CSF metabolic and proteomic profiles in patients prodromal for psychosis

PLoS ONE

Volumn 2, Issue 8, 2007, Pages

  Huang, Jeffrey T ^a   Leweke, F Markus ^b   Tsang, Tsz M ^c   Koethe, Dagmar ^b   Kranaster, Laura ^b   Gerth, Christoph W ^b   Gross, Sonja ^b   Schreiber, Daniela ^b   Ruhrmann, Stephan ^b   Schutlze Lutter, Frauke ^b   Klosterkötter, Joachim ^b   Holmes, Elaine ^c   Bahn, Sabine ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF COLOGNE   (Germany)

^c Faculty of Medicine   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID; NEUROPEPTIDE; PREALBUMIN; PROTEIN VGF23-62; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID CIRCULATION DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; FEMALE; HUMAN; MALE; METABOLOMICS; PATHOPHYSIOLOGY; PROTEOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; PSYCHOSIS; SCHIZOPHRENIA; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; SYMPTOM;

ADULT; FEMALE; GLUCOSE; HUMANS; LACTIC ACID; MALE; METABOLOME; NEUROPEPTIDES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PREALBUMIN; PREDICTIVE VALUE OF TESTS; PROTEOME; PROTEOMICS; SCHIZOPHRENIA, PARANOID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; YOUNG ADULT;

EID: 39749171224     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000756     Document Type: Article

References (29)

1. Yung AR, McGorry PD (1996) The prodromal phase of first-episode psychosis: past and current conceptualizations. Schizophr Bull 22: 353-370.
2. Yung AR, Phillips LJ, Yuen HP, Francey SM, McFarlane CA, et al. (2003) Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group. Schizophr Res 60: 21-32.
3. Marshall M, Lewis S, Lockwood A, Drake R, Jones P, et al. (2005) Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry 62: 975-983.
4. Klosterkotter J, Hellmich M, Steinmeyer EM, Schultze-Lutter F (2001) Diagnosing schizophrenia in the initial prodromal phase. Arch Gen Psychiatry 58: 158-164.
5. Ruhrmann S, Schultze-Lutter F, Klosterkotter J (2003) Early detection and intervention in the initial prodromal phase of schizophrenia. Pharmacopsychiatry 36 Suppl 3: S162-167.
6. Phillips LJ, Yung AR, McGorry PD (2000) Identification of young people at risk of psychosis: validation of Personal Assessment and Crisis Evaluation Clinic intake criteria. Aust N Z J Psychiatry 34 Suppl: S164-169.
7. Huang JT, Lewele FM, Oxley D, Wang L, Harris N, et al. (2006) Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis. PLoS Med 3: e428.
8. Holmes E, Tsang TM, Huang JT, Leweke FM, Koethe D, et al. (2006) Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia. PLoS Med 3: e327.
9. Lencz T, Smith CW, McLaughlin D, Auther A, Nakayama E, et al. (2006) Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biol Psychiatry 59: 863-871.
10. Miller TJ, McGlashan TH, Woods SW, Stein K, Driesen N, et al. (1999) Symptom assessment in schizophrenic prodromal states. Psychiatr Q 70: 273-287.
11. Yung AR, Phillips LJ, Yuen HP, McGorry PD (2004) Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr Res 67: 131-142.
12. Lencz T, Smith CW, Auther AM, Correll CU, Cornblatt BA (2003) The assessment of "prodromal schizophrenia": unresolved issues and future directions. Schizophr Bull 29: 717-728.
13. Seidman LJ, Pantelis C, Keshavan MS, Faraone SV, Goldstein JM, et al. (2003) A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus. Schizophr Bull 29: 803-830.
14. Pierre K, Pellerin L (2005) Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 94: 1-14.
15. Hawkins RA, Mans AM, Davis DW (1986) Regional ketone body utilization by rat brain in starvation and diabetes. Am J Physiol 250: E169-178.
16. Fernandes J, Berger R, Smit GP (1982) Lactate as energy source for brain in glucose-6-phosphatase deficient child. Lancet 1: 113.
17. Levi A, Ferri GL, Watson E, Possenti R, Salton SR (2004) Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor. Cell Mol Neurobiol 24: 517-533.
18. Salton SR, Ferri GL, Hahm S, Snyder SE, Wilson AJ, et al. (2000) VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance. Front Neuroendocrinol 21: 199-219.
19. Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, et al. (1999) Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron 23: 537-548.
20. Schreiber G (2002) The evolutionary and integrative roles of transthyretin in thyroid hormone homeostasis. J Endocrinol 175: 61-73.
21. Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276.
22. Strupp M, Schueler O, Straube A, Von Stuckrad-Barre S, Brandt T (2001) "Atraumatic" Sprotte needle reduces the incidence of post-lumbar puncture headaches. Neurology 57: 2310-2312.
23. Morrison AP, French P, Walford L, Lewis SW, Kilcommons A, et al. (2004) Cognitive therapy for the prevention of psychosis in people at ultra-high risk: randomised controlled trial. Br J Psychiatry 185: 291-297.
24. Miller TJ, McGlashan TH, Rosen JL, Somjee L, Markovich PJ, et al. (2002) Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. Am J Psychiatry 159: 863-865.
25. McGorry PD, Yung AR, Phillips LJ, Yuen HP, Francey S, et al. (2002) Randomized controlled trial of interventions designed to reduce die risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatry 59: 921-928.
26. McGlashan TH, Zipursky RB, Perkins D, Addington J, Miller T, et al. (2006) Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis. Am J Psychiatry 163: 790-799.
27. Schultze-Lutter F, Ruhrmann S, Picker HKJ (2006) The Schizophrenia Proneness Instrument (SPI-A) - a tool for the assessment of basic symptoms. European Psychiatry 21: S27.
28. Miller TJ, McGlashan TH, Rosen JL, Cadenhead K, Cannon T, et al. (2003) Prodromal assessment with the structured interview for prodromal syndromes and die scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 29: 703-715.
29. Wittchen HU, Fydrich T (1997) Strukturiertes Klinisches Interview für DSM-IV. Göttingen: Hogrefe.