156-14-18.
    • (2013) BMC Genet , vol.14 , pp. 18
    • Ohanian, M.1    Humphreys, D.T.2    Anderson, E.3    Preiss, T.4    Fatkin, D.5
  • 85
    • 70849093653 scopus 로고    scopus 로고
    • A high-resolution structure of the pre-microRNA nuclear export machinery
    • Okada, C., Yamashita, E., Lee, S. J., Shibata, S., Katahira, J., Nakagawa, A., et al. (2009). A high-resolution structure of the pre-microRNA nuclear export machinery. Science 326, 1275-1279. doi: 10.1126/science.1178705.
    • (2009) Science , vol.326 , pp. 1275-1279
    • Okada, C.1    Yamashita, E.2    Lee, S.J.3    Shibata, S.4    Katahira, J.5    Nakagawa, A.6
  • 86
    • 79960185923 scopus 로고    scopus 로고
    • Dicer recognizes the 5' end of RNA for efficient and accurate processing
    • Park, J.-E., Heo, I., Tian, Y., Simanshu, D. K., Chang, H., Jee, D., et al. (2011). Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature 475, 201-205. doi: 10.1038/nature10198.
    • (2011) Nature , vol.475 , pp. 201-205
    • Park, J.-E.1    Heo, I.2    Tian, Y.3    Simanshu, D.K.4    Chang, H.5    Jee, D.6
  • 87
    • 0034597777 scopus 로고    scopus 로고
    • Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    • Pasquinelli, A. E., Reinhart, B. J., Slack, F., Martindale, M. Q., Kuroda, M. I., Maller, B., et al. (2000). Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408, 86-89. doi: 10.1038/35040556.
    • (2000) Nature , vol.408 , pp. 86-89
    • Pasquinelli, A.E.1    Reinhart, B.J.2    Slack, F.3    Martindale, M.Q.4    Kuroda, M.I.5    Maller, B.6
  • 88
    • 77951092180 scopus 로고    scopus 로고
    • Targeting of mRNAs by multiple miRNAs: the next step
    • Peter, M. E. (2010). Targeting of mRNAs by multiple miRNAs: the next step. Oncogene 29, 2161-2164. doi: 10.1038/onc.2010.59.
    • (2010) Oncogene , vol.29 , pp. 2161-2164
    • Peter, M.E.1
  • 89
    • 84859892863 scopus 로고    scopus 로고
    • MicroRNA profiling: approaches and considerations
    • Pritchard, C. C., Cheng, H. H., and Tewari, M. (2012). MicroRNA profiling: approaches and considerations. Nat. Rev. Genet. 13, 358-369. doi: 10.1038/nrg3198.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 358-369
    • Pritchard, C.C.1    Cheng, H.H.2    Tewari, M.3
  • 90
    • 84890696135 scopus 로고    scopus 로고
    • Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing
    • Ramalingam, P., Palanichamy, J. K., Singh, A., Das, P., Bhagat, M., Kassab, M. A., et al. (2014). Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing. RNA 20, 76-87. doi: 10.1261/rna.041814.113.
    • (2014) RNA , vol.20 , pp. 76-87
    • Ramalingam, P.1    Palanichamy, J.K.2    Singh, A.3    Das, P.4    Bhagat, M.5    Kassab, M.A.6
  • 91
  • 92
    • 33847665108 scopus 로고    scopus 로고
    • Human polymorphism at microRNAs and microRNA target sites
    • Saunders, M. A., Liang, H., and Li, W.-H. (2007). Human polymorphism at microRNAs and microRNA target sites. Proc. Natl. Acad. Sci. U.S.A. 104, 3300-3305. doi: 10.1073/pnas.0611347104.
    • (2007) Proc. Natl. Acad. Sci. U.S.A , vol.104 , pp. 3300-3305
    • Saunders, M.A.1    Liang, H.2    Li, W.-H.3
  • 93
    • 80053384370 scopus 로고    scopus 로고
    • Genome-wide association study identifies five new schizophrenia loci
    • Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. (2011). Genome-wide association study identifies five new schizophrenia loci. Nat. Genet. 43, 969-976. doi: 10.1038/ng.940.
    • (2011) Nat. Genet , vol.43 , pp. 969-976
  • 94
    • 79951539516 scopus 로고    scopus 로고
    • dPORE-miRNA: polymorphic regulation of microRNA genes
    • Schmeier, S., Schaefer, U., MacPherson, C. R., and Bajic, V. B. (2011). dPORE-miRNA: polymorphic regulation of microRNA genes. PLoS ONE 6:e16657. doi: 10.1371/journal.pone.0016657.
    • (2011) PLoS ONE , vol.6
    • Schmeier, S.1    Schaefer, U.2    MacPherson, C.R.3    Bajic, V.B.4
  • 95
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the RNAi enzyme complex
    • Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., and Zamore, P. D. (2003). Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-208. doi: 10.1016/S0092-8674(03)00759-1.
    • (2003) Cell , vol.115 , pp. 199-208
    • Schwarz, D.S.1    Hutvágner, G.2    Du, T.3    Xu, Z.4    Aronin, N.5    Zamore, P.D.6
  • 96
    • 65749093295 scopus 로고    scopus 로고
    • Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex
    • Sethi, P., and Lukiw, W. J. (2009). Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci. Lett. 459, 100-104. doi: 10.1016/j.neulet.2009.04.052.
    • (2009) Neurosci. Lett , vol.459 , pp. 100-104
    • Sethi, P.1    Lukiw, W.J.2
  • 97
    • 58749083044 scopus 로고    scopus 로고
    • Novel genetic variants in microRNA genes and familial breast cancer
    • Shen, J., Ambrosone, C. B., and Zhao, H. (2009). Novel genetic variants in microRNA genes and familial breast cancer. Int. J. Cancer 124, 1178-1182. doi: 10.1002/ijc.24008.
    • (2009) Int. J. Cancer , vol.124 , pp. 1178-1182
    • Shen, J.1    Ambrosone, C.B.2    Zhao, H.3
  • 98
    • 77951964981 scopus 로고    scopus 로고
    • Posttranscriptional regulation of microRNA biogenesis in animals
    • Siomi, H., and Siomi, M. C. (2010). Posttranscriptional regulation of microRNA biogenesis in animals. Mol. Cell 38, 323-332. doi: 10.1016/j.molcel.2010.03.013.
    • (2010) Mol. Cell , vol.38 , pp. 323-332
    • Siomi, H.1    Siomi, M.C.2
  • 99
    • 84856078759 scopus 로고    scopus 로고
    • A novel mutation within the MIR96 gene causes non-syndromic inherited hearing loss in an Italian family by altering pre-miRNA processing
    • Soldà, G., Robusto, M., Primignani, P., Castorina, P., Benzoni, E., Cesarani, A., et al. (2012). A novel mutation within the MIR96 gene causes non-syndromic inherited hearing loss in an Italian family by altering pre-miRNA processing. Hum. Mol. Genet. 21, 577-585. doi: 10.1093/hmg/ddr493.
    • (2012) Hum. Mol. Genet , vol.21 , pp. 577-585
    • Soldà, G.1    Robusto, M.2    Primignani, P.3    Castorina, P.4    Benzoni, E.5    Cesarani, A.6
  • 101
    • 84926139786 scopus 로고    scopus 로고
    • MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets
    • Strazisar, M., Cammaerts, S., van der Ven, K., Forero, D. A., Lenaerts, A.-S., Nordin, A., et al. (2015). MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets. Mol. Psychiatry. 20, 472-481. doi: 10.1038/mp.2014.53.
    • (2015) Mol. Psychiatry , vol.20 , pp. 472-481
    • Strazisar, M.1    Cammaerts, S.2    van der Ven, K.3    Forero, D.A.4    Lenaerts, A.-S.5    Nordin, A.6
  • 102
    • 69049108754 scopus 로고    scopus 로고
    • SNPs in human miRNA genes affect biogenesis and function
    • Sun, G., Yan, J., Noltner, K., Feng, J., Li, H., Sarkis, D. A., et al. (2009). SNPs in human miRNA genes affect biogenesis and function. RNA 15, 1640-1651. doi: 10.1261/rna.1560209.
    • (2009) RNA , vol.15 , pp. 1640-1651
    • Sun, G.1    Yan, J.2    Noltner, K.3    Feng, J.4    Li, H.5    Sarkis, D.A.6
  • 103
    • 84906283860 scopus 로고    scopus 로고
    • 5' isomiR variation is of functional and evolutionary importance
    • Tan, G. C., Chan, E., Molnar, A., Sarkar, R., Alexieva, D., Isa, I. M., et al. (2014). 5' isomiR variation is of functional and evolutionary importance. Nucleic Acids Res. 42, 9424-9435. doi: 10.1093/nar/gku656.
    • (2014) Nucleic Acids Res , vol.42 , pp. 9424-9435
    • Tan, G.C.1    Chan, E.2    Molnar, A.3    Sarkar, R.4    Alexieva, D.5    Isa, I.M.6
  • 104
    • 67649277689 scopus 로고    scopus 로고
    • The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
    • Trabucchi, M., Briata, P., Garcia-Mayoral, M., Haase, A. D., Filipowicz, W., Ramos, A., et al. (2009). The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 459, 1010-1014. doi: 10.1038/nature08025.
    • (2009) Nature , vol.459 , pp. 1010-1014
    • Trabucchi, M.1    Briata, P.2    Garcia-Mayoral, M.3    Haase, A.D.4    Filipowicz, W.5    Ramos, A.6
  • 105
    • 27944508215 scopus 로고    scopus 로고
    • CLIP: a method for identifying protein-RNA interaction sites in living cells
    • Ule, J., Jensen, K., Mele, A., and Darnell, R. B. (2005). CLIP: a method for identifying protein-RNA interaction sites in living cells. Methods 37, 376-386. doi: 10.1016/j.ymeth.2005.07.018.
    • (2005) Methods , vol.37 , pp. 376-386
    • Ule, J.1    Jensen, K.2    Mele, A.3    Darnell, R.B.4
  • 106
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: microRNAs can up-regulate translation
    • Vasudevan, S., Tong, Y., and Steitz, J. A. (2007). Switching from repression to activation: microRNAs can up-regulate translation. Science 318, 1931-1934. doi: 10.1126/science.1149460.
    • (2007) Science , vol.318 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 107
    • 17844363243 scopus 로고    scopus 로고
    • The contributions of dsRNA structure to Dicer specificity and efficiency
    • Vermeulen, A., Behlen, L., Reynolds, A., Wolfson, A., Marshall, W. S., Karpilow, J., et al. (2005). The contributions of dsRNA structure to Dicer specificity and efficiency. RNA 11, 674-682. doi: 10.1261/rna.7272305.
    • (2005) RNA , vol.11 , pp. 674-682
    • Vermeulen, A.1    Behlen, L.2    Reynolds, A.3    Wolfson, A.4    Marshall, W.S.5    Karpilow, J.6
  • 108
    • 84886096517 scopus 로고    scopus 로고
    • Online resources for miRNA analysis
    • Vlachos, I. S., and Hatzigeorgiou, A. G. (2013). Online resources for miRNA analysis. Clin. Biochem. 46, 879-900. doi: 10.1016/j.clinbiochem.2013.03.006.
    • (2013) Clin. Biochem , vol.46 , pp. 879-900
    • Vlachos, I.S.1    Hatzigeorgiou, A.G.2
  • 109
    • 84901696214 scopus 로고    scopus 로고
    • Argonaute proteins regulate microRNA stability: increased microRNA abundance by Argonaute proteins is due to microRNA stabilization
    • Winter, J., and Diederichs, S. (2011). Argonaute proteins regulate microRNA stability: increased microRNA abundance by Argonaute proteins is due to microRNA stabilization. RNA Biol 8, 1149-1157. doi: 10.4161/rna.8.6.17665.
    • (2011) RNA Biol , vol.8 , pp. 1149-1157
    • Winter, J.1    Diederichs, S.2
  • 110
    • 77951092028 scopus 로고    scopus 로고
    • Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region
    • Wu, S., Huang, S., Ding, J., Zhao, Y., Liang, L., Liu, T., et al. (2010). Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene 29, 2302-2308. doi: 10.1038/onc.2010.34.
    • (2010) Oncogene , vol.29 , pp. 2302-2308
    • Wu, S.1    Huang, S.2    Ding, J.3    Zhao, Y.4    Liang, L.5    Liu, T.6
  • 111
    • 33749984008 scopus 로고    scopus 로고
    • Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing
    • Yeom, K.-H., Lee, Y., Han, J., Suh, M. R., and Kim, V. N. (2006). Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res. 34, 4622-4629. doi: 10.1093/nar/gkl458.
    • (2006) Nucleic Acids Res , vol.34 , pp. 4622-4629
    • Yeom, K.-H.1    Lee, Y.2    Han, J.3    Suh, M.R.4    Kim, V.N.5
  • 112
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi, R., Qin, Y., Macara, I. G., and Cullen, B. R. (2003). Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016. doi: 10.1101/gad.1158803.
    • (2003) Genes Dev , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 113
    • 4444230672 scopus 로고    scopus 로고
    • Structural requirements for pre-microRNA binding and nuclear export by Exportin 5
    • Zeng, Y., and Cullen, B. R. (2004). Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res. 32, 4776-4785. doi: 10.1093/nar/gkh824.
    • (2004) Nucleic Acids Res , vol.32 , pp. 4776-4785
    • Zeng, Y.1    Cullen, B.R.2
  • 114
    • 23044502585 scopus 로고    scopus 로고
    • Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences
    • Zeng, Y., and Cullen, B. R. (2005). Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences. J. Biol. Chem. 280, 27595-27603. doi: 10.1074/jbc.M504714200.
    • (2005) J. Biol. Chem , vol.280 , pp. 27595-27603
    • Zeng, Y.1    Cullen, B.R.2
  • 115
    • 12544255565 scopus 로고    scopus 로고
    • Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha
    • Zeng, Y., Yi, R., and Cullen, B. R. (2005). Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO J. 24, 138-148. doi: 10.1038/sj.emboj.7600491.
    • (2005) EMBO J , vol.24 , pp. 138-148
    • Zeng, Y.1    Yi, R.2    Cullen, B.R.3
  • 116
    • 84927171302 scopus 로고    scopus 로고
    • Genetic variants of microRNA sequences and susceptibility to sepsis in patients with major blunt trauma
    • Zhang, A.-Q., Gu, W., Zeng, L., Zhang, L.-Y., Du, D.-Y., Zhang, M., et al. (2015). Genetic variants of microRNA sequences and susceptibility to sepsis in patients with major blunt trauma. Ann. Surg. 261, 189-196. doi: 10.1097/SLA.0000000000000687.
    • (2015) Ann. Surg , vol.261 , pp. 189-196
    • Zhang, A.-Q.1    Gu, W.2    Zeng, L.3    Zhang, L.-Y.4    Du, D.-Y.5    Zhang, M.6
  • 117
    • 0036845374 scopus 로고    scopus 로고
    • Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    • Zhang, H., Kolb, F. A., Brondani, V., Billy, E., and Filipowicz, W. (2002). Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21, 5875-5885. doi: 10.1093/emboj/cdf582.
    • (2002) EMBO J , vol.21 , pp. 5875-5885
    • Zhang, H.1    Kolb, F.A.2    Brondani, V.3    Billy, E.4    Filipowicz, W.5
  • 118
    • 3142613181 scopus 로고    scopus 로고
    • Single processing center models for human Dicer and bacterial RNase III
    • Zhang, H., Kolb, F. A., Jaskiewicz, L., Westhof, E., and Filipowicz, W. (2004). Single processing center models for human Dicer and bacterial RNase III. Cell 118, 57-68. doi: 10.1016/j.cell.2004.06.017.
    • (2004) Cell , vol.118 , pp. 57-68
    • Zhang, H.1    Kolb, F.A.2    Jaskiewicz, L.3    Westhof, E.4    Filipowicz, W.5
  • 119
    • 78649870594 scopus 로고    scopus 로고
    • The terminal loop region controls microRNA processing by Drosha and Dicer
    • Zhang, X., and Zeng, Y. (2010). The terminal loop region controls microRNA processing by Drosha and Dicer. Nucleic Acids Res. 38, 7689-7697. doi: 10.1093/nar/gkq645.
    • (2010) Nucleic Acids Res , vol.38 , pp. 7689-7697
    • Zhang, X.1    Zeng, Y.2
  • 120
    • 84940119734 scopus 로고    scopus 로고
    • Genetic variability of microRNA genes in 15 animal species
    • Zorc, M., Obsteter, J., Dovc, P., and Kunej, T. (2015). Genetic variability of microRNA genes in 15 animal species. J. Genomics 3, 51-56. doi: 10.7150/jgen.11246.
    • (2015) J. Genomics , vol.3 , pp. 51-56
    • Zorc, M.1    Obsteter, J.2    Dovc, P.3    Kunej, T.4
  • 121
    • 0042121256 scopus 로고    scopus 로고
    • Mfold web server for nucleic acid folding and hybridization prediction
    • Zuker, M. (2003). Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31, 3406-3415. doi: 10.1093/nar/gkg595.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3406-3415
    • Zuker, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.