High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla

Magnetic Resonance in Medicine

Volumn 41, Issue 6, 1999, Pages 1108-1118

  Garrod, S ^a   Humpfer, E ^b   Spraul, M ^b   Connor, S C ^c   Polley, S ^c   Connelly, J ^c   Lindon, J C ^a   Nicholson, J K ^a   Holmes, Elaine ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Bruker Analytik GmbH   (Germany)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

1H NMR spectroscopy; Magic angle spinning; Rat; Renal cortex; Renal papilla; Renal tissue extracts

Indexed keywords

ALCOHOLS; AMINATION; BIOMOLECULES; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RATING; RATS; SPECTROSCOPIC ANALYSIS; TISSUE;

1H NMR SPECTROSCOPY; BIOCHEMICAL COMPOSITION; GLYCEROPHOSPHOCHOLINE; HIGH RESOLUTION MAGIC ANGLE SPINNING; RENAL CORTEX; RENAL PAPILLA; RENAL TISSUE; TRIMETHYLAMINE N OXIDES;

MAGIC ANGLE SPINNING;

AMINO ACID; BETAINE; CHOLINE; GLUCOSE; GLYCEROPHOSPHORYLCHOLINE; INOSITOL; SORBITOL; TISSUE EXTRACT; TRIACYLGLYCEROL; TRIMETHYLAMINE OXIDE;

ANIMAL TISSUE; ARTICLE; INTERMETHOD COMPARISON; KIDNEY CORTEX; KIDNEY MEDULLA; KIDNEY METABOLISM; KIDNEY PAPILLA; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TISSUE DISTRIBUTION;

EID: 0032994024     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2594(199906)41:6<1108::AID-MRM6>3.0.CO;2-M     Document Type: Article

References (25)

1. Andrew ER, Eades RG. Removal of dipolar broadening of NMR spectra of solids by specimen rotation. Nature 1959;183:1802.
2. 1H NMR in solid-phase organic synthesis. J Org Chem 1994;59:7955.
3. Moka D, Vorreuther R, Schicha H, Spraul M, Humpfer E, Lipinski M, Foxall PJD, Nicholson JK, Lindon JC. Magic angle spinning proton nuclear magnetic resonance spectroscopic analysis of intact kidney tissue samples. Anal Comm 1997;34:107-109.
4. 1H nuclear magnetic resonance spectroscopy. J Pharm Biomed Anal 1998; 17:125-137.
5. Millis K, Maas E, Cory DG, Singer S. Gradient high resolution magic angle spinning nuclear magnetic resonance spectroscopy of human adipocyte tissue. Magn Reson Med 1997;38:399-403.
6. 1H MAS NMR spectroscopy. Magn Reson Med 1997;38:334-336.
7. 1H nuclear magnetic resonance analysis of intact prostatic hyperplastic and tumour tissues. Anal Comm 1998;35:113-115.
8. Cheng LL, Ma MJ, Becerra L, Hale T, Tracey I, Lackner A, Gonzalez RG. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci USA 1997;94:6408-6413.
9. Cheng LL, Lean CL, Bogdanova A, Wright SC Jr, Ackerman JL, Brady TJ, Garrido L. Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic angle spinning. Magn Reson Med 1996;36: 653-658.
10. Bagnasco S, Balaban R, Fales HM, Yang YM, Burg M. Predominant osmotically active organic solutes in rat and rabbit renal medullas. J Biol Chem 1886;261:5872-5877.
11. Schmolke M, Schilling A, Keiditsch E, Guder WG. Intrarenal distribution of organic osmolytes in human kidney. Eur J Clin Chem Clin Biochem 1996;34:499-501.
12. 1H NMR spectroscopy of human blood plasma. Anal Chem 1995;67:793-811.
13. Gartland KPR, Bonner FW, Nicholson JK. Investigations into the biochemical effects of region-specific nephrotoxins. Mol Pharmacol 1989;35:242-250.
14. Kendall MD, Warley A, Nicholson JK, Appleton TC. X-ray microanalysis of proximal and distal tubule cells in the mouse kidney, and the influence of cadmium on the concentration of natural intracellular elements. J Cell Sci 1983;62:319-338.
15. Middleton DA, Bradley DP, Connor SC, Mullins PG, Reid D. The effects of sample freezing on proton magic-angle spinning NMR spectra of biological tissue. Magn Reson Med 1998;40:166-169.
16. Bax A, Davis DG. MLEV-17-based two dimensional homonuclear magnetisation transfer spectroscopy. J Magn Reson 1985;65:355-360.
17. 1H magnetic resonance spectra of human urine from normal and pathological states. Anal Biochem 1994;220:284-296.
18. Beckwith-Hall BM, Nicholson JK, Nicholls AW, Foxall PJD, Lindon JC, Connor SC, Abdi M, Connelly J, Holmes E. Nuclear magnetic resonance spectroscopic and pattern recognition investigations into the biochemical effects of hepatotoxins. Chem Res Tox 1998;11:260-272.
19. 1H nuclear magnetic resonance spectra of human urine from normal and pathological states. Anal Biochem 1994;220:284-296.
20. Fan TWM. Metabolite profiling by one-and two-dimensional NMR analysis of complex mixtures. Prog NMR Spectrosc 1996;28:161-219.
21. Jones DP, Miller LA, Chesney RW. The relative roles of external taurine concentration and medium osmolality in the regulation of taurine transport in LLC-PK1 and MDCK cells. Pediatr Res 1995;37:227-232.
22. 1H NMR spectroscopy. J Pharm Biomed Anal 1998;11:897-902.
23. Klahr S, Hammerman M. Renal metabolism. In: Seldin DW, Giebisch G, editors. The kidney: physiology and pathophysiology, vol 1. New York: Raven Press; 1985. p 699-715.
24. 1H NMR studies of reactions of copper-complexes with human blood plasma and urine. Biochem Pharmacol 1992;43:137-145.
25. 1H NMR spectroscopy studies of blood plasma and other biofluids. NMR Biomed 1994;7:243-247.