메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages 402-424

Metabolic Profiling and Phenotyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions

Author keywords

Biomarker; CNS disease; Mass spectrometry; Metabonomics metabolomics metabolic profiling; Nuclear magnetic resonance; Systems biology

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 4 AMINOBUTYRIC ACID; 5 HYDROXYICOSATETRAENOIC ACID; ADENOSINE TRIPHOSPHATE; ADRENALIN; DOPAMINE; GLYCINE DEHYDROGENASE (DECARBOXYLATING); INOSITOL TRISPHOSPHATE; LEUKOTRIENE B4; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; PROSTAGLANDIN D; PROSTAGLANDIN E; PROSTAGLANDIN F1 ALPHA; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TAURINE; TRICARBOXYLIC ACID; BIOLOGICAL MARKER;

EID: 84939564424     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-014-9578-5     Document Type: Review
Times cited : (39)

References (111)
  • 1
    • 84896520449 scopus 로고    scopus 로고
    • Patch clamp electrophysiology and capillary electrophoresis-mass spectrometry metabolomics for single cell characterization
    • COI: 1:CAS:528:DC%2BC2cXivFyrsrY%3D, PID: 24559180
    • Aerts JT, Louis KR, Crandall SR, Govindaiah G, Cox CL, Sweedler JV (2014) Patch clamp electrophysiology and capillary electrophoresis-mass spectrometry metabolomics for single cell characterization. Anal Chem 86:3203–3208. doi:10.1021/ac500168d
    • (2014) Anal Chem , vol.86 , pp. 3203-3208
    • Aerts, J.T.1    Louis, K.R.2    Crandall, S.R.3    Govindaiah, G.4    Cox, C.L.5    Sweedler, J.V.6
  • 2
    • 84876680501 scopus 로고    scopus 로고
    • Metabolomic analysis for first-trimester Down syndrome prediction
    • Bahado-Singh RO et al (2013) Metabolomic analysis for first-trimester Down syndrome prediction. Am J Obstet Gynecol 208(5)371:e1-8. doi:10.1016/j.ajog.2012.12.035
    • (2013) Am J Obstet Gynecol 208(5)371 , pp. e1-e8
    • Bahado-Singh, R.O.1
  • 4
    • 84864002975 scopus 로고    scopus 로고
    • gamma-Aminobutyric acid production by culturable bacteria from the human intestine
    • COI: 1:CAS:528:DC%2BC38XhtFCktbvF, PID: 22612585
    • Barrett E, Ross RP, O’Toole PW, Fitzgerald GF, Stanton C (2012) gamma-Aminobutyric acid production by culturable bacteria from the human intestine. J Appl Microbiol 113:411–417. doi:10.1111/j.1365-2672.2012.05344
    • (2012) J Appl Microbiol , vol.113 , pp. 411-417
    • Barrett, E.1    Ross, R.P.2    O’Toole, P.W.3    Fitzgerald, G.F.4    Stanton, C.5
  • 5
    • 58849130167 scopus 로고    scopus 로고
    • A novel function for fragile X mental retardation protein in translational activation
    • PID: 19166269
    • Bechara EG et al (2009) A novel function for fragile X mental retardation protein in translational activation. PLoS Biol 7:e16
    • (2009) PLoS Biol , vol.7 , pp. e16
    • Bechara, E.G.1
  • 6
    • 77956597651 scopus 로고    scopus 로고
    • High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
    • COI: 1:CAS:528:DC%2BC3cXnsFSjsr8%3D, PID: 20539278
    • Beckonert O et al (2010) High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues. Nat Protoc 5:1019–1032
    • (2010) Nat Protoc , vol.5 , pp. 1019-1032
    • Beckonert, O.1
  • 7
    • 39149126712 scopus 로고    scopus 로고
    • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    • COI: 1:CAS:528:DC%2BD2sXhtlSlsr3E, PID: 18007604
    • Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK (2007) Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc 2:2692–2703. doi:10.1038/nprot.2007.376
    • (2007) Nat Protoc , vol.2 , pp. 2692-2703
    • Beckonert, O.1    Keun, H.C.2    Ebbels, T.M.3    Bundy, J.4    Holmes, E.5    Lindon, J.C.6    Nicholson, J.K.7
  • 8
    • 84869388565 scopus 로고    scopus 로고
    • Structural characterization of plasma metabolites detected via LC-electrochemical coulometric array using LC-UV fractionation, MS, and NMR
    • COI: 1:CAS:528:DC%2BC38XhsFyisrjJ, PID: 23106399
    • Bird SS, Sheldon DP, Gathungu RM, Vouros P, Kautz R, Matson WR, Kristal BS (2012) Structural characterization of plasma metabolites detected via LC-electrochemical coulometric array using LC-UV fractionation, MS, and NMR. Anal Chem 84:9889–9898. doi:10.1021/ac302278u
    • (2012) Anal Chem , vol.84 , pp. 9889-9898
    • Bird, S.S.1    Sheldon, D.P.2    Gathungu, R.M.3    Vouros, P.4    Kautz, R.5    Matson, W.R.6    Kristal, B.S.7
  • 10
    • 84872867557 scopus 로고    scopus 로고
    • ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC
    • COI: 1:CAS:528:DC%2BC3sXhvFKrsrw%3D, PID: 23297193
    • Blankman JL, Long JZ, Trauger SA, Siuzdak G, Cravatt BF (2013) ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC. Proc Natl Acad Sci U S A 110:1500–1505. doi:10.1073/pnas.1217121110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1500-1505
    • Blankman, J.L.1    Long, J.Z.2    Trauger, S.A.3    Siuzdak, G.4    Cravatt, B.F.5
  • 11
    • 84881181817 scopus 로고    scopus 로고
    • Metabolomics in cerebrospinal fluid of patients with amyotrophic lateral sclerosis: an untargeted approach via high-resolution mass spectrometry
    • COI: 1:CAS:528:DC%2BC3sXpvVGgs7s%3D, PID: 23859630
    • Blasco H et al (2013) Metabolomics in cerebrospinal fluid of patients with amyotrophic lateral sclerosis: an untargeted approach via high-resolution mass spectrometry. J Proteome Res 12:3746–3754. doi:10.1021/pr400376e
    • (2013) J Proteome Res , vol.12 , pp. 3746-3754
    • Blasco, H.1
  • 12
    • 84898728770 scopus 로고    scopus 로고
    • Untargeted 1H-NMR metabolomics in CSF: toward a diagnostic biomarker for motor neuron disease
    • COI: 1:CAS:528:DC%2BC2cXlsF2itLY%3D, PID: 24587475
    • Blasco H et al (2014) Untargeted 1H-NMR metabolomics in CSF: toward a diagnostic biomarker for motor neuron disease. Neurology 82:1167–1174. doi:10.1212/WNL.0000000000000274
    • (2014) Neurology , vol.82 , pp. 1167-1174
    • Blasco, H.1
  • 14
    • 0037285461 scopus 로고    scopus 로고
    • Functional categorization of gene expression changes in the cerebellum of a Cln3-knockout mouse model for Batten disease
    • COI: 1:CAS:528:DC%2BD3sXmt1WrsA%3D%3D, PID: 12559844
    • Brooks AI, Chattopadhyay S, Mitchison HM, Nussbaum RL, Pearce DA (2003) Functional categorization of gene expression changes in the cerebellum of a Cln3-knockout mouse model for Batten disease. Mol Genet Metab 78:17–30
    • (2003) Mol Genet Metab , vol.78 , pp. 17-30
    • Brooks, A.I.1    Chattopadhyay, S.2    Mitchison, H.M.3    Nussbaum, R.L.4    Pearce, D.A.5
  • 15
    • 84864594544 scopus 로고    scopus 로고
    • Metabolomic analysis of biochemical changes in the plasma and urine of first-episode neuroleptic-naive schizophrenia patients after treatment with risperidone
    • COI: 1:CAS:528:DC%2BC38XhtVemtbbK, PID: 22800120
    • Cai HL et al (2012) Metabolomic analysis of biochemical changes in the plasma and urine of first-episode neuroleptic-naive schizophrenia patients after treatment with risperidone. J Proteome Res 11:4338–4350. doi:10.1021/pr300459d
    • (2012) J Proteome Res , vol.11 , pp. 4338-4350
    • Cai, H.L.1
  • 16
    • 81755169872 scopus 로고    scopus 로고
    • Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients
    • COI: 1:CAS:528:DC%2BC3MXhsV2ju7jF, PID: 20921955
    • Chan MK, Tsang TM, Harris LW, Guest PC, Holmes E, Bahn S (2011) Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients. Mol Psychiatry 16:1189–1202. doi:10.1038/mp.2010.100
    • (2011) Mol Psychiatry , vol.16 , pp. 1189-1202
    • Chan, M.K.1    Tsang, T.M.2    Harris, L.W.3    Guest, P.C.4    Holmes, E.5    Bahn, S.6
  • 17
    • 84908429261 scopus 로고    scopus 로고
    • Amino acid metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression
    • Chen G et al (2014) Amino acid metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression. Behav Brain Res. doi:10.1016/j.bbr.2014.05.027
    • (2014) Behav Brain Res
    • Chen, G.1
  • 18
    • 0030947540 scopus 로고    scopus 로고
    • Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy
    • COI: 1:CAS:528:DyaK2sXjvFCkurs%3D, PID: 9177231
    • Cheng LL, Ma MJ, Becerra L, Ptak T, Tracey I, Lackner A, Gonzalez RG (1997) Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A 94:6408–6413
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6408-6413
    • Cheng, L.L.1    Ma, M.J.2    Becerra, L.3    Ptak, T.4    Tracey, I.5    Lackner, A.6    Gonzalez, R.G.7
  • 19
    • 84878241830 scopus 로고    scopus 로고
    • The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
    • COI: 1:CAS:528:DC%2BC3sXot1aku7w%3D, PID: 22688187
    • Clarke G et al (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18:666–673. doi:10.1038/mp.2012.77
    • (2013) Mol Psychiatry , vol.18 , pp. 666-673
    • Clarke, G.1
  • 20
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    • COI: 1:CAS:528:DC%2BD1MXhtFWqs7nM, PID: 19667173
    • Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK (2009) Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A 106:14728–14733. doi:10.1073/pnas.0904489106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.K.5
  • 21
    • 33646198860 scopus 로고    scopus 로고
    • Pharmaco-metabonomic phenotyping and personalized drug treatment
    • COI: 1:CAS:528:DC%2BD28Xjs1agt7w%3D, PID: 16625200
    • Clayton TA et al (2006) Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440:1073–1077
    • (2006) Nature , vol.440 , pp. 1073-1077
    • Clayton, T.A.1
  • 22
    • 12244293657 scopus 로고    scopus 로고
    • Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies
    • COI: 1:CAS:528:DC%2BD2cXhtVKit7bK, PID: 15649048
    • Cloarec O et al (2005) Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies. Anal Chem 77:517–526. doi:10.1021/ac048803i
    • (2005) Anal Chem , vol.77 , pp. 517-526
    • Cloarec, O.1
  • 23
    • 84867845255 scopus 로고    scopus 로고
    • The interplay between the intestinal microbiota and the brain
    • COI: 1:CAS:528:DC%2BC38Xhtlylt7%2FJ, PID: 23000955
    • Collins SM, Surette M, Bercik P (2012) The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol 10:735–742. doi:10.1038/nrmicro2876
    • (2012) Nat Rev Microbiol , vol.10 , pp. 735-742
    • Collins, S.M.1    Surette, M.2    Bercik, P.3
  • 24
    • 84874098768 scopus 로고    scopus 로고
    • Branched-chain amino acids alter neurobehavioral function in rats
    • COI: 1:CAS:528:DC%2BC3sXjsFKrtrs%3D, PID: 23249694
    • Coppola A et al (2013) Branched-chain amino acids alter neurobehavioral function in rats. Am J Physiol Endocrinol Metab 304:E405–E413. doi:10.1152/ajpendo.00373.2012
    • (2013) Am J Physiol Endocrinol Metab , vol.304 , pp. E405-E413
    • Coppola, A.1
  • 25
    • 30744443014 scopus 로고    scopus 로고
    • Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies
    • COI: 1:CAS:528:DC%2BD2MXht1yrsLbJ, PID: 16408915
    • Crockford DJ et al (2006) Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies. Anal Chem 78:363–371. doi:10.1021/ac051444m
    • (2006) Anal Chem , vol.78 , pp. 363-371
    • Crockford, D.J.1
  • 26
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
    • COI: 1:CAS:528:DC%2BC38XhtlamurvN, PID: 22968153
    • Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13:701–712. doi:10.1038/nrn3346
    • (2012) Nat Rev Neurosci , vol.13 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 27
    • 84857130435 scopus 로고    scopus 로고
    • Metabolite profiling of Alzheimer’s disease cerebrospinal fluid
    • COI: 1:CAS:528:DC%2BC38Xjt1Sjsbk%3D, PID: 22359596
    • Czech C et al (2012) Metabolite profiling of Alzheimer’s disease cerebrospinal fluid. PLoS ONE 7:e31501. doi:10.1371/journal.pone.0031501
    • (2012) PLoS ONE , vol.7 , pp. e31501
    • Czech, C.1
  • 28
    • 83055168319 scopus 로고    scopus 로고
    • A metabolomic and systems biology perspective on the brain of the Fragile X syndrome mouse model
    • COI: 1:CAS:528:DC%2BC3MXhs1WlurzE, PID: 21900387
    • Davidovic L, Navratil V, Bonaccorso CM, Catania MV, Bardoni B, Dumas ME (2011) A metabolomic and systems biology perspective on the brain of the Fragile X syndrome mouse model. Genome Res 21:2190–2202. doi:10.1101/gr.116764.110
    • (2011) Genome Res , vol.21 , pp. 2190-2202
    • Davidovic, L.1    Navratil, V.2    Bonaccorso, C.M.3    Catania, M.V.4    Bardoni, B.5    Dumas, M.E.6
  • 30
    • 84865804312 scopus 로고    scopus 로고
    • Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes
    • COI: 1:CAS:528:DC%2BC38Xht1ygtb3O, PID: 22868675
    • Dumas ME (2012) Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes. Mol BioSyst 8:2494–2502. doi:10.1039/c2mb25167a
    • (2012) Mol BioSyst , vol.8 , pp. 2494-2502
    • Dumas, M.E.1
  • 31
    • 34247560771 scopus 로고    scopus 로고
    • Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
    • COI: 1:CAS:528:DC%2BD2sXksFersbw%3D, PID: 17435758
    • Dumas ME et al (2007) Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Nat Genet 39:666–672
    • (2007) Nat Genet , vol.39 , pp. 666-672
    • Dumas, M.E.1
  • 32
    • 79959913950 scopus 로고    scopus 로고
    • Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
    • COI: 1:CAS:528:DC%2BC3MXotlCmtL8%3D, PID: 21720319
    • Dunn WB et al (2011) Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc 6:1060–1083. doi:10.1038/nprot.2011.335
    • (2011) Nat Protoc , vol.6 , pp. 1060-1083
    • Dunn, W.B.1
  • 33
    • 84897113069 scopus 로고    scopus 로고
    • Oxidative stress and schizophrenia: recent breakthroughs from an old story
    • Emiliani FE, Sedlak TW, Sawa A (2014) Oxidative stress and schizophrenia: recent breakthroughs from an old story. Curr Opin Psychiatr 27:185–190. doi:10.1097/YCO.0000000000000054
    • (2014) Curr Opin Psychiatr , vol.27 , pp. 185-190
    • Emiliani, F.E.1    Sedlak, T.W.2    Sawa, A.3
  • 34
    • 84878289530 scopus 로고    scopus 로고
    • GC-MS-based urine metabolic profiling of autism spectrum disorders
    • COI: 1:CAS:528:DC%2BC3sXls1eqtLc%3D, PID: 23571465
    • Emond P et al (2013) GC-MS-based urine metabolic profiling of autism spectrum disorders. Anal Bioanal Chem 405:5291–5300. doi:10.1007/s00216-013-6934-x
    • (2013) Anal Bioanal Chem , vol.405 , pp. 5291-5300
    • Emond, P.1
  • 35
    • 0021927818 scopus 로고
    • Diabetes mellitus in Huntington disease
    • COI: 1:STN:280:DyaL2M7lt1Gktg%3D%3D, PID: 3156696
    • Farrer LA (1985) Diabetes mellitus in Huntington disease. Clin Genet 27:62–67
    • (1985) Clin Genet , vol.27 , pp. 62-67
    • Farrer, L.A.1
  • 36
    • 78650666244 scopus 로고    scopus 로고
    • The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping
    • COI: 1:CAS:528:DC%2BC3MXjtVenug%3D%3D
    • Fonville JM et al (2010) The evolution of partial least squares models and related chemometric approaches in metabonomics and metabolic phenotyping. J Chemometr 24:636–649
    • (2010) J Chemometr , vol.24 , pp. 636-649
    • Fonville, J.M.1
  • 37
    • 84908068961 scopus 로고    scopus 로고
    • Reconciling abnormalities of brain network structure and function in schizophrenia
    • Fornito A, Bullmore ET (2014) Reconciling abnormalities of brain network structure and function in schizophrenia. Curr Opin Neurobiol 30C:44–50. doi:10.1016/j.conb.2014.08.006
    • (2014) Curr Opin Neurobiol , vol.30C , pp. 44-50
    • Fornito, A.1    Bullmore, E.T.2
  • 38
    • 84865730611 scopus 로고
    • A set of measures of centrality based on betweenness
    • Freeman LC (1977) A set of measures of centrality based on betweenness. Sociometry 40:35–41
    • (1977) Sociometry , vol.40 , pp. 35-41
    • Freeman, L.C.1
  • 39
    • 84918576232 scopus 로고    scopus 로고
    • Connecting the dots between tau dysfunction and neurodegeneration
    • PID: 25172552
    • Frost B, Gotz J, Feany MB (2014) Connecting the dots between tau dysfunction and neurodegeneration. Trends Cell Biol. doi:10.1016/j.tcb.2014.07.005
    • (2014) Trends Cell Biol
    • Frost, B.1    Gotz, J.2    Feany, M.B.3
  • 40
    • 0032994024 scopus 로고    scopus 로고
    • High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla
    • COI: 1:CAS:528:DyaK1MXktVKksLc%3D, PID: 10371442
    • Garrod S et al (1999) High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla. Magn Reson Med 41:1108–1118
    • (1999) Magn Reson Med , vol.41 , pp. 1108-1118
    • Garrod, S.1
  • 41
    • 0034634448 scopus 로고    scopus 로고
    • An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse
    • COI: 1:CAS:528:DC%2BD3cXotVCktb0%3D, PID: 11078872
    • Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK (2000) An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett 484:169–174
    • (2000) FEBS Lett , vol.484 , pp. 169-174
    • Gavaghan, C.L.1    Holmes, E.2    Lenz, E.3    Wilson, I.D.4    Nicholson, J.K.5
  • 42
    • 84873388502 scopus 로고    scopus 로고
    • Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC38XhvVGrtL3F, PID: 23252551
    • Graham SF, Chevallier OP, Roberts D, Holscher C, Elliott CT, Green BD (2013) Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer’s disease. Anal Chem 85:1803–1811. doi:10.1021/ac303163f
    • (2013) Anal Chem , vol.85 , pp. 1803-1811
    • Graham, S.F.1    Chevallier, O.P.2    Roberts, D.3    Holscher, C.4    Elliott, C.T.5    Green, B.D.6
  • 43
    • 1842430173 scopus 로고    scopus 로고
    • Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3
    • COI: 1:CAS:528:DC%2BD2cXjs1emt7c%3D, PID: 14679302
    • Griffin JL, Cemal CK, Pook MA (2004) Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3. Physiol Genomics 16:334–340
    • (2004) Physiol Genomics , vol.16 , pp. 334-340
    • Griffin, J.L.1    Cemal, C.K.2    Pook, M.A.3
  • 44
    • 0141745000 scopus 로고    scopus 로고
    • Vitamin E deficiency and metabolic deficits in neuronal ceroid lipofuscinosis described by bioinformatics
    • COI: 1:CAS:528:DC%2BD3sXnt1Srug%3D%3D, PID: 12388797
    • Griffin JL, Muller D, Woograsingh R, Jowatt V, Hindmarsh A, Nicholson JK, Martin JE (2002) Vitamin E deficiency and metabolic deficits in neuronal ceroid lipofuscinosis described by bioinformatics. Physiol Genomics 11:195–203. doi:10.1152/physiolgenomics.00100.2002
    • (2002) Physiol Genomics , vol.11 , pp. 195-203
    • Griffin, J.L.1    Muller, D.2    Woograsingh, R.3    Jowatt, V.4    Hindmarsh, A.5    Nicholson, J.K.6    Martin, J.E.7
  • 45
    • 79960114429 scopus 로고    scopus 로고
    • Metabolomics in early Alzheimer’s disease: identification of altered plasma sphingolipidome using shotgun lipidomics
    • COI: 1:CAS:528:DC%2BC3MXpsl2hurY%3D, PID: 21779331
    • Han X et al (2011) Metabolomics in early Alzheimer’s disease: identification of altered plasma sphingolipidome using shotgun lipidomics. PLoS ONE 6:e21643. doi:10.1371/journal.pone.0021643
    • (2011) PLoS ONE , vol.6 , pp. e21643
    • Han, X.1
  • 46
    • 33748354488 scopus 로고    scopus 로고
    • Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia
    • PID: 16933966
    • Holmes E et al (2006) Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia. PLoS Med 3:e327
    • (2006) PLoS Med , vol.3 , pp. e327
    • Holmes, E.1
  • 47
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • COI: 1:CAS:528:DC%2BC3sXhvFGiurbF, PID: 24315484
    • Hsiao EY et al (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155:1451–1463. doi:10.1016/j.cell.2013.11.024
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 48
    • 39749171224 scopus 로고    scopus 로고
    • CSF metabolic and proteomic profiles in patients prodromal for psychosis
    • PID: 17712404
    • Huang JT et al (2007) CSF metabolic and proteomic profiles in patients prodromal for psychosis. PLoS One 2:e756. doi:10.1371/journal.pone.0000756
    • (2007) PLoS One , vol.2 , pp. e756
    • Huang, J.T.1
  • 49
    • 84869398478 scopus 로고    scopus 로고
    • Toward a predictive model of Alzheimer’s disease progression using capillary electrophoresis-mass spectrometry metabolomics
    • COI: 1:CAS:528:DC%2BC38XhtleisLfJ, PID: 22967182
    • Ibanez C, Simo C, Martin-Alvarez PJ, Kivipelto M, Winblad B, Cedazo-Minguez A, Cifuentes A (2012) Toward a predictive model of Alzheimer’s disease progression using capillary electrophoresis-mass spectrometry metabolomics. Anal Chem 84:8532–8540. doi:10.1021/ac301243k
    • (2012) Anal Chem , vol.84 , pp. 8532-8540
    • Ibanez, C.1    Simo, C.2    Martin-Alvarez, P.J.3    Kivipelto, M.4    Winblad, B.5    Cedazo-Minguez, A.6    Cifuentes, A.7
  • 50
    • 84884592615 scopus 로고    scopus 로고
    • Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics
    • Ji Y et al (2012) Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics. Pharmacogenomics J. doi:10.1038/tpj.2012.32
    • (2012) Pharmacogenomics J
    • Ji, Y.1
  • 51
    • 78650513748 scopus 로고    scopus 로고
    • Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics
    • COI: 1:CAS:528:DC%2BC3cXhsFylt7%2FF, PID: 21107318
    • Ji Y et al (2011) Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther 89:97–104. doi:10.1038/clpt.2010.250
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 97-104
    • Ji, Y.1
  • 52
    • 70449552850 scopus 로고    scopus 로고
    • Metabolomic profiling in LRRK2-related Parkinson’s disease
    • PID: 19847307
    • Johansen KK et al (2009) Metabolomic profiling in LRRK2-related Parkinson’s disease. PLoS One 4:e7551. doi:10.1371/journal.pone.0007551
    • (2009) PLoS One , vol.4 , pp. e7551
    • Johansen, K.K.1
  • 53
    • 84880091814 scopus 로고    scopus 로고
    • Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo
    • COI: 1:STN:280:DC%2BC3szhvF2ksg%3D%3D, PID: 23340506
    • Kaddurah-Daouk R et al (2013a) Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. Transl Psychiatry 3:e223. doi:10.1038/tp.2012.142
    • (2013) Transl Psychiatry , vol.3 , pp. e223
    • Kaddurah-Daouk, R.1
  • 54
    • 79960775080 scopus 로고    scopus 로고
    • Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept
    • Kaddurah-Daouk R et al (2011a) Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept. Transl Psychiatr 1. doi:10.1038/tp.2011.22
    • (2011) Transl Psychiatr , pp. 1
    • Kaddurah-Daouk, R.1
  • 56
    • 79956130559 scopus 로고    scopus 로고
    • Metabolomic changes in autopsy-confirmed Alzheimer’s disease
    • PID: 21075060
    • Kaddurah-Daouk R et al (2011b) Metabolomic changes in autopsy-confirmed Alzheimer’s disease. Alzheimers Dement 7:309–317. doi:10.1016/j.jalz.2010.06.001
    • (2011) Alzheimers Dement , vol.7 , pp. 309-317
    • Kaddurah-Daouk, R.1
  • 57
    • 84867031949 scopus 로고    scopus 로고
    • Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile
    • PID: 22993692
    • Kaddurah-Daouk R et al (2012) Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile. Sci Rep 2:667. doi:10.1038/srep00667
    • (2012) Sci Rep , vol.2 , pp. 667
    • Kaddurah-Daouk, R.1
  • 58
    • 84878638145 scopus 로고    scopus 로고
    • Alterations in metabolic pathways and networks in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhtFSqt7rO, PID: 23571809
    • Kaddurah-Daouk R et al (2013b) Alterations in metabolic pathways and networks in Alzheimer’s disease. Transl Psychiatry 3:e244. doi:10.1038/tp.2013.18
    • (2013) Transl Psychiatry , vol.3 , pp. e244
    • Kaddurah-Daouk, R.1
  • 59
    • 84858983547 scopus 로고    scopus 로고
    • KEGG for integration and interpretation of large-scale molecular data sets
    • COI: 1:CAS:528:DC%2BC3MXhs12htbrO, PID: 22080510
    • Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M (2012) KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res 40:D109–D114. doi:10.1093/nar/gkr988
    • (2012) Nucleic Acids Res , vol.40 , pp. D109-D114
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3    Furumichi, M.4    Tanabe, M.5
  • 60
    • 84896726518 scopus 로고    scopus 로고
    • ApoE and Abeta in Alzheimer’s disease: accidental encounters or partners?
    • COI: 1:CAS:528:DC%2BC2cXivFCrtLo%3D, PID: 24559670
    • Kanekiyo T, Xu H, Bu G (2014) ApoE and Abeta in Alzheimer’s disease: accidental encounters or partners? Neuron 81:740–754. doi:10.1016/j.neuron.2014.01.045
    • (2014) Neuron , vol.81 , pp. 740-754
    • Kanekiyo, T.1    Xu, H.2    Bu, G.3
  • 61
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics
    • COI: 1:CAS:528:DC%2BC3MXhtVelsL3L, PID: 21852788
    • Karran E, Mercken M, De Strooper B (2011) The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 10:698–712. doi:10.1038/nrd3505
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 62
    • 84908483881 scopus 로고    scopus 로고
    • Maternal immune activation and abnormal brain development across CNS disorders
    • COI: 1:CAS:528:DC%2BC2cXhvVKmtb7F, PID: 25311587
    • Knuesel I et al (2014) Maternal immune activation and abnormal brain development across CNS disorders. Nat Rev Neurol 10:643–660. doi:10.1038/nrneurol.2014.187
    • (2014) Nat Rev Neurol , vol.10 , pp. 643-660
    • Knuesel, I.1
  • 63
    • 34548410134 scopus 로고    scopus 로고
    • High-performance liquid chromatography separations coupled with coulometric electrode array detectors: a unique approach to metabolomics
    • COI: 1:CAS:528:DC%2BD28XhtFOnurzL, PID: 17035686
    • Kristal BS, Shurubor YI, Kaddurah-Daouk R, Matson WR (2007) High-performance liquid chromatography separations coupled with coulometric electrode array detectors: a unique approach to metabolomics. Methods Mol Biol 358:159–174. doi:10.1007/978-1-59745-244-1_10
    • (2007) Methods Mol Biol , vol.358 , pp. 159-174
    • Kristal, B.S.1    Shurubor, Y.I.2    Kaddurah-Daouk, R.3    Matson, W.R.4
  • 64
    • 77649190353 scopus 로고    scopus 로고
    • Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis
    • COI: 1:CAS:528:DC%2BC3cXitlSmt70%3D, PID: 20096678
    • Kumar A, Bala L, Kalita J, Misra UK, Singh RL, Khetrapal CL, Babu GN (2010) Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis. Clin Chim Acta 411:563–567. doi:10.1016/j.cca.2010.01.016
    • (2010) Clin Chim Acta , vol.411 , pp. 563-567
    • Kumar, A.1    Bala, L.2    Kalita, J.3    Misra, U.K.4    Singh, R.L.5    Khetrapal, C.L.6    Babu, G.N.7
  • 65
    • 84892779084 scopus 로고    scopus 로고
    • 1H NMR metabolomic signatures in five brain regions of the AbetaPPswe Tg2576 mouse model of Alzheimer’s disease at four ages
    • COI: 1:CAS:528:DC%2BC2cXislKruw%3D%3D, PID: 24145382
    • Lalande J et al (2014) 1H NMR metabolomic signatures in five brain regions of the AbetaPPswe Tg2576 mouse model of Alzheimer’s disease at four ages. J Alzheimers Dis JAD 39:121–143. doi:10.3233/JAD-130023
    • (2014) J Alzheimers Dis JAD , vol.39 , pp. 121-143
    • Lalande, J.1
  • 66
    • 60549109881 scopus 로고    scopus 로고
    • Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder
    • COI: 1:CAS:528:DC%2BD1MXit1OktLk%3D, PID: 18256615
    • Lan MJ et al (2009) Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder. Mol Psychiatry 14:269–279
    • (2009) Mol Psychiatry , vol.14 , pp. 269-279
    • Lan, M.J.1
  • 67
    • 84938284690 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease; a source of heterogeneity and target for personalized therapy
    • PID: 25286385
    • Latta CH, Brothers HM, Wilcock DM (2014) Neuroinflammation in Alzheimer's disease; a source of heterogeneity and target for personalized therapy. Neuroscience. doi:10.1016/j.neuroscience.2014.09.061
    • (2014) Neuroscience
    • Latta, C.H.1    Brothers, H.M.2    Wilcock, D.M.3
  • 68
    • 0036182507 scopus 로고    scopus 로고
    • A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy
    • PID: 11840551
    • Le Belle JE, Harris NG, Williams SR, Bhakoo KK (2002) A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy. NMR Biomed 15:37–44
    • (2002) NMR Biomed , vol.15 , pp. 37-44
    • Le Belle, J.E.1    Harris, N.G.2    Williams, S.R.3    Bhakoo, K.K.4
  • 69
    • 84878289356 scopus 로고    scopus 로고
    • Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer’s disease in CRND8 mice
    • COI: 1:CAS:528:DC%2BC3sXktVKisbs%3D, PID: 23494273
    • Lin S et al (2013) Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer’s disease in CRND8 mice. Anal Bioanal Chem 405:5105–5117. doi:10.1007/s00216-013-6825-1
    • (2013) Anal Bioanal Chem , vol.405 , pp. 5105-5117
    • Lin, S.1
  • 70
    • 84898447902 scopus 로고    scopus 로고
    • Plasma phospholipids identify antecedent memory impairment in older adults
    • et al
    • Mapstone et al (2014) Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med 20(4):415–8. doi:10.1038/nm.3466
    • (2014) Nat Med , vol.20 , Issue.4 , pp. 415-418
  • 71
    • 65249083386 scopus 로고    scopus 로고
    • Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy
    • COI: 1:CAS:528:DC%2BD1MXivFOmtbs%3D, PID: 19714815
    • McLoughlin GA et al (2009) Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy. J Proteome Res 8:1943–1952
    • (2009) J Proteome Res , vol.8 , pp. 1943-1952
    • McLoughlin, G.A.1
  • 72
    • 84892609862 scopus 로고    scopus 로고
    • Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems
    • COI: 1:CAS:528:DC%2BC3sXht1GgtLnI, PID: 23938317
    • Meyer U (2014) Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems. Biol Psychiatry 75:307–315. doi:10.1016/j.biopsych.2013.07.011
    • (2014) Biol Psychiatry , vol.75 , pp. 307-315
    • Meyer, U.1
  • 73
    • 33244492432 scopus 로고    scopus 로고
    • The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo
    • COI: 1:CAS:528:DC%2BD28Xhslyhtr8%3D, PID: 16257225
    • Mientjes EJ et al (2006) The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis 21:549–555. doi:10.1016/j.nbd.2005.08.019
    • (2006) Neurobiol Dis , vol.21 , pp. 549-555
    • Mientjes, E.J.1
  • 74
    • 36248935287 scopus 로고    scopus 로고
    • Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression
    • PID: 17653274
    • Mochel F et al (2007) Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression. PLoS ONE 2:e647. doi:10.1371/journal.pone.0000647
    • (2007) PLoS ONE , vol.2 , pp. e647
    • Mochel, F.1
  • 75
    • 33847141978 scopus 로고    scopus 로고
    • N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology
    • COI: 1:CAS:528:DC%2BD2sXitFOrsLw%3D, PID: 17275978
    • Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AM (2007) N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol 81:89–131
    • (2007) Prog Neurobiol , vol.81 , pp. 89-131
    • Moffett, J.R.1    Ross, B.2    Arun, P.3    Madhavarao, C.N.4    Namboodiri, A.M.5
  • 77
    • 0036463681 scopus 로고    scopus 로고
    • Metabonomics: a platform for studying drug toxicity and gene function
    • COI: 1:CAS:528:DC%2BD38Xhs1aksbw%3D
    • Nicholson JK, Connelly J, Lindon JC, Holmes E (2002) Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev 1:153–161
    • (2002) Nat Rev , vol.1 , pp. 153-161
    • Nicholson, J.K.1    Connelly, J.2    Lindon, J.C.3    Holmes, E.4
  • 78
    • 0032694577 scopus 로고    scopus 로고
    • ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • COI: 1:CAS:528:DyaK1MXns12ms7k%3D, PID: 10598751
    • Nicholson JK, Lindon JC, Holmes E (1999) ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica; the fate of foreign compounds in biological systems 29:1181–1189
    • (1999) Xenobiotica; the fate of foreign compounds in biological systems , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 79
    • 84867687830 scopus 로고    scopus 로고
    • Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy
    • COI: 1:CAS:528:DC%2BC38XhsFWisr7E, PID: 22956686
    • Novarino G et al (2012) Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. Science 338:394–397. doi:10.1126/science.1224631
    • (2012) Science , vol.338 , pp. 394-397
    • Novarino, G.1
  • 80
    • 0032168794 scopus 로고    scopus 로고
    • Systematic functional analysis of the yeast genome
    • COI: 1:CAS:528:DyaK1cXls1Onsbc%3D, PID: 9744112
    • Oliver SG, Winson MK, Kell DB, Baganz F (1998) Systematic functional analysis of the yeast genome. Trends Biotechnol 16:373–378
    • (1998) Trends Biotechnol , vol.16 , pp. 373-378
    • Oliver, S.G.1    Winson, M.K.2    Kell, D.B.3    Baganz, F.4
  • 81
    • 83755180492 scopus 로고    scopus 로고
    • Metabolome in progression to Alzheimer’s disease
    • COI: 1:STN:280:DC%2BC38fjtVSksw%3D%3D, PID: 22832349
    • Oresic M et al (2011) Metabolome in progression to Alzheimer’s disease. Transl Psychiatry 1:e57. doi:10.1038/tp.2011.55
    • (2011) Transl Psychiatry , vol.1 , pp. e57
    • Oresic, M.1
  • 82
    • 77950653264 scopus 로고    scopus 로고
    • Stem cells: an overview of the current status of therapies for central and peripheral nervous system diseases
    • COI: 1:CAS:528:DC%2BC3cXjs1Kktbw%3D, PID: 20088765
    • Orlacchio A, Bernardi G, Martino S (2010) Stem cells: an overview of the current status of therapies for central and peripheral nervous system diseases. Curr Med Chem 17:595–608
    • (2010) Curr Med Chem , vol.17 , pp. 595-608
    • Orlacchio, A.1    Bernardi, G.2    Martino, S.3
  • 84
    • 84891791940 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
    • COI: 1:CAS:528:DC%2BC2cXosF2i, PID: 24234439
    • Pawson AJ et al (2014) The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res 42:D1098–D1106. doi:10.1093/nar/gkt1143
    • (2014) Nucleic Acids Res , vol.42 , pp. D1098-D1106
    • Pawson, A.J.1
  • 85
    • 30044447943 scopus 로고    scopus 로고
    • High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease
    • COI: 1:CAS:528:DC%2BD2MXhtlCmsLvP, PID: 16239221
    • Pears MR, Cooper JD, Mitchison HM, Mortishire-Smith RJ, Pearce DA, Griffin JL (2005) High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease. J Biol Chem 280:42508–42514
    • (2005) J Biol Chem , vol.280 , pp. 42508-42514
    • Pears, M.R.1    Cooper, J.D.2    Mitchison, H.M.3    Mortishire-Smith, R.J.4    Pearce, D.A.5    Griffin, J.L.6
  • 87
    • 34648843244 scopus 로고    scopus 로고
    • A neuroscientist’s guide to lipidomics
    • COI: 1:CAS:528:DC%2BD2sXhtVKht77P, PID: 17882252
    • Piomelli D, Astarita G, Rapaka R (2007) A neuroscientist’s guide to lipidomics. Nat Rev Neurosci 8:743–754. doi:10.1038/nrn2233
    • (2007) Nat Rev Neurosci , vol.8 , pp. 743-754
    • Piomelli, D.1    Astarita, G.2    Rapaka, R.3
  • 88
    • 79953687426 scopus 로고    scopus 로고
    • Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains
    • COI: 1:CAS:528:DC%2BC3MXjtFektrc%3D, PID: 21322573
    • Pontoizeau C et al (2011) Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains. J Proteome Res 10:1675–1689. doi:10.1021/pr101000z
    • (2011) J Proteome Res , vol.10 , pp. 1675-1689
    • Pontoizeau, C.1
  • 89
    • 3142745187 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress
    • Prabakaran S et al (2004) Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry 9(684–697):643. doi:10.1038/sj.mp.4001511
    • (2004) Mol Psychiatry , vol.9 , Issue.684-697 , pp. 643
    • Prabakaran, S.1
  • 90
    • 68149116292 scopus 로고    scopus 로고
    • CE-MS in metabolomics
    • COI: 1:CAS:528:DC%2BD1MXhvVWltrc%3D, PID: 19107702
    • Ramautar R, Somsen GW, de Jong GJ (2009) CE-MS in metabolomics. Electrophoresis 30:276–291. doi:10.1002/elps.200800512
    • (2009) Electrophoresis , vol.30 , pp. 276-291
    • Ramautar, R.1    Somsen, G.W.2    de Jong, G.J.3
  • 91
    • 84881550298 scopus 로고    scopus 로고
    • Colonic bacterial metabolites and human health
    • COI: 1:CAS:528:DC%2BC3sXhtFGmu7nE, PID: 23880135
    • Russell WR, Hoyles L, Flint HJ, Dumas ME (2013) Colonic bacterial metabolites and human health. Curr Opin Microbiol 16:246–254. doi:10.1016/j.mib.2013.07.002
    • (2013) Curr Opin Microbiol , vol.16 , pp. 246-254
    • Russell, W.R.1    Hoyles, L.2    Flint, H.J.3    Dumas, M.E.4
  • 92
    • 77953124257 scopus 로고    scopus 로고
    • A metabolomic study of the CRND8 transgenic mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXmtFCgsbs%3D, PID: 20398713
    • Salek RM et al (2010) A metabolomic study of the CRND8 transgenic mouse model of Alzheimer’s disease. Neurochem Int 56:937–947. doi:10.1016/j.neuint.2010.04.001
    • (2010) Neurochem Int , vol.56 , pp. 937-947
    • Salek, R.M.1
  • 93
    • 55949089964 scopus 로고    scopus 로고
    • High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides
    • Schwarz E, Prabakaran S, Whitfield P, Major H, Leweke FM, Koethe D, McKenna P, Bahn S (2008) High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides. J Proteome Res 7(10):4266–4277. doi:10.1021/pr800188y
    • (2008) J Proteome Res , vol.7 , Issue.10 , pp. 4266-4277
    • Schwarz, E.1    Prabakaran, S.2    Whitfield, P.3    Major, H.4    Leweke, F.M.5    Koethe, D.6    McKenna, P.7    Bahn, S.8
  • 96
    • 80052398214 scopus 로고    scopus 로고
    • Human metabolic individuality in biomedical and pharmaceutical research
    • COI: 1:CAS:528:DC%2BC3MXhtFWku7nN, PID: 21886157
    • Suhre K et al (2011a) Human metabolic individuality in biomedical and pharmaceutical research. Nature 477:54–60. doi:10.1038/nature10354
    • (2011) Nature , vol.477 , pp. 54-60
    • Suhre, K.1
  • 97
    • 79957604338 scopus 로고    scopus 로고
    • A genome-wide association study of metabolic traits in human urine
    • COI: 1:CAS:528:DC%2BC3MXmtV2hs7g%3D, PID: 21572414
    • Suhre K et al (2011b) A genome-wide association study of metabolic traits in human urine. Nat Genet 43:565–569. doi:10.1038/ng.837
    • (2011) Nat Genet , vol.43 , pp. 565-569
    • Suhre, K.1
  • 98
    • 73249130205 scopus 로고    scopus 로고
    • Metabolic profiling of human blood serum from treated patients with bipolar disorder employing 1H NMR spectroscopy and chemometrics
    • COI: 1:CAS:528:DC%2BD1MXhtlagt73O, PID: 19863109
    • Sussulini A, Prando A, Maretto DA, Poppi RJ, Tasic L, Banzato CE, Arruda MA (2009) Metabolic profiling of human blood serum from treated patients with bipolar disorder employing 1H NMR spectroscopy and chemometrics. Anal Chem 81:9755–9763. doi:10.1021/ac901502j
    • (2009) Anal Chem , vol.81 , pp. 9755-9763
    • Sussulini, A.1    Prando, A.2    Maretto, D.A.3    Poppi, R.J.4    Tasic, L.5    Banzato, C.E.6    Arruda, M.A.7
  • 99
    • 82555186342 scopus 로고    scopus 로고
    • Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library
    • PID: 22109519
    • Tiziani S, Kang Y, Choi JS, Roberts W, Paternostro G (2011) Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library. Nat Commun 2:545. doi:10.1038/ncomms1562
    • (2011) Nat Commun , vol.2 , pp. 545
    • Tiziani, S.1    Kang, Y.2    Choi, J.S.3    Roberts, W.4    Paternostro, G.5
  • 100
    • 18244363880 scopus 로고    scopus 로고
    • Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy
    • COI: 1:CAS:528:DC%2BD2MXksFGmtrs%3D, PID: 15844164
    • Tsang TM, Griffin JL, Haselden J, Fish C, Holmes E (2005) Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy. Magn Reson Med 53:1018–1024. doi:10.1002/mrm.20447
    • (2005) Magn Reson Med , vol.53 , pp. 1018-1024
    • Tsang, T.M.1    Griffin, J.L.2    Haselden, J.3    Fish, C.4    Holmes, E.5
  • 101
    • 67349196013 scopus 로고    scopus 로고
    • Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington’s disease
    • COI: 1:CAS:528:DC%2BD1MXlvFyqsw%3D%3D, PID: 19148750
    • Tsang TM, Haselden JN, Holmes E (2009) Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington’s disease. Neurochem Res 34:1261–1271. doi:10.1007/s11064-008-9904-5
    • (2009) Neurochem Res , vol.34 , pp. 1261-1271
    • Tsang, T.M.1    Haselden, J.N.2    Holmes, E.3
  • 102
    • 33644843611 scopus 로고    scopus 로고
    • Metabolic characterization of the R6/2 transgenic mouse model of Huntington’s disease by high-resolution MAS 1H NMR spectroscopy
    • COI: 1:CAS:528:DC%2BD28XmtF2rsQ%3D%3D, PID: 16512662
    • Tsang TM, Woodman B, McLoughlin GA, Griffin JL, Tabrizi SJ, Bates GP, Holmes E (2006) Metabolic characterization of the R6/2 transgenic mouse model of Huntington’s disease by high-resolution MAS 1H NMR spectroscopy. J Proteome Res 5:483–492. doi:10.1021/pr050244o
    • (2006) J Proteome Res , vol.5 , pp. 483-492
    • Tsang, T.M.1    Woodman, B.2    McLoughlin, G.A.3    Griffin, J.L.4    Tabrizi, S.J.5    Bates, G.P.6    Holmes, E.7
  • 103
    • 33645085291 scopus 로고    scopus 로고
    • Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles
    • Underwood BR et al (2006) Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. Brain J Neurol 129:877–886. doi:10.1093/brain/awl027
    • (2006) Brain J Neurol , vol.129 , pp. 877-886
    • Underwood, B.R.1
  • 104
    • 35648965648 scopus 로고    scopus 로고
    • Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model
    • PID: 17237885
    • Viola A, Saywell V, Villard L, Cozzone PJ, Lutz NW (2007) Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model. PLoS ONE 2:e157
    • (2007) PLoS ONE , vol.2 , pp. e157
    • Viola, A.1    Saywell, V.2    Villard, L.3    Cozzone, P.J.4    Lutz, N.W.5
  • 105
    • 84355162888 scopus 로고    scopus 로고
    • Rett syndrome: from bed to bench
    • PID: 22192257
    • Weng SM, Bailey ME, Cobb SR (2011) Rett syndrome: from bed to bench. Pediatr Neonatol 52:309–316. doi:10.1016/j.pedneo.2011.08.002
    • (2011) Pediatr Neonatol , vol.52 , pp. 309-316
    • Weng, S.M.1    Bailey, M.E.2    Cobb, S.R.3
  • 106
    • 84888370211 scopus 로고    scopus 로고
    • A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology
    • Wesseling H, Chan MK, Tsang TM, Ernst A, Peters F, Guest PC, Holmes E, Bahn S (2013) A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology. Neuropsychopharmacol 38(12). doi:10.1038/npp.2013.160
    • (2013) Neuropsychopharmacol , vol.38 , Issue.12
    • Wesseling, H.1    Chan, M.K.2    Tsang, T.M.3    Ernst, A.4    Peters, F.5    Guest, P.C.6    Holmes, E.7    Bahn, S.8
  • 107
    • 79956330533 scopus 로고    scopus 로고
    • In vivo evidence for lactate as a neuronal energy source
    • COI: 1:CAS:528:DC%2BC3MXmvFektLk%3D
    • Wyss MT, Jolivet R, Buck A, Magistretti PJ, Weber B (2011) In vivo evidence for lactate as a neuronal energy source. J Neurosci Off J Soc Neurosci 31:7477–7485. doi:10.1523/JNEUROSCI. 0415-11.2011
    • (2011) J Neurosci Off J Soc Neurosci , vol.31 , pp. 7477-7485
    • Wyss, M.T.1    Jolivet, R.2    Buck, A.3    Magistretti, P.J.4    Weber, B.5
  • 108
    • 77954256613 scopus 로고    scopus 로고
    • MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data
    • COI: 1:CAS:528:DC%2BC3cXotVSqu74%3D, PID: 20457745
    • Xia J, Wishart DS (2010) MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data. Nucleic Acids Res 38(Suppl):W71–W77
    • (2010) Nucleic Acids Res , vol.38 , pp. W71-W77
    • Xia, J.1    Wishart, D.S.2
  • 109
    • 77949808387 scopus 로고    scopus 로고
    • Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naive patients with schizophrenia
    • PID: 20209081
    • Yao JK et al (2010a) Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naive patients with schizophrenia. PLoS ONE 5:e9508. doi:10.1371/journal.pone.0009508
    • (2010) PLoS ONE , vol.5 , pp. e9508
    • Yao, J.K.1
  • 110
    • 77956439232 scopus 로고    scopus 로고
    • Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia
    • COI: 1:CAS:528:DC%2BC3cXhtFWqur3F, PID: 19401681
    • Yao JK et al (2010b) Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia. Mol Psychiatry 15:938–953. doi:10.1038/mp.2009.33
    • (2010) Mol Psychiatry , vol.15 , pp. 938-953
    • Yao, J.K.1
  • 111
    • 77954592502 scopus 로고    scopus 로고
    • Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls
    • COI: 1:CAS:528:DC%2BC3cXlvFegsr0%3D, PID: 20337404
    • Yap IK, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK (2010) Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. J Proteome Res 9:2996–3004. doi:10.1021/pr901188e
    • (2010) J Proteome Res , vol.9 , pp. 2996-3004
    • Yap, I.K.1    Angley, M.2    Veselkov, K.A.3    Holmes, E.4    Lindon, J.C.5    Nicholson, J.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.