Interaction between microbes and host intestinal health: Modulation by dietary nutrients and gut-brain-endocrine-immune axis

Current Protein and Peptide Science

Volumn 16, Issue 7, 2015, Pages 592-603

  Chen, Jingshu ^a   Li, Yuan ^b   Tian, Yanan ^c   Huang, Chang ^a   Li, Defa ^a   Zhong, Qing ^d   Ma, Xi ^a,d  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

^c TEXAS A AND M UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Gut brain endocrine immune axis; Intestine; Metabolism; Microbes; Nutrients; Reactions

Indexed keywords

TOLL LIKE RECEPTOR 1; TUMOR NECROSIS FACTOR; FATTY ACID; G PROTEIN COUPLED RECEPTOR; PATTERN RECOGNITION RECEPTOR;

ARTICLE; BACTERIAL COLONIZATION; DIETARY COMPLIANCE; GASTROINTESTINAL TRACT; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE FUNCTION TEST; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; INTESTINE FLORA; MAJOR HISTOCOMPATIBILITY COMPLEX; METABOLIC DISORDER; NONHUMAN; NUTRITIONAL ASSESSMENT; OBESITY; PROTEIN EXPRESSION; ANIMAL; BRAIN; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; ORGANISMAL INTERACTION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA;

ANIMALS; BRAIN; FATTY ACIDS; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; HUMANS; MICROBIAL INTERACTIONS; OBESITY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PATTERN RECOGNITION; SIGNAL TRANSDUCTION;

EID: 84939816469     PISSN: 13892037     EISSN: 18755550     Source Type: Journal    
DOI: 10.2174/1389203716666150630135720     Document Type: Article

References (139)

1. Whitman, W.B.; Coleman, D.C.; Wiebe, W.J. Prokaryotes: the unseen majority. Proc. Natl. Acad. Sci. U. S. A., 1998, 95, 6578- 6583.
2. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature., 2012, 486, 207-214.
3. Ma, X.; Chen, J.; Tian, Y. Pregnane X receptor as the "sensor and effector" in regulating epigenome. J. Cell. Physiol., 2015, 230(4), 752-757.
4. Flint, H.J.; Scott, K.P.; Louis, P.; Duncan, S.H. The role of the gut microbiota in nutrition and health. Nat. Rev. Gastroenterol. Hepatol., 2012, 9, 577-589.
5. Kau, A.L.; Ahern, P.P.; Griffin, N.W.; Goodman, A.L.; Gordon, J.I. Human nutrition, the gut microbiome and immune system. Nature., 2011, 474, 327-336.
6. Musso, G..; Gambino, R.; Cassader, M. Interactions between gut microbiota and host metabolism predisposing to obesity. Annu. Rev. Med., 2011, 62, 361-380.
7. Gill, S.R.; Pop, M.; Deboy, R.T.; Eckburg, P.B.; Turnbaugh, P.J.; Samuel, B.S.; Gordon, J.I.; Relman D.A.; Fraser-Liggett, C.M.; Nelson, K.E. Metagenomic analysis of the human distal gut microbiome. Science, 2006, 312, 1355-1359.
8. Chow, J.; Lee, S.M.; Shen, Y.; Khosravi, A.; Mazmanian, S.K. Host-bacterial symbiosis in health and disease. Adv. Immunol., 2010, 107, 243-274.
9. Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature, 2007, 449(7164), 819-826.
10. Garrett, W.S.; Gordon; Glimcher, L.H. Homeostasis and inflammation in the intestine. Cell, 2010, 140(6), 859-870.
11. Zang, J.; Chen, J.; Wang, A.; Liu, H.; Hu, S.; Che, X.; Ma, Y.; Wang, J.; Wang, C.; Du, G.; Ma, X. Effects of magnesium on the performance of sows and their piglets. J. Anim. Sci. Biotech., 2014, 5(1), 39.
12. Maynard, C.L.; Elson, C.O.; Hatton, R.D.; Weaver, C.T. Reciprocal interactions of the intestinal microbiota and immune system. Nature, 2012, 489(7415), 231-241.
13. Petersson, J.; Schreiber, O.; Hansson, G.C.; Gendler, S.J.; Velcich, A.; Lundberg, J.O.; Roos, S.; Holm, L.; Phillipson, M. Importance and regulation of the colonic mucus barrier in a mouse model of colitis. Am. J. Physiol. Gastrointest. Liver Physiol., 2011, 300, G327-333.
14. Bergstrom, K.S.; Kissoon-Singh, V.; Gibson, D.L.; Ma, C.; Montero, M.; Sham, H.P.; Ryz, N.; Huang, T.; Velcich, A.; Finlay, B.B.; Chadee, K.; Vallance, B.A. Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathog., 2010, 6, e1000902.
15. Heazlewood, C.K.; Cook, M.C.; Eri, R.; Price, G.R.; Tauro, S.B.; Taupin, D.; Thornton, D.J.; Png, C.W.; Crockford, T.L.; Cornall, R.J.; Adams, R.; Kato, M.; Nelms, K.A.; Hong, N.A.; Florin, T.H.; Goodnow, C.C.; McGuckin, M.A. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med., 2008, 5, e54.
16. Hansson, G.C.; Johansson, M.E. The inner of the two Muc2 mucindependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 15064-15069.
17. Fukuda, S.; Toh, H.; Hase, K.; Oshima, K.; Nakanishi, Y.; Yoshimura, K.; Tobe, T.; Clarke, J.M.; Topping, D.L.; Suzuki, T.; Taylor, T.D.; Itoh, K.; Kikuchi, J.; Morita, H.; Hattori, M.; Ohno, H. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature, 2011, 469, 543-547.
18. Vaishnava, S.; Behrendt, C.L.; Ismail, A.S.; Eckmann, L.; Hooper, L.V. Paneth cells directly sense gut commensals and maintain homeostasisat the intestinal host-microbial interface. Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 20858-20863.
19. Macpherson, A.J.; Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science, 2004, 303, 1662-1665.
20. Niess, J.H.; Brand, S.; Gu, X.; Landsman, L.; Jung, S.; McCormick, B.A.; Vyas, J.M.; Boes, M.; Ploegh, H.L.; Fox, J.G.; Littman, D.R.; Reinecker, H.C. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science, 2005, 307, 254-258.
21. Rescigno, M.; Rotta, G.; Valzasina, B.; Ricciardi-Castagnoli, P. Dendritic cells shuttle microbes across gut epithelial monolayers. Immunobiology., 2001, 204, 572-581.
22. Ma, X.; He, P.; Sun, P.; Han, P. Lipoic acid: An immunomodulator that attenuates glycinin-induced anaphylactic reactions in a rat model. J. Agric. Food Chem., 2010, 58(8), 5086-5092.
23. Round, J.L.; Mazmanian, S.K. The gut microbiota shapes intestinal immune responses during health and disease. Nat. Rev. Immunol., 2009, 9, 313-323.
24. Bouskra, D.; Brezillon, C.; Berard, M.; Werts, C.; Varona, R.; Boneca, I.G.; Eberl, G. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature, 2008, 456, 507-510.
25. Khosravi, A.; Yanez, A.; Price, J.G.; Chow, A.; Merad, M.; Goodridge, H.S.; Mazmanian, S.K. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe, 2014, 15(3), 374-381.
26. Duan, J.; Chung, H.; Troy, E.; Kasper, D.L. Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17- producing gamma/delta T cells. Cell Host Microbe, 2010, 7, 140- 150.
27. Rakoff-Nahoum, S.; Paglino, J.; Eslami-Varzaneh, F.; Edberg, S.; Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell, 2004, 118, 229-241.
28. Atarashi, K.; Tanoue, T.; Shima, T.; Imaoka, A.; Kuwahara, T.; Momose, Y.; Cheng, G.H.; Yamasaki, S.; Saito, T.; Ohba, Y.; Taniguchi, T.; Takeda, K.; Hori, S.; Ivanov, I.I.; Umesaki, Y.; Itoh, K.; Honda, K. Induction of colonic regulatory T cells by indigenous Clostridium species. Science, 2011, 331, 337-341.
29. Mazmanian, S.K.; Round, J.L.; Kasper, D.L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature, 2008, 453, 620-625.
30. Fasano, A. Intestinal zonulin: open sesame! Gut, 2001, 49, 159- 162.
31. Han, P.; Ma, X.; Yin, J. The effects of lipoic acid on soybean betaconglycinin- induced anaphylactic reactions in a rat model. Arch. Anim. Nutr., 2010, 64(3), 254-264.
32. Bergelson, J.M. Intercellular junctional proteins as receptors and barriers to virus infection and spread. Cell Host Microbe, 2009, 5(6), 517-521.
33. Raschperger, E.; Thyberg, J.; Pettersson, S.; Philipson, L.; Fuxe, J.; Pettersson, R.F. The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp. Cell Res., 2006, 312, 1566-1580.
34. Antar, A.A.; Konopka, J.L.; Campbell, J.A.; Henry, R.A.; Perdigoto, A.L.; Carter, B.D.; Pozzi, A.; Abel, T.W.; Dermody, T.S. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe, 2009, 5, 59-71.
35. Beau, I.J.; Cotte-Laffitte, J.; Amsellem, R.; Servin, A.L. A protein kinase A-dependent mechanism by which rotavirus affects the distribution and mRNA level of the functional tight junctionassociated protein, occludin, in human differentiated intestinal Caco-2 cells. J. Virol. 2007, 81, 8579-8586.
36. Song, P.; Zhang, R.; Wang, X.; He, P.; Tan, L.; Ma, X. Dietary grape-seed procyanidins decreased post-weaning diarrhea by modulating intestinal permeability and suppressing oxidative stress in rats. J. Agric. Food Chem., 2011, 59, 6227-6232.
37. Geijtenbeek, T.B.; van Vliet, S.J.; Engering, A.; 't Hart, B.A.; van Kooyk, Y. Self- and nonself-recognition by C-type lectins on dendritic cells. Annu. Rev. Immunol., 2004, 22, 33-54.
38. Medzhitov, R.; Janeway, C.A. Jr. Decoding the patterns of self and nonself by the innate immune system. Science, 2002, 296, 298-300.
39. Martinon, F.; Burns, K.; Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell, 2002, 10, 417-426.
40. Anderson, K.V. Toll signaling pathways in the innate immune response. Curr. Opin. Immunol., 2000, 12(1), 13-19.
41. Lemaitre, B.; Nicolas, E.; Michaut L.; Reichhart J.M.; Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 1996, 86(6), 973-983.
42. Medzhitov, R.; Preston-Hurlburt, P.; Janeway C.A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature, 1997, 388(6640), 394-397.
43. Rock, F.L.; Hardiman, G.; Timans, J.C.; Kastelein, R.A.; Bazan, J.F. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U. S. A., 1998, 95(2), 588-593.
44. Chuang, T.; Ulevitch, R.J. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim. Biophys. Acta., 2001, 1518(1-2), 157-161.
45. Frantz, A.L.; Rogier, E.W.; Weber, C.R.; Shen, L.; Cohen, D.A.; Fenton, L.A.; Bruno, M.E.; Kaetzel, C.S. Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin 2, and antibacterial peptides. Mucosal Immunol., 2012, 5(5), 501-512.
46. Fritz, J.H.; Ferrero, R.L.; Philpott, D.J.; Girardin, S.E. Nod-like proteins in immunity, inflammation and disease. Nature Immunol., 2006, 7, 1250-1257.
47. Inohara; Chamaillard; McDonald, C., Nunez, G. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu. Rev. Biochem., 2005, 74, 355-383.
48. Meylan, E.; Tschopp J.; Karin M. Intracellular pattern recognition receptors in the host response. Nature, 2006, 442, 39-44.
49. Ting, J.P.; Davis, B.K. CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu. Rev. Immunol., 2005, 23, 387-414.
50. Fritz, J.H.; Le, Bourhis, L.; Sellge, G.; Magalhaes, J.G.; Fsihi, H.; Kufer, T.A.; Collins, C.; Viala, J.; Ferrero, R.L.; Girardin, S.E.; Philpott, D.J. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity, 2007, 26, 445-459.
51. Kobayashi, K.S.; Chamaillard, M.; Ogura, Y.; Henegariu, O.; Inohara, N.; Nunez, G.; Flavell, R.A. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science, 2005, 307, 731-734.
52. Martinon, F.; Burns, K.; Tschopp, J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell, 2004, 117, 561-574.
53. Beutler, B.; Rietschel, E.T. Innate immune sensing and its roots: the story of endotoxin. Nat. Rev. Immunol., 2003, 3, 169-176.
54. Kawai, T.; Adachi, O.; Ogawa, T.; Takeda, K.; Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity, 1999, 11, 115-122.
55. Poltorak, A.; He, X.; Smirnova, I.; Liu, M.Y.; Van, Huffel, C.; Du, X.; Birdwell, D.; Alejos, E.; Silva, M.; Galanos, C.; Freudenberg, M.; Ricciardi-Castagnoli, P.; Layton, B.; Beutler, B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science, 1998, 282, 2085-2088.
56. Beutler, B.; Milsark, I.W.; Cerami, A.C. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science, 1985, 229, 869-871.
57. de Waal Malefyt, R.; Abrams, J.; Bennett, B.; Figdor, C.G..; de Vries, J.E. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med., 1991, 174, 1209-1220.
58. Fiorentino, D.F.; Zlotnik, A.; Mosmann, T.R.; Howard, M.; O'Garra, A. IL-10 inhibits cytokine production by activated macrophages. J. Immunol., 1991, 147, 3815-3822.
59. Philpott, D.J.; Sorbara, M.T.; Robertson, S.J.; Croitoru, K.; Girardin, S.E. NOD proteins: regulators of inflammation in health and disease. Nat. Rev. Immunol., 2014, 14(1), 9-23.
60. Royet, J.; Gupta, D.; Dziarski, R. Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nat. Rev. Immunol., 2011, 11(12), 837-851.
61. Ogura, Y.; Inohara, N.; Benito, A.; Chen, F.F.; Yamaoka, S.; Nunez, G.. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J. Biol. Chem., 2001, 276(7), 4812-4818.
62. Sterka, D. Jr; Rati, D.M.; Marriott, I. Functional expression of NOD2, a novel pattern recognition receptor for bacterial motifs, in primary murine astrocytes. Glia, 2006, 53(3), 322-330.
63. Girardin, S.E.; Boneca, I.G.; Carneiro, L.A.; Antignac, A.; Jehanno M.; Viala, J.; Tedin, K.; Taha, M.K.; Labigne, A.; Zahringer, U.; Coyle, A.J.; DiStefano, P.S.; Bertin, J.; Sansonetti, P.J.; Philpott, D.J. Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan. Science, 2003, 300, 1584-1587.
64. Chamaillard, M.; Hashimoto, M.; Horie, Y.; Masumoto, J.; Qiu, S.; Saab, L.; Ogura, Y.; Kawasaki, A.; Fukase, K.; Kusumoto, S.; Valvano, M.A.; Foster, S.J.; Mak, T.W.; Nunez, G.; Inohara, N. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol., 2003, 4, 702- 707.
65. Magalhaes, J.G.; Fritz, J.H.; Le, B.L.; Sellge, G.; Travassos, L.H.; Selvanantham, T.; Girardin, S.E.; Gommerman, J.L.; Philpott, D.J. Nod2-dependent Th2 polarization of antigen-specific immunity. J. Immunol., 2008, 181, 7925-7935.
66. Liu, H.; Zhang, J.; Zhang, S.; Yang, F.; Thacker, P.A.; Zhang, G.; Qiao, S.; Ma, X. Oral Administration of Lactobacillus fermentum I5007 Favors Intestinal Development and Alters the Intestinal Microbiota in Formula-fed Piglets. J. Agric. Food Chem., 2014, 62, 860-866.
67. Tremaroli, V.; Backhed, F. Functional interactions between the gut microbiota and host metabolism. Nature, 2012, 489(7415), 242- 249.
68. Ma, X.; Fan, P.X.; Li, L.S.; Qiao, S.Y.; Zhang, G.L.; Li, D.F. Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions. J. Anim. Sci., 2012, 90(Suppl 4), 266-268.
69. Qin, J.; Li, R.; Raes, J.; Arumugam, M.; Burgdorf, K.S.; Manichanh, C.; Nielsen, T.; Pons, N.; Levenez, F.; Yamada, T.; Mende, D.R.; Li, J.; Xu, J.; Li, S.; Li, D.; Cao, J.; Wang, B.; Liang, H.; Zheng, H.; Xie, Y.; Tap, J.; Lepage, P.; Bertalan, M.; Batto, J.M.; Hansen, T.; Le Paslier, D.; Linneberg, A.; Nielsen, H.B.; Pelletier, E.; Renault, P.; Sicheritz-Ponten, T.; Turner, K.; Zhu, H.; Yu, C.; Li, S.; Jian, M.; Zhou, Y.; Li Y.; Zhang, X.; Li, S.; Qin, N.; Yang, H.; Wang, J.; Brunak, S.; Dore, J.; Guarner, F.; Kristiansen, K.; Pedersen, O.; Parkhill, J.; Weissenbach, J.; MetaHIT, C.; Bork, P.; Ehrlich, S.D.; Wang, J. A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 2010, 464, 59-65.
70. Frank, D.N.; St. Amand, A.L.; Feldman, R.A.; Boedeker, E.C.; Harpaz, N.; Pace, N.R. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl. Acad. Sci. U. S. A., 2007, 104, 13780-13785.
71. Ma, X.; Ren, X.; Han, P.; Hu, S.; Wang, J.; Yin, J. SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction. Mol. Biol. Rep., 2010, 37(8), 4003-4011.
72. Xu, J.; Bjursell, M.K.; Himrod, J.; Deng, S.; Carmichael, L.K.; Chiang, H.C.; Hooper, L.V.P.; Gordon, J.I. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science, 2003, 299, 2074-2076.
73. Martens, E.C.; Lowe, E.C.; Chiang, H.; Pudlo, N.A.; Wu, M.; McNulty, N.P.; Abbott, D.W.; Henrissat, B.; Gilbert, H.J.; Bolam, D.N.; Gordon, J.I. Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts. PLoS Biol., 2011, 9(12), e1001221.
74. Donohoe, D.R.; Garge, N.; Zhang, X.; Sun, W.; O'Connell, T.M.; Bunger, M.K.; Bultman, S.J. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab., 2011, 13(5), 517-526.
75. Davie, J.R. Inhibition of histone deacetylase activity by butyrate. J. Nutr., 2003, 133, 2485S-2493S.
76. Brown, A.J.; Goldsworthy, S.M.; Barnes, A.A.; Eilert, M.M.; Tcheang, L.; Daniels, D.; Muir, A.I.; Wigglesworth, M.J.; Kinghorn, I.; Fraser, N.J.; Pike, N.B.; Strum, J.C.; Steplewski, K.M.; Murdock, P.R.; Holder, J.C.; Marshall, F.H.; Szekeres, P.G..; Wilson, S.; Ignar, D.M.; Foord, S.M.; Wise, A.; Dowell S.J. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem., 2003, 278, 11312-11319.
77. Le Poul, E.; Loison, C.; Struyf, S.; Springael, J.Y.; Lannoy, V.; Decobecq, M.E.; Brezillon, S.; Dupriez, V.; Vassart, G.; Van Damme, J.; Parmentier, M.; Detheux, M. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J. Biol. Chem,, 2003, 278, 25481-25489.
78. Maslowski, K.M.; Vieira, A.T.; Ng, A.; Kranich, J.; Sierro, F.; Yu, D.; Schilter, H.C.; Rolph, M.S.; Mackay, F.; Artis, D.; Xavier, R.J.; Teixeira, M.M.; Mackay, C.R. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature, 2009, 461, 1282-1286.
79. Sina, C.; Gavrilova, O.; Forster, M.; Till, A.; Derer, S.; Hildebrand, F.; Raabe, B.; Chalaris, A.; Scheller, J.; Rehmann, A.; Franke, A.; Ott, S.; Hasler, R.; Nikolaus, S.; Folsch, U.R.; Rose-John, S.; Jiang, H.P.; Li, J.; Schreiber, S.; Rosenstiel, P. G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. J. Immunol., 2009, 183, 7514-7522.
80. Suzuki, T.; Yoshida, S.; Hara, H. Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability. Br. J. Nutr., 2008, 100, 297-305.
81. Khosravi, A.; Yanez, A.; Price, J.G.; Chow, A.; Merad, M.; Goodridge, H.S.; Mazmanian, S.K. Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe, 2014, 15, 374-381.
82. Hill, D.A.; Siracusa, M.C.; Abt, M.C.; Kim, B.S.; Kobuley, D.; Kubo, M.; Kambayashi, T.; Larosa, D.F.; Renner, E.D.; Orange, J.S.; Bushman, F.D.; Artis, D. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat. Med., 2012, 18, 538-546.
83. Mazmanian, S.K.; Round, J.L.; Kasper, D.L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature, 2008, 453, 620-625.
84. Naik, S.; Bouladoux, N.; Wilhelm, C.; Molloy, M.J.; Salcedo, R.; Kastenmuller, W.; Deming, C.; Quinones, M.; Koo, L.; Conlan, S.; Spencer, S.; Hall, J.A.; Dzutsev, A.; Kong, H.; Campbell, D.J.; Trinchieri, G.; Segre, J.A.; Belkaid, Y. Compartmentalized control of skin immunity by resident commensals. Science, 2012, 337, 1115-1119.
85. Atarashi, K.; Tanoue, T.; Oshima, K.; Suda, W.; Nagano, Y.; Nishikawa, H.; Fukuda, S.; Saito, T.; Narushima, S.; Hase, K.; Kim, S.; Fritz, J.V.; Wilmes, P.; Ueha, S.; Matsushima, K.; Ohno, H.; Olle, B.; Sakaguchi, S.; Taniguchi, T.; Morita, H.; Hattori, M.; Honda, K. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature, 2013, 500, 232-236.
86. Round, J.L.; Mazmanian, S.K. The gut microbiota shapes intestinal immune responses during health and disease. Nat. Rev. Immunol., 2009, 9, 313-323.
87. Smith, P.M.; Howitt, M.R.; Panikov, N.; Michaud, M.; Gallini, C.A.; Bohlooly-Y.M.; Glickman, J.N.; Garrett, W.S. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science, 2013, 341, 569-573.
88. Han, P.; Yin, J.; He, P.; Ma, X. Dose-effect study of α-lipoic acid supplementation on growth performance and small intestinal development in a weaned rat model. J. Anim. Sci. Biotech., 2011, 2, 27-34.
89. Fukuda, S.; Toh, H.; Hase, K.; Oshima, K.; Nakanishi, Y.; Yoshimura, K.; Tobe, T.; Clarke, J.M.; Topping, D.L.; Suzuki, T.; Taylor, T.D.; Itoh, K.; Kikuchi, J.; Morita, H.; Hattori, M.; Ohno, H. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature, 2011, 469, 543-547.
90. Matsuki, T.; Pedron, T.; Regnault, B.; Mulet, C.; Hara, T.; Sansonetti, P.J. Epithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve. PloS One, 2013, 8, e63053.
91. Lathrop, S.K.; Bloom, S.M.; Rao, S.M.; Nutsch, K.; Lio, C.W.; Santacruz, N.; Peterson, D.A.; Stappenbeck, T.S.; Hsieh, C.S. Peripheral education of the immune system by colonic commensal microbiota. Nature, 2011, 478, 250-254.
92. Olszak, T.; An, D.; Zeissig, S.; Vera, M.P.; Richter, J.; Franke, A.; Glickman, J.N.; Siebert, R.; Baron, R.M.; Kasper, D.L.; Blumberg, R.S. Microbial exposure during early life has persistent effects on natural killer T cell function. Science, 2012, 336, 489-493.
93. Cohen, N.R.; Garg, S.; Brenner, M.B. Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity. Adv. Immunol., 2009, 102, 1-94.
94. Kronenberg, M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu. Rev. Immunol., 2005, 26, 877 -900.
95. Ingar, O.; Erik, J. Sphingolipids in bacteria and fungi. Anaerobe, 2001, 7, 103-112.
96. Kato, M.; Muto, Y.; Tanaka-Bandoh, K.; Watanabe, K.; Ueno, K. Sphingolipid composition in Bacteroides species. Anaerobe, 1995, 1, 135-139.
97. An, D.; Oh, S.F.; Olszak, T.; Neves, J.F.; Avci, F.Y.; Erturk- Hasdemir, D.; Lu, X.; Zeissig, S.; Blumberg, R.S.; Kasper, D.L. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell, 2014, 156, 123-133.
98. Ivanov, I.I.; Littman, D.R. Segmented filamentous bacteria take the stage. Mucosal Immunol., 2010, 3, 209-212.
99. Ivanov, I.I.; Frutos, Rde, L.; Manel, N.; Yoshinaga, K.; Rifkin, D.B.; Sartor, R.B.; Finlay, B.B.; Littman, D.R. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe, 2008, 4, 337- 349.
100. Ivanov, I.I.; Atarashi, K.; Manel, N.; Brodie, E.L.; Shima, T.; Karaoz, U.; Wei, D.; Goldfarb, K.C.; Santee, C.A.; Lynch, S.V.; Tanoue, T.; Imaoka, A.; Itoh, K.; Takeda, K.; Umesaki, Y.; Honda, K.; Littman, D.R. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell, 2009, 139, 485-498.
101. Gaboriau-Routhiau, V.; Rakotobe, S.; Lecuyer, E.; Mulder, I.; Lan, A.; Bridonneau, C.; Rochet, V.; Pisi, A.; De Paepe, M.; Brandi, G.; Eberl, G.; Snel, J.; Kelly, D.; Cerf-Bensussan, N. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity, 2009, 31, 677-689.
102. Huang, C.; Zang, J.J.; Song, P.X.; Fan, P.X.; Chen, J.S.; Liu, D.W.; He, P.L.; Ma, X. Effects of particle size and drying methods of corn on growth performance, digestibility and haematological and immunological characteristics of weaned piglets. Arch. Anim. Nutr., 2015, 69(1), 30-45.
103. Hoverstad, T.; Midtvedt, T. Short-chain fatty acids in germfree mice and rats. J. Nutr., 1986, 116, 1772-1776.
104. Backhed, F.; Ding, H.; Wang, T.; Hooper, L.V.; Koh, G.Y.; Nagy, A.; Semenkovich, C.F.; Gordon, J.I. The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U. S. A., 2004, 101, 15718-15723.
105. Turnbaugh, P.J.; Hamady, M.; Yatsunenko, T.; Cantarel, B.L.; Duncan, A.; Ley, R.E.; Sogin, M.L.; Jones, W.J.; Roe, B.A.; Affourtit, J.P.; Egholm M.; Henrissat, B.; Heath, A.C.; Knight, R.; Gordon J.I. A core gut microbiome in obese and lean twins. Nature, 2009, 457, 480-484.
106. Turnbaugh, P.J.; Ley, R.E.; Mahowald, M.A.; Magrini, V.; Mardis, E.R.; Gordon, J.I. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 2006, 444, 1027-1031.
107. Donohoe, D.R.; Garge, N.; Zhang, X.; Sun, W.; O'Connell, T.M.; Bunger, M.K.; Bultman, S.J. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab., 2011, 13, 517-526.
108. Velagapudi, V.R.; Hezaveh, R.; Reigstad, C.S.; Gopalacharyulu, P.; Yetukuri, L.; Islam, S.; Felin, J.; Perkins, R.; Boren, J.; Oresic, M.; Backhed, F. The gut microbiota modulates host energy and lipid metabolism in mice. J. Lipid Res., 2010, 51, 1101-1112.
109. Backhed F.; Manchester, J.K.; Semenkovich, C.F.; Gordon, J.I. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc. Natl. Acad. Sci. U. S. A., 2007, 104, 979- 984.
110. Mandard, S.; Zandbergen, F.; van Straten, E.; Wahli, W.; Kuipers, F.; Muller, M.; Kersten, S. The fasting-induced adipose factor/ angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J. Biol. Chem., 2006, 281, 934-944.
111. Brown, A.J.; Goldsworthy, S.M.; Barnes, A.A.; Eilert, M.M.; Tcheang, L.; Daniels, D.; Muir, A.I.; Wigglesworth, M.J.; Kinghorn, I.; Fraser, N.J.; Pike, N.B.; Strum, J.C.; Steplewski, K.M.; Murdock, P.R.; Holder, J.C.; Marshall, F.H.; Szekeres, P.G.; Wilson, S.; Ignar, D.M; Foord, S.M.; Wise, A.; Dowell, S.J. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem., 2003, 278, 11312-11319.
112. Le Poul, E.; Loison, C.; Struyf, S.; Springael, J.Y.; Lannoy, V.; Decobecq, M.E.; Brezillon, S.; Dupriez, V.; Vassart, G.; Van Damme, J.; Parmentier, M.; Detheux, M. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J. Biol. Chem., 2003, 278, 25481-25489.
113. Xiong, Y.; Miyamoto, N.; Shibata, K.; Valasek, M.A.; Motoike, T.; Kedzierski, R.M.; Yanagisawa, M. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc. Natl. Acad. Sci. U. S. A., 2004, 101, 1045- 1050.
114. Samuel, B.S.; Shaito, A.; Motoike, T.; Rey, F.E.; Backhed, F.; Manchester, J.K.; Hammer, R.E.; Williams, S.C.; Crowley, J.; Yanagisawa, M.; Gordon, J.I. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl. Acad. Sci. U. S. A., 2008, 105, 16767-16772.
115. Lin, H.C.; Neevel, C.; Chen, J.H. Slowing intestinal transit by PYY depends on serotonergic and opioid pathways. Am. J. Physiol. Gastrointest. Liver Physiol., 2004, 286, G558-G563.
116. Dewulf, E.M.; Cani, P.D.; Neyrinck, A.M.; Possemiers, S.; Van Holle, A.; Muccioli, G.G.; Deldicque, L.; Bindels, L.B.; Pachikian, B.D.; Sohet, F.M.; Mignolet, E.; Francaux, M.; Larondelle, Y.; Delzenne, N.M. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. J. Nutr. Biochem., 2011, 22, 712-722.
117. Bjursell, M.; Admyre, T.; Goransson, M.; Marley, A.E.; Smith, D.M.; Oscarsson, J.; Bohlooly-Y.M. Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab., 2011, 300, E211-E220.
118. Tolhurst, G.; Heffron, H.; Lam, Y.S.; Parker, H.E.; Habib, A.M.; Diakogiannaki, E.; Cameron, J.; Grosse, J.; Reimann, F.; Gribble, F.M. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes, 2012, 61, 364-371.
119. Thomas, C.; Pellicciari, R.; Pruzanski, M.; Auwerx, J.; Schoonjans, K. Targeting bile-acid signalling for metabolic diseases. Nat. Rev. Drug Discov., 2008, 7, 678-693.
120. Wostmann, B.S. Intestinal bile acids and cholesterol absorption in the germfree rat. J. Nutr., 1973, 103, 982-990.
121. Swann, J.R.; Want, E.J.; Geier, F.M.; Spagou, K.; Wilson, I.D.; Sidaway, J.E.; Nicholson, J.K.; Holmes, E. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl. Acad. Sci. U. S. A., 2010, 108, 4523-4530.
122. Swann, J.R.; Want, E.J.; Geier, F.M.; Spagou, K.; Wilson, I.D.; Sidaway, J.E.; Nicholson, J.K.; Holmes, E. Turnover and nature of fecal bile acids in germfree and infected rats fed cholic acid-24- 14C; bile acids and steroids 41. Proc. Natl. Acad. Sci. U. S. A., 2011, 94, 467-471.
123. Sinal, C.J.; Tohkin, M.; Miyata, M.; Ward, J.M.; Lambert, G.; Gonzalez, F.J. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell, 2000, 102, 731-744.
124. van Dijk, T.H.; Grefhorst, A.; Oosterveer, M.H.; Bloks, V.W.; Staels, B.; Reijngoud, D.J.; Kuipers, F. An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr -/- mice. J. Biol. Chem., 2009, 284, 10315-10323.
125. Prawitt, J.; Abdelkarim, M.; Stroeve, J.H.; Popescu, I.; Duez, H.; Velagapudi, V.R.; Dumont, J.; Bouchaert, E.; van Dijk, T.H.; Lucas, A.; Dorchies, E.; Daoudi,M.; Lestavel, S.; Gonzalez, F.J.; Oresic, M.; Cariou, B.; Kuipers, F.; Caron, S.; Staels, B. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes, 2011, 60, 1861-1871.
126. Thomas, C.; Gioiello, A.; Noriega, L.; Strehle, A.; Oury, J.; Rizzo, G.; Macchiarulo, A.; Yamamoto, H.; Mataki, C.; Pruzanski, M.; Pellicciari, R.; Auwerx, J.; Schoonjans, K. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab, 2009, 10, 167-177.
127. Watanabe, M.; Houten, S.M.; Mataki, C.; Christoffolete, M.A.; Kim, B.W.; Sato, H.; Messaddeq, N.; Harney, J.W.; Ezaki, O.; Kodama, T.; Schoonjans, K.; Bianco, A.C.; Auwerx, J.; Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature, 2006, 439, 484-489.
128. Osborn, O.; Olefsky, J.M. The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med., 2012, 18, 363-374.
129. Ma, X.; Zhang, H.; Yuan, L.; Jing, H.; Phil, T.; Li D. CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. Biochem. J., 2011, 439(1), 27-38.
130. Cani, P.D.; Amar, J.; Iglesias, M.A.; Poggi, M.; Knauf, C.; Bastelica, D.; Neyrinck, A.M.; Fava F.; Tuohy, K.M.; Chabo, C.; Waget, A.; Delmee, E.; Cousin, B.; Sulpice, T.; Chamontin, B.; Ferrieres, J.; Tanti J.F.; Gibson, G.R.; Casteilla, L.; Delzenne, N.M.; Alessi, M.C.; Burcelin, R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 2007, 56, 1761-1772.
131. Nishimura, S.; Manabe, I.; Nagasaki, M.; Eto, K.; Yamashita, H.; Ohsugi, M.; Otsu, M.; Hara, K.; Ueki, K.; Sugiura, S.; Yoshimura, K.; Kadowaki, T.; Nagai, R. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med., 2009, 15, 914-920.
132. Winer, S.; Chan, Y.; Paltser, G.; Truong, D.; Tsui, H.; Bahrami, J.; Dorfman, R.; Wang, Y.; Zielenski, J.; Mastronardi, F.; Maezawa, Y.; Drucker, D.J.; Engleman, E.; Winer, D.; Dosch, H.M.; Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med., 2009, 15, 921-929.
133. Liu, J.; Divoux, A.; Sun, J.; Zhang, J.; Clement, K.; Glickman, J.N.; Sukhova, G.K.; Wolters, P.J.; Du, J.; Gorgun, C.Z.; Doria, A.; Libby, P.; Blumberg, R.S.; Kahn, B.B.; Hotamisligil, G.S.; Shi, G.P. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat. Med., 2009, 15, 940-945.
134. Feuerer, M.; Herrero, L.; Cipolletta, D.; Naaz, A.; Wong, J.; Nayer, A.; Lee, J.; Goldfine, A.B.; Benoist, C.; Shoelson, S.; Mathis, D. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med., 2009, 15, 930-939.
135. de La Serre, C.B.; Ellis, C.L.; Lee, J.; Hartman, A.L.; Rutledge, J.C.; Raybould, H.E. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am. J. Physiol. Gastrointest. Liver Physiol., 2010, 299, G440-G448.
136. Brun, P.; Castagliuolo, I.; Di Leo, V.; Buda, A.; Pinzani, M.; Palu, G.; Martines, D. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol., 2007, 292, G518- G525.
137. Cani, P.D.; Possemiers, S.; Van de Wiele, T.; Guiot, Y.; Everard, A.; Rottier, O.; Geurts, L.; Naslain D.; Neyrinck, A.; Lambert, D.M.; Muccioli, G.G.; Delzenne, N.M. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut, 2009, 58, 1091-1103.
138. Ma, X.; Ding, W.; Wang, J.; Wu, G.; Zhang, H.; Yin, J.; Zhou, L.; Li, D. LOC66273 isoform 2, a novel protein highly expressed in white adipose tissue, induces adipogenesis in 3T3-L1 cells. J. Nutr., 2012, 142(3), 448-455.
139. Maccarrone, M.; Gasperi, V.; Catani, M.V.; Diep, T.A.; Dainese, E.; Hansen, H.S.; Avigliano, L. The endocannabinoid system and its relevance for nutrition. Annu. Rev. Nutr., 2010, 30, 423-440.